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13,531 results for “Down Syndrome”
Data from: A naturally occurring canine model of syndromic congenital microphthalmia
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Data from: Paradoxical aortic stiffening and subsequent cardiac dysfunction in Hutchinson–Gilford progeria syndrome
<p>Hutchinson–Gilford progeria syndrome (HGPS) is an ultra-rare disorder with devastating sequelae resulting in early death, presently thought to stem primarily from cardiovascular events. We analyse novel longitudinal cardiovascular data from a mouse model of HGPS (<i>Lmna<sup>G609G/G609G</sup></i>) using allometric scaling, biomechanical phenotyping, and advanced computational modelling and show that late-stage diastolic dysfunction, with preserved systolic function, emerges with an increase in the pulse wave velocity and an associated loss of aortic function, independent of sex. Specifically, there is a dramatic late-stage loss of smooth muscle function and cells and an excessive accumulation of proteoglycans along the aorta, which result in a loss of biomechanical function (contractility and elastic energy storage) and a marked structural stiffening despite a distinctly low intrinsic material stiffness that is consistent with the lack of functional lamin A. Importantly, the vascular function appears to arise normally from the low-stress environment of development, only to succumb progressively to pressure-related effects of the lamin A mutation and become extreme in the peri-morbid period. Because the dramatic life-threatening aortic phenotype manifests during the last third of life there may be a therapeutic window in maturity that could alleviate concerns with therapies administered during early periods of arterial development.</p>
PNAS Freshwater Salinization Syndrome
<p>This report was published online by the National Academy of Sciences - the DOI is https://doi.org/10.1073/pnas.1711234115. This spreadsheet lists the descriptions and trends (sen slopes) for each chemical parameter at each location that was used in that study. All raw data is publicly available and was downloaded from waterwatch.usgs.gov.</p>
Data from: The island syndrome hypothesis is only partially validated in two rodent species in an inland-island system
<p><span>According to the island syndrome and island rule hypotheses, island isolation and reduced area lead to phenotypic shifts in ecologically relevant traits in insular populations compared to mainland ones. These hypotheses have been built up with oceanic islands in mind or islands where isolation is high and colonization rate relatively limited. This set of hypotheses, however, may not be applicable to other inland-island systems or recently fragmented landscapes. </span></p> <p><span>We investigated how island life leads to phenotypic changes in two rodent metapopulations: deer mice and red-backed voles in a fragmented system on a river in Canada. From 2013 to 2016, we sampled 454 deer mice and 665 red-backed voles spread across 10 islands and six mainland sites on river shores. We compared body mass, tail and hindfoot length, exploration, and reaction towards predators, between individuals from island and mainland sites, and assessed the role of connectivity, isolation and area of islands. </span></p> <p><span>Insular individuals from both species were less aggressive towards potential predators and insular mice were more thorough explorers compared to mainland ones. Male mice were heavier and juvenile mice had longer tails on islands. However, contrary to expectations, we found negative relationships between aggressiveness and juvenile exploration score with patch connectivity for mice. Island connectivity significantly affected tail length of mice through a concave relationship. Finally, vole aggressiveness and exploration of male mice were positively correlated to island isolation. </span></p> <p><span>Our study supports only partially the predictions of the island syndrome hypothesis. It provides empirical evidence that inland-island life can modify traits in deer mice, but less so in red-backed voles in a non-oceanic system. It also raises questions about the direct causal factors of these changes in a naturally fragmented landscape, and urges for more predictive models about phenotypic/genetic divergence among populations in natural and artificial fragmented landscapes.</span></p>
Data from: Age and sex prevalence estimate of Joubert Syndrome in Italy
Objective: To estimate the prevalence of Joubert syndrome (JS) in Italy applying standards of descriptive epidemiology, and to provide a molecular characterization of the described patients cohort. Methods: We enrolled all patients with a neuroradiologically confirmed diagnosis of JS and resident in Italy in 2018, and calculated age and sex prevalence, assuming a Poisson distribution. We also investigated the correlation between proband chronological age and age at diagnosis, and performed Next-Generation Sequencing (NGS) analysis on probands' DNA when available. Results: We identified 284 JS patients: the overall, female- and male-specific population-based prevalence rates were 0.47 (95% CI 0.41-0.53), 0.41 (95% CI 0.32-0.49) and 0.53 (95% CI 0.45-0.61) per 100,000 population, respectively. When considering only patients in the age range from 0 to 19 years, the corresponding population-based prevalence rates rose to 1.7 (95% CI 1.49-1.97), 1.62 (95% CI 1.31-1.99) and 1.80 (95% CI 1.49-2.18) per 100,000 population. NGS analysis allowed identifying the genetic cause in 131 out of 219 screened probands. Age at diagnosis was available for 223 probands, with a mean of 6.67 ± 8.10 years, and showed a statistically significant linear relationship with chronological age (r2=0.91; p<0.001). Conclusions: We estimated for the first time the age and sex prevalence of JS in Italy, and investigated their genetic profile. The obtained population-based prevalence rate was approximately 10 times higher than that available in literature for children population.
Contrasting association of Leptin receptor polymorphisms and haplotypes with polycystic ovary syndrome in Bahraini and Tunisian women: a case–control study
<p><span><b>Background</b>. This study examined the contribution of ethnicity to the association of leptin receptor gene (<i>LEPR)</i> genetic variants with polycystic ovary syndrome (PCOS) in Tunisian and Bahraini Arabic-speaking women.<b> </b></span></p> <p><span><b>Methods. </b>Subjects consisted of 320 women with PCOS, and 446 eumenorrhic women from Tunisia, and 242 women with PCOS and 238 controls from Bahrain. Genotyping of (exonic) rs1137100 and rs1137101 and (intronic) rs2025804 <i>LEPR</i> variants was done by allelic exclusion.<b> </b></span></p> <p><span><b>Results. </b>The minor allele frequencies of rs1137100 and rs1137101 were significantly different between PCOS cases and control women from Bahrain but not Tunisia, and <i>LEPR</i> rs1137101 was associated with increased PCOS susceptibility only in Bahraini subjects. Furthermore, rs1137100 was associated with decreased PCOS risk among Bahrainis under codominant and recessive models; rs1137100 was negatively associated with PCOS in Tunisians after controlling for testosterone. In addition, rs2025804 was associated with increased PCOS risk among Tunisian but not Bahraini women, after adjusting for key covariates. Negative correlation was seen between rs1137101 and triglycerides in Tunisians, while HOMA-IR and insulin correlated with rs2025804 and rs1137101 among Bahraini subjects, and rs1137101 correlated with estradiol and prolactin. Taking TAG haplotype as common, positive association of TAA and negative association of TGG haplotype with PCOS was seen among Bahraini women; no three-locus PCOS-associated haplotypes were found in Tunisians.<b> </b></span></p> <p><span><b>Conclusions. </b>T<span>his study is the first to demonstrate the contribution of ethnicity to the association of <i>LEPR</i> gene variants with PCOS</span>, thereby highlighting the significance of controlling for ethnicity in gene association investigations.</span></p>
Long QT syndrome ECG analysis
<p>Automated analysis of ECGs obtained from patients with long QT syndrome (generated from arrhythmia study, Faculty of Medicine, The Chinese University of Hong Kong Project)</p> <p> </p> <p>Disclaimer: These datasets were generated during the course of academic research conducted at the Faculty of Medicine, The Chinese University of Hong Kong, which received ethics approval by The Joint Chinese University of Hong Kong – New Territories East Cluster Clinical Research Ethics Committee of the Hospital Authority. They have been anonymised and are deposited for further advancement of medical research in full compliance with University Regulations and Policy on Dataset Deposit and Sharing. For additional information: https://libguides.lib.cuhk.edu.hk/RDM/dataset_deposit</p> <p> </p> <p>Access is permitted for research purposes only.</p> <p><br> The use of these datasets should provide acknowledgements of such efforts by citing this DOI.</p>
Characterization of the microbiome and immune response in corals with chronic Montipora white syndrome.
<p>Complete code and data files for the Motipora White Syndrome paper. Run in Qiime2 2020.11, mostly on the command line.</p>
Data from: Foraging sparrows exhibit individual differences but not a syndrome when responding to multiple types of novelty
Differences between individuals in correlated responses across contexts have both functional and mechanistic implications. Such syndromes may have either beneficial or harmful consequences when novel changes in the environment occur. We used wild-caught house sparrows, Passer domesticus, to test in functionally relevant circumstances, whether neophobia (initial fear of novelty), habituation, and the learning of novel cues (discriminant learning) were linked by a common underlying mechanism or reflected separate processes. We repeatedly measured individual latencies to approach and also to feed from a familiar feeding site in three contexts: a baseline control for mild disturbance, in the presence of a novel object, and to a novel cue indicating hidden food. House sparrows on average exhibited neophobia, habituated to novel objects, and learned to associate new cues to a reward. We also found evidence for consistent individual differences in in both latencies within most contexts, but there was no evidence of individual differences in plasticity with repeated trials within either the novel object (habituation) or novel cue (learning) contexts. There was also little or no correlation between the two latencies within individuals within contexts. Individual differences in latencies to arrive at the food station exhibited strong correlations across contexts, but latencies to feed were weaker. These results suggest a personality trait that exists regardless of novelty, but no syndrome affecting reactions to different forms of novelty. House sparrows appear strongly plastic when responding to novel environments. Such plasticity is likely favored by the varied consequences of novelty across environments.
Spectrum of mutational signatures in T-cell lymphoma reveals a key role for UV radiation in mycosis fungoides and Sezary syndrome
<p>T-cell non-Hodgkin's lymphomas (NHL) develop following transformation of tissue resident T-cells. We performed a meta-analysis of mutational catalogues derived from whole exome sequencing data from 403 patients with eight subtypes of T-cell NHL to identify mutational signatures and recurrent gene mutations associated with specific causal peaks within these signatures. Signature 1, indicative of age-related deamination, was prevalent across all T-cell NHL subtypes, reflecting the derivation of these malignancies from memory T-cell subsets. Adult T-cell leukemia-lymphoma (ATLL) was specifically associated with signature 17, which was found to strongly correlate with the IRF4 K59R mutation that is exclusive to ATLL. Signature 7, implicating UV exposure as a potential initiating factor was uniquely identified in cutaneous T-cell lymphoma, contributing 52% of the mutational burden in mycosis fungoides and 23% in Sezary syndrome. Importantly this UV signature was observed in CD4+ T-cells isolated from blood suggesting extensive re-circulation of these T-cells through both skin and blood and strongly implicating a role for UV in the pathogenesis of cutaneous T-cell lymphoma.</p>
Data from: Electroacupuncture mimics exercise-induced changes in skeletal muscle gene expression in women with polycystic ovary syndrome
<p class="1stparatext">Context: Autonomic nervous system activation mediates the increase in whole-body glucose uptake in response to electroacupuncture but the mechanisms are largely unknown.</p> <p class="1stparatext">Objective: To identify the molecular mechanisms underlying electroacupuncture-induced glucose uptake in skeletal muscle in insulin-resistant overweight/obese women with and without polycystic ovary syndrome (PCOS).</p> <p class="1stparatext">Design/Participants: In a case-control study, skeletal muscle biopsies were collected from 15 women with PCOS and 14 controls before and after electroacupuncture. Gene expression and methylation was analyzed using Illumina BeadChips arrays.</p> <p class="1stparatext">Results: A single bout of electroacupuncture restores metabolic and transcriptional alterations and induces epigenetic changes in skeletal muscle. Transcriptomic analysis revealed 180 unique genes (<i>q </i>< 0.05) whose expression was changed by electroacupuncture, with 95% of the changes towards a healthier phenotype. We identified DNA methylation changes at 304 unique sites (<i>q </i>< 0.20), and these changes correlated with altered expression of 101 genes (<i>p</i> < 0.05). Among the 50 most upregulated genes in response to electroacupuncture, 38% were also upregulated in response to<b> </b>exercise. We identified a subset of genes that were selectively altered by electroacupuncture in women with PCOS. For example, <i>MSX1 </i>and <i>SRNX1 </i>were decreased in muscle tissue of women with PCOS and were increased by electroacupuncture and exercise. siRNA-mediated silencing of these two genes in cultured myotubes decreased glycogen synthesis, supporting a role for these genes in glucose homeostasis.</p> <p class="1stparatext">Conclusion: Our findings provide evidence that electroacupuncture normalizes gene expression in skeletal muscle in a manner similar to acute exercise. Electroacupuncture might therefore be a useful way of assisting those who have difficulties performing exercise.</p>
Data from: Behavioral syndromes shape evolutionary trajectories via conserved genetic architecture
Behaviors are often correlated within broader syndromes, creating the potential for evolution in one behavior to drive evolutionary changes in other behaviors. Despite demonstrations that behavioral syndromes are common, this potential for evolutionary effects has not been demonstrated. Here we show that populations of field crickets (Gryllus integer) exhibit a genetically conserved behavioral syndrome structure, despite differences in average behaviors. We found that the distribution of genetic variation and genetic covariance among behavioral traits was consistent with genes and cellular mechanisms underpinning behavioral syndromes rather than correlated selection. Moreover, divergence among populations' average behaviors was constrained by the genetically conserved behavioral syndrome. Our results demonstrate that a conserved genetic architecture linking behaviors has shaped the evolutionary trajectories of populations in disparate environments—illustrating an important way for behavioral syndromes to result in shared evolutionary fates.
Data from: Efficacy of a probiotic bacterium to treat bats affected by the disease white-nose syndrome
The management of infectious diseases is an important conservation concern for a growing number of wildlife species. However, effective disease control in wildlife is challenging because feasible management options are often lacking. White-nose syndrome (WNS) is an infectious disease of hibernating bats that currently threatens several North American species with extinction. Currently, no effective treatments exist for WNS. We conducted a laboratory experiment to test the efficacy of treatment with Pseudomonas fluorescens, a bacterium that naturally occurs on bats, to reduce disease severity and improve survival of little brown bats (Myotis lucifugus) exposed to Pseudogymnoacus destructans, the fungal pathogen that causes WNS. Application of the bacteria at the time of P. destructans infection reduced several measures of disease severity and increased survival, whereas bacterial treatment prior to pathogen exposure had no effect on survival and worsened disease severity. Our results suggest that probiotic treatment with Ps. fluorescens has potential for WNS disease management but the timing of application is critical and should coincide with natural exposure of bats to P. destructans. More broadly, these results add to the growing knowledge of how the natural host microbiota can influence disease outcomes.
Data from: Modelling the potential efficacy of treatments for white-nose syndrome in bats
<p class="western">1. The fungal disease white-nose syndrome (WNS) has caused mass mortality in some species of North American bats during hibernation. </p> <p class="western">2. We use population viability models to test if a hypothetical WNS treatment or management action could facilitate the recovery of WNS-affected little brown myotis (<i>Myotis lucifugus</i>) populations. We modelled scenarios altering three parameters: (1) WNS severity (population growth rate of WNS-affected populations; λ<sub>WNS</sub>); (2) proportion of population treated; and (3) treatment improvement in winter survival (TIWS). </p> <p class="western">3. Our models predict that a treatment or management action that targets an entire population with a TIWS of 40% (the average TIWS in bat trials to date) will cause a population to stabilize or increase if WNS causes an annual decline of less than 70% (i.e. λ<sub>WNS</sub>>=0.30). However, for severe WNS (λ<sub>WNS</sub>=0.10), the TIWS must be at least 54% to cause the population to stabilize or increase. Where only a proportion of a WNS-affected population is treated, population stability is much harder to achieve unless the impact of WNS attenuates over time.</p> <p class="western">4. Our models suggest that a treatment or management action only facilitates the recovery of WNS-affected populations if WNS is mild, a large proportion of bats can be treated, TIWS is high, and/or WNS severity attenuates over time.</p> <p class="western"><span>5. </span><i>Synthesis and applications</i><i><span>.</span></i><span> We mode</span><span><span>lled</span></span><span> the predicted abundance trajectory of white-nose syndrome (WNS)-affected little brown myotis (</span><i><span>Myotis lucifugus</span></i><span>) populations </span><span><span>in response to hypothetical treatment or management actions. Our two types of models incorporate the complete range of possible scenarios varying three parameters: (1) population growth rate of the WNS-affected population</span></span><span><span>, (2) the improvement in winter </span></span><span><span>survival associated with the </span></span><span><span>treatment or management action, and (3) the proportion of the population treated. </span></span><span><span><span><span>We suggest that our models, which can be explored using online Shiny applications, should be used in the planning phase of treatment or management action programs for WNS.</span></span></span></span></p>
Data from: Resistance in persisting bat populations after white-nose syndrome invasion
Increases in anthropogenic movement have led to a rise in pathogen introductions and the emergence of infectious diseases in naive host communities worldwide. We combined empirical data and mathematical models to examine changes in disease dynamics in little brown bat (Myotis lucifugus) populations following the introduction of the emerging fungal pathogen Pseudogymnoascus destructans, which causes the disease white-nose syndrome. We found that infection intensity was much lower in persisting populations than in declining populations where the fungus has recently invaded. Fitted models indicate that this is most consistent with a reduction in the growth rate of the pathogen when fungal loads become high. The data are inconsistent with the evolution of tolerance or an overall reduced pathogen growth rate that might be caused by environmental factors. The existence of resistance in some persisting populations of little brown bats offers a glimmer of hope that a precipitously declining species will persist in the face of this deadly pathogen. This article is part of the themed issue 'Human influences on evolution, and the ecological and societal consequences'.
Plant dispersal syndromes are unreliable as predictors of zoochory and long-distance dispersal by ungulates and waterbirds
<p>Plant dispersal syndromes are allocated based on diaspore morphology and used to predict mechanisms of dispersal. Many authors assume that only angiosperms with endozoochory, epizoochory or anemochory syndromes have a long-distance dispersal (LDD) mechanism. Too much faith is often placed in classical syndromes to explain historical dispersal events and to predict future ones. The "endozoochory syndrome" is actually a "frugivory syndrome" and has often diverted attention from endozoochory by non-frugivores (e.g. waterbirds and large herbivores) that disperse a broad range of angiosperms, for which they likely provide the maximum dispersal distances. Neither the endozoochory nor the epizoochory syndromes provide helpful predictions of which plants non-frugivores disperse, or by which mechanism. We combined data from Albert et al. (2015a), Soons et al. (2016) and Julve (1998) to show that only 4% of European plant species dispersed by ungulate endozoochory belong to the corresponding syndrome, compared to 36% for ungulate epizoochory and 8% for endozoochory by migratory ducks. In contrast, the proportions of these species that are assigned to an "unassisted syndrome" are 37%, 31% and 28%, respectively. Since allocated syndromes do not adequately account for zoochory, empirical studies often fail to find the expected relationship between syndromes and LDD events such as those underlying the colonization of islands or latitudinal migration. We need full incorporation of existing zoochory data into dispersal databases, and more empirical research into the relationship between plant traits and the frequency and effectiveness of different dispersal mechanisms (paying attention to unexpected vectors). Acknowledging the broad role of non-frugivores in facilitating LDD is crucial to improve predictions of the consequences of global change, such as how plant distributions respond to climate change, and how alien plants spread. Networks of dispersal interactions between these vertebrates and plants are a vital but understudied part of the Web of Life. The datasets we present here illustrate these limitations of syndromes, and include data from Brochet et al. (2010) regarding the syndromes of plants dispersed by Eurasian Teal via epizoochory or endozoochory.</p>
Effects of immersive virtual reality with treadmill in subjects with Rett Syndrome: a pilot study
<p>This dataset is related to a group of 9 girls affected by Rett Syndrome that performed three/four sessions of virtual reality based activity by means of the GRAIL system (Motek).</p><p>Participants underwent an initial assessment of the cognitive and motor aspects using the Modified Raven matrix, the Rett Assessment Rating Scale (RARS) and the Rett Syndrome Gross Motor Scale (GMS). These baseline assessments were performed by an experienced therapist prior to the access to the GRAIL.</p><p>The project consisted of 4 sessions of GRAIL activities in 1 week. During the first 3 sessions, exergames and augmented feedback activities were proposed. During the fourth session a gait analysis was conducted for the subjects with a suitable motor and behavioral level .</p><p>During all the sessions, a video recording was conducted to detect facial expression of the subjects, in order to use this data to compute the "happiness index". The exergames were administered until the therapists detected any sign of discomfort by the subject.</p><p>The outcome of the training, reported in the database were:</p><ul><li>happiness index</li><li>endurance time</li><li>performance speed</li><li>attention focus on scenario</li><li>suitability evaluation questionnaire</li><li>multistep gait analysis with the GRAIL (only 4 patients).</li></ul><p>The Happiness Index and the Suitability Evaluation Questionnaire investigated the feasibility and tolerability of the training with positive results. Additionally, an increase in walking speed, endurance time and focus attention was detected. When possible, subjects underwent a gait assessment whose results provide insights, although preliminary, concerning differences in gait pattern amongst the recruited subjects. Despite the small sample size, the dataset suggests new strategies for Rett rehabilitation.</p><p> </p>
Sociodemographic and Work-Related Factors Associated with Burnout Syndrome in Healthcare Professionals
<p><span>Background: Burnout syndrome, intensified during the COVID-19 pandemic, has profoundly impacted healthcare professionals' mental health globally. This study in Peru aimed to investigate sociodemographic and work-related factors associated with burnout dimensions among healthcare workers. Methods: Employing a cross-sectional predictive design, this study encompassed 1,844 healthcare professionals across three major hospitals in Peru. A carefully selected sample of 334 participants, ranging in age from 22 to 68 years and including both genders, was studied. Data collection involved a comprehensive sociodemographic work form and the Maslach Burnout Inventory (MBI), which is recognized for its robust psychometric properties. The research included thorough psychometric, descriptive, and inferential analyses, using linear regression to test various predictive models. Results: The study found that emotional exhaustion was significantly associated with several factors, including employment status (R² = 0.010), marital status (R² = 0.003), and length of service (R² = 0.015). Depersonalization showed a significant correlation with gender (R² = 0.015) and the amount of daily patient contact. Personal accomplishment was notably influenced by gender (R² = 0.039) and length of service (R² = 0.025). Conclusions: The research identified several key factors contributing to burnout, notably being female, having a contracted employment status, shorter service duration (specifically 6 to 10 years), and engaging in 1 to 6 hours of patient contact per day. These insights are crucial for understanding burnout in healthcare settings and underscore the need for targeted interventions and support strategies for healthcare professionals.</span></p>
Short and long-term effects of endogenous cortisol on personality traits and behavioral syndromes
<p>Animals express consistent individual differences in some behaviours, termed animal personality but behaviours can also considerably vary within individuals, within minutes or hours, due to environmental stimuli. Consistent among-individual variation is often assumed to be mediated by hormonal mechanisms. Hormones are also involved in flexible and fast responses towards environmental stimuli. Even though basic mechanisms by which hormones regulate behaviours are known, much of the quantitative patterns underlying hormone-behaviour interactions within and among individuals, remain unclear. Here, we conducted two experiments to investigate the immediate, short-term effects of experimentally elevated cortisol titres on well-known animal personality traits (Experiment 1) and the potential long-term effects of such experimentally elevated cortisol titres (Experiment 2) in the medium-sized cavy (<em>Cavia aperea</em>). Therefore, we tested how personality traits related to stress-coping, novelty seeking and social behaviour react within hours towards elevated cortisol. In Experiment 2, we tested if a three-weeks elevation of cortisol affects the same personality traits after cessation of the hormone treatment. We investigated effects on the mean levels of behaviours, i.e., the personality type, the temporal consistency, i.e., repeatability and among-individual correlations of traits. In experiment 1, we found cortisol to lead to more aggressive behaviour and more passive stress-coping while other traits were unaffected. In experiment 2, we found no long-term persisting effects. Both measured hormones, cortisol and testosterone, showed correlations to several personality traits, these correlations were, however, unaffected by the cortisol treatment. Animals receiving the cortisol treatment showed higher repeatability, for one stress-coping trait and lower repeatability for testosterone concentration. Interestingly, sexes differed only in few mean trait expressions but showed different correlation structures across traits. Taken together, our data indicate that personality traits in adult individuals are very consistent and only react via short-term fluctuations towards internal hormonal signals.</p>
Data from: An experimental paradigm for triggering a depressive syndrome
<p><span>Research investigating whether depression is an adaptation or a disorder has been hindered by the lack of an experimental paradigm that can test causal relationships. Moreover, studies attempting to induce the syndrome often fail to capture the suite of feelings, thoughts, and behaviours that characterize depression. An experimental paradigm for triggering depressive symptoms can improve our etiological understanding of the syndrome. The present study attempts to induce core symptoms of depression, particularly those related to rumination, in a healthy, non-clinical sample through a controlled social experiment. These symptoms are sad or depressed mood, anhedonia, feelings of worthlessness or guilt, and difficulty concentrating.</span><span> 134 undergraduate students were randomly assigned to either an Exclusion (EX) or Inclusion (IN) group. Participants in the Exclusion group were exposed to a modified Cyberball paradigm, designed to make them feel socially excluded, followed by a dual-interference task to </span><span>assess whether their exclusion interfered with their working memory. </span><span>Excluded participants: (1) self-reported a significant increase in sadness and decrease in happiness, but not anxiety or calmness; (2) scored significantly higher in four of five variables related to depressive rumination; and (3) performed significantly worse on a dual-interference task, suggesting an impaired ability to concentrate.</span></p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.