Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,145
datasets available to search
ShareScore release 0.9.0
Dataset results
1,145 results for “somatic”
Somatic mutations distinguish melanocyte subpopulations in human skin
GEO Series GSE286964. Homo sapiens. 2 samples. Type: Other.
Reprogramming of mouse somatic cells into pluripotent stem cells using a combination of small molecules
GEO Series GSE48411. Mus musculus. 8 samples. Type: Expression profiling by array.
Germline and Somatic Genetic Landscape of Pediatric Rhabdomyosarcoma
Dynamic approaches that integrate population-based research and molecular biology are needed to explain the mechanisms underlying pediatric rhabdomyosarcoma (RMS) and to determine novel prevention strategies. RMS, the most common soft-tissue sarcoma in children and adolescents, has one of the poorest 5-year survival rates among all pediatric cancers (less than 65%). One of the strongest risk factors for RMS is having a cancer predisposition syndrome. The syndromes that are most commonly seen among those with RMS are Li-Fraumeni, neurofibromatosis type 1, Costello, Noonan, and DICER1. Based on smaller clinic-based studies, only about 7% of RMS cases are thought to be associated with the genes responsible for these syndromes. However, there have been no population-based assessments to support this estimate. Even in the most recent large-scale evaluations of germline mutations in predisposition genes among children with cancer, very few RMS cases were included (43 cases). Furthermore, no distinctions were made between the major histologic subtypes of RMS: embryonal (eRMS) and alveolar (aRMS), which display differences in terms of age distribution, incidence, and cytogenetics. For instance, nearly 80% of alveolar cases are driven by a chromosomal translocation between either PAX3 or PAX7 and FOXO1, whereas these fusions are not seen in embryonal cases. In fact, RMS research is shifting from categorization based on histology to fusion status (eRMS is overwhelmingly fusion-negative). Another limitation in previous studies has been the inability to evaluate the frequency of de novo germline mutations (DNMs) in cancer predisposition genes due to the absence of any well-characterized cohorts of RMS case-parent trios. Therefore, a major gap in our understanding of the role of cancer predisposition in pediatric RMS that limit translational impact is there have been no population-based assessments to determine the true impact of these mutations on pediatric RMS, which limits clinical sequencing guidelines and surveillance protocols in these children. The objective of this project is to advance our understanding of the relationship between cancer predisposition genes and pediatric RMS. Our central hypotheses are: 1) mutations in cancer predisposition genes are more common than expected in children with RMS; and 2) children with fusion-negative tumors have a higher burden of germline mutations than those with fusion-positive tumors. The framework for this study relies on more than 600 well annotated samples collected from newly diagnosed RMS patients and stored in the Children's Oncology Group (COG) Biopathology Center.
Effects of 4-nitrophenol on testicular somatic cells [TM4]
GEO Series GSE150448. Mus musculus. 6 samples. Type: Expression profiling by array.
A XEN-like state bridges somatic cells to pluripotency during chemical reprogramming
GEO Series GSE73631. Mus musculus. 21 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article: SENSE OF OWNERSHIP INFLUENCE ON TACTILE PERCEPTION: IS THE PREDICTIVE CODING ACCOUNT VALID FOR THE SOMATIC RUBBER HAND ILLUSION?
<p><strong><span>Table including demographic data (sex, age, and education), Laterality Quotient score, Proprioceptive drift data, Body Ownership Questionnaire data, and Two-Point Discrimination score</span></strong></p>
Fig. 7 in Direct somatic embryogenesis of drought resistance pistachio (Pistacia vera L.) and expression analysis of somatic embryogenesis-related genes
Fig. 7. Flow chart of somatic embryogenesis system for pistachio. Bar 2 mm.
Genome-Wide Reinforcement of DNA Methylation Occurs during Somatic Embryogenesis in Soybean
GEO Series GSE94299. Glycine max. 59 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Chromatin Reprogramming of In Vitro Fertilized and Somatic Cell Nuclear Transfer Bovine Embryos During Embryonic Genome Activation [single cell ATAC-seq]
GEO Series GSE236607. Bos indicus x Bos taurus; Bos taurus. 938 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Diverse development potency and metabolic shape of extended pluripotency are faithfully transferred to somatic cells via cell fusion reprogramming
GEO Series GSE210520. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Trichostatin A does not correct specific errors of somatic cell nuclear transfer on the transcriptomic level; highlighing the non-random nature of oocyte-mediated reprogramming errors.
GEO Series GSE57247. Bos taurus. 16 samples. Type: Expression profiling by array.
Somatic Rescue and Cancer Mutations in Telomere Biology Disorders
GEO Series GSE249209. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
The Ecdysone Receptor Coactivator Taiman Links Yorkie to Transcriptional Control of Germline Stem Cell Factors in Somatic Tissue
GEO Series GSE157188. Drosophila melanogaster. 4 samples. Type: Expression profiling by high throughput sequencing.
Failure to maternally reprogram histone methylation causes developmental delay due to germline transcription in somatic tissues
GEO Series GSE151340. Caenorhabditis elegans. 6 samples. Type: Expression profiling by high throughput sequencing.
Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells
GEO Series GSE243933. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Histone demethylase KDM6A promotes somatic cell reprogramming by epigenetically regulate PTEN and IL-6 signal pathway [RNA-seq]
GEO Series GSE138815. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Chromatin Accessibility Dynamics in the Reprogramming of Somatic Cells to Pluripotency
GEO Series GSE270236. Mus musculus. 20 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Role of the histone demethylase Kdm6b/Jmjd3 in somatic cell reprogramming [RNA-Seq]
GEO Series GSE74998. Mus musculus. 29 samples. Type: Expression profiling by high throughput sequencing.
Somatic polyploidy supports biosynthesis and tissue function by increasing transcriptional output [RNA-seq]
GEO Series GSE280911. Caenorhabditis elegans; Pristionchus pacificus. 6 samples. Type: Expression profiling by high throughput sequencing.
High-resolution transcriptional analysis of immunoglobulin variable regions reveals the absence of direct relationships between somatic hypermutation, nascent transcription and epigenetic marks [MutPE
GEO Series GSE202039. Homo sapiens; Mus musculus. 36 samples. Type: Other.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.