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12,871 results for “aging;”
Old stone sculpture, midle ages.
Stone sculpture found near the St. Olav's Church in Avaldsnes, Rogaland - Norway in 1922. Decorative part of a stone building, either the church or the adjacent royal hall. The sculpture depicts a mans head with locks of hair. Made of soap stone but has become heavily worn during the course of time. Museums ID: S11724 Source: Objaverse 1.0 / Sketchfab
Iron Age Button-loop Fastener
Iron Age copper alloy and enamel button-loop dress fastener, from Rait, Perthshire. From the collection of Perth Museum & Art Gallery, Perth & Kinross Council. accession: PERGM 2013.30 27.1x12.4x15.9mm Source: Objaverse 1.0 / Sketchfab
Fragment of pottery. Middle ages.
Fragment of pottery. Middle ages. Museum id number: S9454 VF15 Found in: Stavanger, Rogaland - Norway. Source: Objaverse 1.0 / Sketchfab
Iron Age Votive Offering, Castilla La Mancha
Bronze ex-voto (votive offering) in the shape of a human head. from the site of Alarcos, Ciudad Real, Castilla-La Mancha, Spain. Iron Age. In the collection of the Ciudad Real Museum. Catalog number DO000044. Processed in Reality Capture from 400 images. Exvoto16. Sanctuary of the Alarcos oppidum. Citation: This work is part of the collaboration agreement signed in 2020 between the Junta de Comunidades de Castilla-La Mancha and Global Digital Heritage for the digitization of the Cultural Heritage of Castilla-La Mancha region. We want to publicly thank the collaboration of the Museum of Ciudad Real, especially by its director José Ignacio de la Torre. Source: Objaverse 1.0 / Sketchfab
NMB&H, Iron Age Horse Tack Part
"Early Iron Age Bronze tutul with hollow sides for strapping. Diameter 2.6 cm. From the site of Čitluci on Glasinac (eastern Bosnia) Tumulus I, Grave 5 (princely grave). Late 6th c. BCE. Artifact in the National Museum of Bosnia and Herzegovina. Processed in Reality Capture from 392 images. GDH ID No. 2888 This project is a collaboration between Global Digital Heritage and the National Museum of Bosnia and Herzegovina in Sarajevo." Source: Objaverse 1.0 / Sketchfab
Wmid-5003d2 - Incomplete Middle Bronze Age spear
An incomplete copper alloy, tip from a spearhead, probably of Middle Bronze Age period, dating from c. BC 1500 to c. BC 1150. The object is broadly triangular in plan and broadly lozenge shaped in cross section. The object has a blunt point at the top, which seems to have sustained some damage. From the point the sides of the object taper out, ensuring the object is wider at the base. There is a central raised ridge running vertically down the middle of the spear head, this appears on both sides. There is an old horizontal break at the base of the object, probably indicating the spear was broken in antiquity. There are traces of small sides loops. There is damage to both edges of the blade. For more information, please visit the online database record available at: https://finds.org.uk/database/artefacts/record/id/1063942# Source: Objaverse 1.0 / Sketchfab
Supplementary material 1 from: Baum S, Weih M, Bolte A (2012) Stand age characteristics and soil properties affect species composition of vascular plants in short rotation coppice plantations. BioRisk 7: 51-71. https://doi.org/10.3897/biorisk.7.2699
Number of plots containing the respective species is stated.
Matrimid-JUC-62 and Matrimid-PCN-250 mixed matrix membranes displaying light-responsive gas separation and beneficial ageing characteristics for CO2/N2 separation
<p>FTIR, TGA, XRD and gas permeation results for our study of Matrimid-JUC-62 and Matrimid-PCN-250 mixed matrix membranes, including light-responsive properties.</p> <p>Published in: Prasetya, N., Teck, A.A., Ladewig, B.P., <em>Matrimid-JUC-62 and Matrimid-PCN-250 mixed matrix membranes displaying light-responsive gas separation and beneficial ageing characteristics for CO<sub>2</sub>/N<sub>2</sub> separation</em>, (2018) <strong>Scientific Reports</strong>, 8 (1), 2944. </p> <p>doi:<a href="http://dx.doi.org/10.1038/s41598-018-21263-7">10.1038/s41598-018-21263-7</a></p>
Figure 5 in Assessing age, growth, and reproduction of Alburnus mossulensis and Acanthobrama marmid (Cyprinidae) populations in Karakaya Dam Lake (Turkey)
Figure 5. Age and length (FL) relationship due to age groups in A. marmid females.
Figure 6 in Assessing age, growth, and reproduction of Alburnus mossulensis and Acanthobrama marmid (Cyprinidae) populations in Karakaya Dam Lake (Turkey)
Figure 6. Age and length (FL) relationship due to age groups in A. marmid males.
Risky sexual behaviours and utilization of HIV testing services among the adolescent girls and young women aged between 15-24 years in Kibra Sub County, Nairobi County, Kenya
<p><strong>Introduction: </strong>HIV remains a significant global health challenge, disproportionately affecting adolescent girls and young women (AGYW). HIV testing is crucial in controlling the infection and reducing its prevalence. Understanding risky sexual behaviors among AGYW is pivotal in aligning prevention interventions. Despite global prevention efforts, testing gaps persist among AGYW, linked to risky sexual behavior (RSB). This study explores the association between these behaviors and HIV testing utilization among AGYW (aged 15-24) in Kibra Sub County, Nairobi.</p> <p><strong>Methods: </strong>A cross-sectional study sampled 379 AGYW from three wards in Kibra Sub County in Nairobi County. To be an eligible participant, one must have been a resident for at least one year before the time of the study and aged between 15-24 years, employing standardized structured interviewer-administered questionnaires and statistical analyses. Results were analyzed using Chi-square tests and logistic regression. Data was collected between June to July 2023.</p> <p><strong>Results: </strong>Overall, HIV testing prevalence was 60.7% (n=230). Those aged 20-24 were 71.3% (n=164), with secondary education were 63.5% (n=146) and married 28.7% (66) were more likely to undergo testing. Participants engaging in risky behaviors such as lack of condom use (3.96 times more likely), experiencing gender-based violence (4.65 times more likely), or contracting STIs (2.85 times more likely) had higher odds of seeking HIV testing services.</p> <p><strong>Conclusion: </strong>This study establishes a clear link between risky sexual behaviors and HIV testing among AGYW, with a 60.7% testing prevalence; however, gaps still exist. Efforts to enhance testing rates are vital. Interventions should align with acceptable methods, focusing on this high-risk group to ensure effective HIV care and prevention.</p>
Fertility decline in Aedes aegypti mosquitoes is associated with reduced maternal transcript deposition and does not depend on female age
<p>Female mosquitoes undergo multiple rounds of reproduction known as gonotrophic cycles. A gonotrophic cycle spans the period from blood meal intake to egg laying. Nutrients from vertebrate host blood are necessary for completing egg development. During oogenesis, a female pre-packages mRNA into her oocytes, and these maternal transcripts drive the first two hours of embryonic development before zygotic genome activation. In this study, we profiled transcriptional changes in 1-2 hour-old <em>Aedes aegypti</em> embryos across two gonotrophic cycles. We found that homeotic genes which are regulators of embryogenesis are downregulated in embryos from the second gonotrophic cycle. Interestingly, embryos produced by <em>Ae. aegypti</em> females progressively reduced their ability to hatch as the number of gonotrophic cycles increased. We show that this fertility decline is due to increased reproductive output and not the mosquitoes' age. Moreover, we found a similar decline in fertility and fecundity across three gonotrophic cycles in <em>Ae. albopictus</em>. Our results are useful for predicting mosquito population dynamics to inform vector control efforts.</p>
Microglia protect against age-associated brain pathologies - all scRNAseq datasets
<p>Zipped cellranger_matrices file contains the filtered_feature_bc_matrices and the raw_feature_bc_matrices obtained from cellranger for the young (E...), middle-aged(S...), old (...vo...) and thalamic (TH...) datasets. </p> <p> The cellinfo csv files give the metadata for each cell kept in the analysis, with a relationship between each barcode and information such as the umi counts or the cell type annotation.</p> <p>The metadata file gives information about each sample, to trace back the sample names used in cellranger to the biological samples. On other tabs it also has qc information such as the thresholds used for each sample.</p> <p>The raw fastq files and RDS files are available at GEO: GSE267545 and GEO:GSE215440 with the same metadata as here as well as the SingleCellExperiment in form of RDS objects (with information such as normalised reads and dimensional reduction embedings) available at GEO: GSE267545</p> <p>The code used to do the analysis is available in Anna-Williams GitHub and also in ZENODO: </p> <p> https://github.com/Anna-Williams/David-young (10.5281/zenodo.11199128) for the young dataset</p> <p> https://github.com/Anna-Williams/David-old (10.5281/zenodo.11199278) for the middle-aged dataset</p> <p>https://github.com/Anna-Williams/David-vold (10.5281/zenodo.11199322) for the old dataset<br>https://github.com/Anna-Williams/David-Thalamus (10.5281/zenodo.11199349) for the thalamic dataset<br>https://github.com/Anna-Williams/David-AgeIntegration (10.5281/zenodo.11199367) for the integration between the young, middle-aged and old datasets.</p> <p> </p> <p>Microglia are brain-resident macrophages that contribute to central nervous system development, maturation, and preservation. Here, we examine the consequences of lifelong absence of microglia on ageing using the Csf1rΔFIRE/ΔFIRE mouse model. In juvenile Csf1rΔFIRE/ΔFIRE mice, we show that microglia are largely dispensable for the transcriptomic maturation of other brain cell types. In contrast, with advancing age, multiple pathologies accumulate in Csf1rΔFIRE/ΔFIRE brains, astrocytes and oligodendrocyte-lineage cells become increasingly dysregulated, and white matter integrity declines, mimicking many of the pathological features of human CSF1R-related leukoencephalopathy. The thalamus is particularly sensitive to neuropathological changes in the absence of microglia, with atrophy, neuron loss, vascular disturbances, macroglial dysregulation, and severe calcifications all detected in this region. Thalamic calcification formation, which often occurs with normal ageing, is dramatically accelerated in Csf1rΔFIRE/ΔFIRE brains but can be prevented via transplantation of wild-type microglia. Our results indicate that lifelong absence of microglia results in an age-related neurodegenerative condition that can be prevented by the transplantation of healthy microglia.</p>
Loss of alpha Ba-crystallin, but not alpha A-crystallin, increases age-related cataract in the zebrafish lens
<p>The vertebrate eye lens is an unusual organ in that most of its cells lack nuclei and the ability to replace aging protein. The small heat shock protein α-crystallins evolved to become key components of this lens, possibly because of their ability to prevent aggregation of aging protein that would otherwise lead to lens opacity. Most vertebrates express two α-crystallins, αA- and αB-crystallin, and mutations in each are linked to human cataract. In a mouse knockout model, only the loss of αA-crystallin led to early-stage lens cataract. We have used the zebrafish as a model system to investigate the role of α-crystallins during lens development. Interestingly, while zebrafish express one lens-specific αA-crystallin gene (<em>cryaa</em>), they express two αB-crystallin genes, with one evolving lens specificity (<em>cryaba</em>) and the other retaining the broad expression of its mammalian ortholog (<em>cryabb</em>). In this study, we used individual mutant zebrafish lines for all three α-crystallin genes to determine the impact of their loss on age-related cataract. Surprisingly, unlike mouse knockout models, we found that the loss of the αBa-crystallin gene <em>cryaba</em> led to an increase in lens opacity compared to <em>cryaa</em> null fish at 24 months of age. Loss of αA-crystallin did not increase the prevalence of cataract. We also used single-cell RNA-Seq and RT-qPCR data to show a shift in the lens expression of zebrafish α-crystallins between 5 and 10 days post fertilization (dpf), with 5 and 6 dpf lenses expressing <em>cryaa</em> almost exclusively, and expression of <em>cryaba</em> and <em>cryabb</em> becoming more prominent after 10 dpf. These data show that <em>cryaa</em> is the primary α-crystallin during early lens development, while the protective role for <em>cryaba</em> becomes more important during lens aging. This study is the first to quantify cataract prevalence in wild-type aging zebrafish, showing that lens opacities develop in approximately 25% of fish by 18 months of age. None of the three α-crystallin mutants showed a compensatory increase in the expression of the remaining two crystallins, or in the abundant βB1-crystallin. Overall, these findings indicate an ontogenetic shift in the functional importance of individual α-crystallins during zebrafish lens development. Our finding that the lens-specific zebrafish αBa-crystallin plays the leading role in preventing age-related cataract adds a new twist to our understanding of vertebrate lens evolution.</p>
Figures. Exploring the Archived Web in a Highly Transformative Age. Proceedings. dir. S.Gebeil & J.-C. Peyssard
<p>Given recent global crises, the imperative to preserve and analyze online content has never been more vital to enhancing our comprehension of contemporary changes. This book, the outcome of an 5th international RESAW conference that convened experts from 50 disciplines across 17 countries in Marseille in June 2023, tackles the multifaceted challenges of web archiving. It underscores the dual roles of web archiving, as a cultural heritage and as essential source material for researchers delving into contemporary events and the evolution of digital culture. Through 20 chapters, it explores the development of web archiving and examines how technical, cultural, geopolitical, societal and environmental shifts impact its conception, study and dissemination. </p> <p> </p>
Data from: Age-specific induction of mutant p53 drives clonal hematopoiesis and acute myeloid leukemia in adult mice
<p>The investigation of the mechanisms behind p53 mutations in acute myeloid leukemia (AML) has been limited by the lack of suitable mouse models, which historically have resulted in lymphoma rather than leukemia. This study introduces two new AML mouse models. One model induces mutant p53 and <em>Mdm2</em> haploinsufficiency in early development, showing the role of Mdm2 in myeloid-biased hematopoiesis and AML predisposition, independent of p53. The second model mimics clonal hematopoiesis by inducing mutant p53 in adult hematopoietic stem cells, demonstrating that the timing of p53 mutation determines AML versus lymphoma development. In this context, age-related changes in hematopoietic stem cells (HSCs), collaborates with mutant p53 to predispose towards myeloid transformation rather than lymphoma development. Our study unveils new insights into the cooperative impact of HSC age, <em>Trp53</em> mutations and <em>Mdm2</em> haploinsufficiency on clonal hematopoiesis and the development of myeloid malignancies.</p>
Effect of long-term physical disability and aging on extracellular matrix biogenesis in human skeletal muscle
<p>Supplemental Table for a study <strong>Effect of long-term physical disability and aging on extracellular matrix biogenesis in human skeletal muscle</strong></p>
At matched loads, aging does not alter ankle, muscle, or tendon stiffness
<p>Older adults have difficulty maintaining balance when faced with postural disturbances, a task that is influenced by the stiffness of the triceps surae and Achilles tendon. Age-related changes in Achilles tendon stiffness have been reported at matched levels of effort, but measures typically have not been made at matched loads, which is important due to age-dependent changes in strength. Moreover, there has been limited investigation into age-dependent changes in muscle stiffness. Here, we investigate how age alters muscle and tendon stiffness and their influence on ankle stiffness. We hypothesized that age-related changes in muscle and tendon contribute to reduced ankle stiffness in older adults and evaluated this hypothesis when either load or effort were matched. We used B-mode ultrasound with joint-level perturbations to quantify ankle, muscle, and tendon stiffness across a range of loads and efforts in seventeen healthy younger and older adults. At matched loads relevant to standing and the stance phase of walking, there was no significant difference in ankle, muscle, or tendon stiffness between groups (all p > 0.13). However, at matched effort, older adults exhibited asignificant decrease in ankle (27%; p = 0.008), muscle (37%; p = 0.02), and tendon stiffness (22%; p = 0.03) at 30% of maximum effort. This is consistent with our finding that older adults were 36% weaker than younger adults in plantarflexion (p = 0.004). Together, these results indicate that, at the loads tested in this study, there are no age-dependent changes in the mechanical properties of muscle or tendon, only differences in strength that result in altered ankle, muscle, and tendon stiffness at matched levels of effort.</p>
White matter hyperintensity maps in aging and neurodegenerative diseases
<div>The files contain voxel-wise white matter hyperintensity (WMH) maps for 11 different neurodegenerative disease cohorts from the <em>Canadian</em> Consortium on Neurodegeneration in Aging (<em>CCNA</em>) COMPASS-ND dataset in the MNI-ICBM152-2009c space.</div> <div> </div> <div>For more information regarding the participants and method details, see: </div> <div>Dadar, M., Mahmoud, S., Zhernovaia, M., Camicioli, R., Maranzano, J., Duchesne, S., & CCNA Group. (2022). White matter hyperintensity distribution differences in aging and neurodegenerative disease cohorts. <em>NeuroImage: Clinical</em>, <em>36</em>, 103204.</div>
Data from: Age dominates flight distance and duration, while body size shapes flight speed in Bombus terrestris L. (Hymenoptera: Apidae)
<p>Flight plays crucial role in the fitness of insect pollinators, such as bumble bees. Despite their relatively large body size compared to their wings, bumble bees can fly under difficult ambient conditions, such as cooler temperatures. While their body size is often positively linked to their foraging range and flight ability, the influence of age remains less explored. Here, we studied the flight performance (distance, duration, and speed) of aging bumble bee workers using tethered flight mills. Additionally, we measured their intertegular distance (ITD) and dry mass as proxies for their body size. We found that flight distance and duration was predominantly influenced by age, challenging assumptions that age does not play a key role in foraging and task allocation. From the age of 7 to 14 days, flight distance and duration increased six-fold and five-fold, respectively. Conversely, body size primarily impacted the maximum and average flight speed of workers. Our findings indicate that age substantially influences flight distance and duration in bumble bee workers, affecting foraging performance and potentially altering task allocation strategies. This underscores the importance of considering individual age and physiological changes alongside body size/mass in experiments involving bumble bee workers.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.