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Dataset results
1,986 results for “valve”
Stretch responsive miRNAs in human aortic valve interstitial cells
GEO Series GSE49558. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Spinster homolog 1 (spns1)-dependent endocardial autophagy-lysosomal pathway drives valve morphogenesis through the control of Notch1 signaling.
GEO Series GSE246850. Danio rerio. 4 samples. Type: Expression profiling by high throughput sequencing.
Multiple cell trypes, incluiding melanocytes, contribute to elastogenesis in the developing murine aortic valve
GEO Series GSE254500. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Non-canonical Telomerase Reverse Transcriptase Controls Osteogenic Reprogramming of Aortic Valve Cells Through STAT5
GEO Series GSE274226. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
RNAseq of mitral valves from Fbn1 mutant and control mice at 5 months
GEO Series GSE137681. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to the article "Culture into perfusion-assisted bioreactor promotes valve-like tissue maturation of recellularized pericardial membrane"
<p>This record contains raw data related to the article “<strong>Culture into perfusion-assisted bioreactor promotes valve-like tissue maturation of recellularized pericardial membrane</strong>”</p> <p><strong>Abstract</strong></p> <p>Derivation of tissue-engineered valve replacements is a strategy to overcome the limitations of the current valve prostheses, mechanical or biological. In an effort to set living pericardial material for aortic valve reconstruction, we have previously assessed the efficiency of a recellularization strategy based on a perfusion system enabling mass transport and homogenous distribution of aortic valve-derived ‘interstitial’ cells inside decellularized pericardial material. In the present report, we show that oscillating perfusion favours deposition of valve proteins in the decellularized pericardium determining a partial tissue maturation. Investigation of cell dynamics inside the recellularized tissue constructs showed proliferation of valve cells inside the pericardial material and activity of a proliferation-supporting pathway, likely controlled by the YAP transcription factor, a crucial component of the Hippo-dependent signalling cascade. These results represent a step forward in the definition of a strategy to produce a fully engineered tissue for replacing the failing aortic valves.</p> <p> </p>
Data from: Severity of mitral valve degeneration is associated with chromosome 15 loci in Whippet dogs
Mitral valve degeneration (MVD) is the most common form of heart disease in dogs, frequently leading to left-sided congestive heart failure and cardiac mortality. Although breed-specific disease characteristics and overrepresentation point towards a genetic origin for MVD, a causative mutation and complete molecular pathogenesis are unknown. Whippet dogs are overrepresented in incidence of MVD, suggesting an inherited component in this breed. Expressivity of this condition is variable with some dogs showing evidence of more severe disease at earlier ages than other dogs. This phenomenon makes a traditional case versus control genetic study prone to phenotyping error. This study sought to avoid these common pitfalls by identifying genetic loci associated with severity of MVD in Whippets through a genome-wide association study (GWAS). 138 Whippet dogs were characterized for MVD by echocardiographic examination and a novel disease severity score was developed and adjusted for age in each subject. Single nucleotide polymorphism (SNP) genotype data (170k Illumina CanineHD SnpChip) was obtained for DNA isolated from blood of each study subject. Continuous variable genome wide association was performed after correction for population stratification by efficient mixed model association expedited (EMMAX) in 130 dogs. A genome wide significant association was identified on chromosome 15 (peak locus 57,770,326; Padj = 0.049) and secondary loci of suggestive association were identified on chromosome 2 (peak locus 37,628,875; Padj = 0.079). Positional candidate genes were identified within the primary and secondary loci including follistatin-related protein 5 precursor (FSTL5) and Rho GTPase-activating protein 26 (ARHGAP26). These results support the hypothesis that severity of MVD in whippets has a genetic basis and warrants further study by either candidate gene sequencing or next-generation techniques.
Bayard Station Valve House
"Bayard Station was once the headquarters for the Chesapeake Gas Company of Baltimore City, which merged with several other companies eventually becoming BGE. During the station's heyday, the gas works spread over 14 acres. The complex included the Valve House; four large telescoping holding tanks, called "gasometers;" and a series of processing buildings, of which one remains today across Hamburg Street. The gas was manufactured, stored in the gasometers, and then piped into the valve house where it was compressed before being directed into the main lines of the city." -[Baltimore Heritage](https://explore.baltimoreheritage.org/items/show/115) Today, this building is home to an architectural salvage company called [Housewerks](https://housewerkssalvage.com/pages/about-us). Since they purchased the building in 2005, they have worked to preserve the structure and have placed it on the National Register of Historic Places. Created in RealityCapture from 839 images taken with a Nikon D750 and a drone. Source: Objaverse 1.0 / Sketchfab
Dataset related to the article "Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance"
<p>This record contains raw data related to the article "Isolated Valve Amyloid Deposition in Aortic Stenosis: Potential Clinical and Pathophysiological Relevance"</p> <p>Abstract: Amyloid deposition within stenotic aortic valves (AVs) also appears frequent in the absence of cardiac amyloidosis, but its clinical and pathophysiological relevance has not been investigated. We will elucidate the rate of isolated AV amyloid deposition and its potential clinical and pathophysiological significance in aortic stenosis (AS). In 130 patients without systemic and/or cardiac amyloidosis, we collected the explanted AVs during cardiac surgery: 57 patients with calcific AS<br>and 73 patients with AV insufficiency (41 with AV sclerosis and 32 without, who were used as controls). Amyloid deposition was found in 21 AS valves (37%), 4 sclerotic AVs (10%), and none of the controls. Patients with and without isolated AV amyloid deposition had similar clinical and echocardiographic characteristics and survival rates. Isolated AV amyloid deposition was associated with higher degrees of AV fibrosis (p = 0.0082) and calcification (p < 0.0001). Immunohistochemistry analysis suggested serum amyloid A1 (SAA1), in addition to transthyretin (TTR), as the protein possibly involved in AV amyloid deposition. Circulating SAA1 levels were within the normal range<br>in all groups, and no difference was observed in AS patients with and without AV amyloid deposition. In vitro, AV interstitial cells (VICs) were stimulated with interleukin (IL)-1β which induced increased SAA1-mRNA both in the control VICs (+6.4 ± 0.5, p = 0.02) and the AS VICs (+7.6 ± 0.5, p = 0.008). In conclusion, isolated AV amyloid deposition is frequent in the context of AS, but it does not appear to have potential clinical relevance. Conversely, amyloid deposition within AV leaflets, probably promoted by local inflammation, could play a role in AS pathophysiology.</p>
Dataset related to the article "Non-stenotic fibro-calcific aortic valve as a predictor of myocardial infarction recurrence"
<p>This record contains raw data related to the article "Non-stenotic fibro-calcific aortic valve as a predictor of myocardial infarction recurrence"</p> <p>Aims</p> <p>Patients with acute myocardial infarction (AMI) are at increased risk of recurrent cardiovascular events. Non-stenotic aortic valve fibro-calcific remodelling (called aortic valve sclerosis; AVSc), reflecting systemic damage, may serve as a new marker of risk. This study aims to stratify subgroups of AMI patients with specific probabilities of recurrent AMI and to evaluate the importance of AVSc in this setting.</p> <p>Methods and results</p> <p>Consecutive AMI patients (n = 2530) were admitted at Centro Cardiologico Monzino (2010–19) and followed up for 5 years. Patients were divided into study (n = 1070) and test (n = 966) cohorts. Topological data analysis (TDA) was used to stratify patient subgroups, while Kaplan–Meier and Cox regression analyses were used to evaluate the significance of baseline characteristics. Topological data analysis identified 11 subgroups of AMI patients with specific baseline characteristics. Two subgroups showed the highest rate of re-infarction after 5 years from the indexed AMI with a combined hazard ratio (HR) of 3.8 [95% confidence interval (CI): 2.7–5.4] compared with the other subgroups. This was confirmed in the test cohort (HR = 3.1; 95% CI: 2.2–4.3). These two subgroups were mostly men, with hypertension and dyslipidaemia, who exhibit<br>a higher prevalence of AVSc, higher levels of high-sensitive C-reactive protein and creatinine. In the year-by-year analysis, AVSc, adjusted for all confounders, showed an independent association with the increased risk of re-infarction (odds ratio of ∼2 at all time points), in both the study and the test cohorts (all P < 0.01).</p> <p>Conclusion</p> <p>AVSc is a crucial variable for identifying AMI patients at high risk of recurrent AMI and its presence should be considered when assessing the management of AMI patients. The inclusion of AVSc in risk stratification models may improve the accuracy of predicting the likelihood of recurrent AMI, leading to more personalized treatment decisions.<br><br></p>
Straightened segmentation in 4D cardiac CT: A practical method for multiparametric characterization of the landing zone for transcatheter pulmonary valve replacement
<p>Supplementary files (8 videos, 2 tables) for ''Straightened segmentation in 4D cardiac CT: A practical method for multiparametric characterization of the landing zone for transcatheter pulmonary valve replacement''</p>
Heart valve characterization on the high-resolution normal multiscan CECT dataset
<p>Back and forth longitudinal section through the heart showing the identification of the two leaflets in the mitral valve and their thickness distribution. Back and forth transverse section through the heart showing the identification of the three cusps in the aortic valves and their thickness distribution.</p>
Replication Package for: Private Sector Provision as an Escape Valve: The Mexico Diabetes Experiment
<p>Bronsoler, A., Gruber, J., & Seira, E. (2023). <em>Private Sector Provision as an “Escape Valve”: The Mexico Diabetes Experiment .</em></p> <p><em>Replication package for tables and figures. Includes publically available data and de-identified experimental data.</em></p>
Clifton Park Valve House
I fell in love with this mysterious structure the first time I saw it! In the late 19th century, it housed large wheels that helped channel water from the Lake Montebello reservoir to the surrounding city of Baltimore. Today, it is risks getting torn down and [efforts to preserve the building are ongoing](https://www.preservationmaryland.org/valve-house/). "The Lake Clifton Valve House, or Gate House, is a massive octagonal stone structure. Large Romanesque archways alternate with Gothic style windows which once contained stained glass. Remnants of the colorful glass patterns may still be seen in the turret, atop an intricate tile roof supported by a complicated system of iron trusses." -[Maryland Historical Trust](https://mht.maryland.gov/nr/NRDetail.aspx?NRID=50) Created in RealityCapture from 618 images taken with a drone. Source: Objaverse 1.0 / Sketchfab
Mitralign Percutaneous Annuloplasty System for Chronic Functional Mitral Valve Regurgitation
ClinicalTrials.gov study NCT01740583. IPD Sharing: Not stated. Countries: 4. Publications: 0.
Multiparametric SCores for Prediction of Myocardial fIbrosis in Patients With MITral vAlve pRolapse
ClinicalTrials.gov study NCT06341166. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Patient-Centered Approach for Treatment Decisions in Mitral Valve Prolapse
ClinicalTrials.gov study NCT06738537. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
EUROPT Clinical Trial to Study the Efficacy of One-Way Valve Implantation (New Treatment Algorithm) in Patients With Heterogeneous Emphysema
ClinicalTrials.gov study NCT00730301. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Non-Contrast Magnetic Resonance Angiography Assessment of Patients Referred for Transcatheter Aortic Valve Implantation
ClinicalTrials.gov study NCT02007967. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Assessment of St Jude Medical Portico Re-sheathable Transapical Aortic Valve System
ClinicalTrials.gov study NCT01742598. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.