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2,532 results for “at present”
CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy
<p>Tumors exploit numerous immune checkpoints including those deployed by myeloid cells to curtail anti-tumor immunity. Here, we show that the C-type lectin receptor CLEC-1 expressed by myeloid cells senses dead cells killed by programmed necrosis. Moreover, we identified TRIM21 as an endogenous ligand over-expressed in various cancers. Interestingly, we observed that in mice CLEC-1 blockade combined with chemotherapy to prolong survival in tumor models. Loss of CLEC-1 reduced the accumulation of immunosuppressive myeloid cells in tumors and invigorated the activation state of dendritic cells (DCs), thereby increasing T cell responses. Mechanistically, we found that the absence of CLEC-1 increased the cross-presentation of dead-cell associated antigens by conventional type-1 DCs. Importantly, we identified anti-human CLEC-1 antagonist antibodies able to enhance anti-tumor immunity in CLEC-1 humanized mice. Altogether, our results demonstrate that CLEC-1 acts as an immune checkpoint in myeloid cells and support CLEC-1 as a novel target for cancer immunotherapy.</p>
Supplementary material 1 from: Aspöck U, Aspöck H, Liu X (2017) The Nevrorthidae, mistaken at all times: phylogeny and review of present knowledge (Holometabola, Neuropterida, Neuroptera). Deutsche Entomologische Zeitschrift 64(2): 77-110. https://doi.org/10.3897/dez.64.13028
Specimens examined and records on which the distribution maps are based : Data type: (measurement/occurence/multimedia/etc.)
Supplementary material 4 from: Aspöck U, Aspöck H, Liu X (2017) The Nevrorthidae, mistaken at all times: phylogeny and review of present knowledge (Holometabola, Neuropterida, Neuroptera). Deutsche Entomologische Zeitschrift 64(2): 77-110. https://doi.org/10.3897/dez.64.13028
Strict consensus tree of 7712 most parsimonious trees generated from the primary data matrix : Data type: (measurement/occurence/multimedia/etc.)
Peptidoform analysis of IP-MS data allows detection of differentially present bait proteoforms
<p>Datasets supporting iPTMs manuscript (https://doi.org/10.1101/2024.01.23.576810)</p>
Illustrative materials for presentation B1113, European Fuel Cell Forum 2024, Lucerne, Switzerland.
<p>Internal EIS data file (text): 18eis1_700c_cc-6a_180h2o+20h2+500air.eisdf</p> <p>Formal equivalent circuit model file (text): 18_drt20240502085244.eism</p> <p>Equivalent circuit model file (text): 18_eqc20240502090321.eism</p> <p>DRT report: 18_drt20240502085232.xlsx</p> <p>Augmented DRT report: 18aug_drt20240502092610.xlsx</p> <p>Equivalent circuit fit report: 18_eqc20240502090124.xlsx<br><br></p>
Figure 2 in The current state of DNA barcoding of macroalgae in the Mediterranean Sea: presently lacking but urgently required
Figure 2: Rhodophyta data by country from Taxonomy page on the Barcode of Life Data System (BOLD). Source: http://www.boldsystems.org/index.php/TaxBrowser_Home
Figure 6 in The current state of DNA barcoding of macroalgae in the Mediterranean Sea: presently lacking but urgently required
Figure 6: Pinnate fronds of Caulerpa taxifolia var. distichophylla growing among the white flabellate blades of Padina sp. Photo taken in Maltese waters in June 2017.
Figure 1 in The current state of DNA barcoding of macroalgae in the Mediterranean Sea: presently lacking but urgently required
Figure 1: Polygon used to delineate the Mediterranean Sea whilst searching for records in the Barcode of Life Data System (BOLD). Source: http://www.boldsystems.org/
Figure 5 in The current state of DNA barcoding of macroalgae in the Mediterranean Sea: presently lacking but urgently required
Figure 5: DNA barcoding of macroalgae by Mediterranean country: Italy, France, Croatia, Spain and Greece lead in the literature-based results.
Figure 4 in The current state of DNA barcoding of macroalgae in the Mediterranean Sea: presently lacking but urgently required
Figure 4: DNA barcoding by country obtained from the literature-based results of 121 papers: USA, Canada, Korea, Australia, Chile and France lead in the number of barcodes world-wide.
Genetic diversity and spread dynamics of SARS-CoV-2 variants present in African populations
<p>The dynamics of coronavirus disease-19 (COVID-19) have been extensively researched in many settings around the world, but little is known about these patterns in Africa. 7540 complete nucleotide genomes from 51 African nations were obtained and analysed from the National Center for Biotechnology Information (NCBI) and Global Initiative on Sharing Influenza Data (GISAID) databases to examine genetic diversity and spread dynamics of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) lineages circulating in Africa. Utilising a variety of clade and lineage nomenclature schemes, we looked at their diversity, and used maximum parsimony inference methods to recreate their evolutionary divergence and history. According to this study, only 465 of the 2610 Pango lineages found to have existed in the world circulated in Africa after three years of the COVID-19 pandemic outbreak, with five different lineages dominating at various points during the outbreak. We identified South Africa, Kenya, and Nigeria as key sources of viral transmissions between Sub-Saharan African nations. These findings provide insight into the viral strains that are circulating in Africa and their evolutionary patterns.</p>
Table presenting field data, isotopic data and 10Be exposure ages of cliffs and caprock-derived boulders sampled on the southern slope of the mesa of Szczeliniec Wielki (Central Sudetes, Stołowe Mountains, SW Poland)
<p><span>This research was funded by National Science Centre, Poland, research project no. 2020/39/D/ST10/00861.</span></p> <p><span>The data in the table presents the results of cosmogenic </span><sup><span>10</span></sup><span>Be exposure dating of cliffs and hillslope boulders resting on the southern slope of the sandstone mesa of Szczeliniec Wielki (Central Sudetes, Stołowe Mountains, SW Poland). The total of 20 samples was collected with growing distance from the present-day cliff lines. The samples were collected in October 2021, whereas their treatment and analyses were conducted in the following months at the University of Zurich (UZH) and ETH Zurich, Switzerland.</span></p> <p> </p> <p> </p>
Equilibrium chemical composition of impact-produced hot cloud during isentropic expansion. The initial temperature T0 is 4000 K, the initial pressure P0 is 5, 20, and 80 bar. Calculations are performed using the EQL program. Abundances of considered species are presented in molar fractions.The elemental composition of impact-produced cloud is taken as a mixture of CI chondrite, mare basalts, and ferroan anorthosite with a ratio of 1:25:25 by mass as in Berezhnoy (2013).
<p>Considered species include ions, neutral gas-phase species, and condensates. Ions are written as ...(+) (for example, Al(+)). Condensates (solids and liquids) are written as ...(c) or ...(c;...). Examples of condensates are Al2O3(c) and Al2O3(c; gamma). For species marked in theirs names as (cr, l) in Gurvich et al. (1989) (for example, Al2O3(cr, l)) it is possible to determine a state of matter (liquid or solid). The content of studied species is 0 if the relative molar fraction is less than 1e-21. </p> <p>The elemental composition of impact-produced cloud is taken as a mixture of CI chondrite, mare basalts, and ferroan anorthosite with a ratio of 1:25:25 by mass as in Berezhnoy (2013). </p> <p>Calculations of the equilibrium chemical composition of impact-produced clouds were performed starting from an initial temperature of 4000 K at different initial pressures of 5, 20, and 80 bar, corresponding to entropies equal to 7.2, 5.56, and 4.25 kJ / (kg×K), respectively. </p> <p>Berezhnoy, A.A., 2013. Chemistry of impact events on the Moon. Icarus 226, 205-211.</p> <p>Gurvich L.V., Veitz I.V. et al. Thermodynamic properties of individual substances. Fourth edition in 5 volumes. Hemisphere Pub Co. New York-London, 1989.</p>
Development of species known from each of Maranhão's river basins. Numbers of species from the original CLOFFBR-MA in blue, additions from the present update in red. in CLOFFBR-MA - update 1 - supplement to Checklist of the freshwater fishes of Maranhão, Brazil.
Development of species known from each of Maranhão's river basins. Numbers of species from the original CLOFFBR-MA in blue, additions from the present update in red.
FIGURA 4 in Una nueva especie del género Corbicula (Bivalvia: Cyrenidae) presente en el bajo Ebro
FIGURA 4. Hábitats donde se localizaron los ejemplares de CorbiculO sp.A: canal de riego de Camarles,con el fondo tapizado con material plástico,a su vez infestado de puestas de PomOceO mOculOtO; B: azud de Tivenys / Xerta;C: playa fluvial a escasos metros del azud;D-F: ejemplares vivos de CorbiculO sp.en fondo de arena y grava en el río Ebro.
FIGURA 2 in Una nueva especie del género Corbicula (Bivalvia: Cyrenidae) presente en el bajo Ebro
FIGURA 2. Fotografía de ejemplares de CorbiculO sp.,en diferentes estadios de desarrollo.Escalas:A: 0,5 cm;B-I: 1 cm.
Safina WP3 contents (short presentation)
<p><span>This work has been funded by the European Union - NextGenerationEU under the Italian </span> <span>Ministry of University and Research (MUR) National Innovation Ecosystem grant ECS00000041 </span> <span>– VITALITY – CUP E13C22001060006</span></p>
Safina WP1 contents (short presentation)
<p><span>This work has been funded by the European Union - NextGenerationEU under the Italian </span> <span>Ministry of University and Research (MUR) National Innovation Ecosystem grant ECS00000041 </span> <span>– VITALITY – CUP E13C22001060006</span></p>
Safina WP4 contents (short presentation)
<p><span>This work has been funded by the European Union - NextGenerationEU under the Italian </span> <span>Ministry of University and Research (MUR) National Innovation Ecosystem grant ECS00000041 </span> <span>– VITALITY – CUP E13C22001060006</span></p>
EUreka3D presentation video
<p><span>EUreka3D is an EU co-funded project under the Digital Europe Programme t</span><span>o support digital transformation of the cultural heritage sector, with a specific focus on 3D. It is a support project for the wider EU initiative aimed at creating a European common data space for cultural heritage.</span></p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.