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129
datasets available to search
ShareScore release 0.9.0
Dataset results
129 results for “Skeletal muscle function”
The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defense in skeletal muscles
GEO Series GSE73572. Mus musculus. 2 samples. Type: Expression profiling by array.
Direct reprogramming of mouse fibroblasts into functional skeletal muscle progenitors
GEO Series GSE92336. Mus musculus. 5 samples. Type: Expression profiling by array.
Functional dissection of metabolic trait-associated variants in steady state and stimulated human skeletal muscle cells
GEO Series GSE282191. Homo sapiens. 47 samples. Type: Other; Expression profiling by high throughput sequencing.
The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age.
GEO Series GSE280700. Macaca mulatta; Homo sapiens; Rattus; Mus musculus. 114 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by genome tiling array.
Evaluation of Skeletal Muscle Function Using Ultrasonic Elastography
ClinicalTrials.gov study NCT05805332. IPD Sharing: Not stated. Countries: 0. Publications: 0.
The liver clock tunes transcriptional rhythms in skeletal muscle to regulate mitochondrial function [C2C12]
GEO Series GSE308278. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Increased global DNA methylation disrupts skeletal muscle homeostasis, promotes age-related decline in muscle function, and reduces muscle plasticity
GEO Series GSE244432. Mus musculus. 12 samples. Type: Methylation profiling by high throughput sequencing.
Characterization of the equine skeletal muscle transcriptome identifies novel functional responses to exercise training
GEO Series GSE21269. Equus caballus. 13 samples. Type: Expression profiling by high throughput sequencing.
The biphasic and age-dependent impact of Klotho on hallmarks of aging and skeletal muscle function
GEO Series GSE156343. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
DNA G-quadruplex profiling in skeletal muscle stem cells reveals functional and mechanistic insights [CUT&RUN]
GEO Series GSE289448. Mus musculus; Homo sapiens. 21 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Characterizing SERCA Function in Murine Skeletal Muscles after 35-37 Days of Spaceflight from RR-1 and RR-9 (calcium uptake and Western blot in soleus and tibialis anterior)
It is well established that microgravity exposure causes significant muscle weakness and atrophy via muscle unloading. On Earth, muscle unloading leads to a disproportionate loss in muscle force and size with the loss in muscle force occurring at a faster rate. Although the exact mechanisms are unknown, a role for Ca2+ dysregulation has been suggested. The sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA) pump actively brings cytosolic Ca2+ into the SR, eliciting muscle relaxation and maintaining low intracellular Ca2+ ([Ca2+]i). SERCA dysfunction contributes to elevations in [Ca2+]i, leading to cellular damage, and may contribute to the muscle weakness and atrophy observed with spaceflight. Here, we investigated SERCA function, SERCA regulatory protein content, and reactive oxygen/nitrogen species (RONS) protein adduction in murine skeletal muscle after 35-37 days of spaceflight. In male and female soleus muscles, spaceflight led to drastic impairments in Ca2+ uptake despite significant increases in SERCA1a protein content. We attribute this impairment to an increase in RONS production and elevated total protein tyrosine (T) nitration and cysteine (S) nitrosylation. Contrarily, in the tibialis anterior (TA), we observed an enhancement in Ca2+ uptake, which we attribute to a shift towards a faster muscle fiber type (i.e., increased myosin heavy chain IIb and SERCA1a) without elevated total protein T-nitration and S-nitrosylation. Thus, spaceflight affects SERCA function differently between the soleus and TA. This dataset derives results from the calcium uptake (spectrofluorometry) and Western blot assays.
Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions
GEO Series GSE299537. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
System-wide analysis of Dhx36 function in skeletal muscle satellite cells reveals its binding with 5’UTR G4 structure to promote Gnai2 RNA translation [CLIP-seq]
GEO Series GSE151122. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Heterogeneous Origins and Functions of Mouse Skeletal Muscle Resident Macrophages
GEO Series GSE142480. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Identifying signals from the skeletal muscle niche that regulate satellite cell function
GEO Series GSE67117. Mus musculus. 13 samples. Type: Expression profiling by high throughput sequencing.
NAD Depletion in Skeletal Muscle does not Compromise Muscle Function or Accelerate Aging
GEO Series GSE282353. Rattus; Mus musculus; Macaca mulatta; Homo sapiens. 48 samples. Type: Methylation profiling by array.
System-wide analysis of Dhx36 function in skeletal muscle satellite cells reveals its binding with 5’UTR G4 structure to promote Gnai2 RNA translation
GEO Series GSE151124. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Resident mesenchymal progenitor cells require autocrine IGF-I for function in homeostatic and regenerating skeletal muscle
GEO Series GSE282309. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
The Unique Function of Runx1 in Skeletal Muscle Differentiation and Regeneration is Mediated by an ETS Interaction Domain (RNA-Seq)
GEO Series GSE248045. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
Physiological and functional characterization for high-throughput optogenetic skeletal muscle exercise assays [60min]
GEO Series GSE306857. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.