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2,012
datasets available to search
ShareScore release 0.9.0
Dataset results
2,012 results for “Kinase”
Transcriptomic analysis of the effects of expression of CDK8/CDK19 and their kinase-inactive mutants in HEK293 cells (WT) and their CDK8/19 double-knockout (dKO) derivatives
GEO Series GSE200753. Homo sapiens. 57 samples. Type: Expression profiling by high throughput sequencing.
RNA-seq analysis of Entamoeba histolytica glycerol 3-phosphate dehydrogenase (G3PDH) and glycerol kinase (EhGK) gene silencing strain
GEO Series GSE240436. Entamoeba histolytica. 9 samples. Type: Expression profiling by high throughput sequencing.
The Mediator kinase module regulates transcriptional memory after heat stress by resolving blocked RNA polymerase complexes
GEO Series GSE232094. Arabidopsis thaliana. 36 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling in three primary human cell lines treated with atorvastatin or an inhibitor of Rho kinase
GEO Series GSE8686. Homo sapiens. 36 samples. Type: Expression profiling by array.
Network of nutrient sensing pathways and a conserved kinase cascade integrates osmolarity and carbon sensing in Neurospora crassa
GEO Series GSE95681. Neurospora crassa. 42 samples. Type: Expression profiling by high throughput sequencing.
Creatine Kinase B Regulates Glycolysis and de novo Lipogenesis Pathways to Control Lipid Accumulation During Adipogenesis
GEO Series GSE307820. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
p38 MAP kinase signaling in microglia plays a sex-specific protective role in CNS autoimmunity and regulates microglial transcriptional states [male]
GEO Series GSE185044. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
PELP1/SRC-3-dependent regulation of metabolic kinases drives therapy resistant ER+ breast cancer [3D]
GEO Series GSE159275. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
LATS kinase-mediated selective disruption of CTCF genomic binding
GEO Series GSE114319. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Leukotriene B4 receptor 1 antagonist in combination with kinase MST1/2 inhibitor has potential for treatment of myocardial infarction
GEO Series GSE181935. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Down-regulation of Polo-like kinase 4 (PLK4) induces G1 arrest via activation of the p38/p53/p21 signalling pathway in bladder
GEO Series GSE180958. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Blockade of oncogenic IkappaB kinase activity in ABC DLBCL by small molecule BET protein inhibitors
GEO Series GSE58791. Homo sapiens. 12 samples. Type: Expression profiling by array.
Developmental regulation of ERK signaling by mitotic kinases
GEO Series GSE262055. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide CRISPR Screen Identifies BUB1 Kinase as a Druggable Vulnerability in Malignant Pleural Mesothelioma
GEO Series GSE292620. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Targeting DNA topoisomerases or checkpoint kinases forces a shift in global protein homeostasis, triggering widespread protein aggregation
GEO Series GSE173940. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Data from: Neuropathy with vascular endothelial growth factor receptor tyrosine kinase inhibitors
Objective: To explore the association of peripheral neuropathy with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) use in cancer patients. Methods: Published data search up to November 2018 reporting peripheral neuropathy in cancer patients treated with VEGFR-TKIs was performed. The primary outcome was presence of peripheral neuropathy at the end of the trial. Random-effects meta-analysis was performed to estimate Relative Risk (RR) of individual treatment. Results: Thirty Randomized Clinical Trials (RCTs) including 12,490 cancer patients were included in this analysis. Eight studies compared VEGFR-TKIs with placebo and the remaining studies compared VEGFR-TKIs with the standard chemotherapeutic regimen. When compared against placebo VEGFR-TKIs were associated with a higher risk of peripheral neuropathy (RR=1.76, 95% CI 1.13-2.75, p-value 0.01). Similarly, a stronger association was noted for sensory neuropathy with VEGFR-TKIs monotherapy (RR = 1.61; 95% CI 1.09-2.37, p = 0.02). Risk of peripheral neuropathy with VEGFR-TKIs was higher even when they were compared against control (either placebo or standard chemotherapeutic agents); RR=1.08, 95% CI 1.01-1.15, p-value 0.03. High-grade neuropathy (RR 1.28, 95% CI 1.06-1.54, p-value <0.01) and high-grade sensory neuropathy (RR 1.38, 95% CI 1.09-1.74, p-value <0.01) were noted more frequently with VEGFR-TKIs treatment compared against control. Conclusions: VEGFR-TKIs therapy appeared to be associated with an increased risk of neuropathy.
Figure 2 from: Sivakumar B, Kaliappan I (2023) Lead drug discovery from imidazolinone derivatives with Aurora kinase inhibitors. Pharmacia 70(4): 1529-1540. https://doi.org/10.3897/pharmacia.70.e114935
Figure 2
Figure 1 from: Sivakumar B, Kaliappan I (2023) Lead drug discovery from imidazolinone derivatives with Aurora kinase inhibitors. Pharmacia 70(4): 1529-1540. https://doi.org/10.3897/pharmacia.70.e114935
Figure 1
Structural Dynamics Support Electrostatic Interactions in the Active Site of Adenylate Kinase - WT and A37G mutant
<p>Tinker MD trajectories of AdK WT and mutants as described in the paper published in ChemBioChem, e202200097.</p>
Targeting non-canonical NF-κB signalling in CYLD cutaneous syndrome by selective inhibition of IκB kinase alpha
<p>CYLD cutaneous syndrome (CCS) skin tumours develop from puberty onwards, can number in the hundreds and progressively grow over time. CCS patients lack medical therapies and require repeated surgery to control tumour burden. CYLD loss of heterozygosity drives tumour growth, and CCS tumours have previously been shown to demonstrate increased canonical NF-KB and Wnt signalling. Here, we demonstrate evidence of non-canonical NF-κB signalling in CCS tumours, with increased p100 to p52 processing and RelB protein expression. Utilising complementary transcriptomics and proteomics on patient derived CCS tumour cell fractions, we identify IκB kinase alpha (IKKα) as a candidate target in the non-canonical NF-κB signalling pathway. A novel, highly selective, IKKα inhibitor in patient derived CCS tumour spheroid cultures demonstrated that IKKα inhibition reduced tumour spheroid viability. These data provide the pre-clinical rationale for the assessment of topical IKKα inhibitors as a novel treatment for CCS.</p> <p>Here we provide CellRanger processed data and an annotated anndata object (.h5ad).</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.