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1,304 results for “Cognitive impairments”
Frequency of biologically-defined AD in relation to age, sex, APOEε4 and cognitive impairment in a prospective cohort study
<p><b>Objective:</b> <span> To assess the frequency of biologically-defined Alzheimer's disease (AD) in relation to age, sex and <i>APOEε4</i>, as well as rates of discordance between clinically- and biologically defined AD. </span></p> <p><b>Methods:</b> <span>We assessed cognitively unimpaired (CU) elderly (n=166), amnestic MCI (n=77) and probable AD dementia (n=62) subjects who underwent evaluation by dementia specialists and neuropsychologists in addition to amyloi</span>d-PET with [<sup>18</sup>F]AZD4694<span> and tau-PET with [<sup>18</sup>F]MK6240. Individuals were grouped according to their AD biomarker profile. Positive predictive value for biologically-defined AD was assessed in relation to clinical diagnosis. Frequency of AD biomarker profiles were assessed using logistic regressions with odds ratios and 95% CIs.</span></p> <p><b>Results:</b> <span>The clinical diagnosis of probable AD dementia demonstrated good agreement with biologically-defined AD (positive predictive value: 85.2%). 7.88% of CU elderly subjects were positive for both amyloid-PET and tau-PET. Frequency of biologically-defined AD increased with age (OR: 1.14; p<0.0001) and frequency of <i>APOEε4</i> allele carriers (Single <i>ε4: </i>OR: 3.82; <i>p</i><0.0001; Double <i>ε4: </i>OR: 17.55, <i>p</i><0.0001). </span></p> <p><b>Discussion:</b> While we observed <span>strong, but not complete, agreement between clinically-defined "probable AD" dementia and biomarker positivity for both amyloid</span>-β<span> and tau, we also observed that biologically-defined AD was not rare in CU elderly. A</span>bnormal tau-PET was almost exclusively observed in individuals with abnormal amyloid-PET. <span>Our results highlight that even in tertiary care memory clinics, detailed evaluation by dementia specialists systematically underestimates the frequency of biologically-defined AD and related entities. </span></p>
Exploring global trends in brain stimulation research for cognitive impairment and related disorders: A bibliometric review
<p><span>The dataset was gathered from the Web of Science Core Collection database (WoSCC), comprising scientific publications indexed by the Social Sciences Citation Index (SSCI), Science Citation Index Expanded (SCI-E), and Arts & Humanities Citation Index (AHCI), by using various keyword searching strategy. Based on this dataset, a bibliometric analysis was done.</span></p>
Mild Cognitive Impairment
<p>Data of Mild Cognitive Impairment Patients.</p>
PubChem lists to Study the Exposome of Mild Cognitive Impairment and Alzheimer's Disease on Cerebrospinal Fluid
<p>Collection of 4 lists of chemicals associated to Alzheimer's disease (AD) and related disorders. </p> <p>The following table describes the mentioned lists. </p> <table> <tbody> <tr> <td>Name</td> <td>Description</td> </tr> <tr> <td>AD-database</td> <td>Database of 41,917 chemicals related to AD and other neurodegenerative disorders. CIDs co-ocurring with the 27 selected MeSH terms (*see below) were merged and mapped to the parent CIDS.</td> </tr> <tr> <td>TOP1</td> <td>List of 1,268 chemicals having D000544 (AD MeSH code) as the first neighbor .</td> </tr> <tr> <td>SC20</td> <td>List of 247 chemicals created after truncating by 1/20 of the maximum co-ocurrence score of the chemical neighbors for D000544. </td> </tr> <tr> <td>AD-CTD</td> <td>List of 86 chemicals specifically related to AD in the Comparative Toxicogenomic Database (CTD)</td> </tr> </tbody> </table> <p> *Selected MeSH terms for the AD-database: D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647,D000647 and D000647.</p> <p>HMDB-CSF can be downloaded <a href="https://csfmetabolome.ca/downloads"><strong>here</strong></a>.</p> <p>PubChemLite for Exposomics (version 1.12.0) can be found <a href="https://doi.org/10.5281/zenodo.6936117"><strong>here</strong></a>.</p>
A Digital Cognitive Behavioural Therapy for Insomnia Intervention in Mild Cognitive Impairment and Mild Dementia
ClinicalTrials.gov study NCT07363928. IPD Sharing: NO. Countries: 1. Publications: 13.
Effects of Single and Dual Task Training in Individuals With Mild Cognitive Impairment
ClinicalTrials.gov study NCT04301960. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Cognitive Impairment in Kidney Disease
ClinicalTrials.gov study NCT00905619. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
A Complex Intervention Study on a Palliative Rehabilitation Blended Learning Program to Support Relatives and Health Care Providers of People With ALS and Cognitive Impairments in Coping With Challeng
ClinicalTrials.gov study NCT04638608. IPD Sharing: NO. Countries: 1. Publications: 3.
An Observational Study Using Multimodal Sensors to Measure Cognitive Health in Adults and Distinguish Mild Cognitive Impairment From Normal Aging
ClinicalTrials.gov study NCT05058950. IPD Sharing: YES. Countries: 1. Publications: 1.
OptiCogs: A Multicomponent Intervention to Rehabilitate Cognitive Impairment in People Post-stroke
ClinicalTrials.gov study NCT05414539. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effectiveness of Tai Chi to Improve Cognitive Function in Older Adults With Mild Cognitive Impairment
ClinicalTrials.gov study NCT04248400. IPD Sharing: NO. Countries: 1. Publications: 1.
A 12-weeks Study to Evaluate the Dietary Fiber and Probiotics Treatment in Prevention and Intervention of Weight-gain and Cognitive Impairment of Schizophrenia or Bipolar Disorder
ClinicalTrials.gov study NCT03379597. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Metformin Treatment on Cognitive Impairment of Schizophrenia Co-morbid Metabolic Syndrome
ClinicalTrials.gov study NCT03271866. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Prediction of Delayed Cognitive Impairment in Cardiac Arrest Survivors With Good Neurological Outcomes
ClinicalTrials.gov study NCT05830422. IPD Sharing: NO. Countries: 1. Publications: 4.
Immersive Virtual Reality for Dual-task Training in Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial
ClinicalTrials.gov study NCT05730790. IPD Sharing: NO. Countries: 1. Publications: 10.
Vascular Alteration and Evolution of Cognitive Impairment
ClinicalTrials.gov study NCT01351961. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Working Memory Training in Patients with Mild Cognitive Impairment
ClinicalTrials.gov study NCT06734286. IPD Sharing: NO. Countries: 1. Publications: 21.
Dance Intervention to Improve Executive Function and Physical Performance in Older Adults With Cognitive Impairment
ClinicalTrials.gov study NCT07105800. IPD Sharing: NO. Countries: 1. Publications: 13.
Using Immersive Virtual Reality for Cognitive Therapy in Elderly with Mild Cognitive Impairment
ClinicalTrials.gov study NCT06838494. IPD Sharing: YES. Countries: 1. Publications: 1.
Improvement of Memory in Mild Cognitive Impairment
ClinicalTrials.gov study NCT05708001. IPD Sharing: Not stated. Countries: 1. Publications: 4.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.