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1,013 results for “Acetylation”
Data from: Nɛ-acetyl lysine derivatives with zinc binding groups as novel HDAC inhibitors
HDAC inhibitors have been developed very rapidly in clinical trials and even in approvals for treating several cancers. However, there are few reported HDAC inhibitors designed from Nε-acetyl lysine. In current study, we raised a novel design, which is about Nε-acetyl lysine analogues containing amide acetyl groups with the hybridization of ZBG groups as novel HDAC inhibitors.
Data from: Lysine-14 acetylation of histone H3 in chromatin confers resistance to the deacetylase and demethylase activities of an epigenetic silencing complex
The core CoREST complex (LHC) contains histone deacetylase HDAC1 and histone demethylase LSD1 held together by the scaffold protein CoREST. Here we analyze the purified LHC with modified peptide and reconstituted semisynthetic mononucleosome substrates. LHC demethylase activity toward methyl-Lys4 in histone H3 is strongly inhibited by H3 Lys14 acetylation, and this appears to be an intrinsic property of the LSD1 subunit. Moreover, the deacetylase selectivity of LHC unexpectedly shows a marked preference for H3 acetyl-Lys9 versus acetyl-Lys14 in nucleosome substrates but this selectivity is lost with isolated acetyl-Lys H3 protein. This diminished activity of LHC for Lys14 deacetylation in nucleosomes is not merely due to steric accessibility based on the pattern of sensitivity of the LHC enzymatic complex to hydroxamic acid-mediated inhibition. Overall, these studies have revealed how a single Lys modification can confer a composite of resistance in chromatin to a key epigenetic enzyme complex involved in gene silencing.
Microscopy-based assessment of H3K27-acetylation at RNA polymerase II clusters during early stages of zebrafish embryo development (additional data)
<p>Additional data for the the following main repository: <a href="https://doi.org/10.5281/zenodo.8019735">https://doi.org/10.5281/zenodo.8019735</a></p>
Fig. 4 in Unveiling fungal detoxification pathways of the cruciferous phytoalexin rapalexin A: Sequential L-cysteine conjugation, acetylation and oxidative cyclization mediated by Colletotrichum spp.
Fig. 4. Synthesis of N-acetyl-S-(8-methoxy-4H-thiazolo[5,4-b]indol-2-yl)-L-cysteine (5).
Fig. 8 in Unveiling fungal detoxification pathways of the cruciferous phytoalexin rapalexin A: Sequential L-cysteine conjugation, acetylation and oxidative cyclization mediated by Colletotrichum spp.
Fig. 8. In situ synthesis and transformation of 4-methoxy-3-indoleamine (14).
A Study to Evaluate the Safety of Aceneuramic Acid Extended Release (Ace-ER; UX001) Tablets in Glucosamine (UDP-N-acetyl)-2-Epimerase (GNE) Myopathy (GNEM) (Also Known as Hereditary Inclusion Body Myo
ClinicalTrials.gov study NCT02731690. IPD Sharing: Not stated. Countries: 3. Publications: 0.
Efficacy and Safety of Acetyl L-Carnitine in COVID-19 Patients With Mild-to-Moderate Disease
ClinicalTrials.gov study NCT04623619. IPD Sharing: NO. Countries: 0. Publications: 7.
A Randomised Controlled Trial, Of N-Acetyl Cysteine (NAC), for Premanifest Huntingtin Gene Expansion Carriers
ClinicalTrials.gov study NCT05509153. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Study to Evaluate the Safety and Efficacy of Aceneuramic Acid Extended-Release (Ace-ER) Tablets in Patients With Glucosamine (UDP-N-acetyl)-2-epimerase Myopathy (GNEM) or Hereditary Inclusion Body Myo
ClinicalTrials.gov study NCT02736188. IPD Sharing: Not stated. Countries: 7. Publications: 0.
Effect of Oral N-Acetyl Cysteine in Prevention of Necrotizing Enterocolitis in Preterm Neonates With Feeding Intolerance
ClinicalTrials.gov study NCT06202911. IPD Sharing: NO. Countries: 1. Publications: 0.
The Effect of N-Acetyl-L-Cysteine, on Inflammatory and Oxidative Stress Markers in Pulmonary Sarcoidosis
ClinicalTrials.gov study NCT01587001. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Efficacy of Adding Intravenous N-acetyl Cysteine in Colon Surgeries
ClinicalTrials.gov study NCT03589495. IPD Sharing: YES. Countries: 0. Publications: 1.
Effectiveness of N-acetyl Cysteine, Acetyl L- Carnitine and Medicated Paraffin Oil in Aluminium Phosphide Poisoning
ClinicalTrials.gov study NCT04509258. IPD Sharing: NO. Countries: 1. Publications: 0.
Trial of Famotidine & N-Acetyl Cysteine for Outpatients With COVID-19
ClinicalTrials.gov study NCT04545008. IPD Sharing: NO. Countries: 1. Publications: 0.
An Open Label Phase 2 Extension Study of Higher Dose Sialic Acid-Extended Release (SA-ER) Tablets and Sialic Acid-Immediate Release (SA-IR) Capsules in Patients With Glucosamine (UDP-N-acetyl)-2-Epime
ClinicalTrials.gov study NCT01830972. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Acetyl-L-Carnitine in the Treatment of Septic Shock
ClinicalTrials.gov study NCT00592488. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Role of N-acetyl-l-cysteine (NAC) as an Adjuvant to Opioid Treatment in Patients With Chronic Neuropathic Pain
ClinicalTrials.gov study NCT01840345. IPD Sharing: Not stated. Countries: 1. Publications: 0.
N-Acetyl Cysteine Plus Naltrexone in Methamphetamine Dependence
ClinicalTrials.gov study NCT00332605. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Randomized Double Blinded Study to Examine the Use of N-acetyl Cysteine for the Prevention and Treatment of HAAF in Patients With Type 1 Diabetes
ClinicalTrials.gov study NCT02206152. IPD Sharing: Not stated. Countries: 1. Publications: 0.
An Open-Label Study of N-Acetyl Cysteine in Children With Autism
ClinicalTrials.gov study NCT00676195. IPD Sharing: YES. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.