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793 results for “Startes”
Supplemental Dataset Excel files and Source Data Excel file for "START domains generate paralog-specific regulons from a single network architecture"
<p>Supplemental Dataset Excel files and Source Data Excel file for "START domains generate paralog-specific regulons from a single network architecture" in Nat Comms</p>
Congenital disorder of glycosylation caused by starting site-specific variant in syntaxin-5
<p>The SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) protein syntaxin-5 (Stx5) is essential for Golgi transport. In humans, the <em>STX5</em> mRNA encodes two protein isoforms, Stx5 Long (Stx5L) from the first starting methionine and Stx5 Short (Stx5S) from an alternative starting methionine at position 55. In this study, we identified a novel human disorder caused by a single missense substitution in the second starting methionine (p.M55V), resulting in complete loss of the short isoform. Patients suffer from an early fatal multisystem disease, including severe liver disease, skeletal abnormalities and abnormal glycosylation. Primary human dermal fibroblasts isolated from these patients showed defective glycosylation, altered Golgi morphology as measured by electron microscopy and mislocalization of glycosyltransferases. Measurements of anterograde trafficking, based on biotin-synchronizable forms of Stx5 (the RUSH system), and of cognate binding SNAREs, based on Förster resonance energy transfer (FRET), revealed that the short isoform of Stx5 is essential for intra-Golgi transport. This is the first time a mutation in an alternative starting codon is linked to human disease, demonstrating that the site of translation initiation is an important new layer of regulating protein trafficking.</p>
Datasets from the RecSys 2021 article "Cold Start Similar Artists Ranking with Gravity-Inspired Graph Autoencoders"
<p>We publicly release :</p> <ol> <li>the anonymized deezer_graph<em>.csv</em> and deezer_features<em>.csv</em> datasets</li> <li>the pre-trained node embedding vectors from all pre-trained models</li> </ol> <p>described in the <a href="https://github.com/deezer/similar_artists_ranking/">deezer/similar_artists_ranking/</a> GitHub repository.</p>
Switching between Numerical Black-box Optimization Algorithms with Warm-starting Policies - Reproduction artifacts
<p># Reproducibility instructions</p> <p>This document details the steps to reproduce the results presented in the paper 'Chaining of Numerical Black-box Algorithms: Investigating the Impact of Warm-Starting and the Switching Point'</p> <p>## Algorithm code<br> The code for the individual algorithms and the switching routines is included in the 'dynas.zip' folder. </p> <p>## Data collection<br> To collect the performance data for the static algorithms, the file 'data_collection.py' can be used. This file runs all 5 static algorithm on the function suite used in the paper, using the 'ioh' package. To run it, please modify the 'ioh_dir' variable to a place where the data should be stored. <br> The resulting data is made available under the 'static.zip' file.</p> <p>## Processing code<br> The code which processes the performance data into the list of usecases is part of the 'Processing_R' notebook. <br> This results in a set of rds-files with the data in IOHanalyzer's internal format, and in a csv file ('Split_performances_relative.csv') with the selected usecases. </p> <p>This csv file can then be read in using the 'visualization' notebook, which can generate Figure 1 from the paper. This notebook can then be used to count the specific usecases, which is the data shown in Table 1. The csv-file containing the selected usecases ('usecases.csv') is also generated here.</p> <p>The 'usecases' csv file can be used in the 'Data_collection_switch' notebook to run the dynamic configurations. This results in the 'Dynamic.zip' data, which can again be read using IOHanalyzer in the 'Processing_R' notebook. This then generates several csv-files, for both the static and dynamic case, containing the per-run hitting times ('RT_samples.zip'). These are then used in the 'Visualization' notebook to generate figure 3 and 4, as well as table 2. </p> <p>## Countour plots<br> The code for generating Figure 5 is included in the end of the 'Visualization' notebook.</p> <p>## Performance comparison plot<br> Figure 6 has been generated using IOHanalyzer web-interface (iohanalyzer.liacs.nl), by uploading the files in 'cma_bfgs.zip'. </p> <p>## Switch point impact plot<br> Figure 7 has been generated using the 'split_experiment' notebook</p>
Getting Started with PCP2
<p>An overview of how to install and get started with using the PCP2 Toolkit for training and using object detection, segmentation and classification models based on Mask R-CNN</p>
Data for: The start of frozen dates over northern permafrost regions with the changing climate
<p>The soil freeze-thaw cycle in the permafrost regions has a significant impact on regional surface energy and water balance. Although increasing efforts have been made to understand the responses of spring thawing to climate change, the mechanisms controlling the global interannual variability of the start date of permafrost frozen (SOF) remain unclear. Using long-term SOF from the combinations of multiple satellite microwave sensors between 1979–2020, and analytical techniques, including partial correlation, ridge regression, path analysis, and machine learning, we explored the responses of SOF to multiple climate change factors, including warming (surface and air temperature), start date of permafrost thawing (SOT), soil properties (soil temperature and volume of water), and the snow depth water equivalent (SDWE). Overall, climate warming exhibited the maximum control on SOF, but SOT in spring was also an important driver of SOF variability; among the 65.9% significant SOT and SOF correlations, 79.3% were positive, indicating an overall earlier thawing would contribute to an earlier frozen in winter. The machine learning analysis also suggested that apart from warming, SOT ranked as the second most important determinant of SOF. Therefore, we identified the mechanism responsible for the SOT-SOF relationship using the SEM analysis, which revealed that soil temperature change exhibited the maximum effect on this relationship, irrespective of the permafrost type. Finally, we analyzed the temporal changes in these responses using the moving window approach and found an increased effect of soil warming on SOF. Therefore, these results provide important insights into understanding and predicting SOF variations with future climate change.</p>
Data from: Effect of valve opening on starting performance of pump as turbine
<p><span>The study on transient characteristics of pump as turbines during atypical startup has not been deeply explored yet.</span> <span>In order to reveal the transient characteristics of a small centrifugal pump reversing as turbine during startup process in this paper, the transient hydraulic performance experiments are conducted for three steady rotational speed cases. Under the condition of each case, three, five, and three valve opening scenarios are completed to measure the performance. The dimensionless analysis are also employed so as to better reveal transient behavior of the pump as turbine during atypical startup. The results show that the rise rate of each performance parameter is different, wherein the shaft power and rotational speed have the fastest rising rate, followed by the flow rate, and the head rise is the slowest. It is clearly seen that the shock phenomenon in static pressure easily occurs at the outlet of pump as turbine. With the increase of valve opening, the dimensionless flow rate, head, and power coefficient all show the evolution trend of gradually increasing.</span></p>
School Start Time Dataset
<p>This is a student dataset</p>
Effectiveness of Differing Levels of Support for Family Mealtimes on Obesity Prevention Among Head Start Preschools
ClinicalTrials.gov study NCT02487251. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study to Assess the Benefit of Treatment Beyond Progression With Enzalutamide in Men Who Are Starting Treatment With Docetaxel After Worsening of Their Prostate Cancer When Taking Enzalutamide Alone
ClinicalTrials.gov study NCT02288247. IPD Sharing: YES. Countries: 16. Publications: 1.
Quick Start Initiation of the Contraceptive Vaginal Ring in Adolescents
ClinicalTrials.gov study NCT00369967. IPD Sharing: NO. Countries: 1. Publications: 10.
Trial Comparing Start Stimulation of Recombinant Follicle Stimulating Hormone (rFSH) on Cycle Day 2 Versus Cycle Day 5 in In Vitro Fertilization (IVF)
ClinicalTrials.gov study NCT00823472. IPD Sharing: Not stated. Countries: 2. Publications: 1.
A Trial of Lenvatinib (E7080) in Subjects With Iodine-131 Refractory Differentiated Thyroid Cancer to Evaluate Whether an Oral Starting Dose of 18 Milligram (mg) Daily Will Provide Comparable Efficacy
ClinicalTrials.gov study NCT02702388. IPD Sharing: Not stated. Countries: 16. Publications: 2.
STudy to vAlidate telemetRic ECG Systems for firsT Dose Administration of Fingolimod (START)
ClinicalTrials.gov study NCT01585298. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of Immunogenicity and Safety of Two Formulations of GSK Biologicals' Human Rotavirus (HRV) Vaccine (444563), in Healthy Infants Starting at Age 6-12 Weeks
ClinicalTrials.gov study NCT02914184. IPD Sharing: YES. Countries: 8. Publications: 1.
EARLY 3-months Aggrenox Treatment Started Within 24 Hrs of Ischemic Stroke Onset vs. After One Week 100 mg ASA
ClinicalTrials.gov study NCT00562588. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Trial Assessing the Effectiveness of Ivabradine Started at Discharge From the Observation Unit
ClinicalTrials.gov study NCT03168529. IPD Sharing: NO. Countries: 1. Publications: 2.
Efficacy of the START-Play Program for Infants With Neuromotor Disorders
ClinicalTrials.gov study NCT02593825. IPD Sharing: NO. Countries: 1. Publications: 6.
Screening to Augment Referral to Treatment- Project START
ClinicalTrials.gov study NCT01539525. IPD Sharing: NO. Countries: 1. Publications: 2.
Comparison of Standard vs Higher Starting Dose of Insulin Glargine in Chinese Patients With Type 2 Diabetes (Glargine Starting Dose)
ClinicalTrials.gov study NCT02836704. IPD Sharing: YES. Countries: 1. Publications: 2.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.