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1,127 results for “Cell cycle”
Single-nucleus transcriptomics identifies dysregulation of cell cycle control and synaptic pathways during the progression of murine proneural gliomas.
GEO Series GSE309333. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Tumor treating fields affect mesothelioma cell proliferation by exerting histotype-dependent cell cycle checkpoint activations and transcriptional modulations"
<p>This record contains data related to article "Tumor treating fields affect mesothelioma cell proliferation by exerting histotype-dependent cell cycle checkpoint activations and transcriptional modulations"</p> <p>Although clinical antitumor activity of Tumor Treating Fields (TTFields) has been reported in malignant pleural mesothelioma (MPM) patients, the mechanisms behind the different selectivity displayed by the various MPM histotypes to this physical therapy has not been elucidated yet.</p> <p>Taking advantage of the development of well characterized human MPM cell lines derived from pleural effusion and/or lavages of patients’ thoracic cavity, we investigated the biological effects of TTFields against these cells, representative of epithelioid, biphasic and sarcomatoid histotypes. Growth inhibition and cell cycle perturbations caused by TTFields were investigated side by side with RNA-Seq analyses at different exposure times to identify pathways involved in cell response to treatment.</p> <p>We observed significant differences of response to TTFields among the cell lines. Cell cycle analysis revealed that the most sensitive cells (epithelioid CD473) were blocked in G<sub>2</sub>M phase followed by formation of polyploid cells. The least sensitive cells (sarcomatoid CD60) were only slightly affected by TTFields with a general delay in all cell cycle phases. Apoptosis was present in all samples, but while epithelioid cell death was already observed during the first 24h of treatment, sarcomatoid cells needed longer times before they engaged apoptotic pathways.</p> <p>RNA-Seq experiments demonstrated that TTFields induced a transcriptional response already detectable at early time points (8h). The number of differentially expressed genes was higher in CD473 than in CD60 cells, involving several pathways, such as those pertinent to cell cycle checkpoints, DNA repair and histone modifications.</p> <p>Our data provide further support to the notion that the antitumor effects of TTFields are not simply related to a non-specific reaction to a physical stimulus, but are dependent on the biological background of the cells and the particular sensitivity to TTFields observed in epithelioid MPM cells is associated with a higher transcriptional activity than that observed in sarcomatoid models.</p>
De Novo Purine Synthesis Mediates Circadian Control of Cell Cycle in Zebrafish
GEO Series GSE51279. Danio rerio. 29 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing.
Cell cycle heterogeneity directs spontaneous 2C state entry and exit in mouse embryonic stem cells (RNA-Seq)
GEO Series GSE171258. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Induced Endothelial Cell Cycle Arrest Prevents Arterio-venous Malformations in Hereditary Hemorrhagic Telangiectasia
GEO Series GSE244923. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
BPTF cooperates with MYCN/MYC to link neuroblastoma cell cycle control with epigenetic cell states
GEO Series GSE256511. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Effects of hair keratin on cell cycle regulation of human periodontal ligament cells in histidine-tryptophan-ketoglutarate-based storage media
GEO Series GSE269474. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Cell cycle analysis of histone marks and 4C in human Fucci ESCs
GEO Series GSE61176. Homo sapiens. 28 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
Novel Ribociclib Derivative RB-1 Exhibits Anti-breast Cancer Actions by Regulating p53 and Cell Cycle Pathways
GEO Series GSE294375. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
GIST cell cycle dysregulation is required for progression to high-risk disease but not for resistance to kinase inhibitors
GEO Series GSE59841. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Profiling of Cell cycle genes dysregulated by knockdown of lncRNAs at 8q24.21 using Nanostring Gene Expression Assay
GEO Series GSE38966. Homo sapiens. 24 samples. Type: Expression profiling by array.
Pentamethylquercetin induces Hep3B liver cancer cell apoptosis and cell cycle arrest via the ERK/NF-κB signaling pathway
GEO Series GSE244233. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
B-cell transcription factor PAX5 functions as a tumor suppressor by regulating the cell cycle in primary effusion lymphoma
GEO Series GSE160276. Homo sapiens. 2 samples. Type: Expression profiling by array.
Cell cycle-dependent YTHDF2 promotes mitotic entry by repressing WEE1
GEO Series GSE134700. Homo sapiens. 40 samples. Type: Expression profiling by high throughput sequencing; Other.
Cohesin interacts with a panoply of splicing factors required for cell cycle progression and genomic organization
GEO Series GSE114539. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Immunomodulatory properties of slowly cycling and mesenchymal-like castration-resistant prostate cancer stem cells
GEO Series GSE123160. Mus musculus. 70 samples. Type: Expression profiling by high throughput sequencing.
Large scale mapping of environmental-genetic interactions illustrates the dynamic nature of cell cycle and DNA repair regulation
GEO Series GSE312636. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing; Other.
Single cell sequencing to investigate the alteration of urea cycle in DFMO treated mouse
GEO Series GSE175805. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Cancer associated mutants of eIF1A impair Rps3/Rps10 binding and enhance scanning of cell cycle genes
GEO Series GSE116983. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Other.
Mcph1 inactivation affected cell cycle progression and survival of neocortical progenitors at the molecular level
GEO Series GSE140976. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.