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1,036
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Dataset results
1,036 results for “Cell mechanics”
Mechanisms of drugs-resistance in small cell lung cancer III
GEO Series GSE280212. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Multi-tissue single cell profiling of genetically diverse mouse models reveals mechanisms of resilience to obesity and diabetes [scATAC-seq_islet]
GEO Series GSE272038. Mus musculus. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
KRAS inhibitor-resistance in MET-amplified KRASG12C 1 non-small cell lung cancer induced by RAS- and non-RAS-mediated cell signaling mechanism
GEO Series GSE179212. Homo sapiens. 4 samples. Type: Expression profiling by array.
Protective effect and mechanism of lipid perioxide in TNF-a induced apoptosis of intestinal epithelial cells in IBD.
GEO Series GSE249872. Mus musculus; Homo sapiens. 22 samples. Type: Expression profiling by high throughput sequencing.
Single-cell and spatial transcriptomic atlas of pathological scars uncovers neuro-fibroblast crosstalk mechanisms across scar types
GEO Series GSE307504. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Other.
Caloric Restriction Triggers Anti-tumor Immunity via a Mechanism Involving NK Cells and Transcription Factor Eomesdermin
GEO Series GSE121488. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
A Time-dependent Glia cell-Mediated Neuroprotective Effects of Kv7/KCNQ channel opener QO-83 in Ischemic Stroke: Mechanisms of Action and Therapeutic Potential
GEO Series GSE244576. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional and chromatin-based partitioning mechanisms uncouple protein scaling from cell size
GEO Series GSE167842. Schizosaccharomyces pombe; Saccharomyces cerevisiae. 72 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Estrogen-independent Epigenetic Mechanisms Regulate Gender Dimorphisms in Cardiac Reparative Functions of Bone Marrow Progenitor Cells [Cut & Tag]
GEO Series GSE253057. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Cell-type-specific RNA Pol II activity maps in intact-tissues: gateway to mammalian gene regulatory mechanisms in vivo [ChIP-seq]
GEO Series GSE278912. Mus musculus. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Cord blood multipotent stromal cells exploit a unique immune suppressive mechanism
GEO Series GSE23366. Homo sapiens. 2 samples. Type: Expression profiling by array.
Dataset related to the article "Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1"
<p>This record contains graph data related to the article “<strong>Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1</strong>”</p> <p> </p> <p>Abstract</p> <p><strong>Rationale</strong> - Despite the preferred application of arterial conduits, the greater saphenous vein (SV) remains indispensable for coronary bypass grafting (CABG), especially in multi-vessel coronary artery disease (CAD). The objective of the present work was to address the role of mechanical forces in the activation of maladaptive vein bypass remodeling, a process determining progressive occlusion and recurrence of ischemic heart disease.</p> <p><strong>Methods </strong>- We employed a custom bioreactor to mimic the coronary shear and wall mechanics in human SV vascular conduits and reproduce experimentally the biomechanical conditions of coronary grafting and analyzed vein remodeling process by histology, histochemistry and immunofluorescence. We also subjected vein-derived cells to cyclic uniaxial mechanical stimulation in culture, followed by phenotypic and molecular characterization using RNA and proteomic methods. We finally validated our results <em>in vitro</em> and using a model of SV carotid interposition in pigs.</p> <p><strong>Results - </strong>Exposure to pulsatile flow determined a remodeling process of the vascular wall involving reduction in media thickness. Smooth muscle cells (SMCs) underwent conversion from contractile to synthetic phenotype. A time-dependent increase in proliferating cells expressing mesenchymal (CD44) and early SMC (SM22α) markers, apparently recruited from the SV adventitia, was observed especially in CABG-stimulated vessels. Mechanically stimulated SMCs underwent transition from contractile to synthetic phenotype. MALDI-TOF-based secretome analysis revealed a consistent release of Thrombospondin-1 (TSP-1), a matricellular protein involved in TGF-β-dependent signaling. TSP-1 had a direct chemotactic effect on SV adventitia resident progenitors (SVPs); this effects was inhibited by blocking TSP-1 receptor CD47. The involvement of TSP-1 in adventitial progenitor cells differentiation and graft intima hyperplasia was finally contextualized in the TGF-β-dependent pathway, and validated in a saphenous vein into carotid interposition pig model.</p> <p><strong>Conclusions -</strong> Our results provide the evidence of a matricellular mechanism involved in the human vein arterialization process controlled by alterations in tissue mechanics, and open the way to novel potential strategies to block VGD progression based on targeting cell mechanosensing-related effectors.</p>
Systems pharmacology dissection of cell specific cholesterol regulation mechanisms
<p>Documentation of codes used for modeling cholesterol regulation in the manuscript "Systems pharmacology dissection of cell specific cholesterol regulation mechanisms"</p>
Redox-dependent mechanisms of dysregulation of P19 cell line apoptosis in hypoxia
<p>Dissertation research dataset.</p> <p>Modulation of oxidative modification of proteins (glutathionylation and carbonylation) and redox homeostasis of the tumor cell under hypoxia are one of the promising approaches to targeted regulation of apoptosis.</p>
Keizer et al. "Live-cell micromanipulation of a genomic locus reveals interphase chromatin mechanics'" – Data, software and documentation (main github repository)
<p>Files that will be uploaded to <a href="https://github.com/CoulonLab/Keizer-et-al">https://github.com/CoulonLab/Keizer-et-al</a> upon acceptance.</p>
Mechanism of cytotoxic action of A549 cell during photothermal therapy
<p>Figures</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.