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1,615 results for “tumour”
Single cell data from Imaging Mass Cytometry of mouse lung tumours treated with KRAS-G12C and immune checkpoint inhibitors (Dataset 3)
Open the record for dataset details and reuse information.
Transcriptome profiling associated with CARD11 overexpres-sion in Colorectal Cancer implicates a potential role for Tumour Immune Microenvironment and Cancer pathways modulation via NF-κB
<p>tables for CARD11</p>
Systematic assessment of tumour purity and its clinical implications
<p>Supplemental data for the study: Systematic assessment of tumour purity and its clinical implications</p>
Transcriptome profiling associated with CARD11 overexpres-sion in Colorectal Cancer implicates a potential role for Tumour Immune Microenvironment and Cancer pathways modulation via NF-κB
<p>Images for CARD11 study in IJMS</p>
Source data sets_Figure 1, 2, 6_Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity
<p>Flow cytometry data files associated with Copland <em>et al., </em><strong><em><span>Salmonella </span></em></strong><strong><span>cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity.</span></strong></p> <p><span>Data associated to Figures 1, 2 and 6. <br></span></p>
Exploration of Biomarkers for the Susceptibility, Early Detection and Treatment Response of Brain Tumours using Epidemiological Techniques
<p>The following resource is from Lily Andrews thesis entitled: Exploration of Biomarkers for the Susceptibility, Early Detection and Treatment Response of Brain Tumours using Epidemiological Techniques. This presents tables that were too large to place in the appendix of the thesis.</p>
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease
<p>***<strong>These data supersede the previous release. Please disregard data uploaded prior to October 30th as the metadata was incorrect - note the correct data in Supplementary Table 1</strong>***</p> <p>A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease. </p> <p>GEO ID for bam files and CellRanger pipeline output (filtered and unfiltered): <strong>GSE282122</strong></p> <p>TAURUS_raw_counts_annotated_final.h5ad: This file is the pooled data across all cell types</p> <p>UMAP_combined_objects.txt.gz: This file has the corresponding UMAP for pooled data</p> <p>PC_combined_objects.txt.gz: This file has the corresponding PC for pooled data</p> <p>paired_sample_list.csv: This file has the paired samples used in analysis for baseline/longitudinal analysis. For baseline analyses, please use baseline samples > 6.5 inflammation score to recapitulate the analyses in the paper.</p> <p>Other data to be uploaded to Zenodo include H&E slides. Please access interactive MDV browser here.</p>
An innovative non-invasive technique for subcutaneous tumour measurements
<p>In oncological drug development, animal studies continue to play a central role in which the volume of subcutaneous tumours is monitored to assess the efficacy of new drugs. The tumour volume is estimated by taking the volume to be that of a regular spheroid with the same dimensions. However, this method is subjective, insufficiently traceable, and is subject to error in the accuracy of volume estimates as tumours are frequently irregular.</p> <p><span>This paper reviews the standard technique for tumour volume assessment, calliper measurements, by conducting a statistical review of a large dataset consisting of 2,500 tumour volume measurements from 1,600 mice by multiple operators across 6 mouse strains and 20 tumour models. Additionally, we explore the impact of six different tumour morphologies on volume estimation and the detection of treatment effects using a computational tumour growth model. Finally, we propose an alternative method to callipers for estimating volume – BioVolume<sup>TM</sup>, a 3D scanning technique. BioVolume simultaneously captures both stereo RGB (Red, Green and Blue) images from different light sources and infrared thermal images of the tumour in under a second. It then detects the tumour region automatically and estimates the tumour volume in under a minute. Furthermore, images can be processed in parallel within the cloud and so the time required to process multiple images is similar to that required for a single image. We present data of a pre-production unit test consisting of 297 scans from over 120 mice collected by four different operators.</span></p> <p><span>This work demonstrates that it is possible to record tumour measurements in a rapid minimally invasive, morphology-independent way, and with less human-bias compared to callipers, whilst also improving data traceability. Furthermore, the images collected by BioVolume may be useful, for example, as a source of biomarkers for animal welfare and secondary drug toxicity / efficacy.</span></p>
Data from: Resource competition promotes tumour expansion in experimentally evolved cancer
Tumour progression involves a series of phenotypic changes to cancer cells, each of which presents therapeutic targets. Here, using techniques adapted from microbial experimental evolution, we investigate the evolution of tumour spreading - a precursor for metastasis and tissue invasion - in environments with varied resource supply. Evolutionary theory predicts that competition for resources within a population will select for individuals to move away from a natal site (i.e. disperse), facilitating the colonisation of unexploited resources and decreasing competition between kin. After approximately 100 generations in environments with low resource supply, we find that MCF7 breast cancer spheroids (small in vitro tumours) show increased spreading. Conversely, spreading slows compared to the ancestor where resource supply is high. Common garden experiments confirm that the evolutionary responses differ between selection lines; with lines evolved under low resource supply showing a plastic spreading phenotype. These differences in spreading behaviour between selection lines are heritable (stable across multiple generations), and show that the divergently evolved lines differ in their response to resource supply. It is possible that prolonged resource limitation itself causes a stable switch toward dispersal-like behaviour and an increased sensitivity to resource availability without the need for genetic change. Different clinical strategies may be needed depending on whether tumour progression is due to stable or plastic effects. This study highlights the effectiveness of experimental evolution approaches in cancer cell populations and demonstrates how simple model systems might enable us to observe and measure key selective drivers of clinically important traits.
pelvic bone tumour dataset
<p>pelvic bone tumour dataset used for deep learning for 2d segmentation and 2d classification of pelvic bone tumours types</p>
Fig. 7 in Alkaloids isolated from Tropaeolum tuberosum with cytotoxic activity and apoptotic capacity in tumour cell lines
Fig. 7. Effects of compounds on the apoptosis of different tumoral cells. Untreated cells as negative reference, with Dimethylenastron (CTK8F1368), as positive reference compound at IC50 = 0.23 μM, with compound 1 at IC50 = 29.06 μM and compound 2 at IC50 = 1.33 μM, for 72 h and were stained with fluorochromes Rho123 (Rhodamine 123) and IP (Propidium Iodide) and evaluated by flow cytometry. p <0.0001 (t Tukey, Two-way ANOVA).
A Bioequivalence Study of Docetaxel Injection in Patients With Solid Tumours
ClinicalTrials.gov study NCT04889599. IPD Sharing: NO. Countries: 1. Publications: 1.
Venous Thromboembolism in Primary Pancreatic Tumour Resection
ClinicalTrials.gov study NCT05964621. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Validation of Tie2 as the First Tumour Vascular Response Biomarker for VEGF Inhibitors: VALTIVE1
ClinicalTrials.gov study NCT04523116. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Complications of Transurethral Resection of the Bladder Tumour
ClinicalTrials.gov study NCT03029663. IPD Sharing: Not stated. Countries: 1. Publications: 1.
TITAN (Tumoural Injection of T-VEC and Isolated Limb Perfusion)
ClinicalTrials.gov study NCT03555032. IPD Sharing: NO. Countries: 1. Publications: 1.
Atezolizumab With Stereotactic Ablative Radiotherapy in Patients With Metastatic Tumours
ClinicalTrials.gov study NCT02992912. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study to Assess Neuroendocrine Tumour (NET) Patients Currently Treated by Somatuline Autogel for History of Carcinoid Syndrome Associated With Episodes of Diarrhea
ClinicalTrials.gov study NCT01234168. IPD Sharing: Not stated. Countries: 8. Publications: 1.
Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible Sensitivity
ClinicalTrials.gov study NCT04273061. IPD Sharing: NO. Countries: 1. Publications: 39.
Effects of Dexmedetomidine During IRE Procedures for Solid Tumours
ClinicalTrials.gov study NCT02044224. IPD Sharing: Not stated. Countries: 1. Publications: 5.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.