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175
datasets available to search
ShareScore release 0.9.0
Dataset results
175 results for “Single-molecule”
A subcellular map of translational machinery composition and regulation at the single-molecule level [ALIBi_ER_vs_cyto]
GEO Series GSE283888. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Single-molecule regulatory architectures captured by chromatin fiber sequencing [Dm AdMTase-seq]
GEO Series GSE146937. Drosophila melanogaster. 19 samples. Type: Other.
Single-molecule regulatory architectures captured by chromatin fiber sequencing
GEO Series GSE146942. Drosophila melanogaster; Homo sapiens. 32 samples. Type: Other.
A subcellular map of translational machinery composition and regulation at the single-molecule level [ALIBi_Lsg1_KD]
GEO Series GSE283890. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Multi-cell type deconvolution using a probabilistic model of single-molecule DNA methylation haplotypes
GEO Series GSE239605. Homo sapiens. 205 samples. Type: Methylation profiling by high throughput sequencing.
Single-molecule identification of the target RNAs of different RNA binding proteins simultaneously in cells
GEO Series GSE200711. Homo sapiens. 54 samples. Type: Other.
Structural and Mechanistic Insights into the Dual-nuclease domain Defense Protein as a Single-Molecule Anti-Phage System
GEO Series GSE311613. Escherichia coli. 6 samples. Type: Expression profiling by high throughput sequencing.
Live-cell 3D single-molecule tracking reveals how NuRD modulates enhancer dynamics
GEO Series GSE179007. Mus musculus. 27 samples. Type: Other.
Massively multiplex single-molecule oligonucleosome footprinting
GEO Series GSE162410. Homo sapiens; unidentified plasmid. 22 samples. Type: Other.
Single-cell single-molecule spatial transcriptomics using CosMx on colectomy specimens collected during Pouch surgery in IBD patients.
GEO Series GSE283625. Homo sapiens. 8 samples. Type: Other.
High-throughput single-molecule long-read RNA sequencing analysis of tissue-specific genes and isoforms in lettuce (Lactuca sativa L.)
GEO Series GSE264560. Lactuca sativa. 12 samples. Type: Expression profiling by high throughput sequencing.
Single-molecule chromatin configurations link transcription factor binding to expression in human cells [RNA-seq]
GEO Series GSE276515. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Single-molecule Dynamics of Enhanceosome Assembly In Embryonic Stem Cells
GEO Series GSE54103. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Single-molecule RNA-FISH analysis reveals stochasticity in reactivation of latent HIV-1 regulated by Nuclear Orphan Receptors NR4A and cMYC
GEO Series GSE241207. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Single-molecule regulatory architectures captured by chromatin fiber sequencing [Hs Fiber-seq]
GEO Series GSE146941. Homo sapiens. 4 samples. Type: Other.
Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling
GEO Series GSE186634. Saccharomyces cerevisiae. 33 samples. Type: Expression profiling by high throughput sequencing.
Single-Molecule Direct RNA Sequencing Reveals the Shaping of Epitranscriptome Across Multiple Species
GEO Series GSE246632. Chlamydomonas reinhardtii; Arabidopsis thaliana; Mus musculus; Oryza sativa; Homo sapiens. 13 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Single-molecule regulatory architectures captured by chromatin fiber sequencing [Hs AdMTase-seq]
GEO Series GSE146938. Homo sapiens. 4 samples. Type: Other.
Cross-validation of distance measurements in proteins by PELDOR/DEER and single-molecule FRET
<p>Pulsed electron-electron double resonance spectroscopy (PELDOR/DEER) and single-molecule Förster resonance energy transfer spectroscopy (smFRET) are frequently used to determine conformational changes, structural heterogeneity and inter probe distances in biological macromolecules. They provide qualitative information that facilitates mechanistic understanding of biochemical processes and quantitative data for structural modeling. To provide a comprehensive comparison of the accuracy of PELDOR/DEER and smFRET, we use a library of double cysteine variants of four proteins that undergo large-scale conformational changes upon ligand binding. With either method, we use established standard experimental protocols and data analysis routines to determine inter-probe distances in the presence and absence of ligands. The results are compared to distance predictions from structural models. Despite an overall satisfying and similar distance accuracy, some inconsistencies are identified, which we attribute to the use of cryoprotectants for PELDOR/DEER and label-protein interactions for smFRET. This large-scale cross-validation of PELDOR/DEER and smFRET highlights the strengths, weaknesses, and synergies of these two important and complementary tools in integrative structural biology.</p>
Tracking live-cell single-molecule dynamics enables measurements of heterochromatin-associated protein-protein interactions
<p>for manuscript "Tracking live-cell single-molecule dynamics enables measurements of heterochromatin-associated protein-protein interactions"</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.