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15,733 results for “article”
Raw Data for the article: COVID-19 safety measures at the Radiology Unit of a Transplant Institute: the non-COVID-19 patient's confidence with safety procedures
<p><strong>Purpose: </strong>To support the wellbeing of both patients and their families, our aim was to investigate the satisfaction of non-COVID in- and out-patients regarding safety measures implemented at our radiology unit of a transplant institute against COVID infection.</p> <p><strong>Materials and methods: </strong>Over a five-month period, adult patients' feedback was obtained by a questionnaire on the fear of contracting COVID-19 during a radiology examination, the perceived delay in treatment, and the following safety measures implemented: modified schedules to limit the number of patients in the waiting area and to maximize social distancing; assistance by staff when visitors were not admitted; cleaning and disinfection of machines; mask wearing and hand hygiene of staff; and staff advice on hand hygiene and infection control precautions.</p> <p><strong>Results: </strong>Over a five-month period, our preliminary results (387 patients) showed general patient satisfaction (99.1%) with safety measures applied at our radiology unit. Patients were satisfied with distancing and assistance by staff (100%), cleaning and disinfection (91%), mask wearing and hand hygiene of the staff (97%), and staff advice (94%). There was some criticism of the perceived delay in treatment (7.3%) and in the scheduling of the waiting list (5.4%), with 5.4% fearing contracting the virus. Patients' awareness of safety measures and confidence in the hospital preparedness policy was perceived by all interviewers, and 100% appreciated being questioned.</p> <p><strong>Conclusion: </strong>The feedback given by the non-COVID patient helps to measure the quality in health care, to improve the quality service, and to protect and satisfy more vulnerable patients, also during the COVID-19 pandemic.</p>
Raw Data for the article: Atrial fibrillation ablation improves late survival after concomitant cardiac surgery
<p><strong>Objective: </strong>Preoperative atrial fibrillation (AF) increases risk of stroke, heart failure, and all-cause mortality after cardiac surgery. Despite encouraging results and guideline recommendations, surgical ablation (SA) for AF concomitant with other heart surgery remains low. In the current study we aimed to address the long-term mortality after SA concomitant with cardiac surgery.</p> <p><strong>Methods: </strong>This report pertains to the HEart surgery In atrial fibrillation and Supraventricular Tachycardia (HEIST) registry. We identified 20,765 adult patients (62% male) with preoperative AF who underwent conventional sternotomy heart surgery between 2010 and 2021 in 8 tertiary centers in Poland, Netherlands, and Italy. We used Cox proportional hazards models for computations and propensity score matching to minimize differences in baseline characteristics.</p> <p><strong>Results: </strong>Of included patients, 2755 (13.4%) underwent SA for AF. The highest rates of SA were observed for mitral interventions (mitral valve repair or replacement and tricuspid intervention, 25.2%), lowest for isolated coronary artery bypass grafting (6.2%). Patients in the SA group were younger (mean age 64.5 ± 9.0 years vs 68.7 ± 16.0 years; P < .001) and lower risk (mean European System for Cardiac Operative Risk Evaluation [EuroSCORE] II, 4.1 vs 5.7; P < .001). During the 11-year study period, there was a mortality reduction associated with SA (hazard ratio, 0.57; 95% CI, 0.52-0.62; P < .001). After propensity matching, 2750 pairs with similar baseline characteristics were identified. SA was associated with 16% mortality decline (hazard ratio, 0.84; 95% CI, 0.75-0.94; P = .003).</p> <p><strong>Conclusions: </strong>In this multicenter, retrospective, propensity matched study, SA concomitant with other cardiac surgery was associated with improved long-term survival regardless of baseline surgical risk.</p>
Raw Data for the article: Clinical Insights to Complete and Incomplete Surgical Revascularization in Atrial Fibrillation and Multivessel Coronary Disease
<p><strong>Objectives: </strong>Although endorsed by international guidelines, complete revascularization (CR) with Coronary Artery Bypass Grafting (CABG) remains underused. In higher-risk patients such as those with pre-operative atrial fibrillation (AF), the effects of CR are not well studied.</p> <p><strong>Methods: </strong>We analyzed patients' data from the HEIST (HEart surgery In AF and Supraventricular Tachycardia) registry. Between 2012 and 2020 we identified 4770 patients with pre-operative AF and multivessel coronary artery disease who underwent isolated CABG. We divided the cohort according to the completeness of the revascularization and used propensity score matching (PSM) to minimize differences between baseline characteristics. The primary endpoint was all-cause mortality.</p> <p><strong>Results: </strong>Median follow-up was 4.7 years [interquartile range (IQR) 2.3-6.9]. PSM resulted in 1,009 pairs of complete and incomplete revascularization. Number of distal anastomoses varied, accounting for 3.0 + -0.6 vs. 1.7 + -0.6, respectively. Although early (< 24 h) and 30-day post-operative mortalities were not statistically different between non-CR and CR patients [Odds Ratio (OR) and 95% Confidence Intervals (CIs): 1.34 (0.46-3.86); <em>P</em> = 0.593, Hazard Ratio (HR) and 95% CIs: 0.88 (0.59-1.32); <em>P</em> = 0.542, respectively] the long term mortality was nearly 20% lower in the CR cohort [HR (95% CIs) 0.83 (0.71-0.96); <em>P</em> = 0.011]. This benefit was sustained throughout subgroup analyses, yet most accentuated in low-risk patients (younger i.e., < 70 year old, with a EuroSCORE II < 2%, non-diabetic) and when off-pump CABG was performed.</p> <p><strong>Conclusion: </strong>Complete revascularization in patients with pre-operative AF is safe and associated with improved survival. Particular survival benefit with CR was observed in low-risk patients undergoing off-pump CABG.</p>
Raw Data for the article: High-Resolution Secretome Analysis of Chemical Hypoxia Treated Cells Identifies Putative Biomarkers of Chondrosarcoma
<p>Chondrosarcoma is the second most common bone tumor, accounting for 20% of all cases. Little is known about the pathology and molecular mechanisms involved in the development and in the metastatic process of chondrosarcoma. As a consequence, there are no approved therapies for this tumor and surgical resection is the only treatment currently available. Moreover, there are no available biomarkers for this type of tumor, and chondrosarcoma classification relies on operator-dependent histopathological assessment. Reliable biomarkers of chondrosarcoma are urgently needed, as well as greater understanding of the molecular mechanisms of its development for translational purposes. Hypoxia is a central feature of chondrosarcoma progression. The hypoxic tumor microenvironment of chondrosarcoma triggers a number of cellular events, culminating in increased invasiveness and migratory capability. Herein, we analyzed the effects of chemically-induced hypoxia on the secretome of SW 1353, a human chondrosarcoma cell line, using high-resolution quantitative proteomics. We found that hypoxia induced unconventional protein secretion and the release of proteins associated to exosomes. Among these proteins, which may be used to monitor chondrosarcoma development, we validated the increased secretion in response to hypoxia of glyceraldehyde 3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme well-known for its different functional roles in a wide range of tumors. In conclusion, by analyzing the changes induced by hypoxia in the secretome of chondrosarcoma cells, we identified molecular mechanisms that can play a role in chondrosarcoma progression and pinpointed proteins, including GAPDH, that may be developed as potential biomarkers for the diagnosis and therapeutic management of chondrosarcoma.</p>
Article_sacha
<p>The following is described in the repository comments: In the attached data you will find information on the rheological data required for the analysis and the protocols for microbiological and proximal characterization</p>
Raw Data for the article: Continuous Renal Replacement Therapy after Liver Transplantation: Peri-Operative Associated Factors and Impact on Survival
<p>Continuous renal replacement therapy (CRRT) following orthotopic liver transplantation (OLT) is usually started for multifactorial reasons, with variable incidence among series. This paper presents a single-center retrospective observational study on the early use (within one week) of CRRT after consecutive cadaveric OLT from January 2008 to December 2016. Preoperative patient characteristics and intraoperative data were collected, and patients were divided into two groups (CRRT and no CRRT) to explore the factors associated with the use of CRRT. Repeated measurements of postoperative creatinine were analyzed with generalized estimating equation (GEE) models. Among 528 OLT patients, 75 (14.2%) were treated with CRRT at least once in the first week. Patients treated with CRRT showed lower survival in a Kaplan-Meier curve (log-rank <em>p</em> value &lt; 0.01). Patients treated with CRRT had a more severe preoperative profile, with a significantly higher age, MELD, BUN, creatinine, and total bilirubin, as well as a longer surgery time and a higher number of transfusions of red blood cells, plasma, and platelets (all <em>p</em> values &lt; 0.05). In a stepwise multiple analysis, the following characteristics remained independently associated with the use of CRRT: the MELD score OR 1.12 (95% CL: 1.07-1.16), <em>p</em> value &lt; 0.001, and the preoperative value for blood urea nitrogen OR 1.016 (95% CL: 1.010-1.023), <em>p</em> value &lt; 0.001. The early use of CRRT after OLT occurred at a low rate in this large cohort; however, it was associated with worse outcomes. Apart from the preoperative severity, repeated intraoperative hypotension episodes, which were likely modifiable or preventable, were associated with the increased use of CRRT and higher postoperative creatinine.</p>
Raw Data for the article: Risk factors for bile leakage after liver resection for neoplastic disease
<p>Biliary leakage (BL) remains the most frequent and feared complication after hepatoresective surgery. Placement of the abdominal drainage at the end of liver surgery remains controversial due to the delicate balance between risks and potential benefits in case of BL. The study was aimed to detect possible risk factors for BL occurrence after liver surgery. We enrolled all oncologic patients who underwent liver resection from June 2016 to March 2021. BL was diagnosed according to the ISGLS definition. We have examined demographic characteristics of the patients, type of neoplasia, presence of cirrhosis, neoadjuvant chemotherapy and type of intervention. Uni- and multivariable analyses were performed to assess the predictive value of potential predictor of BL. A total of 379 patients were enrolled in the study, 16 (4.2%) of which developed BL. Among others, at univariate analysis the occurrence of BL was found to be associated with bilio-digestive anastomosis (OR: 9.75, C.I. 2.7-34.7, p < 0.001) and neoadjuvant chemotherapy (OR: 0.09, C.I 0.01,-0.88, p = 0.039). Multivariable analysis selected the body mass index (OR: 1.21, 95%C.I.: 1.04-1.41, p = 0.015), anatomical resection (OR: 8.35, 95% C.I.: 2.01-34.74, p = 0.004), and blood loss (OR: 1.09, 95%C.I.: 1.05-1.13, p < 0.001). Identification of patients at greater risk of BL can help in the choice of positioning the drainage at the end of liver surgery.</p>
Raw Data for the article: Cigarette smoke promotes inflammasome-independent activation of caspase-1 and -4 leading to gasdermin D cleavage in human macrophages
<p>Mechanisms and consequences of gasdermin D (GSDMD) activation in cigarette smoke (CS)-associated inflammation and lung disease are unknown. GSDMD is a downstream effector of caspase-1, -8, and -4. Upon cleavage, GSDMD generates pores into cell membranes. Different degrees of GSDMD activation are associated with a range of physiological outputs ranging from cell hyperactivation to pyroptosis. We have previously reported that in human monocyte-derived macrophages CS extract (CSE) inhibits the NLRP3 inflammasome and shifts the response to lipopolysaccharide (LPS) towards the TLR4-TRIF axis leading to activation of caspase-8, which, in turn, activates caspase-1. In the present work, we investigated whether other ASC-dependent inflammasomes could be involved in caspase activation by CSE and whether caspase activation led to GSDMD cleavage and other downstream effects. Presented results demonstrate that CSE promoted ASC-independent activation of caspase-1 leading to GSDMD cleavage and increased cell permeability, in the absence of cell death. GSDMD cleavage was strongly enhanced upon stimulation with LPS+CSE, suggesting a synergistic effect between the two stimuli. Noteworthy, CSE promoted LPS internalization leading to caspase-4 activation, thus contributing to increased GSDMD cleavage. Caspase-dependent GSDMD cleavage was associated with mitochondrial superoxide generation. Increased cleaved GSDMD was found in lung macrophages of smokers compared to ex-smokers and non-smoking controls. Our findings revealed that ASC-independent activation of caspase-1, -4, and -8 and GSDMD cleavage upon exposure to CS may contribute to macrophage dysfunction and feed the chronic inflammation observed in the smokers' lung.</p>
Raw Data for the article: How important is the role of iterative liver direct surgery in patients with hepatocellular carcinoma for a transplant center located in an area with a low rate of deceased donation?
<p><strong>Introduction: </strong>Hepatocellular carcinoma (HCC) accounts for nearly 90% of primary liver cancers, with estimates of over 1 million people affected by 2025. We aimed to explore the impacting role of an iterative surgical treatment approach in a cohort of HCC patients within the Milan criteria, associated with clinical risk factors for tumor recurrence (RHCC) after liver transplant (LT) and loco-regional therapies (LRT), as well as liver resection (LR) and/or microwave thermal ablation (MWTA).</p> <p><strong>Methods: </strong>We retrospectively analyzed our experience performed during an 8-year period between January 2013 and December 2021 in patients treated for HCC, focusing on describing the impact on preoperative end-stage liver disease severity, oncologic staging, tumor characteristics, and surgical treatments. The Cox model was used to evaluate variables that could predict relapse risks. Relapse risk curves were calculated according to the Kaplan-Meier method, and the log-rank test was used to compare them.</p> <p><strong>Results: </strong>There were 557 HCC patients treated with a first-line approach of LR and/or LRTs (<em>n</em> = 335) or LT (<em>n</em> = 222). The median age at initial transplantation was 59 versus 68 for those whose first surgical approach was LR and/or LRT. In univariate analysis with the Cox model, nodule size was the single predictor of recurrence of HCC in the posttreatment setting (HR: 1.61, 95% CI: 1.05-2.47, <em>p</em> = 0.030). For the LRT group, we have enlightened the following clinical characteristics as significantly associated with RHCC: hepatitis B virus infection (which has a protective role with HR: 0.34, 95% CI: 0.13-0.94, <em>p</em> = 0.038), number of HCC nodules (HR: 1.54, 95% CI: 1.22-1.94, <em>p</em> < 0.001), size of the largest nodule (HR: 1.06, 95% CI: 1.01-1.12, <em>p</em> = 0.023), serum bilirubin (HR: 1.57, 95% CI: 1.03-2.40, <em>p</em> = 0.038), and international normalized ratio (HR: 16.40, 95% CI: 2.30-118.0, <em>p</em> = 0.006). Among the overall 111 patients with RHCC in the LRT group, 33 were iteratively treated with further curative treatment (12 were treated with LR, two with MWTA, three with a combined LR-MWTA treatment, and 16 underwent LT). Only one of 18 recurrent patients previously treated with LT underwent LR. For these RHCC patients, multivariable analysis showed the protective roles of LT for primary RHCC after IDLS (HR: 0.06, 95% CI: 0.01-0.36, <em>p</em> = 0.002), of the time relapsed between the first and second IDLS treatments (HR: 0.97, 95% CI: 0.94-0.99, <em>p</em> = 0.044), and the impact of previous minimally invasive treatment (HR: 0.28, 95% CI: 0.08-1.00, <em>p</em> = 0.051).</p> <p><strong>Conclusion: </strong>The coexistence of RHCC with underlying cirrhosis increases the complexity of assessing the net health benefit of ILDS before LT. Minimally invasive surgical therapies and time to HCC relapse should be considered an outcome in randomized clinical trials because they have a relevant impact on tumor-free survival.</p>
Aligned DNA sequence matrix for phylogenetic analyses in the article "A new species of spiny-backed tree frog, genus Osteocephalus (Anura: Hylidae), from the Yanachaga Chemillén National Park in central Peru"
<p>Aligned DNA sequence matrix for phylogenetic analyses of the article "Systematics of Huicundomantis, a new subgenus of Pristimantis (Anura, Strabomantidae) with extraordinary cryptic diversity and eleven new species"</p> <p>The matrix is in NEXUS format and has 14791 bp and 38 terminals.</p> <p>Partitions are as follows:</p> <p>charset 12S_16S = 1-2442;<br> charset mtGenome_other_genes = 2443-9180; charset nonCoding = 3132- 3138 4776- 4857 5203- 5214;<br> charset codonPos1 = 2443-3130\3 3139-4774\3 4858-5200\3 5215-9178\3;<br> charset codonPos2 = 2444-3131\3 3140-4775\3 4859-5201\3 5216-9179\3;<br> charset codonPos3 = 2445-3129\3 3141-4773\3 4860-5202\3 5217-9180\3;<br> charset 16S_ND1nonCoding = 9181- 9428 10390- 10506 ;<br> charset 16S_ND1codonPos1 = 9429-10389\3;<br> charset 16S_ND1codonPos2 = 9430-10387\3;<br> charset 16S_ND1codonPos3 = 9431-10388\3;<br> charset POMCcodonPos1 = 10507-11068\3;<br> charset POMCcodonPos2 = 10508-11066\3;<br> charset POMCcodonPos3 = 10509-11067\3;<br> charset CO1codonPos1 = 11069-12608\3;<br> charset CO1codonPos2 = 11070-12609\3;<br> charset CO1codonPos3 = 11071-12610\3;<br> charset CytbcodonPos1 = 12611-13757\3;<br> charset CytbcodonPos2 = 12612-13758\3;<br> charset CytbcodonPos3 = 12613-13759\3;<br> charset ND2codonPos1 = 13760-14789\3;<br> charset ND2codonPos2 = 13761-14790\3;<br> charset ND2codonPos3 = 13762-14791\3;</p>
data set regarding to article Comparison of diagnostic value of SARC-F and its four modified versions in Polish community-dwelling older adults
<p>This data set corresponds with the article titled Comparison of diagnostic value of SARC-F and its four modified versions in Polish community-dwelling older adults</p>
Datasets and R script to replicate the theoretical modeling from the article entitled Multiple hosts, multiple impacts: the role of vertebrate host diversity in shaping mosquito life history and pathogen transmission
<p>Datasets and R script to replicate the theoretical modeling from the article entitled "<strong> </strong>Multiple hosts, multiple impacts: the role of vertebrate host diversity in shaping mosquito life history and pathogen transmission" by Vantaux A., Moiroux N., Dabire K. R., Cohuet A., Lefevre T. 2023</p>
Experimental material of the article "An Empirical Experiment of a Usability Requirements Elicitation Method based on Interviews"
<p>Questionnaires, problems description and solution, and raw data of the paper "An Empirical Experiment of a Usability Requirements Elicitation Method based on Interviews"</p>
DATASET RELATED TO ARTICLE"SORL1 GENE MUTATION AND OCTAPEPTIDE REPEAT INSERTION IN PRNP GENE IN A CASE PRESENTING WITH RAPIDLY PROGRESSIVE DEMENTIA AND CEREBRAL AMYLOID ANGIOPATHY"
<p><strong>electropherogram of prnp octarepeat region</strong></p> <p><strong>ngs analysis of causal and risk genes associated to dementia</strong></p> <p><strong>prnp octarepeat region analysis by size discrimination of pcr amplicons</strong></p>
datset related to article "NEUROSYPHILIS MIMICKING BEHAVIORAL VARIANT OF FRONTOTEMPORAL DEMENTIA IN A 59-YEAR-OLD MAN"
<p>neuropsychological data (raw data) of patient involved in the study at title</p>
Data set for the article "One-time freeze-thawing or carbon input events have long-term legacies in soil microbial communities"
<p>The following are data and code used for statistical analysis and figure plotting in the manuscript</p> <p>Gorka et al. (2023) "One-time freeze-thawing or carbon input events have long-term legacies in soil microbial communities", Geoderma, <a href="https://doi.org/10.1016/j.geoderma.2023.116399">https://doi.org/10.1016/j.geoderma.2023.116399</a></p> <p>It contains the following files:</p> <ol> <li>Microbial PLFA and NLFA analysis files (contained in <em>Fatty_acid_analysis.zip</em>) <ul> <li>PLFA and NLFA abundance data, in nmol C g<sup>-1</sup> dw (in <em>fatty_acid_data.csv</em>)</li> <li>Taxonomic specificities of fatty acids, needed for R-script to run (in <em>phylum.csv</em>)</li> <li>An R Script reproducing the statistical analysis, figure plotting and output for tables, as used in the manuscript (<em>Fatty_acid_analysis.R</em>)</li> </ul> </li> <li>Soil C and N stoichiometry analysis files (contained in <em>TOC_TN_analysis.zip</em>) <ul> <li>Dissolved organic C (DOC), total dissolved N (TN), and C and N in microbial biomass (Cmic, Nmic) abundance data, in mg g<sup>-1</sup> dw (in <em>toc_tn_data.csv</em>)</li> <li>An R Script reproducing the statistical analysis, figure plotting and output for tables, as used in the manuscript (<em>TOC_TN_analysis.R</em>)</li> </ul> </li> </ol>
DATASET RELATED TO ARTICLE "MISSENSE MUTATION IN ATXN2 GENE (C.2860C > T) IN AN AMYOTROPHIC LATERAL SCLEROSIS PATIENT WITH AGGRESSIVE DISEASE PHENOTYPE"
<p><strong>NGS_analysis PERFORMED AT fONDAZIONE BESTA AND CARRIED OUT AS PART OF THE STUDY MENTIONED AT TITLE</strong></p>
Dataset related toa article: "Dystonia as a prominent feature of TCF20-associated neurodevelopmental disorder: Expanding the phenotype"
<p>Sanger sequences (.abi files) validating variants found with whole exome sequencing</p>
Dataset related to article "MASSIVE IRON ACCUMULATION IN PKAN-DERIVED NEURONS AND ASTROCYTES: LIGHT ON THE HUMAN PATHOLOGICAL PHENOTYPE"
<p>The database contains the microxygraphy data included in the article at title</p>
Datset related to article: "ACTB gene mutation in combined Dystonia-Deafness syndrome with parkinsonism: Expanding the phenotype and highlighting the long-term GPi DBS outcome"
<p>Sanger sequences (.abi files) validating variants found with whole exome sequencing</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.