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183
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ShareScore release 0.9.0
Dataset results
183 results for “Base editing”
CRISPR-Cas9-based editing of histone H3 arginine 17 reveals its methylation-dependent regulation of Yap signaling and early mouse embryo development (RNA-seq data set)
GEO Series GSE111970. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Precise and broad scope genome editing based on high-specificity Cas9 nickases
GEO Series GSE153471. Homo sapiens. 15 samples. Type: Other.
Efficient genetic editing of human intestinal organoids using ribonucleoprotein-based CRISPR
GEO Series GSE241659. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
A modular dCas9-based recruitment platform for combinatorial epigenome editing
GEO Series GSE241460. Homo sapiens. 23 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Expanded repertoire of RNA-editing-based detection for RNA binding protein interactions (5)
GEO Series GSE232519. Homo sapiens. 36 samples. Type: Other.
Systemic comparison of dCas9-based DNA methylation editing systems for specificity and stability [RNAseq_secondRun]
GEO Series GSE297435. Homo sapiens. 42 samples. Type: Expression profiling by high throughput sequencing.
Genotoxic effects of base and prime editing in human hematopoietic stem cells [NHEJ_BaseE_MultiLocus]
GEO Series GSE239852. Homo sapiens. 149 samples. Type: Other.
Harnessing Self-Labeling Enzymes for Selective and Concurrent A-to-I and C-to-U RNA Base Editing
GEO Series GSE160945. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Genotoxic effects of base and prime editing in human hematopoietic stem cells
GEO Series GSE218464. Homo sapiens. 717 samples. Type: Expression profiling by high throughput sequencing; Other.
Base editing mutagenesis maps functional alleles to tune human T cell activity
GEO Series GSE244774. Homo sapiens. 52 samples. Type: Other.
Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic proxy for EPO-increasing therapies.
<p>Summary statistics for the genome-wide association study meta-analysis of circulating EPO in 6,127 individuals of European and African American descent. Effect sizes are aligned to allele 1. </p> <p>Description of column names:<br> # Marker - this is the marker name; chromosome:position<br> # Allele1 - the first allele for this marker in the first file where it occurs<br> # Allele2 - the second allele for this marker in the first file where it occurs<br> # Freq1 - weighted average of frequency for allele 1 across all studies<br> # FreqSE - corresponding standard error for allele frequency estimate<br> # MinFreq - minimum frequency for allele 1 across all studies<br> # MaxFreq - maximum frequency for allele 1 across all studies<br> # Effect - overall estimated effect size for allele1<br> # StdErr - overall standard error for effect size estimate<br> # P-value - meta-analysis p-value<br> # Direction - summary of effect direction for each study, with one '+' or '-' per study. Order of the studies is InCHIANTI, BLSA, HealthABC Europeans, PREVEND, HealthABC African Americans<br> # HetISq - I^2 statistic which measures heterogeneity on scale of 0-100%<br> # HetChiSq - chi-squared statistic in simple test of heterogeneity<br> # df - degrees of freedom for heterogeneity statistic<br> # HetPVal - P-value for heterogeneity statistic<br> # TotalSampleSize - overall sample size for that variant in the meta-analysis</p> <p> </p>
Identification and single-base gene-editing functional validation of a cis-EPO variant as a genetic proxy for EPO-increasing therapies.
<p>Raw fast-qc files for RNA sequencing analysis of whole <em>EPO</em> gene knock-outs generated through CRISPR-Cas9 gene-editing in HEK-293 cells compared to wild-type controls. </p> <p>Wild-type cell-lines (Empty 1 - Empty 4) were transfected with empty CRISPR-Cas9 constructs to ensure cells were treated under the same experimental conditions. Whole EPO gene knock-outs were generated using a double gRNA approach with CRISPR-Cas9 gene-targeting. Two whole EPO gene knock-out cell-lines were generated (KO-A and KO-B).</p> <p>Library preparation was performed using the TruSeq DNA HT Library Preparation Kit using the 3’ poly-A tail primer Oligo(dT) from Illumina (Illumina, California, USA). RNA Sequencing was performed using the Illumina HiSeq 2500 high-throughput sequencing system (Illumina, California, USA). We resulted in 75 bp paired-end sequences.</p> <p> </p>
Figure 1 from: Klein A (2016) Crowdsourcing voice editing and quality assessment of data collected from the largest mobile phone-based research study of Parkinson disease. Research Ideas and Outcomes 2: e8848. https://doi.org/10.3897/rio.2.e8848
Figure 1 - Amazon's Mechanical Turk Web site.
Figure 8 from: Klein A (2016) Crowdsourcing voice editing and quality assessment of data collected from the largest mobile phone-based research study of Parkinson disease. Research Ideas and Outcomes 2: e8848. https://doi.org/10.3897/rio.2.e8848
Figure 8 - Example artifacts in mPower voice recordings.
Base-Edited Hematopoietic Stem/Progenitor Cell X-Linked Severe Combined Immunodeficiency Gene Therapy
ClinicalTrials.gov study NCT06851767. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Base-edited Autologous Hematopoietic Stem Cell Transplantation in Treating Patients With β-thalassemia Major
ClinicalTrials.gov study NCT06065189. IPD Sharing: NO. Countries: 1. Publications: 0.
Long-term Follow-up Study of Lentiviral-based Gene-edited Immune Cell Therapy
ClinicalTrials.gov study NCT05377307. IPD Sharing: NO. Countries: 1. Publications: 0.
CS-121 APOC3 Base Editing in Children and Adolescents With Hyperchylomicronemia
ClinicalTrials.gov study NCT07371767. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Base Edited CAR7 T Cells to Treat T Cell Malignancies (TvT CAR7)
ClinicalTrials.gov study NCT05397184. IPD Sharing: NO. Countries: 1. Publications: 0.
Base Edited CAR T Cells Against AML: Deep Conditioning Ahead of Allogeneic Stem Cell Transplantation
ClinicalTrials.gov study NCT05942599. IPD Sharing: NO. Countries: 1. Publications: 0.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.