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194
datasets available to search
ShareScore release 0.9.0
Dataset results
194 results for “Cause and effect”
shRNA-based miRNA overexpression results in significant off-target effects caused by isomiR production [miRNA-seq]
GEO Series GSE241301. Homo sapiens. 10 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Domestication causes large-scale effects on gene expression in rainbow trout: Analysis of the muscle transcriptome
GEO Series GSE16901. Coregonus clupeaformis; Osmerus mordax; Oncorhynchus mykiss; Salmo salar; Oncorhynchus tshawytscha. 12 samples. Type: Expression profiling by array.
Estrogen receptor alpha mutations in breast cancer cells cause gene expression changes through constant activity and through secondary effects [ChIP-seq]
GEO Series GSE148277. Homo sapiens. 37 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
shRNA-based miRNA overexpression results in significant off-target effects caused by isomiR production [mRNA-seq]
GEO Series GSE241300. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
shRNA-based miRNA overexpression results in significant off-target effects caused by isomiR production [miRNA-seq PC-3]
GEO Series GSE264166. Homo sapiens. 2 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Parental exposure to gamma radiation causes progressively altered transcriptomes that are linked to adverse effects in zebrafish offspring
GEO Series GSE98539. Danio rerio. 14 samples. Type: Expression profiling by high throughput sequencing.
Estrogen receptor alpha mutations in breast cancer cells cause gene expression changes through constant activity and through secondary effects [ATAC-seq]
GEO Series GSE148278. Homo sapiens. 26 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
A maternal-effect Padi6 variant causes nuclear and cytoplasmic abnormalities in oocytes as well as failure of epigenetic reprogramming and zygotic genome activation in embryos [scRNA-seq]
GEO Series GSE245423. Mus musculus. 96 samples. Type: Expression profiling by high throughput sequencing.
Estrogen receptor alpha mutations in breast cancer cells cause gene expression changes through constant activity and through secondary effects [RNA-seq]
GEO Series GSE148276. Homo sapiens. 44 samples. Type: Expression profiling by high throughput sequencing.
A multiplexed assay for exon recognition reveals that an unappreciated fraction of rare genetic variants cause large-effect disruptions to splicing
GEO Series GSE120695. Homo sapiens. 20 samples. Type: Other.
Estrogen receptor alpha mutations in breast cancer cells cause gene expression changes through constant activity and through secondary effects
GEO Series GSE148279. Homo sapiens. 107 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
shRNA-based miRNA overexpression results in significant off-target effects caused by isomiR production [DU-145 cells]
GEO Series GSE247987. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Domestication causes large-scale effects on gene expression in rainbow trout: Analysis of the liver transcriptome
GEO Series GSE16897. Osmerus mordax; Coregonus clupeaformis; Oncorhynchus tshawytscha; Oncorhynchus mykiss; Salmo salar. 14 samples. Type: Expression profiling by array.
A maternal-effect Padi6 variant causes nuclear and cytoplasmic abnormalities in oocytes as well 2 as failure of epigenetic reprogramming and zygotic genome activation in embryos
GEO Series GSE245426. Mus musculus. 193 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Other.
Data from: Effective polyploidy causes phenotypic delay and influences bacterial evolvability
Whether mutations in bacteria exhibit a noticeable delay before expressing their corresponding mutant phenotype was discussed intensively in the 1940s to 1950s, but the discussion eventually waned for lack of supportive evidence and perceived incompatibility with observed mutant distributions in fluctuation tests. Phenotypic delay in bacteria is widely assumed to be negligible, despite the lack of direct evidence. Here, we revisited the question using recombineering to introduce antibiotic resistance mutations into E. coli at defined time points and then tracking expression of the corresponding mutant phenotype over time. Contrary to previous assumptions, we found a substantial median phenotypic delay of three to four generations. We provided evidence that the primary source of this delay is multifork replication causing cells to be effectively polyploid, whereby wild-type gene copies transiently mask the phenotype of recessive mutant gene copies in the same cell. Using modeling and simulation methods, we explored the consequences of effective polyploidy for mutation rate estimation by fluctuation tests and sequencing-based methods. For recessive mutations, despite the substantial phenotypic delay, the per-copy or per-genome mutation rate is accurately estimated. However, the per-cell rate cannot be estimated by existing methods. Finally, with a mathematical model, we showed that effective polyploidy increases the frequency of costly recessive mutations in the standing genetic variation (SGV), and thus their potential contribution to evolutionary adaptation, while drastically reducing the chance that de novo recessive mutations can rescue populations facing a harsh environmental change such as antibiotic treatment. Overall, we have identified phenotypic delay and effective polyploidy as previously overlooked but essential components in bacterial evolvability, including antibiotic resistance evolution.
Effectiveness of Public Service Announcements in Promoting Social Causes
Open the record for dataset details and reuse information.
EFFECT ON QUALITY OF COCON AND COCON YARN STUDY OF CAUSING FACTORS
Open the record for dataset details and reuse information.
Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria
ClinicalTrials.gov study NCT00785135. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effectiveness and Safety of T-MSAT on Inpatients With Acute Low Back Pain Caused by Traffic Accidents : A Randomized Controlled Trial
ClinicalTrials.gov study NCT04554446. IPD Sharing: NO. Countries: 1. Publications: 0.
GLP-1 Response and Effect in Individuals With Obesity Causing Genetic Mutations
ClinicalTrials.gov study NCT02082496. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.