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240
datasets available to search
ShareScore release 0.9.0
Dataset results
240 results for “Cardiotoxicity”
Cardiotoxic effects of mycotoxin citrinin on mammalian cells revealed by transcriptome profiling
GEO Series GSE234049. Rattus norvegicus. 4 samples. Type: Expression profiling by high throughput sequencing.
High-Throughput Screening of Human Induced Pluripotent Stem Cell Cardiomyocytes Predicts Tyrosine Kinase Inhibitor Cardiotoxicity
GEO Series GSE88944. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Cardiomyocytes Infected by SARS-CoV-2 Recruit Cardiotoxic Macrophages [scRNA-seq dataset]
GEO Series GSE151878. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic profiling of human cardiac cells predicts protein kinase inhibitor-associated cardiotoxicity [Conv]
GEO Series GSE146095. Homo sapiens. 70 samples. Type: Expression profiling by high throughput sequencing.
Multi-Lineage Heart-Chip Models Drug Cardiotoxicity and Enhances Maturation of Human Stem Cell-Derived Cardiovascular Cells
GEO Series GSE241223. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
The mechanism of cardiotoxicity induced by evodiamine and matrine was revealed by epitranscriptomics
GEO Series GSE274753. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing; Other.
Multiscale profiling of tyrosine kinase inhibitor cardiotoxicity reveals mechanosensitive ion channel PIEZO1 as cardioprotective [bulk RNA-seq]
GEO Series GSE309795. Homo sapiens. 72 samples. Type: Expression profiling by high throughput sequencing.
Magnesium Hexacyanoferrate Nanocatalyst Attenuates Chemodrug-Induced Cardiotoxicity through Ferromodulation-Driven Anti-Apoptosis
GEO Series GSE213983. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Multiscale mapping of transcriptomic signatures for cardiotoxic drugs
GEO Series GSE253490. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
Data from: Determining the genetic basis of anthracycline-cardiotoxicity by response QTL mapping in induced cardiomyocytes
Anthracycline-induced cardiotoxicity (ACT) is a key limiting factor in setting optimal chemotherapy regimes, with almost half of patients expected to develop congestive heart failure given high doses. However, the genetic basis of sensitivity to anthracyclines remains unclear. We created a panel of iPSC-derived cardiomyocytes from 45 individuals and performed RNA-seq after 24h exposure to varying doxorubicin dosages. The transcriptomic response is substantial: the majority of genes are differentially expressed and over 6000 genes show evidence of differential splicing, the later driven by reduced splicing fidelity in the presence of doxorubicin. We show that inter-individual variation in transcriptional response is predictive of in vitro cell damage, which in turn is associated with in vivo ACT risk. We detect 447 response-expression QTLs and 42 response-splicing QTLs, which are enriched in lower ACT GWAS p-values, supporting the in vivo relevance of our map of gene tic regulation of cellular response to anthracyclines.
Early Detection of Patients at Risk of Developing Anthracycline Cardiotoxicity With TEP/CT -FDG
ClinicalTrials.gov study NCT04892667. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Multicentre Study to Determine the Cardiotoxicity of R-CHOP Compared to R-COMP in Patients With Diffuse Large B-Cell Lymphoma
ClinicalTrials.gov study NCT00575406. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Neuromodulation of Cardiovascular Risks Associated With Cardiotoxic Chemotherapy
ClinicalTrials.gov study NCT05921253. IPD Sharing: NO. Countries: 1. Publications: 0.
Dietary Restriction to Prevent Cardiotoxicity in Breast Cancer Patients
ClinicalTrials.gov study NCT06622954. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Defining Robust Predictors of Chemotherapy Related Cardiotoxicity
ClinicalTrials.gov study NCT05159479. IPD Sharing: NO. Countries: 1. Publications: 0.
Low-dose CT-based Method for Detection of Subclinical Anthracycline-induced Cardiotoxicity
ClinicalTrials.gov study NCT03553654. IPD Sharing: NO. Countries: 1. Publications: 0.
Risk Analysis of Cardiotoxic Medication Use Due to Sodium Arsenite Chloride Injection
ClinicalTrials.gov study NCT06060132. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Exercise Preconditioning and Breast Cancer Cardiotoxicity
ClinicalTrials.gov study NCT02842658. IPD Sharing: NO. Countries: 1. Publications: 0.
Defining Late Onset Occult Asymptomatic Cardiotoxicity in Childhood Cancer Survivors Exposed to Anthracycline Therapy
ClinicalTrials.gov study NCT01671696. IPD Sharing: NO. Countries: 1. Publications: 0.
Cardiotoxicity of Targeted Therapy for HER-2 Positive Breast Cancer Patients at High Altitude
ClinicalTrials.gov study NCT05063643. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.