Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,257
datasets available to search
ShareScore release 0.9.0
Dataset results
1,257 results for “Human infections”
Targeting host-virus interactions: In silico analysis of the binding of human milk oligosaccharides to viral proteins involved in respiratory infections
<p><span>Respiratory viral infections, a major public health concern, necessitate the continuous development of novel antiviral strategies, particularly in the face of emerging and re-emerging pathogens. In this study, we </span><span>explored</span><span> the potential of human milk oligosaccharides (HMOs) as broad-spectrum antiviral agents against key respiratory viruses. </span><span>By examining the</span><span> structural mimicry of host cell receptors and </span><span>their </span><span>known biological functions, including antiviral activities, we assessed the </span><span>ability</span><span> of HMOs to bind and potentially inhibit viral proteins crucial for host</span><span> </span><span>cell entry. Our <em>in silico</em> analysis </span><span>focused</span><span> on viral proteins integral to host-virus interactions</span><span>, namely,</span><span> the hemagglutinin protein of influenza, fusion proteins of respiratory syncytial and human metapneumovirus, and the spike protein of SARS-CoV-2. Using molecular docking and simulation studies, we </span><span>demonstrated</span><span> that HMOs exhibit varying binding affinities to these viral proteins, suggesting their potential as viral entry inhibitors. </span><span>This</span><span> study </span><span>identified</span><span> several HMOs with promising binding profiles, highlighting their potential in antiviral drug development. This research provides a foundation for utilizing HMOs as a natural source for designing new therapeutics, offering a novel approach in the fight against respiratory viral infections.</span></p>
Source data for: Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro biofilm and in vivo implant infections
<p class="CxSpFirst">Implant-associated <i>Staphylococcus aureus</i> infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could provide an alternative approach to improve the diagnosis and potential treatment of biofilm-related infections. Here we show that mAbs targeting common surface components of <i>S. aureus</i> can recognize clinically relevant biofilm types. The mAbs were also shown to bind a collection of clinical isolates derived from different biofilm-associated infections (endocarditis, prosthetic joint, catheter). We identify two groups of antibodies: one group that uniquely binds <i>S. aureus </i>in biofilm state and one that recognizes <i>S. aureus </i>in both biofilm and planktonic state. Furthermore, we show that a mAb recognizing wall teichoic acid (WTA; clone 4497) specifically localizes to a subcutaneously implanted pre-colonized catheter in mice. In conclusion, we demonstrate the capacity of several human mAbs to detect <i>S. aureus</i> biofilms<i> in vitro</i> and <i>in vivo</i>.</p>
Dataset: Co-administration of adjuvanted recombinant Ov-103 and Ov-RAL2 vaccines confer protection against natural challenge in a bovine O. ochengi infection model of human onchocerciasis
<p class="MsoNormal"><span>[Abstract from accompanying manuscript]</span></p> <p class="MsoNormal"><span>Onchocerciasis (river blindness), caused by the filarial nematode <em>Onchocerca volvulus</em>, is a neglected tropical disease endemic to sub-Saharan Africa. Worldwide, an estimated 20.9 million individuals live with infected and a further 205 million are at risk of disease. Current control methods rely on mass drug administration of ivermectin to suppress microfilarial development. Presently, there are no viable treatment options effective against the long-lived adult worms. The identification and development of efficacious vaccine candidates as complementary tools to support ongoing elimination efforts are therefore a major objective of onchocerciasis research. </span></p> <p class="MsoNormal"><span>We evaluated the immunogenicity and protective effects of co-administering two leading <em>O. volvulus</em>-derived recombinant vaccine candidates (<em>Ov</em>-103 and <em>Ov</em>-RAL2) in cattle with subsequent natural exposure to <em>Onchocerca ochengi, </em>a close phylogenetic relative of <em>O. volvulus</em>.</span></p> <p class="MsoNormal"><span>Immunisation induced strong IgG responses against both vaccine candidates. Following natural exposure to <em>O. ochengi</em>, vaccination status and resulting serum antibody response was associated with delayed nodule development and onset of microfilaridermia. Peptide arrays identified several <em>Ov</em>-103 and <em>Ov</em>-RAL2-specific epitopes recognised by IgG from immunised cattle which warrant further investigation. Our data provide supporting evidence for ongoing development of a recombinant vaccine for control of human onchocerciasis.</span></p>
Figure 4 in Philophthalmus hechingeri n. sp. (Digenea: Philophthalmidae), a Human-Infecting Eye Fluke from the Asian Mud Snail, Batillaria attramentaria
Figure 4. The adult stage of Philophthalmus hechingeri n. sp. Line drawing of ventral view. Abbreviations: c, cirrus; ca, caecum; cs, cirrus sac; gp, genital pore; mg, Mehlis' gland; mt, metraterm; o, ovary; os, oral sucker; p, pharynx; sr, seminal receptacle; sv, seminal vesicle; t, testis; u, uterus; v, vitellarium; vs, ventral sucker.
Figure 5 in Philophthalmus hechingeri n. sp. (Digenea: Philophthalmidae), a Human-Infecting Eye Fluke from the Asian Mud Snail, Batillaria attramentaria
Figure 5. The larval stages of Philophthalmus hechingeri n. sp. (A) Daughter redia. (B) Cercaria. (C) Excysted juvenile.
Figure 1. A in Philophthalmus hechingeri n. sp. (Digenea: Philophthalmidae), a Human-Infecting Eye Fluke from the Asian Mud Snail, Batillaria attramentaria
Figure 1. A map showing places related to Philophthalmus hechingeri n. sp. Black, gray, and white circles represent the occurrence of human philophthalmosis (Mimori et al., 1982; Sato et al., 2019), the snail collection site of this study, and the snail collection sites of Hechinger (2007), respectively.
Figure 3 in Philophthalmus hechingeri n. sp. (Digenea: Philophthalmidae), a Human-Infecting Eye Fluke from the Asian Mud Snail, Batillaria attramentaria
Figure 3. Mitochondrial DNA-based genetic analyses of philophthalmid species. (A) A maximum likelihood phylogenetic tree of the genus Philophthalmus. The tree was made using sequences of COI (693 nucleotide sites) under the substitution model HKYþG. The DNA accession number of each taxon is shown in parentheses. The tree was rooted by the outgroup taxon, Fasciola hepatica (M93388). The outgroup was removed from the tree to save space. Bootstrap percentages are indicated at branching points. A scale bar indicates the number of substitutions per nucleotide site. (B) A parsimony network of COI haplotypes (849 nucleotide sites) of Philophthalmus hechingeri n. sp. in a seashore of the Seto Inland Sea. The size of circles indicates the frequency of the haplotypes. Numerals within the circles mean the number of haplotypes. A closed circle indicates a haplotype, which is identical to that of Philophthalmus sp. from human in Aichi Prefecture (Sato et al., 2019). Tiny circles are hypothetical haplotypes.
Figure 2. A in Philophthalmus hechingeri n. sp. (Digenea: Philophthalmidae), a Human-Infecting Eye Fluke from the Asian Mud Snail, Batillaria attramentaria
Figure 2. A maximum likelihood phylogenetic tree of the family Philophthalmidae. The tree was made using sequences of 28S rDNA (874 nucleotide sites) under the substitution model GTRþI. The tree was rooted by the outgroup taxon, Sphaeridiotrema globulus (GQ890331). The outgroup was removed from the tree to save space. The isolates obtained in this study are highlighted in bold face. The DNA accession number of each philophthalmid is shown in parentheses. Bootstrap percentages are indicated at branching points. A scale bar indicates the number of substitutions per nucleotide site.
Supplementary Materials for Discovery of Hub Genes and Construction of Competitive Endogenous RNA Network in Human Cytomegalovirus Infection Using Computational and Bioinformatics Tools
<p><span>Table S1: List of targeted genes by 41 differentially expressed microRNAs (DEMs) agreed in Targetscan and miRDB; Table S2: Significant biological process (BP) of 144 genes associated with Human Cytomegalovirus (HCMV); Table S3: Significant cellular components (CC) of 144 genes associated with HCMV; Table S4: Enriched molecular function (MF) of 144 genes associated with HCMV; Table S5: Pathways significantly affected by 144 genes in HCMV; Figure S1: Number of interactions for each gene in protein-protein interaction (PPI) network.</span></p>
Genome graphs detect human polymorphisms in active epigenomic states during influenza infection: validation
<p>Sanger sequencing and qPCR validation data for "Genome graphs detect human polymorphisms in active epigenomic states during influenza infection" manuscript.</p>
Knowledge, attitudes, and practices towards human papillomavirus infection and vaccination: a cross-sectional study among university students in Astana, Kazakhstan. Dataset
<p>Dataset and code book for the study entitled <strong>Knowledge, attitudes, and practices towards human papillomavirus infection and vaccination: a cross-sectional study among university students in Astana, Kazakhstan.</strong></p>
Underlying dataset for the manuscript titled "Identification of RTS,S/AS01 vaccine-induced humoral biomarkers predictive of protection against controlled human malaria infection"
<p><span>The antibody binding data included in this dataset is associated with the manuscript “Spreng, R.L., Seaton, K.E. et al., <em><span>Identification of RTS,S/AS01 vaccine-induced humoral biomarkers predictive of protection against controlled human malaria infection; </span></em><span>Accepted for Publication in JCI Insight (2024)</span>. These data come from the characterization of serum samples from four controlled human malaria infection (CHMI) clinical trials of the RTS,S vaccine, including NCT01366534 (referred to as MAL068), NCT01857869 (referred to as MAL071), NCT03162614 (referred to as MAL092), and NCT03824236 (referred to as MAL102).</span></p>
Establishing a Controlled Human Hookworm Infection Model at Leiden University Medical Center
ClinicalTrials.gov study NCT03126552. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of Doravirine (MK-1439) in Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Participants (MK-1439-005)
ClinicalTrials.gov study NCT01466985. IPD Sharing: YES. Countries: 0. Publications: 1.
Safety and Efficacy of Doravirine, Tenofovir, Lamivudine (MK-1439A) in Participants Infected With Treatment-Naïve Human Immunodeficiency Virus (HIV) -1 With Transmitted Resistance (MK-1439A-030)
ClinicalTrials.gov study NCT02629822. IPD Sharing: YES. Countries: 0. Publications: 1.
A Strep Throat Controlled Human Infection Trial in Healthy Adults
ClinicalTrials.gov study NCT06992141. IPD Sharing: YES. Countries: 1. Publications: 1.
Mobile Outreach Screening of High-Risk Human Papillomavirus Infection in Women with Limited Access to Health Services in Seine-Saint-Denis (greater Paris Area, France)
ClinicalTrials.gov study NCT06656611. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
An Efficacy and Safety Study of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in the Treatment of Chronic Hepatitis C Virus in Participants Who Are Co-Infected With Human Immunodeficiency Virus:C-EDGE CO
ClinicalTrials.gov study NCT02105662. IPD Sharing: YES. Countries: 0. Publications: 4.
Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection
ClinicalTrials.gov study NCT02527460. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The Effect of Antacids on the Pharmacokinetics (PK) of Raltegravir in Human Immunodeficiency Virus (HIV)-Infected Participants (MK-0518-824)
ClinicalTrials.gov study NCT02473367. IPD Sharing: YES. Countries: 0. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.