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29,897 results for “activism”
Figure 3 in A PROTOCOL FOR RECORDING BEHAVIORAL ACTIVITY DURING LONGEVITY STUDIES OF ADULT CHIRONOMIDAE Abstract
Figure 3. Percent of behaviors recorded by adult flies collected from Hay Creek during longevity experiments with adults incubated at different temperatures.
Variation in foraging activity influences area-restricted search behaviour by bottlenose dolphins
<p>Area-restricted search (ARS) behaviour is commonly used to characterise spatio-temporal variation in foraging activity of predators, but evidence of the drivers underlying this behaviour in marine systems is sparse. Advances in underwater sound recording techniques and automated processing of acoustic data now provide opportunities to investigate these questions where species use different vocalisations when encountering prey. Here, we used passive acoustics to investigate drivers of ARS behaviour in a population of dolphins, to determine if residency in key foraging areas increased following encounters with prey. Analyses were based on two independent proxies of foraging: echolocation buzzes (widely used as foraging proxies), and bray calls (vocalizations linked to salmon predation attempts). Echolocation buzzes were extracted from echolocation data loggers and bray calls from broadband recordings by a convolutional neural network (CNN). We found a strong positive relationship between the duration of encounters and the frequency of both foraging proxies, supporting the theory that bottlenose dolphins engage in ARS behaviour in response to higher prey encounter rates. This study provides empirical evidence for one driver of ARS behaviour and demonstrates the potential for applying passive acoustic monitoring in combination with deep learning-based techniques to investigate the behaviour of vocal animals. </p>
Expression of mgtA encoding a magnesium transporter is activated in the absence of the main Mg2+ transporter CorA in Salmonella
<p><i>Salmonella</i> imports magnesium via three known transporters, the widely conserved CorA transporter and the MgtA and MgtB P-type ATPases. CorA is expressed under various growth conditions whereas the other two magnesium transporters, MgtA and MgtB, are expressed under conditions of magnesium starvation under the positive control of the PhoP-PhoQ regulatory system. <br>Our recent results suggest that production of MgtA, but not that of MgtB, is activated in the absence of the main Mg2+ transporter CorA (Metaane <i>et al </i>2022, 2023 ) <br>This hypothesis was further validated in this study by using transcriptional and translational <i>lacZ </i>fusions in the <i>mgtA </i>and <i>mgtB</i> genes. In addition, our data suggest that regulation of expression of MgtA in the absence of CorA is post-transcriptional . </p><p><strong>This work was supported by the French National Research Agency (ANR-19-CE44-0005-01, PERIOMET project).</strong> </p><p>Metaane S, Monteil V, Ayrault S, Bordier L, Levi-Meyreuis C, Norel F. The stress sigma factor sigmaS/RpoS counteracts Fur repression of genes involved in iron and manganese metabolism and modulates the ionome of <i>Salmonella enterica </i>serovar Typhimurium. PLoS One 2022;17(3):e0265511.</p><p>Metaane S, Monteil V, Douché T, Giai Gianetto Q, Matondo M, Maufrais C, Norel F. Loss of CorA, the primary magnesium transporter of <i>Salmonella, </i>is alleviated by MgtA and PhoP-dependent compensatory mechanisms. PLoS One 2023;18(9):e0291736.</p><p> </p>
Mll3 suppresses tumorigenesis by activating the Ink4a/Arf locus
<p>Mutations in genes encoding components of chromatin modifying and remodeling complexes are among the most frequently observed somatic events in human cancers. For example, missense and nonsense mutations targeting the mixed lineage leukemia family member 3 (<em>MLL3</em>/<em>KMT2C</em>) histone methyltransferase occur in a range of solid tumors and heterozygous deletions encompassing <em>MLL3</em> occur in a subset of aggressive leukemias. Although <em>MLL3</em> loss can promote tumorigenesis in mice, the molecular targets and biological processes by which MLL3 suppresses tumorigenesis remain poorly characterized. Here we combined genetic, epigenomic, and animal modeling approaches to demonstrate that one of the mechanisms by which MLL3 links chromatin remodeling to tumor suppression is by co-activating the <em>Cdkn2a</em> tumor suppressor locus. Disruption of <em>Mll3</em> cooperates with <em>Myc</em> overexpression in the development of murine hepatocellular carcinoma (HCC), in which MLL3 binding to the <em>Cdkn2a</em> locus is blunted, resulting in reduced H3K4 methylation and low expression levels of the locus-encoded genes, <em>Ink4a</em> and <em>Arf</em>. Conversely, elevated <em>MLL3</em> expression increases its binding to the CDKN2A locus and co-activates gene transcription. Endogenous Mll3 restoration reverses these chromatin and transcriptional effects and triggers <em>Ink4a</em>/<em>Arf</em>-dependent apoptosis. Underscoring the human relevance of this epistasis, we found that genomic alterations in <em>MLL3</em> and <em>CDKN2A</em> display mutual exclusivity in human HCC samples. These results collectively point to a new mechanism for disrupting CDKN2A activity during cancer development and, in doing so, link MLL3 to an established tumor suppressor network.</p>
pKa of GH18 chitinases in the inactive and active conformation
<p>This directory contains all files required to plot the theoretical pKa of D1, D2, and E from mouse AMCase, human AMCase, and other GH18 chitinases presented in <strong>Figure 4</strong> and <strong>Supplemental Figure 4 </strong>of <a href="https://www.biorxiv.org/content/10.1101/2023.06.03.542675">Díaz et al.<em> </em>(2023)</a>.</p> <p>Structure models were analyzed using PyMOL. Data was analyzed using Graphpad Prism. Figures were compiled using Adobe Illustrator.</p> <p> </p> <p>Files included in this directory:</p> <p><strong>Figures</strong></p> <p>- contains PDFs of Graphpad plots for the pKa of human AMCase, mouse AMCase, and GH18 chitinases D2 in the <em>active </em>or <em>inactive </em>conformation.</p> <p> </p> <p><strong>PDB2PQR</strong></p> <p>- contains all log files from PDB2PQR sorted by data type (mouse AMCase <em>active</em> and <em>inactive </em>D2, human AMCase <em>active</em> and <em>inactive </em>D2, and GH18 chitinase <em>active</em> and <em>inactive </em>D2).</p> <p> </p> <p><strong>PyMOL</strong></p> <p>- contains PyMOL script and session file for each data type (mouse AMCase <em>active</em> and <em>inactive </em>D2, human AMCase <em>active</em> and <em>inactive </em>D2, and GH18 chitinase <em>active</em> and <em>inactive </em>D2) shown in <strong>Figure 4</strong>.</p> <p> </p> <p><strong>Reference Models</strong></p> <p>- contains all structure models shown in <strong>Figure 4</strong>.</p> <p> </p> <p>Contact:<br> Roberto Efraín Díaz, robertoefrain.diaz@ucsf.edu</p> <p>James Fraser, jfraser@fraserlab.com</p>
In silico design, docking simulation, and ANN-QSAR model for predicting the anticoagulant activity of thiourea isosteviol compounds as FXa inhibitors
<p>The present work combined molecular modeling and docking approach for searching and designing novel thiourea isosteviol-based compounds as potential FXa inhibitors. Elaborated regression model establishes the relationships between experimentally determined anticoagulant activity and molecular descriptors and enables the prediction of FXa inhibitory activity for novel compounds. The obtained results proved that the Artificial Neural Network algorithm facilitates the search for the most promising isosteviol derivatives incorporating thiourea fragments as FXa inhibitors. Moreover, docking simulation confirms the prominent binding of the newly in silico designed molecules with the active sites of the protein, which may be the lead molecules and can be further optimized for the efficient pharmacodynamic and pharmacokinetic profiles. The enclosed files are representations of molecular structures of thiourea isosteviol compounds with experimentally tested FXa inhibitory activity (i20-i39) geometrically optimized in hyperchem, newly in silico designed thiourea isosteviol compounds geometrically optimized in hyperchem (e1-e11), one file contains molecular descriptors for optimized structures calculated in Dragon and there is also a code for ANN QSAR model for predicting activity of novel thiourea isosteviol compounds. </p>
Overview of key residues for mAMCase activity.
<p>This directory contains all files to analyze the aromatic, polar, catalytic, and ligand-binding residues as well as overall protein structure as presented in <strong>Supplemental Figure 5</strong> in the manuscript <a href="https://www.biorxiv.org/content/10.1101/2023.06.03.542675">Díaz et al.<em> </em>(2023)</a>.</p> <p>Structure models were analyzed in PyMOL. Figures were compiled using Adobe Illustrator.</p> <p> </p> <p>Contact:</p> <p>Roberto Efraín Díaz, robertoefrain.diaz@ucsf.edu</p> <p>James Fraser, jfraser@fraserlab.com</p>
Solvent‑activated 3D‑printed electrodes and their electroanalytical potential
<p>Dataset including: electrochemical data, SEM data, surface tension, .stl for the labware design. </p>
Data set for "Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing"
<p>Data set for: Kiritani T, Pala A, Gasselin C, Crochet S, Petersen CCH (2023) Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing. PLOS ONE 18: e0287174. doi: 10.1371/journal.pone.0287174</p> <p>There are 2 files in this upload:</p> <p>1. The file named "2023_Kiritani_PLOSONE.pdf" is the Open Access pdf of the online publication in PLOS ONE.</p> <p>2. The file named "Kiritani_data_code.zip" (~5 GB) is a zipped version of a folder "Kiritani_data_code" (~5 GB), which contains the data analysed in the study along with the Matlab codes used to generate the published figures. To access the data and codes, first unzip the file. You need to install the Matlab 'Signal Processing' and 'Curve Fitting' Toolboxes. In Matlab, add the path of the folder 'Kiritani_data_code' and all subfolders. Directly from this folder, you should first run the codes in the folder 'Data_Analysis_Codes', sequentially executing 'Analysis_1.m' through to 'Analysis_9.m'. Note, execution of 'Analysis_9.m' can take a long time (~1 hour on a good desktop PC). You can then run the codes in the folder 'Figure_Plotting_Codes' to generate the figures published in the journal article. In the folder 'Data', you can also find a DataViewer to visualise the data sets, which you can run by executing 'DataViewer.m' directly from the subfolder ‘Data’.</p> <p> </p>
Wrist-worn sensor validation for heart rate variability and electrodermal activity detection in a stressful driving environment
<p>The current dataset contributes to assess the accuracy of the Empatica 4 (E4) wristband for the detection of heart rate variability (HRV) and electrodermal activity (EDA) metrics in stress-inducing conditions and growing-risk driving scenarios. Heart Rate Variability (HRV) and ElectroDermal Activity (EDA) signals were recorded over six experimental conditions (i.e., Baseline, Video Clip, Scream, No Risk Driving, Low-Risk Driving, and High-Risk Driving) and by means of two measurement systems: the E4 device and a gold standard system. The raw quality of the physiological signals was enhanced by means of robust semi-automatic reconstruction algorithms. Heart Rate Variability time-domain parameters showed high accuracy in motion-free experimental conditions, while Heart Rate Variability frequency-domain parameters reported sufficient accuracy in almost every experimental condition.</p>
Dataset for "Synchronous multi-segmental activity between metachronal waves controls locomotion speed in Drosophila larvae"
<p>Dataset for publication "Synchronous multi-segmental activity between metachronal waves controls locomotion speed in Drosophila larvae". </p>
CEP-based Activity Detection Services generated from IoT Data
<p>Data set accompanying the paper "Data-driven Generation of Services for IoT-based Online Activity Detection" submitted to the International Conference on Service-Oriented Computing (ICSOC) 2023.</p> <p>The data set has 6 automatically generated activity detection services (*.siddhi files) for 6 different types of activities executed by 6 different production stations in a smart factory. The *.siddhi files have to be deployed to and activated on an instance of the <a href="http://siddhi.io">Siddhi</a> complex event processing platform.</p> <p>The data set includes the corresponding low-level IoT data for each activity (<strong>activity signature</strong>) that was used to generate the activity detection service (*.txt files). It also includes a visual representation of the activity signature for each type of activity (*.png files). To test the activity detection services, the *.txt files have to be read line by line, each line has to be send as one MQTT message to an MQTT broker and topic that the activity detection service is also listening to (standard: localhost).</p>
Comparison of children's physical activity profiles before and after COVID-19 lockdowns - dataset
<p>This dataset represents a subset of the Active-6 data used to produce the children's activity profiles reported in the manuscript 'Comparison of children's physical activity profiles before and after COVID-19 lockdowns: a latent profile analysis'. Included in this repository is the dataset and a data dictionary.</p> <p>This dataset has been made available so that future researchers can replicate the study findings using the data. If you wish to use the data for any purpose other than replicating the study findings, please contact the Principal Investigator Professor Russ Jago (russ.jago@bristol.ac.uk) to discuss this.</p>
Associated data underlying the publication "Flipped Classroom Real-World Activities for Learning Open Computing Concepts"
<p>Various “open” concepts in Computing, such as open standards, open data, open licenses or system interoperability are becoming more important in the professional lives of software engineers. However, students usually do not receive a systematic education about these concepts ; rather they sporadically learn about a subset of these topics. This paper presents the revised version of the Open Computing course in the University of Zagreb, Faculty of Electrical Engineering and Computing (FER), which teaches a clear set of current topics focused on open data and correlating concepts. The new e-learning course is carried out using the “flipped classroom” educational method ; students construct their knowledge in a set of real-world mini-activities throughout the course, instead of passively learning from the official course resources. In this paper, we discuss our flipped classroom activities, their relation to revised Bloom’s taxonomy of educational objectives, and present the evaluation of the first course instance us- ing this model. Students’ feedback shows they welcome this change in approach, finding the course useful and interesting, and preferring this method to the traditional full lecture setting.</p>
Hidden and total fishing activity hotspots in the Mediterranean Sea between 2017 and 2022 estimated from AIS data
<p>Hidden and total fishing activity hotspots in the Mediterranean Sea between 2017 and 2022 estimated from AIS data</p>
Too hot or too disturbed? Temperatures more than hikers affect circadian activity of females in northern chamois
<p>This dataset contains: i) the activity level recorded by activity sensors for each 5-minutes boot for each individual, ii) the mean daily temperature assessed from ERA5 reanalysis combined with a micro-climate model, iii) the individual exposure to human disturbance for 62 adult female chamois monitored in the National Game and Hunting Reserve of Les Bauges massif (NGHRB), France, between June and September 2004-2020. This dataset is used in the analyses of the scientific paper “Too hot or too disturbed? Temperatures more than hikers affect circadian activity of females in northern chamois" (in prep).</p>
Fig. 2 in Anti-tumour necrosis factor activity in saliva of various tick species and its appearance during the feeding period
Fig. 2. Anti-tumour necrosis factor (TNF) activity in tick salivary glands during feeding. Salivary gland extract (SGE) was prepared from females of Ixodes ricinus (Linnaeus, 1758) either unfed (day 0) or fed for 2, 4, 6 and 8 days. Various concentrations of SGE protein were preincubated for 1.5 h with 2 ng/ml of mouse recombinant TNF before the cytokine ELISA was performed. PBS instead of SGE was added into negative control. Results are presented as the mean ± SD of triplicate wells. *The difference between saliva-treated and untreated group was signif- icant at P <0.05.
Demontration Activities Data Set on the performances of the Photocatalytic pilot plant In Demosite 4 (Galeb, Omis, Croatia) Deliverable 5.6
<p>Raw data (TOC and emerging contaminants time profiles) concernig the validation experiment of the photocatalytic pilot plant for tertiary water treatment deployed in ProjectO demosite 4. The data are presented in D5.6 and pertain three months of demonstration activities</p>
Рис. 3. Ритм ночной активности паукообразных Mesobuthus eupeus, Galeodes araneoides, Lycosa praegrandis. Fig. 3. The rhythm of the night activity of arachnids Mesobuthus eupeus, Galeodes araneoides, Lycosa praegrandis. in Comparison of trophic spectra and hunting strategies of some large arachnids (Arachnida: Scorpiones, Solifugae, Aranei) in semi-desert biocenoses of Gobustan (Eastern Azerbaijan)
Рис. 3. Ритм ночной активности паукообразных Mesobuthus eupeus, Galeodes araneoides, Lycosa praegrandis. Fig. 3. The rhythm of the night activity of arachnids Mesobuthus eupeus, Galeodes araneoides, Lycosa praegrandis.
Extending the application of connectivity metrics within the framework of the characterization of the dynamic behaviour of a WDS subjected to users' activity
<p>Water distribution networks (WDNs) are complex combinations of nodes and links, and the current tendency is to modify their topological structure through the closure of isolation valves for monitoring and water quality reasons. For their analysis, several approaches based on graph theory have recently been proposed, mainly considering steady-state flow conditions. However, in their real functioning, WDNs are continuously subjected to pressure transients generated by manoeuvres on regulation devices or by users’ activity. This study investigates the application of some metrics from graph theory, already used in the context of steady-state analysis, for assessing the effects of changes in the topological structure of a network ‒ due for example to sectorization or branching operations ‒ on its transient response when subjected to manoeuvres on devices such as hydrants, pumps, etc. or users’ activity. The analysis shows that some connectivity metrics can effectively reflect the dynamic pressure behaviour of the network and, thus, provide useful indications for design and management operations taking into account unsteady flow features.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.