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10,735 results for “dependability”
Single-cell multiomics study of cell-type-specific neuron activation unravels context-dependent gene regulation of brain disorders [029]
GEO Series GSE289518. Homo sapiens. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Cholera toxin mediates cAMP-dependent CTLA-2 secretion by dendritic cells to induce regulatory T cells in the EAE model
GEO Series GSE79274. Mus musculus. 6 samples. Type: Expression profiling by array.
Density dependence influences competition and hybridization at an invasion front - occupancy and istope data
<p>Occupancy data and stable isotope data associated with the publication ' Density dependence influences competition and hybridization at an invasion front' in <em>Diversity and Distributions.</em></p>
Range-dependent flexibility in the acoustic field of view of echolocating porpoises (Phocoena phocoena)
<p>Data from: Range-dependent flexibility in the acoustic field of view of echolocating porpoises (Phocoena phocoena). eLife 2015;10.7554/eLife.05651</p> <p>Abstract:</p> <p>Toothed whales use sonar to detect, locate, and track prey. They adjust emitted sound intensity, auditory sensitivity and click rate to target range, and terminate prey pursuits with high-repetition-rate, low-intensity buzzes. However, their narrow acoustic field of view (FOV) is considered stable throughout target approach, which could facilitate prey escape at close-range. Here we show that, like some bats, harbour porpoises can broaden their biosonar beam during the terminal phase of attack but, unlike bats, maintain the ability to change beamwidth within this phase. Based on video, MRI, and acoustic-tag recordings, we propose this flexibility is modulated by the melon and implemented to accommodate dynamic spatial relationships with prey and acoustic complexity of surroundings. Despite independent evolution and different means of sound generation and transmission, whales and bats adaptively change their FOV, suggesting that beamwidth flexibility has been an important driver in the evolution of echolocation for prey tracking.</p> <p>The data set contains all the audio and video data from the trials with the 48-hydrophone array used in the final analysis.</p>
Radial dependence of SEP peak fluxes and fluences: Multi-spacecraft observations based on Parker Solar Probe, Solar Orbiter, and near-Earth particle detectors
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Supplemental Tables-Murine neonatal oxidant lung injury: NRF2-dependent predisposition to adulthood respiratory viral infection and protection by maternal antioxidant
<p>This is a part of manuscript submitted for the special issue of <a href="https://www.mdpi.com/journal/antioxidants"><em>Antioxidants</em></a> (ISSN 2076-3921). This special issue belongs to the section "<a href="https://www.mdpi.com/journal/antioxidants/sections/health_outcomes_antioxidants_oxidative_stress">Health Outcomes of Antioxidants and Oxidative Stress</a>". </p> <p>Table S1: Prenatal sulforaphane-altered lung genes in postnatal air-exposed <em>Nrf2<sup>+/+</sup></em> mice (n = 523, moderated t-Test, <em>p </em>< = 0.01), Table S2: Prenatal sulforaphane-altered 918 lung genes in postnatal air-exposed <em>Nrf2<sup>-/-</sup></em> mice (n = 918, moderated t-Test, <em>p </em>< =0.01), Table S3: Prenatal sulforaphane-neonatal hyperoxia interaction 258 genes in <em>Nrf2<sup>+/+</sup></em> mice (2-Way ANOVA, <em>p </em>< =0.01), Table S4: Prenatal sulforaphane and neonatal hyperoxia interaction 239 genes in <em>Nrf2<sup>-/-</sup></em> mice (2-Way ANOVA, <em>p </em>< = 0.01), Table S5: Prenatal sulforaphane-modulated genes in <em>Nrf2<sup>+/+</sup></em> placenta (t-Test unpaired p-value <em>p </em>< = 0.05 ), Table S6: Prenatal sulforaphane-modulated genes in <em>Nrf2<sup>-/-</sup></em> placenta (t-Test unpaired p-value <em>p </em>< =0.05 ).</p>
Experimental dataset: TEMPERATURE DEPENDENCE ON STOCHATIC DYNAMIC DIFFUSION COEFFICIENTS OF HEATED ELECTROSPRAY IONIZATION AND ATMOSPHERIC PRESSURE CHEMICAL IONIZATION MASS SPECTROMETRIC INTENSITIES OF ANALYTE IONS OF CONFIGURATIONALLY LOCKED POLYENES – THEORY AND EXPERIMENT
<p>Experimental dataset of heated electrospray ionization and atmospheric pressure chemical ionization mass spectra of configurationally locked polyenes. The dataset is empirical proof of the validity of our new model equation connecting among the stochatic dynamic diffusion parameter, the temperature and the mass spectrometric measurable variable 'intensity' of an observable peak of analyte ion.</p>
Europe's economic dependency on trade with China - Full results
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The Role of AI Chatbots on E-Commerce Platforms: Understanding Its Influence on Customer Trust and Dependability
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Activity-Dependent Remodeling of Corticostriatal Axonal Boutons During Motor Learning
<p>Source Data</p>
Dataset related to the article "Oxidized LDL-dependent pathway as new pathogenic trigger in Arrhythmogenic Cardiomyopathy."
<p>This record contains raw data related to the article “Oxidized LDL-dependent pathway as new pathogenic trigger in Arrhythmogenic Cardiomyopathy".</p> <p>Arrhythmogenic Cardiomyopathy (ACM) is hallmarked by ventricular fibro-adipogenic alterations, contributing to cardiac dysfunctions and arrhythmias. Although genetically-determined (e.g. <em>PKP2</em> mutations), ACM phenotypes are highly variable. More data on phenotype modulators, clinical prognosticators, and etiological therapies are awaited. We hypothesized that oxidized low-density-lipoproteins (oxLDL)-dependent activation of PPARγ, a recognized effector of ACM adipogenesis, contribute to disease pathogenesis.</p> <p>ACM patients showing high plasma concentration of oxLDL display severe clinical phenotypes in terms of fat infiltration, ventricular dysfunction, and major arrhythmic event risk.</p> <p>In ACM patient-derived cardiac cells, we demonstrated that oxLDL are major cofactors of adipogenesis. Mechanistically, the increased lipid accumulation is mediated by oxLDL cell internalization through CD36, ultimately resulting in PPARγ upregulation.</p> <p>By boosting oxLDL in a <em>Pkp2</em> heterozygous knock-out mice through high-fat-diet feeding, we confirmed <em>in vivo</em> the oxidized lipids dependency of cardiac adipogenesis and right ventricle systolic impairment, which are counteracted by atorvastatin treatment.</p> <p>The modulatory role of oxidized lipids on ACM adipogenesis, demonstrated at cellular, mouse, and patient levels, represents a novel risk stratification tool and a target for ACM pharmacological strategies.</p>
Datasets related to article "Frequency-dependent functional connectivity in resting state networks"
<p><strong>DATASET #1</strong></p> <p>Power measured for the six resting state networks (DMN, DAN, VAN, LN, SMN, VN) and frequency bands (delta, theta, alpha, beta, gamma) of each participant.</p> <p> </p> <p><strong>DATASET #2</strong></p> <p>Intra-network and inter-network connectivity measured for the six resting state networks (DMN, DAN, VAN, LN, SMN, VN) and frequency bands (delta, theta, alpha, beta, gamma) of each participant.</p>
Phytoplankton and cyanobacteria abundances in mid‐21st century lakes depend strongly on future land use and climate projections
<p>These are the data used to create the figures for this publication.</p>
Are Viscoelastic Tests Clinically Useful to Identify Platelet-Dependent Bleeding in High-Risk Cardiac Surgery Patients?
<p>Baryshnikova E, Di Dedda U, Ranucci M. Are Viscoelastic Tests Clinically Useful to Identify Platelet-Dependent Bleeding in High-Risk Cardiac Surgery Patients? Anesth Analg. 2022 Dec 1;135(6):1198-1206. doi: 10.1213/ANE.0000000000006231. Epub 2022 Oct 13. PMID: 36227767.</p> <p>Abstract</p> <p><strong>Background: </strong>Postoperative use of platelet function testing to rule out microvascular bleeding due to platelet dysfunction after cardiac surgery still lacks strong reference data and reliable cutoff values, yielding a clinically adequate sensitivity and specificity. The present study aims to investigate the performance of two different point-of-care viscoelastic devices and platelet aggregometry in expressing surgery-dependent platelet dysfunction and anticipating postoperative major bleeding in a cohort of high-risk patients.</p> <p><strong>Methods: </strong>Prospective cohort study of 50 adult patients who were on antiplatelet drugs discontinued for no more than 7 days (clopidogrel and prasugrel) or 5 days (ticagrelor) undergoing cardiac surgery with cardiopulmonary bypass (CPB). Coagulation and platelet function testing, including QUANTRA, ROTEM, and Multiplate, were assessed preoperatively and postoperatively. Chest drain blood loss was measured in the first 12 postoperative hours. Perioperative bleeding was assessed using a modified version of the Universal Definition of Perioperative Bleeding (UDPB) in cardiac surgery, modified to not consider anemia-correcting packed red cells transfusions in the absence of bleeding >600 mL/12 h. Major bleeding was identified as UDPB class II or higher.</p> <p><strong>Results: </strong>Multiplate adenosine diphosphate (ADPtest) was significantly ( P = .001) reduced after CPB, whereas TRAPtest was not. The platelet component (PC) as extrapolated by ROTEM data (EXTEM MCF-FIBTEM MCF) was unchanged after CPB, while the A10 PC (PC at 10 minutes) was significantly ( P = .001) reduced. The QUANTRA platelet contribution to clot stiffness (PCS) was significantly ( P = .001) reduced, as well. At the ROC analysis for the predictive ability of the post-CPB platelet function testing, the best discrimination was obtained by the QUANTRA PCS, with an area under the curve (AUC) (95% confidence interval [CI]) of 0.80 (0.66-0.91), P = .001, followed by the ROTEM A10 PC with AUC (95% CI) of 0.75 (0.51-0.99), P = .004, and PC with AUC (95% CI) of 0.74 (0.50-0.99), P = .009. The Multiplate ADPtest had an AUC (95% CI) of 0.67 (0.42-0.91), and the TRAPtest had an AUC (95% CI) of 0.62 (0.37-0.86). The cutoff values identified were 13 hPa for the QUANTRA PCS, 40 mm for the ROTEM A10, and 48.5 mm for the ROTEM PC, with negative predictive values of 84%, 81%, and 86%, respectively, and positive predictive values of 55%, 53%, and 69%, respectively.</p> <p><strong>Conclusions: </strong>QUANTRA PCS, ROTEM A10 PC, and Multiplate ADPtest showed a significant decrease after CPB, whereas ROTEM PC and Multiplate TRAPtest did not. Major bleeding was predicted with a moderate to good discrimination by the post-CPB viscoelastic tests (PCS, PC, and A10 PC).</p>
Sex-dependent association between variability in infants' OXTR methylation at birth and negative affectivity at 3 months
<p>I<strong>ntroduction</strong>.This database includes the raw data linked with the paper “Sex-dependent association between variability in infants' OXTR methylation at birth and negative affectivity at 3 months”. This publication is part of the longitudinal and multi-centric “Measuring the outcomes of maternal COVID-19-related prenatal exposure (MOM-COPE)” research project. In this paper, we report data on sex differences in the association between the infants’ DNA methylation of the oxytocin receptor gene (OXTRm) at birth and negative affectivity at 3 months of age.</p> <p><strong>Procedures</strong>. Infants’ methylation status was assessed in 13 CpG sites within the OXTR gene intron 1 region (chr3: 8810654–8810919) in buccal cells at birth while 3-months-age infants’ negative affectivity was assessed by mothers using the Infant Behavior Questionnaire- Revised short-form (Gartstein & Rothbart, 2003).</p> <p><strong>Analytical plan</strong>. A principal component analysis (PCA) was used to reduce the number of CpG sites into a smaller set of factors (i.e., PC1 and PC2). Sex differences in mean levels of methylation at all CpG sites as well as at PC1 and PC2 were tested through independent sample t-tests. Separate hierarchical regression models were performed to evaluate the independent and interactive effects of infant OXTRm (respectively, PC1 and PC2) and sex on negative affectivity.</p> <p><strong>Findings in brief. </strong>OXTRm at 12 CpG sites was higher in females than in males. Moreover, higher infants’ OXTRm at 6 spe- cific CpG sites was associated with greater negative affectivity in males, but not in females. These findings advance the possibility that epigenetic pathways involving OXTRm may be one such factor which operates through sex-dependent mechanisms to shape variability in temperamental negative affectivity.</p>
Why Don't Developers Update Library Dependencies?
<p>This includes files for the following paper.</p><blockquote><p>Why Don't Developers Update Library Dependencies?</p></blockquote>
Growth phase dependent gene expression of Salmonella Typhimurium SL1344 parental strain and isogenic ∆relA, ∆spoT ppGpp null strain
GEO Series GSE48478. Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344; Salmonella enterica. 24 samples. Type: Expression profiling by array.
TonEBP-deficiency accelerates age-dependent intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expression
GEO Series GSE135270. Mus musculus. 12 samples. Type: Expression profiling by array.
ALKBH1-mediated DNA N6-methyladenine Modification Regulates H3K9me3-dependent Heterochromatin in Neural Tube Development [RNA-Seq]
GEO Series GSE268763. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
METTL3-dependent m6A RNA methylation regulates activation of the NLRP3 inflammasome
GEO Series GSE216483. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.