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2,236 results for “inhalation”
Data from: Video education versus face-to-face education on inhaler technique for patients with well-controlled or partly-controlled asthma: a phase IV, open-label, non-inferiority, multicenter, randomized, controlled trial
Background: Education on inhaler technique is critical for effective asthma treatment. However, traditionally used face-to-face education is a time-consuming, costly, and often laborious. The current study evaluated the efficacy of a newly developed video-based inhaler technique education method. Methods: A total of 184 subjects with well-controlled or partly-controlled asthma were enrolled from 12 hospitals in South Korea from 30 November 2015 to 01 June 2016. Subjects were randomly divided into two groups in a 1:1 ratio; a control group that received face-to-face education, and an study group that received video education. All subjects received fluticasone propionate plus salmeterol xinafoate (Fluterol® 250/50 inhalation capsules) for 12 weeks. The primary outcome measure was forced expiratory volume in the 1st second (FEV1) at 12 weeks. The secondary outcome measures were change in FEV1 at 4 weeks, change in asthma control test (ACT) score, and changes in various inhaler technique parameters. These measures were assessed with a non-inferiority margin of 10% between the control group and the study group. Results: FEV1 was significantly improved at 12 weeks in the control group and the study group. After adjustment, FEV1 improvement was not significantly inferior in the study group compared to the control group. The secondary outcome measures, including change in FEV1 at 4 weeks, ACT score, and various parameters pertaining to inhaler technique and satisfaction at 4 and 12 weeks did differ not significantly in the two groups. In subgroup analysis of elderly subjects and subjects with well-controlled asthma, FEV1 was significantly improved at 12 weeks in the study group but not the control group. Conclusion: The newly developed video education technique investigated functioned as a suitable substitute for face-to-face education on inhaler technique (dry powder inhalation capsule) in patients with stable asthma, particularly in elderly patients and patients with well-controlled asthma.
Data from: Estimation of inhalation flow profile using audio-based methods to assess inhaler medication adherence
Asthma and chronic obstructive pulmonary disease (COPD) patients are required to inhale forcefully and deeply to receive medication when using a dry powder inhaler (DPI). There is a clinical need to objectively monitor the inhalation flow profile of DPIs in order to remotely monitor patient inhalation technique. Audio-based methods have been previously employed to accurately estimate flow parameters such as the peak inspiratory flow rate of inhalations, however, these methods required multiple calibration inhalation audio recordings. In this study, an audio-based method is presented that accurately estimates inhalation flow profile using only one calibration inhalation audio recording. Twenty healthy participants were asked to perform 15 inhalations through a placebo Ellipta™ DPI at a range of inspiratory flow rates. Inhalation flow signals were recorded using a pneumotachograph spirometer while inhalation audio signals were recorded simultaneously using the Inhaler Compliance Assessment device attached to the inhaler. The acoustic (amplitude) envelope was estimated from each inhalation audio signal. Using only one recording, linear and power law regression models were employed to determine which model best described the relationship between the inhalation acoustic envelope and flow signal. Each model was then employed to estimate the flow signals of the remaining 14 inhalation audio recordings. This process repeated until each of the 15 recordings were employed to calibrate single models while testing on the remaining 14 recordings. It was observed that power law models generated the highest average flow estimation accuracy across all participants (90.89±0.9% for power law models and 76.63±2.38% for linear models). The method also generated sufficient accuracy in estimating inhalation parameters such as peak inspiratory flow rate and inspiratory capacity within the presence of noise. Estimating inhaler inhalation flow profiles using audio based methods may be clinically beneficial for inhaler technique training and the remote monitoring of patient adherence.
Preprocedural Fasting and Nitrous Oxide -Oxygen Inhalation Analgesia for Dental Treatment of Children
ClinicalTrials.gov study NCT00263289. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Pharmacokinetic Study Evaluating Staccato® Alprazolam 1 mg Inhaler in Smokers Versus Non-Smokers
ClinicalTrials.gov study NCT03516305. IPD Sharing: NO. Countries: 1. Publications: 0.
Treatment of Acute Asthma in ER With Combination of Systemic Steroids and Inhaled Steroids
ClinicalTrials.gov study NCT00397267. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Inspiratory Flow Parameters and Handling of Easyhaler and Turbuhaler Inhalers
ClinicalTrials.gov study NCT00984906. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Dynamic Assessment of Right Ventricular Function With Inhaled Nitric Oxide During Cardiac MRI
ClinicalTrials.gov study NCT02220023. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety of Single Doses of Indacaterol Delivered Via a Single Dose Dry Powder Inhaler (SDDPI) Compared to Placebo in Patients With Persistent Asthma
ClinicalTrials.gov study NCT00403637. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Tiotropium/Salmeterol Inhalation Powder (Spiriva Handihaler and Salmeterol Polyethylene (PE) Capsule) in Chronic Obstructive Pulmonary Disease (COPD)
ClinicalTrials.gov study NCT00662740. IPD Sharing: YES. Countries: 18. Publications: 0.
Clinical Trial Investigating the Effects of EP395 Following an Inhaled Endotoxin Challenge in Healthy Adults
ClinicalTrials.gov study NCT06677918. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of Inhaled Iloprost in Pediatric Pulmonary Hypertension (PH) After Surgery
ClinicalTrials.gov study NCT01310751. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Inhalational Anesthesia vs TIVA in Endoscopic Tympanoplasty
ClinicalTrials.gov study NCT05993039. IPD Sharing: NO. Countries: 1. Publications: 0.
Inhaled Hypertonic Saline for Bronchiolitis
ClinicalTrials.gov study NCT02253576. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study To Evaluate the Safety of XW001 Inhalation in Children With RSV
ClinicalTrials.gov study NCT05779995. IPD Sharing: NO. Countries: 1. Publications: 0.
Differential Gene Expression in Lung and Peripheral Blood After Inhaled Allergen Challenge
ClinicalTrials.gov study NCT00671593. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Inhaled Sodium Pyruvate for the Treatment of Cystic Fibrosis.
ClinicalTrials.gov study NCT00308243. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Inhaled Iloprost, Dynamic Hyperinflation, and Oxidative Stress in COPD Patients
ClinicalTrials.gov study NCT01941225. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of the Respimat Inhaler vs. a HFA MDI Using Berodual in Patients With COPD With Poor MDI Technique.
ClinicalTrials.gov study NCT00267917. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Single-dose, Randomised, Crossover, Placebo-controlled Study Assessing Two Fixed-dose Combinations of Inhaled Long-acting Beta-agonist and Corticosteroid
ClinicalTrials.gov study NCT02094274. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Study Evaluating Inhaled AeroLEF (Liposome-Encapsulated Fentanyl)in Normal Healthy Subjects
ClinicalTrials.gov study NCT00708318. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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