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2,012 results for “Kinase”
Kinases in motion: impact of protein and small molecule interactions on kinase conformations
<p><span>Protein kinases act as central molecular switches in the control of cellular functions. Alterations in the regulation and function of protein kinases may provoke diseases including cancer. In this study we investigate the conformational states of such disease associated kinases using the high sensitivity of the Kinase Conformation (KinCon)reporter system. We first tracked BRAF kinase activity conformation changes upon melanoma drug binding. Second, we also use the KinCon reporter technology to examine the impact of regulatory protein interactions on LKB1kinase tumor suppressor functions. Third, we explore the conformational dynamics of RIP kinases in response to TNF pathway activation and small molecule interactions. Finally, we show that CDK4/6 interactions with regulatory proteins alter conformations which remain unaffected in the presence of clinically applied inhibitors. Apart from its predictive value, the KinCon technology helps identify cellular factors that impact drug efficacies. The understanding of the dynamics of full-length protein kinases when interacting with small molecule inhibitors or regulatory proteins is crucial for designing more effective therapeutic strategies.</span></p>
Crystal structure of the LRR ectodomain from the plant immune receptor kinase SOBIR1 from Arabidopsis thaliana - sulphur SAD datasets
<p>This dataset includes the raw X-ray diffraction images collected on 06.11.2017 at beam line PXIII of the Swiss Light Source (SLS) Villigen, Switzerland. Native (dts_xxx, λ=1.033201 Å, 1 360° wedge at 0.1° oscillation) and redundant sulphur single-wavelength anomalous dispersion (SAD) data (ssad_xxx, λ= 2.078524 Å, 3 360° wedges at 0.1° oscillation) were collected to 1.75 Å and 3.12 Å resolution. The dataset includes a .bz2 archive of the XDS processing for native and sulphur SAD data, data were scaled together in xscale, the resulting xscale.hkl and nat1.hkl contain the integrated intensities and crystallographic structure factors. The corresponding coordinates have been deposited with the Protein Data Bank (http://rcsb.org) with ID 6R1H.</p>
Supplemental Data for "LRRK2 kinase activity regulates lysosomal glucocerebrosidase activity in neurons derived from Parkinson's disease patients"
<p>Sequencing of <em>GBA1</em> gene (all exons) and <em>LRRK2</em> (Exon 31 and 41) for all lines included in the manuscript: LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients. We do not observed unexpected point mutations in these genes in non-mutant cell lines. Primers for exon amplification and sequencing of GBA1 were obtained from Stone et al., 2000. PCR conditions were obtained from Lesage et al., 2011, Neumann et al., 2009, and Stone et al., 2000. </p>
Code and data for "An allosteric switch ensures efficient unidirectional information transmission by the histidine kinase DesK from Bacillus subtilis"
<p>Code and data used in the paper "An allosteric switch ensures efficient unidirectional information transmission in the histidine kinase DesK from <em>Bacillus subtilis"</em></p>
Targeting Phosphoglycerate Kinases by Tatridin A, a natural sesquiterpenoid endowed with anti-cancer activity, by a proteomic platform
<p>Tatridin A (TatA) is a germacrane sesquiterpenoid that contains one E- and one Z- double bond in its 10-membered ring, which is fused to a 3-methylene-di-hydrofuran-2-one moiety. Through a combination of limited proteolysis and molecular docking, it has been discovered that TatA interacts with the active domains of Phosphoglycerate Kinase 1 (PGK1), thereby altering its hinge region. This interaction may account for TatA's inhibitory potency on the enzyme activity. The pdb files of the best complex between TatA and human PGK1 (pdbID: 2WZB) and human PGK2 (obtained from the AlphaFold database with identification number AF-P07205-F1) are reported here, obtained through molecular docking analysis performed using the SwissDock web server.</p>
Kinase Lego Kit
<p>Kinase Lego Kit</p>
Phase Ib/II Clinical Study of Pexa-Vec (Vaccinia GM CSF / Thymidine Kinase-Deactivated Virus) Combined With Recombinant Whole Human Anti-PD-L1 Monoclonal Antibody (ZKAB001) in Metastatic Melanoma
ClinicalTrials.gov study NCT04849260. IPD Sharing: NO. Countries: 1. Publications: 0.
Innovative Biomarkers of Cardiovascular Complications Associated With Second-generation Bruton Tyrosine Kinase Inhibitor Treatments: a Single-center Cohort Study
ClinicalTrials.gov study NCT07174141. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Tyrosine Kinase Inhibitors in Metastastic Adenoid Cystic Carcinoma
ClinicalTrials.gov study NCT04974866. IPD Sharing: NO. Countries: 1. Publications: 0.
Personalized Kinase Inhibitor Therapy Combined With Chemotherapy in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia
ClinicalTrials.gov study NCT02779283. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Aurora B/C Kinase Inhibitor GSK1070916A in Treating Patients With Advanced Solid Tumors
ClinicalTrials.gov study NCT01118611. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dysregulated Tyrosine Kinase Signaling in Leukemia
ClinicalTrials.gov study NCT00277056. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Mobile Intervention (txt4TKI) for the Improvement of Tyrosine Kinase Inhibitor Management in Patients With Chronic Myeloid Leukemia
ClinicalTrials.gov study NCT04694820. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Treatment of Arthritis With Syk Kinase Inhibition (TASKI-1)
ClinicalTrials.gov study NCT00326339. IPD Sharing: Not stated. Countries: 2. Publications: 0.
A Study to Compare Bempegaldesleukin (BEMPEG: NKTR-214) Combined With Nivolumab and Tyrosine Kinase Inhibitor (TKI) to Nivolumab and TKI Alone in Participants With Previously Untreated Kidney Cancer T
ClinicalTrials.gov study NCT04540705. IPD Sharing: Not stated. Countries: 8. Publications: 0.
Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes
ClinicalTrials.gov study NCT00171912. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Evaluate the Effect of Venetoclax on Participants Receiving a Covalent Bruton's Tyrosine Kinase Inhibitor (cBTKi) for First-line Chronic Lymphocytic Leukemia (1L CLL) to Achieve Deep Durabl
ClinicalTrials.gov study NCT06524375. IPD Sharing: YES. Countries: 1. Publications: 0.
Cyclin-Dependent Kinase (CDK)4/6 Inhibitor Abemaciclib for Neurofibromatosis Type I (NF1) Related Atypical Neurofibromas
ClinicalTrials.gov study NCT04750928. IPD Sharing: YES. Countries: 1. Publications: 0.
Vitamin C and Tyrosine Kinase Inhibitor in Lung Cancer Patients With Epidermal Growth Factor Receptor Mutations
ClinicalTrials.gov study NCT03799094. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of DCC-3084 in Participants With Advanced Malignancies Driven by the Mitogen-Activated Protein Kinase (MAPK) Pathway
ClinicalTrials.gov study NCT06287463. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.