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Dataset results
94 results for “trabectedin”
Trabectedin derails transcription-coupled nucleotide excision repair to induce DNA breaks in highly transcribed genes
GEO Series GSE245883. Homo sapiens. 30 samples. Type: Other.
Immunometabolic actions of trabectedin and lurbinectedin on human macrophages: Relevance for their antitumor activity
GEO Series GSE235390. Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing.
Effectiveness of irinotecan plus trabectedin in a desmoplastic small round cell tumor patient-derived xenograft [II]
GEO Series GSE227897. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Retrospective Study to Analyze the Efficacy and Safety of Trabectedin and Pegylated Liposomal Doxorubicin (PLD ) in the Treatment of Patients With Platinum-sensitive Recurrent Ovarian Cancer (ROC), Ac
ClinicalTrials.gov study NCT02394015. IPD Sharing: Not stated. Countries: 0. Publications: 0.
YONDELIS (Trabectedin) Single Patient Compassionate Use / Expanded Access
ClinicalTrials.gov study NCT01427582. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Pharmacometabolomic of Trabectedin in Soft Tissue Patients
ClinicalTrials.gov study NCT04394728. IPD Sharing: NO. Countries: 0. Publications: 0.
A Study of Trabectedin in Patients With Advanced Ovarian Cancer
ClinicalTrials.gov study NCT00050414. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Assessing the Combination of Durvalumab (MEDI4736) and Trabectedin in Solid Tumors
ClinicalTrials.gov study NCT03496519. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Trabectedin, Doxorubicin and Olaratumab in Patients With Metastatic or Recurrent Leiomyosarcoma
ClinicalTrials.gov study NCT03437070. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Trabectedin and Irinotecan for Refractory Pediatric Sarcomas
ClinicalTrials.gov study NCT02509234. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effectiveness of irinotecan plus trabectedin in a desmoplastic small round cell tumor patient-derived xenograft
GEO Series GSE220172. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Trabectedin Promotes Oncolytic Virus Antitumor Efficacy, Viral Gene Expression, and Immune Effector Function in Models of Bone Sarcoma
GEO Series GSE260551. Mus musculus; Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Comparison Between Gene Expression Profiles of Sensitive and Resistant Trabectedin Liposarcoma Cell Lines
GEO Series GSE20350. Homo sapiens. 4 samples. Type: Expression profiling by array.
Dataset related to article "Inhibition of tumor-associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti-PD-1 therapy"
<p>This record contains data related to article “Inhibition of tumor-associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti-PD-1 therapy". </p> <p>A considerable proportion of cancer patients are resistant or only partially responsive to immune checkpoint blockade immunotherapy. Tumor-Associated Macrophages (TAMs) infiltrating the tumor stroma suppress the adaptive immune responses and, hence, promote tumor immune evasion. Depletion of TAMs or modulation of their protumoral functions is actively pursued, with the purpose of relieving this state of immunesuppression. We previously reported that trabectedin, a registered antitumor compound, selectively reduces monocytes and TAMs in treated tumors. However, its putative effects on the adaptive immunity are still unclear. In this study, we investigated whether treatment of tumor-bearing mice with trabectedin modulates the presence and functional activity of T-lymphocytes. In treated tumors, there was a significant upregulation of T cell-associated genes, including CD3, CD8, perforin, granzyme B, and IFN-responsive genes (MX1, CXCL10, and PD-1), indicating that T lymphocytes were activated after treatment. Notably, the mRNA levels of the Pdcd1 gene, coding for PD-1, were strongly increased. Using a fibrosarcoma model poorly responsive to PD-1-immunotherapy, treatment with trabectedin prior to anti-PD-1 resulted in improved antitumor efficacy. In conclusion, pretreatment with trabectedin enhances the therapeutic response to checkpoint inhibitor-based immunotherapy. These findings provide a good rational for the combination of trabectedin with immunotherapy regimens.</p> <p> </p>
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.