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109
datasets available to search
ShareScore release 0.9.0
Dataset results
109 results for “TERT”
Effects of 35 days oral exposure of adult female Sprague-Dawley rats to p-tert-octylphenol on uterine gene expression
GEO Series GSE14528. Rattus norvegicus. 8 samples. Type: Expression profiling by array.
TERT Promoter DNA methylation landscape in human cancer cell lines and tumors
GEO Series GSE120511. Homo sapiens. 129 samples. Type: Expression profiling by high throughput sequencing.
Effects of single oral exposure of adult Sprague-Dawley rats to p-tert-octylphenol on uterine gene expression
GEO Series GSE14527. Rattus norvegicus. 8 samples. Type: Expression profiling by array.
tert-Butylphenyl Diphenyl Phosphate (CAS No. 56803-37-3): 5-Day Rat Gavage Toxicogenomic Study
GEO Series GSE123429. Rattus norvegicus. 21 samples. Type: Expression profiling by array.
Affymetrix SNP array data for a Diffuse Large B-cell Lymphoma case with a TERT promoter variant who later developed Chronic Myelomonocytic Leukemia
GEO Series GSE133150. Homo sapiens. 1 samples. Type: Genome variation profiling by SNP array.
Small molecule TERT activator prevents aging and cognitive decline [ChIP-seq]
GEO Series GSE231455. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Contribution of DNA methylation profiling in the classification of TRIO::TERT sarcomas
GEO Series GSE261891. Homo sapiens. 5 samples. Type: Genome variation profiling by SNP array.
Chromosomal rearrangements juxtapose the TERT coding sequence to strong enhancer elements
GEO Series GSE147181. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dataset associated with the journal publication "EXTRA-NUCLEAR TERT COUNTERACTS OXIDATIVE STRESS AND PROMOTES PROGRESSION IN PAPILLARY THYROID CARCINOMA"
<p>Abstract:</p> <p>The reactivation of TERT is associated with poor outcome in papillary thyroid cancer (PTC). Extra-telomeric functions of TERT were reported, with a protective role against oxidative stress (OS). The aim of the present study was to explore the extra-nuclear TERT localization in PTC and its role in cancer progression.</p> <p>TERT nuclear export under OS were analyzed in K1 PTC cell line. We investigated the role of different TERT localizations using specific TERT constructs that limit its localization to the nucleus or to the mitochondria. The effect of SRC kinase inhibitor PP2, which reduces TERT nuclear export, was investigated as well. Moreover, TERT localization was analyzed in 39 PTC tissues and correlated with the genetic profile and the level of OS, DNA damage and apoptosis in the tumors and with the clinical characteristics of the patients.</p> <p><a name="_Hlk150318531"></a>We demonstrated that TERT is exported from the nucleus in response to OS induced either from H2O2 or the BRAF inhibitor PLX4720. We proved that extra-nuclear TERT reduces mitochondrial OS and induces mitochondrial fragmentation. Moreover, limiting mitochondrial TERT localization reduced proliferation, migration, AKT phosphorylation and glycolysis and increased DNA damage and p21 expression. Finally, in PTC tissues the fraction of mitochondrial/nuclear TERT resulted inversely correlated with OS and p21 expression and associated with tumor persistence.</p> <p>In conclusion, our data indicate that extra-nuclear TERT is involved in reducing the effect of excessive OS, thus <a name="_Hlk150318490"></a>promoting cancer cell survival. Extra-nuclear TERT may thus represent a marker of cancer progression and a possible therapeutic target in PTC.</p> <p> </p> <p>This dataset of raw data cannot be made publicly available as it contains sensitive information, but may be made available to interested researchers on reasonable request at m.muzza@auxologico.it</p>
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.