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207
datasets available to search
ShareScore release 0.9.0
Dataset results
207 results for “APC”
RNAs enriched at protrusions of control or APC knockdown fibroblasts
GEO Series GSE82229. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
scRNA-seq and TCR-seq of T cells and APCs in tumor-draining lymph nodes with versus without pharmacological LXR activation.
GEO Series GSE275714. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing; Other.
APC and P53 mutations synergize to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer [bulk RNA-seq]
GEO Series GSE198757. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Chromatin binding profiles of the APC tumor suppressor and changes in gene expression following APC silencing
GEO Series GSE99264. Homo sapiens. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Bcl9 and Pygo synergize downstream of Apc to effect intestinal neoplasia in mouse models recapitulating Familial Adenomatous Polyposis (RNA-Seq)
GEO Series GSE121142. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of APC knock down HCEC 1CT cells compared to the wild type HCEC 1CT cells.
GEO Series GSE152562. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Bcl9 and Pygo synergize downstream of Apc to effect intestinal neoplasia in mouse models recapitulating Familial Adenomatous Polyposis (Illumina Beadchip)
GEO Series GSE121130. Mus musculus. 32 samples. Type: Expression profiling by array.
RNAseq comparison of Whole crypt mRNA levels between Control, conditional Notchless KO, Apc KO and Notchless-Apc KO mice 24h or 48h after induction
GEO Series GSE144233. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Single-cell analysis of Villin-Cre;Apc min;Lef1 fl/fl (VApcMinL) and ApcMin intestinal adenoma cells at the age of 11 wks
GEO Series GSE174097. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Inflammatory environment and oxidized LDL convert circulating human proangiogenic cells (PACs) into functional antigen presenting cells (APCs)
GEO Series GSE60208. Homo sapiens. 22 samples. Type: Expression profiling by array.
Protective interaction of human phagocytic APC subsets with Cryptococcus neoformans induces genes associated with metabolism and antigen presentation
GEO Series GSE216963. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Effects of mitochondrial stress on intestinal tumor development depends on Apc status
<p>Mitochondrial stress triggers both metabolic and transcriptomic reprogramming but its effects on tumor development remains unclear. It is also unknown whether the genetic status has any influence on the capacity of mitochondrial stress to control tumor development. To explore these issues, we generated a mouse model lacking the lipid transfer protein Stard7 in intestinal epithelial cells (IECs) and assessed tumor development in both Wnt-dependent tumor initiation and in inflammation-driven tumor development. The loss of Stard7 in both models of intestinal tumors impaired mitochondrial Complex I activity, led to a severe metabolic and lipidomic reprogramming and potentiated mTORC1 activation. As a result, levels of enzymes involved in serine biosynthesis were enhanced in Stard7-deficient IECs showing or not constitutive Wnt signaling. Strikingly, despite similar molecular signatures upon Stard7 deficiency in intestinal crypts showing or not constitutive Wnt signaling, Stard7 contributed to tumor development in AOM/DSS-treated mice but inhibits Wnt-driven cancer initiation in the intestine. Apc+/Min mice lacking Stard7 in IECs developed more tumors in the distal colon. Collectively, our results suggest that the Apc genetic status critically controls the effects of mitochondrial stress on intestinal tumor development.</p>
Safety and Efficacy of APC-0101 in Preterm Infants With Respiratory Distress Syndrome
ClinicalTrials.gov study NCT06776783. IPD Sharing: NO. Countries: 1. Publications: 0.
Dose-Escalation and Safety Study of APC-100 for the Treatment of Prostate Cancer
ClinicalTrials.gov study NCT01436214. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Azithromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis
ClinicalTrials.gov study NCT04454151. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous Polyposis
ClinicalTrials.gov study NCT02175914. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of APC and Epo on the Inflammatory Response During Sepsis
ClinicalTrials.gov study NCT00229034. IPD Sharing: Not stated. Countries: 1. Publications: 0.
APC-111 Once a Day (QD) for 7 Days vs. Penicillin Taken Four Times a Day (QID) for 10 Days in Patients With Strep Throat
ClinicalTrials.gov study NCT00095368. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect on Orencia (Abatacept) on the Apoptosis of T Cells, B Cells and APC Cells in Rheumatoid Arthritis
ClinicalTrials.gov study NCT01717846. IPD Sharing: Not stated. Countries: 1. Publications: 0.
APC-111 MP Tablet Once a Day vs.Penicillin VK Four Times a Day Both for 10 Days in Patients With Strep Throat
ClinicalTrials.gov study NCT00242281. IPD Sharing: Not stated. Countries: 2. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.