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125
datasets available to search
ShareScore release 0.9.0
Dataset results
125 results for “JNK”
POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation
GEO Series GSE130577. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Genes regulated by JNK signaling in MDA231-LM2 breast cancer cells
GEO Series GSE98237. Homo sapiens. 15 samples. Type: Expression profiling by array.
Transient inhibition of JNK pathway improves hematopoietic stem cell engraftment
GEO Series GSE165501. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Toggling of BRD4 functions is triggered through its phosphorylation by JNK [ChIP-seq]
GEO Series GSE252981. Homo sapiens. 22 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
POSH2 Promotes Breast Cancer Stem-Like Properties through JNK Activation and PTX3 Upregulation [PTX3_OE]
GEO Series GSE130572. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Diploid Hepatocytes Resist Acetaminophen-Induced Liver Injury Through Suppressed JNK Signaling
GEO Series GSE303454. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
A chromatin-modifying function of JNK during embryonic stem cell differentiation
GEO Series GSE25533. Mus musculus. 43 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
JNK activation of BIM promotes hepatic oxidative stress, steatosis and insulin resistance in obesity
GEO Series GSE102982. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Control, TNFα and TNFα+JNK I treated GSCs
GEO Series GSE194222. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Frequent Loss-of-Function Mutations in MLK4 Suppresses Signaling in the JNK-cJUN-p21/p15 Pathway to Promote Growth of Colon Cancer Cells
GEO Series GSE59196. Homo sapiens. 24 samples. Type: Expression profiling by array.
JNK promotes epithelial cells anoikis by transcriptional and post-translational regulation of BH3-only proteins
GEO Series GSE88856. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling
GEO Series GSE83810. Mus musculus. 12 samples. Type: Expression profiling by array.
A chromatin-modifying function of JNK during stem cell differentiation
GEO Series GSE25532. Mus musculus. 33 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Identification of the JNK Signaling Pathway as a Functional Target of the Tumor Suppressor PTEN
GEO Series GSE7562. Homo sapiens. 12 samples. Type: Expression profiling by array.
The JNK and Hippo pathways control epithelial integrity and prevent tumour initiation by regulating an overlapping transcriptome [RNA-Seq]
GEO Series GSE272049. Drosophila melanogaster. 18 samples. Type: Expression profiling by high throughput sequencing.
Overlapping role of c-Jun N-terminal kinase (JNK) 1 and 2 in imidazole ketone erastin-induced ferroptosis
GEO Series GSE234894. Homo sapiens. 8 samples. Type: Expression profiling by array.
Aalpi18529 regulates vitellogenesis of Aedes albopictus via the Gadd45a-mediated JNK-dependent nurse cell apoptosis pathway {RNA-seq]
GEO Series GSE266102. Aedes albopictus. 6 samples. Type: Expression profiling by high throughput sequencing.
Apolipoprotein A-IV reduced metabolic inflammation in white adipose tissue by inhibiting IKK and JNK signaling in adipocytes
GEO Series GSE211980. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
The JNK and Hippo pathways control epithelial integrity and prevent tumour initiation by regulating an overlapping transcriptome [DamID-seq]
GEO Series GSE273449. Drosophila melanogaster. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dataset related to article "JNK signaling activation in the Ube3a maternal deficient mouse model"
<p><em>The file contains raw data related to the article "JNK signaling activation in the Ube3a maternal deficient mouse model", available from <a href="https://www.sciencedirect.com/science/article/pii/S0969996120300875?via%3Dihu">https://www.sciencedirect.com/science/article/pii/S0969996120300875?via%3Dihub</a>.</em></p> <p> </p> <p><strong>Abstract of the manuscript</strong></p> <p>Deficiency of the E3 ubiquitin ligase UBE3A leads to the neurodevelopmental disorder Angelman syndrome (AS), while higher levels are linked to autism spectrum disorder. The mechanisms underlying the downstream effects of UBE3A loss or gain of function in these disorders are still not well understood, and treatments are still lacking. Here, using the Ube3a maternal loss (Ube3a<sup>m-/p+</sup>) mouse model, we report an important JNK signaling activation in the hippocampus, cortex and cerebellum correlating with the onset of behavioral defects and biochemical marker alterations in the post-synaptic element, suggesting important spine pathology. JNK activation occurs at 7 and persists up till 23 weeks in Ube3a<sup>m-/p+</sup> mice in two different cellular compartments: the nucleus and the post-synaptic protein-enriched fraction. To study JNK's role in Ube3a<sup>m-/p+</sup> pathology we treated mice with the specific JNK inhibitor peptide, D-JNKI1, from 7 to 23 weeks of age. Preventing JNK action in vivo restores the post-synaptic protein-enriched fraction defects and the cognitive impairment in these mice. Our results imply a critical role of UBE3A-JNK signaling in the pathogenesis of UBE3A-related disorders. In particular, it was clear that JNK is a key player in regulating AS synaptic alterations and the correlated cognitive impairments, in fact, its specific inhibition tackles Ube3a<sup>m-/p+</sup> pathology. This study sheds new light on the neuronal functions of UBE3A and offers new prospects for understanding the pathogenesis of UBE3A-related disorders.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.