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30,948 results for “Profile”
Supplemental Material from: Immune Profiling of Thyroid Carcinomas Suggests the Existence of Two Major Phenotypes: an ATC-like and a PDTC-like
<p>Supplemental Material from: Immune Profiling of Thyroid Carcinomas Suggests the Existence of Two Major Phenotypes: an ATC-like and a PDTC-like</p>
Pilot 2 visitor profiles
<p>This dataset will include all the information used to create the profiles of the visitors participating in the experiments of pilot 2. This way, the dataset contents will be used to model the users that will play the games of the pilot and so help the apps to personalise the options to be offered to them in order to get a more appealing experience for every visitor.</p> <p>This dataset will comprise information about the visitors who participate in the games, including psycho-demographic data, cognitive style, and interests mined from social networks. All the information will be anonymised and the storage will be organised by assigning an anonymised identifier to every participant.</p>
Supplementary materials for the manuscript entitled "Comprehensive Identification, Phylogenetic Analysis and Expression Profiling of Multicopper Oxidase Genes in Maize"
<p><strong>Table S1. </strong>Gene IDs and names of maize and Arabidopsis MCOs</p> <p><strong>Figure S1.</strong> Phylogenetic tree of protein sequences of multicopper oxidase (MCO) of maize and Arabidopsis with rectangular layout. Branches are not cladogram-transformed. Shown in nodes are bootstrap support. The tree is polar layout, and branches are cladogram-transformed. Maize IDs are labeled in brown. Clades representative of<em> SKS</em>, <em>LAC</em> and <em>AAO</em> are labeled in blue, red and green, respectively. The tree is reconstructed by PhyML with 1000 bootstrap replicates.</p> <p><strong>Figure S2. </strong>Chromosome map depicting location of maize <em>MCO</em>s, with gene IDs shown in the map. Figure legend is the same as Figure 2.</p> <p><strong>Figure S3. </strong>Phylogenetic tree of maize and Arabidopsis <em>AAO</em>s. The trees are rectangular layout. The tree is reconstructed by PhyML with 1000 bootstrap replicates. Shown in nodes are bootstrap support.</p>
Data for manuscript: The orbital anisotropy profiles of nearby globular clusters from Gaia Data Release 2
<p>We upload the data used in our paper here so that our results may be reproduced. We include the dataset of stars that survive our cuts, the profiles we plot, and the manual points selected as part of our CMD cut. See the paper for details. The first version of this paper is published on the arXiv with ID: arXiv:1903.11070. </p>
Phenotype profile of monocytes differentiated in the presence of semen Fucosylated Clusterin
<p>Having shown that fucosylated clusterin effectively interacts with macrophages via DC-SIGN, we then analyzed its influence on the phenotype of macrophages. In these experiments, monocytes were cultured for 5 days with M-CSF, in the absence or presence of semen fucosylated clusterin. Then, the cells were cultured for additional 24 hours with or without LPS and the phenotype were analyzed. Fucosylated clusterin-treated macrophages failed to upregulate the expression of HLA-DR and CD86 induced by LPS but not the expression of CD40, CD80 and PDL-1. These results are represented on Figure 6 from the publication: Aberrant fucosylation enables breast cancer clusterin to interact with dendritic cell-specific ICAM-grabbing non-integrin (DC-SIGN). </p>
Zebrafish behavioral profiling identifies ligands, targets, and neurons related to sedation and paradoxical excitation
<p>Anesthetics are generally associated with sedation, but some anesthetics can also increase brain and motor activity — a phenomenon known as paradoxical excitation. Previous studies have identified GABAA receptors as the primary targets of most anesthetic drugs, but how these compounds produce paradoxical excitation is poorly understood. To identify and understand such compounds, we applied a behavior-based drug profiling approach. Here, we show that a subset of central nervous system depressants cause paradoxical excitation in zebrafish. Using this behavior as a readout, we screened thousands of compounds and identified dozens of hits that caused paradoxical excitation. Many hit compounds modulated human GABAA receptors, while others appeared to modulate different neuronal targets, including the human serotonin-6 receptor. Ligands at these receptors generally decreased neuronal activity, but paradoxically increased activity in the caudal hindbrain. Together, these studies identify ligands, targets, and neurons affecting sedation and paradoxical excitation in vivo in zebrafish.</p>
Measuring similarity between gene interaction profiles
<p>This repository contains the following:</p> <p>Original genetic interaction score matrices for the genes. Also contains a binarized version of this data based on a threshold of 0.05, for use in the binary distance measures.</p> <p>The distance measure matrices that were calculated based on the genetic interaction score matrices; Pearson, Maryland bridge, Ochiai, and Braun-Blanquet matrices for the one-square case and the same for the two-squares case.</p> <p>Lists of all the genes used.</p> <p>Lists of modules for each of the eight distance measure matrices, with the genes for each.</p> <p>Summary statistics for the two-squares distance matrices, network and module summary statistics for the two-squares modules, and stats on how many modules for each of the eight different module clusterings could be mapped to subnetworks found in Tong et al. (reference 14 in the paper).</p> <p>A figure containing distribution of distance measure values for the two-square distance matrices.</p> <p>View the readme file for full details.</p>
Large repeated measures experiments of acoustic Doppler current profiler (ADCP) streamflow measurements under steady flow conditions (Chauvan 2016 regatta)
<p>From 8 to 10 November 2016, 50 laboratories or teams (from 8 different countries) with 50 ADCPs, simultaneously conducted more than 600 ADCP discharge measurements in steady flow conditions (around 14 m<sup>3</sup>/s released by a dam), during three half-days, over 500 m along the Taurion River at Saint-Priest-de-Taurion, France. 26 cross-sections with various shapes and flow conditions, and more or less favourable conditions, were distributed along the river. A specific experiment procedure, which consisted of circulating every team over half of the cross-sections, was implemented in order to quantify the impact of site selection on the discharge measurement<br> uncertainty.</p> <p>The experimental design is presented in Despax et al (2017) available at <a href="https://irsteadoc.irstea.fr/cemoa/PUB00055007">https://irsteadoc.irstea.fr/cemoa/PUB00055007</a></p> <p>Despax, A., Hauet, A., Le Coz, J., Dramais, G., Blanquart, B., Besson, D., & Belleville, A. (2017). Inter-laboratory comparison of discharge measurements with Acoustic Doppler Current Profilers Chauvan field experiments. 8, 9 and 10th November 2016. (Technical report). Lyon, France: Groupe Doppler. (92 p.)</p> <p> </p>
Hovmöller diagram of ARGO subsurface temperature anomalies with histograms of daily profile data count
<p>Hovmöller diagram of ARGO subsurface temperature anomalies with histograms of daily profile data count over two different zones in the pacific ocean. The anomalies were computed from GODAS reanalysis over a 1981-2010 climatology .</p>
Long Profiles and Valley Width Data for Arroyo Hondo, Alameda Creek, and the Eel River
<p>These files contain 4 columns of data. Column 1 is distance downstream, column 2 is river elevation, column 3 is floodplain width, column 4 is an identifier indicating whether there is a landslide intersecting the channel at that location, in which case it is 1. For the Eel River site, we use lidar data as described by Mackey and Roering (2011). For the Alameda Creek/Arroyo Hondo site, we use one-ninth second USGS NED data. </p>
Integrated Probabilistic Annotation (IPA): A Bayesian-based annotation method for metabolomic profiles integrating biochemical connections, isotope patterns and adduct relationships - Supplementary Data
<ol> <li>Supplementary_data_1: data and code for standards analysis and database update</li> <li>Supplementary_data_2.zip: data and code used for the generation of the synthetic experiment</li> <li>Supplementary_data_3.zip: data, code, and results of the <em>E. coli</em> dataset analysis</li> <li>Supplementary_data_4.zip: data, code, and results of the beer dataset analysis</li> <li>Supplementary_data_5.zip: data, code, and results of the comparison with xMSannotator</li> </ol>
Unique Solid Phase Microextraction Sampler Reveals Distinctive Biogeochemical Profiles among Various Deep-Sea Hydrothermal Vents
<p>Repository data for the publication named "<strong>Unique Solid Phase Microextraction Sampler Reveals Distinctive Biogeochemical Profiles among Various Deep-Sea Hydrothermal Vents"</strong></p>
Endocrine profile of the vcd-induced perimenopausal model rat
<p>During the transition to menopause, women experience a variety of physical and psychological symptoms that are directly or indirectly linked to changes in hormone secretion. Establishing animal models with intact ovaries is essential for understanding these interactions and finding new therapeutic targets. In this study, we assessed the endocrine profile, as well as the estrous cycle, in the 4-vinylcyclohexene diepoxide (VCD)-induced follicular depletion rat model in 10-day intervals over 1 month to accurately establish the best period for studies of the transition period.</p>
Stellar Density Profiles of Dwarf Spheroidal Galaxies: Posterior Distributions
<p>This archive contains samples from the posterior distributions of our 3-plummer, 1-plummer, 3-steeper and 1-steeper fits for 38 dwarf spheroidal galaxies.</p>
The Ubiquitin Ligase WWP1 Contributes to Shifts in Matrix Proteolytic Profiles and a Myocardial Ageing Phenotype with Diastolic Heart Failure
<p><strong><em>Aims</em></strong>. Ubiquitylation is a key event that regulates protein turnover, and induction of the ubiquitin ligase E3 WWP1 has been associated with age. Left ventricular hypertrophy (LVH) commonly occurs as a function of age and can cause heart failure with a preserved ejection fraction (EF; HFpEF). We hypothesized that overexpression (O/E) of WWP1 in the heart would cause LVH as well as functional and structural changes consistent with the ageing HFpEF phenotype.</p> <p><strong><em>Methods and Results.</em></strong> Global WWP1 O/E was achieved in mice (n=11) and echocardiography (40 MHz) performed to measure LV mass, EF, Doppler velocities (early-E, late/atrial-A), myocardial relaxation (E’), and isovolumetric relaxation time (IVRT) at 4, 6, and 8 weeks. Age matched wild type animals (n=15) were included as referent controls. LV EF was identical (60+1% vs 60+1%, p>0.90) with no difference in LV mass (67+3 vs 75+5, p>0.25) at 4 weeks. LVH and diastolic dysfunction occurred with WWP1 O/E wherein LV mass increased by over two-fold, E/A fell (impaired passive filling), and E/E’ was lower and IVRT prolonged (impaired LV relaxation). Collagen percent area increased by over two-fold with WWP1 O/E and increased expression of determinants of fibrosis and growth (qPCR) were also concomitantly increased.</p> <p><strong><em>Conclusion.</em></strong> Inducing WWP1 expression caused LVH with significant diastolic dysfunction, consistent with the HFpEF phenotype. Thus, targeting the WWP1 pathway may be a novel therapeutic target for this intractable form of HF associated with ageing</p>
Profile Comparer Extended: phylogeny of LPMO families using profile hidden Markov model alignments
<p>searchable pdf phylogenetic tree (Fig S1) and sequence data (Table S1) belonging to the paper "Profile Comparer Extended: phylogeny of LPMO families using profile hidden Markov model alignments"</p>
Shigella Congo red secretion profile unaltered Western blots
<p>These are unaltered raw Western blot images (Image Lab files) of a Congo red secretion assay testing the type three secretion profiles of <em>Shigella</em> strains expressing engineered Spa47 mutants.</p>
Text-fig. 2. Lithologic profiles from "Kazimierz" openpit and BK-110 borehole. in Micropalaeontological Taphocoenoses Of The Miocene Poznań Formation (Konin Area, Central Poland)
Text-fig. 2. Lithologic profiles from "Kazimierz" openpit and BK-110 borehole.
Life in the fastlane? A comparative analysis of gene expression profiles across annual, semi-annual, and non-annual killifishes (Cyprinodontiformes: Nothobranchiidae)
<ol> <li>Read Counts per gene</li> <li>All read counts by inidividual and species</li> <li>Species abbreviations key</li> <li>R script for data analyses</li> </ol>
Processed CODEX Datasets from - Graph deep learning for the characterization of tumour microenvironments from spatial protein profiles in tissue specimens
<p>This entry provides access to processed CODEX data files of three studies analyzed in the article "Graph deep learning for the characterization of tumour microenvironments from spatial protein profiles in tissue specimens". Details of datasets can be found in the Methods section of the article.</p> <p>For each dataset:</p> <ul> <li>A comma-separated values (CSV) file containing metadata of regions is included</li> <li>A zip file containing multiple CSV files is included: <ul> <li>`{region_id}.cell_data.csv`, a table containing three columns: "CELL_ID", "X", and "Y". This table provides centroid locations for all cells segmented in this region.</li> <li>`{region_id}.expression.csv`, a table containing multiple columns: "CELL_ID", "DAPI", "CD45", etc. This table provides detailed protein biomarker expression quantified and normalized for all cells in this region.</li> <li>`{region_id}.cell_types.csv`, a table containing two columns: "CELL_ID" and "CELL_TYPE". This table provides cell type annotations for all cells in this region.</li> <li>`{region_id}.cell_features.csv`, a table containing two columns: "CELL_ID" and "SIZE". This table provides morphology descriptors (only containing cell size for these studies) for all cells in this region.</li> </ul> </li> </ul> <p>These data files are also available through the Enable Medicine Public Study page: <a href="https://app.enablemedicine.com/portal/atlas-library/studies/92394a9f-6b48-4897-87de-999614952d94?sid=1168">https://app.enablemedicine.com/portal/atlas-library/studies/92394a9f-6b48-4897-87de-999614952d94?sid=1168</a>. Raw multiplexed immunofluorescence images will be accessible through the visualizer app of Enable Medicine Portal.</p> <p>Codes for this study are stored in <a href="https://gitlab.com/enable-medicine-public/space-gm">https://gitlab.com/enable-medicine-public/space-gm</a>. Please direct all further questions and/or issues to the gitlab repository or lead contact (A.E.T.).</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.