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1,127
datasets available to search
ShareScore release 0.9.0
Dataset results
1,127 results for “Cell cycle”
αKG-driven RNA polymerase II transcription of cyclin D1 licenses malic enzyme 2 to promote cell cycle progression
GEO Series GSE221723. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Analysis of global transcriptional changes in H. neptunium cells lacking the cell cycle regulatory genes pleC, divJ or divK
GEO Series GSE134343. Hyphomonas neptunium. 8 samples. Type: Expression profiling by high throughput sequencing.
Cell Cycle Reprogramming Mediates Acquired Oxaliplatin Resistance in Pancreatic Cancer [cell lines]
GEO Series GSE300379. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
LSD1 promotes oncogenesis via H3K9 demethylation-mediated cell cycle gene expression and cellular senescence inhibition
GEO Series GSE77448. Homo sapiens. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Acetate Triggers Epigenetic Activation of Cell Cycle Arrest via ACSS2-H2A.Zac Axis in Esophageal Squamous Cell Carcinoma [RNA-seq]
GEO Series GSE309714. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Localized phosphorylation of RNA Polymerase II by G1 cyclin-Cdk promotes cell cycle entry
GEO Series GSE169271. Saccharomyces cerevisiae. 38 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
ChIP-Seq of Histone Deacetylases and Cell Cycle-Regulators in Multiple Myeloma cells
GEO Series GSE86450. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
CDK7 inhibition interdicts deregulated transcription and cell cycle control in multiple myeloma [Resistant_MM_Cell_Lines_6Hr_RNA-seq]
GEO Series GSE172442. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
The cell death negative regulator, CaRLK1 gene, causes metabolic alterations of pyruvate and alanine via the glyoxylate cycle under hypoxia
GEO Series GSE47671. Nicotiana tabacum. 12 samples. Type: Expression profiling by array.
The m5C reader Ybx1 regulates embryonic cortical neurogenesis by promoting the progenitor cell cycle progression.
GEO Series GSE253132. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing; Other.
OTX2 drives medulloblastoma proliferation via direct regulation of cell cycle genes and inhibits differentiation
The transcription factor OTX2 has been implicated as an oncogene in medulloblastoma, which is the most common malignant brain tumor in children. It is highly expressed in most medulloblastomas and amplified in a subset of them. The role of OTX2 in medulloblastoma and its downstream targets are unclear. Therefore, we generated D425 medulloblastoma cells in which we can silence endogenous OTX2 by inducible shRNA. Silencing of OTX2 strongly inhibited cell proliferation and resulted in a neuronal-like differentiation.
Cell-cycle deregulation in diffuse large B-cell lymphoma promotes critical dependence on the cyclin-G associated kinase
GEO Series GSE279610. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease
<p>Dataset from Bischof C, Mirtschink P, Yuan T, Wu M, Zhu C, Kaur J, Pham MD, Gonzalez-Gonoggia S, Hammer M, Rogg EM, Sharma R, Bottermann K, Gercken B, Hagag E, Berthonneche C, Sossalla S, Stehr SN, Maxeiner J, Duda MA, Latreille M, Zamboni N, Martelli F, Pedrazzini T, Dimmeler S, Krishnan J. Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease. Sci Transl Med. 2021 Dec 8;13(623):eabi7964. doi: 10.1126/scitranslmed.abi7964. Epub 2021 Dec 8. PMID: 34878823.</p> <p>Abstract</p> <p>Endoreplication, duplication of the nuclear genome without cell division, occurs in disease to drive morphologic growth, cell fate, and function. Despite its criticality, the metabolic underpinnings of disease-induced endoreplication and its link to morphologic growth are unknown. Heart disease is characterized by endoreplication preceding cardiac hypertrophy. We identify ATP synthase as a central control node and determinant of cardiac endoreplication and hypertrophy by rechanneling free mitochondrial ADP to methylenetetrahydrofolate dehydrogenase 1 L (MTHFD1L), a mitochondrial localized rate-limiting enzyme of formate and de novo nucleotide biosynthesis. Concomitant activation of the adenosine monophosphate–activated protein kinase (AMPK)–retinoblastoma protein (Rb)-E2F axis co-opts metabolic products of MTHFD1L function to support DNA endoreplication and pathologic growth. Gain- and loss-of-function studies in genetic and surgical mouse heart disease models and correlation in individuals confirm direct coupling of deregulated energetics with endoreplication and pathologic overgrowth. Together, we identify cardiometabolic endoreplication as a hitherto unknown mechanism dictating pathologic growth progression in the failing myocardium.</p>
Cell cycle gene expression control
GEO Series GSE13232. Saccharomyces cerevisiae. 49 samples. Type: Expression profiling by array.
The Functional Role of Gab1 and MAPK Signaling in Hair Cycle and Stem Cell Quisecence
GEO Series GSE35780. Mus musculus. 44 samples. Type: Expression profiling by array.
Non-redundant functions of H2A.Z.1 and H2A.Z.2 in chromosome segregation and cell cycle progression
GEO Series GSE173113. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Knockdown of Atoh8 in Neurog3-expressing mouse ductal cells mPAC results in altered expression of multiple cell cycle related genes
GEO Series GSE43537. Mus musculus. 6 samples. Type: Expression profiling by array.
Sensory domain of the cell cycle kinase CckA regulates the differential DNA binding of the master regulator CtrA in Caulobacter crescentus
GEO Series GSE113724. Caulobacter vibrioides. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
CDK7 inhibition interdicts deregulated transcription and cell cycle control in multiple myeloma [Sensitive_MM_Cell_Lines_RNA-seq]
GEO Series GSE172444. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Anti-leukemic effects of glucocorticoids in childhood acute lymphoblastic leukemia: conserved transcriptional pathway to cell cycle arrest but not to cell death
GEO Series GSE73578. Homo sapiens. 133 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.