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316
datasets available to search
ShareScore release 0.9.0
Dataset results
316 results for “Cognitive aging”
The Cognitive Effects of 6- and 12-weeks Administration of a Food Supplement Containing Phosphatidylserine in Healthy Children Aged 8 to 12 Years
ClinicalTrials.gov study NCT05177978. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cognitive Aging and Training With Video-games
ClinicalTrials.gov study NCT02007616. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Increasing Lean Protein Intake in Preschool-age Children and Assessing Effects on Cognition and Select Health Outcomes
ClinicalTrials.gov study NCT06882252. IPD Sharing: NO. Countries: 1. Publications: 2.
Microbiome of the Ageing Gut and Its Effect on Human Gut Health and Cognition.
ClinicalTrials.gov study NCT04199195. IPD Sharing: YES. Countries: 1. Publications: 1.
Data from: General perceptual-cognitive abilities: age and position in soccer
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Frequency of biologically-defined AD in relation to age, sex, APOEε4 and cognitive impairment in a prospective cohort study
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Data from: Circulating cortisol and cognitive and structural brain measures in a middle-aged cohort: the Framingham Heart Study
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Data from: Cognition at age 70: life course predictors and associations with brain pathologies
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Data from: Differential aging trajectories in motivation, inhibitory control and cognitive flexibility in Barbary macaques (Macaca sylvanus)
<p>Across the life-span, the performance in problem-solving tasks varies strongly, due to age-related variation in cognitive abilities as well as the motivation to engage in a task. Nonhuman primates provide an evolutionary perspective on human cognitive and motivational aging, as they lack an insight into their own limited lifetime, and aging trajectories are not affected by customs and societal norms. To test age-related variation in inhibitory control, cognitive flexibility, and persistence, we presented Barbary macaques (<i>Macaca sylvanus</i>), living at La Forêt des Singes in Rocamadour (France), with three problem-solving tasks. We conducted 297 trials with 143 subjects aged 2—30 years. We found no effect of age on success and latency to succeed in the inhibitory control task. In the cognitive flexibility task, 21 out of 99 monkeys were able to switch their strategy, but there was no evidence for an effect of age. Yet, the persistence in the motivation task as well as the overall likelihood to participate in any of the tasks declined with increasing age. These results suggest that motivation declines earlier than the cognitive abilities assessed in this study, corroborating the notion that non-human primates and humans show similar changes in motivation in old age.</p>
Data from: Accelerated epigenetic age and cognitive decline among urban-dwelling adults
Objectives. Epigenetic modifications are closely linked with aging, but their relationship with cognition remains equivocal. Given known sex differences in epigenetic aging, we explored sex-specific associations of three DNA methylation-based (DNAm) measures of epigenetic age acceleration (EAA) with baseline and longitudinal change in cognitive performance among middle-aged urban adults. Methods. We used exploratory data from a sub-group of participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study with complete DNA samples and whose baseline ages were >50.0y (2004-2009) to estimate three DNAm EAA measures: (A) universal epigenetic age acceleration (AgeAccel); (B) intrinsic epigenetic age acceleration (IEAA) ; and (C) extrinsic epigenetic age acceleration (EEAA). Cognitive performance was measured at baseline visit (2004-2009) and first follow-up (2009-2013) with 11 test scores covering global mental status and specific domains such as learning/memory, attention, visuo-spatial, psychomotor speed, language/verbal and executive function executive. A series of mixed-effects regression models were conducted adjusting for covariates and multiple testing (N=147-156, ~51% men, k=1.7-1.9 observations/participant, mean follow-up time~4.7y). Results. EEAA, a measure of both biological age and immunosenescence, was consistently associated with greater cognitive decline among men on tests of visual memory/visuo-constructive ability (Benton Visual Retention Test: γ11=0.0512±0.0176, p=0.004) and attention/processing speed (Trail making test, part A: γ11=0.219±0.080, p=0.007). AgeAccel and IEAA were not associated with cognitive change in this sample. Conclusions. EEAA capturing immune system cell aging was associated with faster decline among men in domains of attention and visual memory. Larger longitudinal studies are needed to replicate our findings.
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 6 To 10
ClinicalTrials.gov study NCT00754013. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Efficacy of Human Umbilical Cord Blood Plasma Infusion for Age-Related Cognitive Decline
ClinicalTrials.gov study NCT04566757. IPD Sharing: UNDECIDED. Countries: 0. Publications: 4.
Post-Operative Cognitive Dysfunction in Normal Aging Patients Undergoing Elective Orthopedic Surgery
ClinicalTrials.gov study NCT04267328. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Using Teleneuropsychology to Optimize Cognition in Healthy Aging: the Web-based Breakfast Game
ClinicalTrials.gov study NCT05506852. IPD Sharing: YES. Countries: 1. Publications: 0.
French Study to Evaluate the Impact of a Cognitive Therapy on Urinary Incontinent Women of All Age's Perineal Settings.
ClinicalTrials.gov study NCT03797365. IPD Sharing: UNDECIDED. Countries: 0. Publications: 13.
A Relational Research Recruitment and Engagement Intervention for Cognitive Aging Research
ClinicalTrials.gov study NCT05444244. IPD Sharing: NO. Countries: 1. Publications: 0.
Accelerated Age-related Cognitive Decline: Impact of Exercise on Executive Function and Neuroplasticity
ClinicalTrials.gov study NCT05655325. IPD Sharing: YES. Countries: 1. Publications: 0.
Comparison of Desflurane With Sevoflurane for School-age Children in Postoperative Cognitive Function
ClinicalTrials.gov study NCT02909413. IPD Sharing: UNDECIDED. Countries: 0. Publications: 9.
Evaluating The Efficacy And Safety Of Donepezil Hydrochloride (Aricept) In The Treatment Of The Cognitive Dysfunction Exhibited By Children With Down Syndrome, Aged 11 To 17
ClinicalTrials.gov study NCT00754052. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Investigating the Combined Effects of Intermittent Hypoxia and Exercise on Cognitive and Cerebral Function in Middle-Aged Adults
ClinicalTrials.gov study NCT06874387. IPD Sharing: NO. Countries: 0. Publications: 3.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.