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117
datasets available to search
ShareScore release 0.9.0
Dataset results
117 results for “cochlea”
Temporal profiling of gene expression in cochleae of wild type and alpha9 null mice
GEO Series GSE18567. Mus musculus. 24 samples. Type: Expression profiling by array.
Expression data from Igf-1 -/- and Igf-1+/+ mouse cochleas
GEO Series GSE11821. Mus musculus. 2 samples. Type: Expression profiling by array.
Single-cell gene expression profile of adult cochlea in NIHL vs. VPA-NIHL
GEO Series GSE218326. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea
GEO Series GSE289514. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Analysis of the gene expression within the cochlea of aging C57BL6j mice.
GEO Series GSE35234. Mus musculus. 12 samples. Type: Expression profiling by array.
Single-cell RNA sequencing of mouse and human cochlea
GEO Series GSE135913. Homo sapiens; Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Comprehensive transcriptome analysis of the cochleae of 7-month-old Fabp7 (+/+) and Fabp7 (-/-) mice
GEO Series GSE83599. Mus musculus. 6 samples. Type: Expression profiling by array.
scRNA-seq of P2 mouse cochlea
GEO Series GSE135737. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
Pterostilbene Protects Cochlea from Ototoxicity in Streptozotocin-Induced Diabetic Rats by Inhibiting Apoptosis
<p>Diabetes mellitus (DM) causes ototoxicity by inducing oxidative stress, microangiopathy, and apoptosis in the cochlear sensory hair cells. The natural anti-oxidant pterostilbene (PTS) (trans-3,5-dimethoxy-4-hydroxystylbene) has been reported to relieve oxidative stress and apoptosis in DM, but its role in diabetic-induced ototoxicity is unclear. This study aimed to investigate the effects of dose-dependent PTS on the cochlear cells of <em>streptozotocin</em> (STZ)-induced diabetic rats. The study included 30 albino male Wistar rats that were randomized into five groups: non-diabetic control (Control), diabetic control (DM), and diabetic rats treated with intraperitoneal PTS at 10, 20, or 40 mg/kg/day during the four-week experimental period (DM + PTS10, DM + PTS20, and DM + PTS40). Distortion product otoacoustic emission (DPOAE) tests were performed at the beginning and end of the study. At the end of the experimental period, apoptosis in the rat cochlea was investigated using caspase-8, cytochrome-c, and terminal deoxyribonucleotidyl transferase-mediated dUTP-biotin end labeling (TUNEL). Quantitative real-time polymerase chain reaction was used to assess the mRNA expression levels of the following genes: <em>CASP-3</em>, BCL-associated X protein (<em>BAX</em>), and<em> BCL-2</em>. Body weight, blood glucose, serum insulin, and malondialdehyde (MDA) levels in the rat groups were evaluated. The mean DPOAE amplitude in the DM group was significantly lower than the means of the other groups (0.9–8 kHz; P < 0.001 for all). A dose-dependent increase of the mean DPOAE amplitudes was observed with PTS treatment (P < 0.05 for all). The Caspase-8 and Cytochrome-c protein expressions and the number of TUNEL-positive cells in the hair cells of the Corti organs of the DM rat group were significantly higher than those of the PTS treatment and control groups (DM > DM + PTS10 > DM + PTS20 > DM + PTS40 > Control; P < 0.05 for all). PTS treatment also reduced cell apoptosis in a dose-dependent manner by increasing the mRNA expression of the anti-apoptosis <em>BCL2</em> gene and by decreasing the mRNA expressions of both the pro-apoptosis <em>BAX</em> gene and its effector <em>CASP-3</em> and the ratio of <em>BAX/BCL-2</em> in a dose-dependent manner (P < 0.05 compared to DM for all). PTS treatment significantly improved the metabolic parameters of the diabetic rats, such as body weight, blood glucose, serum insulin, and MDA levels, consistent with our other findings (P < 0.05 compared to DM for all). PTS decreased the cochlear damage caused by diabetes, as confirmed by DPOAE, biochemical, histopathological, immunohistochemical, and molecular findings. This study reports the first in vivo findings to suggest that PTS may be a protective therapeutic agent against diabetes-induced ototoxicity.</p>
scRNA-seq of P2 and P7 mouse cochlea and utricle
GEO Series GSE172327. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
MYO7a is required for the functional integrity of the mechanoelectrical transduction complex in the outer hair cells of the adult cochlea.
GEO Series GSE246143. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Gene expression pattern after insertion of dexamethasone-eluting electrode into the guinea pig cochlea.
GEO Series GSE53866. Cavia porcellus. 8 samples. Type: Expression profiling by array.
Age-related changes in gene expression in mouse cochlea
GEO Series GSE121856. Mus musculus. 6 samples. Type: Expression profiling by array.
Characterization of the transcriptomes of Atoh1-induced hair cells in the mouse cochlea
GEO Series GSE129533. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling of miR-183/96 knock out mouse cochlea
GEO Series GSE106599. Mus musculus. 8 samples. Type: Expression profiling by array.
RNA-seq for mRNA expression profile in the cochlea of coffee or green tea extract treated and control mice
GEO Series GSE189798. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Characterization of Transcriptomes of Apical OHCs and Basal OHCs in Cochlea
GEO Series GSE111302. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.