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15,733 results for “article”
Dataset related to the article "Cardiac Biomarkers and Autoantibodies in Endurance Athletes: Potential Similarities with Arrhythmogenic Cardiomyopathy Pathogenic Mechanisms"
<p>This record contains raw data related to the article “Cardiac Biomarkers and Autoantibodies in Endurance Athletes: Potential Similarities with Arrhythmogenic Cardiomyopathy Pathogenic Mechanisms". </p> <p>The "Extreme Exercise Hypothesis" states that when individuals perform training beyond the ideal exercise dose, a decline in the beneficial effects of physical activity occurs. This is due to significant changes in myocardial structure and function, such as hemodynamic alterations, cardiac chamber enlargement and hypertrophy, myocardial inflammation, oxidative stress, fibrosis, and conduction changes. In addition, an increased amount of circulating biomarkers of exercise-induced damage has been reported. Although these changes are often reversible, long-lasting cardiac damage may develop after years of intense physical exercise. Since several features of the athlete's heart overlap with arrhythmogenic cardiomyopathy (ACM), the syndrome of "exercise-induced ACM" has been postulated. Thus, the distinction between ACM and the athlete's heart may be challenging. Recently, an autoimmune mechanism has been discovered in ACM patients linked to their characteristic junctional impairment. Since cardiac junctions are similarly impaired by intense physical activity due to the strong myocardial stretching, we propose in the present work the novel hypothesis of an autoimmune response in endurance athletes. This investigation may deepen the knowledge about the pathological remodeling and relative activated mechanisms induced by intense endurance exercise, potentially improving the early recognition of whom is actually at risk.</p>
raw data for the article "Diamine Synthesis via the Nitrogen-Directed Azidation of sigma- and pi- C-C Bonds"
<p>Raw NMR, MS and IR data for the article "Diamine Synthesis via the Nitrogen-Directed Azidation of sigma- and pi- C-C Bonds" published in the Journal of the American Chemical Society, DOI: </p> <p><a href="https://doi.org/10.1021/jacs.1c06700">https://doi.org/10.1021/jacs.1c06700</a></p> <p>The number of the folders correspond to compounds numbers in the article. All details concerning conditions and equipment for measurements can be found in the supporting information of the article.</p>
Data deposition of the article 'Multi-Omics analysis identifies a lncRNA-related prognostic signature to predict bladder cancer recurrence'
<p>Data deposition of the article 'Multi-Omics analysis identifies a lncRNA-related prognostic signature to predict bladder cancer recurrence'</p>
Dataset related to article "Quantitative determination of niraparib and olaparib tumor distribution by mass spectrometry imaging"
<p><em>The .zip file contains raw data related to the article "Quantitative determination of niraparib and olaparib tumor distribution by mass spectrometry imaging", available from <a href="https://www.ijbs.com/v16p1363.htm">https://www.ijbs.com/v16p1363.htm</a>.</em></p> <ul> <li><em>The folder "<strong>fig 1 2 3 NIRA</strong>" contains raw data related to the experiments with niraparib presented in figures 1, 2 and 3 </em></li> <li><em>The folder "<strong>fig 1 2 3 OLA</strong>" contains raw data related to the experiments with olaparib presented in figures 1, 2 and 3 </em></li> <li><em>The folders "<strong>fig 4</strong>" and "<strong>fig 6</strong>" contain raw data related to figures 4 and 6, respectively.</em></li> </ul> <p><strong>For any additional information on how to read and reuse the dataset please contact Dr. Ubezio at paolo.ubezio@marionegri.it.</strong></p> <p> </p> <p><strong>ABSTRACT OF THE MANUSCRIPT:</strong></p> <p><strong>Rationale</strong>: Optimal intratumor distribution of an anticancer drug is fundamental to reach an active concentration in neoplastic cells, ensuring the therapeutic effect. Determination of drug concentration in tumor homogenates by LC-MS/MS gives important information about this issue but the spatial information gets lost. Targeted mass spectrometry imaging (MSI) has great potential to visualize drug distribution in the different areas of tumor sections, with good spatial resolution and superior specificity. MSI is rapidly evolving as a quantitative technique to measure the absolute drug concentration in each single pixel.</p> <p><strong>Methods</strong>: Different inorganic nanoparticles were tested as matrices to visualize the PARP inhibitors (PARPi) niraparib and olaparib. Normalization by deuterated internal standard and a custom preprocessing pipeline were applied to achieve a reliable single pixel quantification of the two drugs in human ovarian tumors from treated mice.</p> <p><strong>Results</strong>: A quantitative method to visualize niraparib and olaparib in tumor tissue of treated mice was set up and validated regarding precision, accuracy, linearity, repeatability and limit of detection. The different tumor penetration of the two drugs was visualized by MSI and confirmed by LC-MS/MS, indicating the homogeneous distribution and higher tumor exposure reached by niraparib compared to olaparib. On the other hand, niraparib distribution was heterogeneous in an ovarian tumor model overexpressing the multidrug resistance protein P-gp, a possible cause of resistance to PARPi.</p> <p><strong>Conclusions</strong>: The current work highlights for the first time quantitative distribution of PAPRi in tumor tissue. The different tumor distribution of niraparib and olaparib could have important clinical implications. These data confirm the validity of MSI for spatial quantitative measurement of drug distribution providing fundamental information for pharmacokinetic studies, drug discovery and the study of resistance mechanisms.</p>
Supplementary animation of the article by Khaykin et al. Persistence of moist plumes from overshooting convection in the Asian monsoon anticyclone""
<p>Back trajectories released at B7 point of StratoClim Geophysica flight F7</p>
Dataset for Article: Hybrid Flexible Flowshop with Transportation Times at CP 2021
<p>This dataset contains the benchmark data used for the article "Hybrid Flexible Flowshop with Transportation Times" to appear at the 27th International Conference on Principles and Practice of Constraint Programming in Montpellier, France, from October 25th - 29th, 2021. The data consist of a MiniZinc program cp2021.mzn, and an archive of datafiles in MiniZinc data format. The archive contains 25 instances each of sizes 20, 25, 30, 40, 50, 100, 200, 400 jobs. A detailed description of the program and the data is given in the original article. </p>
Supporting data for the article "Continuing invariant solutions towards the turbulent flow"
<p>Supporting data for the article "Continuing invariant solutions towards the turbulent flow": numerical code and computed invariant solutions</p>
Supplemental Material to Journal Article "Effect of individual blade pitch angle misalignment on the remaining useful life of wind turbines"
<p>This set supplements the figure data to the article "Effect of individual blade pitch angle misalignment on the remaining useful life of wind turbines", DOI: <a href="http://doi.org/10.5194/wes-6-1079-2021">10.5194/wes-6-1079-2021</a>.</p>
raw data for the article "Direct Photoexcitation of EthynylBenziodoXolones: An Alternative to Photocatalysis for Alkynylation Reactions"
<p>Raw NMR, MS and IR data for the article "Direct Photoexcitation of EthynylBenziodoXolones: An Alternative to Photocatalysis for Alkynylation Reactions" published in Angewandte Chemie, International Edition, DOI: </p> <p>https://onlinelibrary.wiley.com/doi/10.1002/anie.202110257R1</p> <p>The number of the folders correspond to compounds numbers in the article. All details concerning conditions and equipment for measurements can be found in the supporting information of the article.</p>
Data for the research article: "Detecting Seismo-ionospheric Anomalies Possibly Associated with the 2019 Ridgecrest (California) Earthquakes by GNSS, CSES and Swarm Observations"
<p>The zip archives contain 10 .mat files (MATLAB readable). Each .mat file can be loaded into the MATLAB workspace using the <em>load</em> command.</p>
Raw data fort the article: FLUOROSCOPY-GUIDED BILIARY PROCEDURES IN A PREGNANT, LIVER TRANSPLANT PATIENT: FETUS RADIATION PROTECTION
<p>We report three cases of clinically necessary, fluoroscopy-guided, percutaneous biliary procedures performed safely in a pregnant, liver transplant recipient using three different angiography suites. The uterine cumulative equivalent dose was 0.25 mSv, a value obtained by adding the doses of the three procedures described above, and which is relatively low when compared with the naturally occurring background radiation exposure for a 9-month pregnancy (~0.5-1 mSv). Our experience shows that staff knowledge, awareness and liaison promote the application of all dose reduction strategies possible while still achieving the clinical aim despite using different angiographic equipment.</p>
Raw data for the article: A Randomized Controlled Trial of Antithrombin Supplementation During Extracorporeal Membrane Oxygenation
<p><strong>Objectives: </strong>Supplementation of antithrombin might decrease the amount of heparin needed to achieve a given anticoagulation target during extracorporeal membrane oxygenation. However, exogenous antithrombin itself may increase the risk of bleeding. We conceived a study to evaluate the effect of antithrombin supplementation in adult patients requiring venovenous extracorporeal membrane oxygenation for respiratory failure on heparin dose, adequacy of anticoagulation, and safety.</p> <p><strong>Design: </strong>Prospective randomized controlled trial.</p> <p><strong>Setting: </strong>ICUs of two Italian referral extracorporeal membrane oxygenation centers.</p> <p><strong>Patients: </strong>Adult patients requiring venovenous extracorporeal membrane oxygenation for severe respiratory failure and unfractionated heparin for systemic anticoagulation.</p> <p><strong>Interventions: </strong>Before extracorporeal membrane oxygenation start, patients were randomized to either receive antithrombin concentrate to maintain a plasmatic level 80-120% (treatment) or not (control) during the extracorporeal membrane oxygenation course.</p> <p><strong>Measurements and main results: </strong>The primary outcome was the total amount of heparin required to maintain activated partial thromboplastin time ratio 1.5-2. Secondary outcomes were anti-factor Xa, the incidence of hemorrhagic and thrombotic events, and the amount of blood products transfused. Twenty-four patients in the treatment group and 24 in the control group were included in the intention-to-treat analysis. Antithrombin was 109.5% (93.0-123.0%) in the treatment group and 84.0% (68.5-98.0%) in the control group (p = 0.001). Supplementation of antithrombin did not decrease heparin dose (13.5 international units/kg/hr [9.6-17.9 international units/kg/hr] vs 15.1 international units/kg/hr [10.7-18.3 international units/kg/hr] in the treatment and control group, respectively; p = 0.33) and anti-Factor Xa levels (0.4 international units/mL [0.3-0.5 international units/mL] vs 0.3 international units/mL [0.2-0.5 international units/mL] in the treatment group and control group respectively; p = 0.65). Bleeding, blood product transfusions, and thrombosis were not different in the two groups.</p> <p><strong>Conclusions: </strong>Antithrombin supplementation may not decrease heparin requirement nor diminish the incidence of bleeding and/or thrombosis in adult patients on venovenous extracorporeal membrane oxygenation.</p>
Dataset for FLEXCHX Article CET(86)2021_Table2
<p>Dataset for FLEXCHX Article Production of synthesis gas from biomass residues by staged fixed-bed gasification - results from pilot test campaigns CET(86)2021_Table2</p>
Belgian Statutory Article Retrieval Dataset (BSARD)
<p>The Belgian Statutory Article Retrieval Dataset (BSARD) is a French native corpus for studying statutory article retrieval. BSARD consists of more than 22,600 statutory articles from Belgian law and about 1,100 legal questions posed by Belgian citizens and labeled by experienced jurists with relevant articles from the corpus.</p>
Raw data for the article: Mind the stimulation site: Enhancing and diminishing sentence comprehension with anodal tDCS
<p>In a previous sham-controlled study, we showed the feasibility of increasing language comprehension in healthy participants by applying anodal transcranial direct current stimulation (atDCS) over the left inferior frontal gyrus (LIFG). In the present work, we present a follow-up experiment targeting with atDCS the left inferior parietal cortex (LIPC) while participants performed the same auditory comprehension task used in our previous experiment. Both neural sites (LIFG and LIPC) are crucial hubs of Baddeley’s model of verbal short-term memory (vSTM).</p> <p>AtDCS over LIPC decreased accuracy as compared to sham and LIFG stimulation, suggesting the involvement of this area in sentence comprehension. Crucially, our results highlighted that applying tDCS over different hubs of the same neural network can lead to opposite behavioural results, with relevant implications from a clinical perspective.</p>
Supporting data for the article "Rediscovery and redescription of Niphargus enslini Karaman, 1932 (Amphipoda, Niphargidae) in southern Germany"
<p>This repository contains supporting data for the article "Rediscovery and redescription of <em>Niphargus enslini </em>Karaman, 1932 (Amphipoda, Niphargidae) in southern Germany".</p> <p>Included in this dataset are:</p> <p>- a zipped folder containing the COI chromatograms from this study (COI_chromatograms.zip);</p> <p>- a Sequencher 4.1 project file containing the COI chromatograms assembled into contigs (COI_chromatograms.SPF);</p> <p>- a FASTA alignment of the COI sequences including sequences from the litterature (COI_virei_enslini.fas);</p> <p>- a zipped folder containing the 28S chromatograms from this study (28S_chromatograms.zip);</p> <p>- a Sequencher 4.1 project file containing the 28S chromatograms assembled into contigs (28S_chromatograms.SPF);</p> <p>- a FASTA alignment of the 28S sequences including sequences from the litterature (28S_comprehensive_dataset.fas).</p>
Raw data for the article: A commentary on "Simultaneous versus staged resection for synchronous colorectal liver metastases: A population-based cohort study". Importance of avoiding any other additional risk in selected patients with synchronous colorectal liver metastases
<p>We read with great interest the article of Dr. Bogach and Colleagues, in which they have evaluated trends of resection for synchronous colorectal cancer liver metastases (CRLM) and associated patient outcomes with a retrospective cohort study from 2006 to 2015 in the province of Ontario, Canada.</p>
dataset relared to article "Childhood‑onset dystonia‑causing KMT2B variants result in a distinctive genomic hypermethylation profile"
<p>Sanger sequences (.abi files) of all patients of Fondazione Besta cohort.</p>
Aligned DNA sequence matrix for phylogenetic analyses in the article "Our unknown neighbor: a new species of rain frog of the genus Pristimantis (Amphibia: Anura: Strabomantidae) from the city of Loja, southern Ecuador"
<p>The aligned matrix is in fasta format. Genes are arranged as follows:</p> <p>12S = 1–909</p> <p>16S = 910–1787</p> <p>RAG-1 = 1788–2399</p>
Dataset related to article "Systematic review and meta-analysis of preclinical studies testing mesenchymal stromal cells for traumatic brain injury"
<p>Mesenchymal stromal cells (MSCs) are widely used in preclinical models of traumatic brain injury (TBI). Results are promising in terms of neurological improvement but are hampered by wide variability in treatment responses. We made a systematic review and meta-analysis: 1) to assess the quality of evidence for MSC treatment in TBI rodent models; 2) to determine the effect size of MSCs on sensorimotor function, cognitive function and anatomical damage; 3) to identify MSC-related and protocol-related variables associated with greater efficacy; 4) to understand whether MSC manipulations boost therapeutic efficacy.</p> <p>The meta-analysis included 80 studies. After TBI, MSCs improved sensorimotor and cognitive deficits, and reduced anatomical damage. Stratified meta-analysis on sensorimotor outcome showed similar efficacy for different MSC sources and for syngeneic or xenogenic transplants. Efficacy was greater when MSCs were delivered in the first week post-injury, and when implanted directly into the lesion cavity. The greatest effect size was for cells embedded in matrices or for MSC-derivatives.</p> <p>MSC therapy is effective in preclinical TBI models, improving sensorimotor, cognitive and anatomical outcomes, with large effect sizes. These findings support clinical studies in TBI.</p> <p>The present dataset reports extrapolated data used for the meta-analysis</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.