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Dataset results
1,112 results for “effector”
Dataset related to article "NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions"
<p>This record contains data related to article "NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions"</p> <p> </p> <p>Human Vδ2 cells are innate-like γδ T effectors performing potent immune surveillance against tumors. The constitutive expression of NKG2A identifies a subset of Vδ2 T cells licensed with an intrinsic hyper-responsiveness against cancer. Indeed, the transcriptomic profiles of NKG2A+ and NKG2A- cells characterize two distinct "intralineages" of Vδ2 T lymphocytes that appear early during development, keep their phenotypes, and show self-renewal capabilities in adult life. The hyper-responsiveness of NKG2A+ Vδ2 T cells is counterbalanced by the inhibitory signaling delivered by human leukocyte antigen E (HLA-E) expressed on malignant cells as a tumor-escape mechanism. However, either masking or knocking out NKG2A restores the capacity of Vδ2 T cells to exert the highest effector functions even against HLA-E+ tumors. This is highly relevant in the clinic, as the different degrees of engagement of the NKG2A-HLA-E checkpoint in hepatocellular carcinoma, glioblastoma, and non-small cell lung cancer directly impact patients' overall survival. These findings open avenues for developing combined cellular and immunologic anticancer therapies.</p>
IL-23 stabilizes an effector Treg program in the tumor microenvironment
GEO Series GSE224072. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Codon-mediated translational control of M. oryzae effectors
GEO Series GSE297821. Oryza sativa. 6 samples. Type: Expression profiling by high throughput sequencing.
Effector differentiation and therapeutic reinvigoration of CD8+ T cells in chronic infection depend on KLF2-directed lymph node homing
GEO Series GSE268824. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Hematopoietic database: including HSCs, progenitors and effector cells
GEO Series GSE55732. Mus musculus. 0 samples. Type: Expression profiling by array; Third-party reanalysis.
Single cell gene and protein expression of 2W:I-Ab specific cells from effector and memory T cells after aLm infection.
GEO Series GSE250239. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Differentially Expressed Genes in Males and Females with Ankylosing Spondylitis (AS): Discrete Effectors in IL-17-producing Cells of Patients with AS.
GEO Series GSE221786. Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing.
IL-25-induced effector-memory ILC2s mediate small intestinal adaptation [scRNA-Seq 1]
GEO Series GSE301975. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Ets1 dampens expression of Tbet and CD8- or NK-like effector programing in postselection iNKT1 cells [RNA-seq]
GEO Series GSE278708. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Effectors enabling adaptation to mitochondrial complex I loss in Hürthle cell carcinoma
GEO Series GSE228870. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
Fumarylacetoacetate hydrolase targeted by a Fusarium graminearum effector positively regulates wheat FHB resistance and yield and promotes heading
GEO Series GSE254427. Triticum aestivum. 6 samples. Type: Expression profiling by high throughput sequencing.
Cxcr3+ CD62L+ effector CD8+ T cells function as precursor of central memory cells
GEO Series GSE184804. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Zfp335 establishes neonatal immune tolerance through safeguarding effector Treg lineage commitment and maintenance [RNA-seq]
GEO Series GSE189075. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
High-throughput discovery and characterization of viral transcriptional effectors in human cells
GEO Series GSE224325. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing.
Single-cell analysis revealed the role of CD8+ effector T cells in preventing cardioprotective macrophage differentiation in the early phase of heart failure
GEO Series GSE183405. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
NR2F2 is a key downstream effector of NF1 loss in estorgen receptor positive breast cancer
GEO Series GSE217418. Homo sapiens. 136 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
The NAE1-mediated neddylation operates as an essential posttranslational modification checkpoint for effector CD8+ T cells
GEO Series GSE289216. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Dhx9 controls effector CD8 T cell differetiation program
GEO Series GSE161489. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
The root-knot nematode effector MiEFF12 targets the host ER quality control system to suppress immune responses and allow parasitism
GEO Series GSE263603. Arabidopsis thaliana. 3 samples. Type: Expression profiling by high throughput sequencing.
The Root-Knot Nematode Effector MiEFF18 Targets the Core Spliceosomal Protein SmD1 and Facilitates Giant Cell Formation
GEO Series GSE153171. Arabidopsis thaliana. 9 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.