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2,009 results for “disruption”
Data for: First Successful Hindcasts of the 2016 Disruption of the Stratospheric Quasibiennial Oscillation
<p>These data were used for making plots in the article entitled "First Successful Hindcasts of the 2016 Disruption of the Stratospheric Quasibiennial Oscillation". Data format is NetCDF3.</p>
Gene biomarkers for the assessment of thyroid-disrupting activity in zebrafish embryos
<p>We have conducted an exposure study on zebrafish embryos using thyroidal active compounds. Based on OECD guideline 236, freshly fertilized zebrafish embryos were exposed to two sublethal concentrations of triiodothyronine (T3), 6-Propyl-2-thiouracil (6-PTU), methimazole (MMI) and iopanoic acid (IOP) until 96 hours post fertilization. RNA was extracted and sequenced to identify thyroid-related gene expression patterns. .</p> <p>The uploaded data archive consists of three major data types:<br>1. MultiQC reports from raw RNA-Seq read processing and QC<br>2. Result tables from differential gene expression analysis (DGEA) with DESeq2 (apeglm shrunk results indicated by "reslfs")<br>3. Result tables from Overrespresentation Analysis (ORA) with clusterProfiler</p> <p>Gene count normalization and DGEA was conducted with DESeq2 (<a href="https://genomebiology.biomedcentral.com/articles/10.1186/s13059-014-0550-8">Love et al., 2014</a>, DOI 10.1186/s13059-014-0550-8). Three biological replicates per condition, exposure treatments were compared with respect to the control group in a pairwise fashion, applying Wald’s t-test. P values were corrected for multiple testing with independent hypothesis weighting (IHW) (<a href="https://www.nature.com/articles/nmeth.3885">Ignatiadis et al., 2016</a>, DOI 10.1038/nmeth.3885 ) after Benjamini-Hochberg (BH). To improve the signal to statistical noise ratio, the obtained log<sub>2</sub>-fold change (lfc) values were shrunk with the apeglm method described by Zhu and colleagues (<a href="https://academic.oup.com/bioinformatics/article/35/12/2084/5159452?login=true">2019</a>, DOI 10.1093/bioinformatics/bty895 ) before DGEA result tables were subjected to ORA via clusterProfiler (<a href="https://www.liebertpub.com/doi/10.1089/omi.2011.0118">Yu et al., 2012</a>, DOI 10.1089/omi.2011.0118).</p> <p>The ArrayExpress accession numbers E-MTAB-14185 (IOP), E-MTAB-14184 (MMI), E-MTAB-14183 (T3) and E-MTAB-9054 (6-PTU), provide access to the raw and DESeq2 normalized gene count matrices upon which these analysis were performed. Genes were annotated through the biomaRt package (<a href="https://www.nature.com/articles/nprot.2009.97.pdf?origin=ppub">Durinck et al., 2009</a>, DOI 10.1038/nprot.2009.97 ) in R (<a href="https://www.r-project.org/">R Core Team 2021</a>).</p>
Relative importance of intensity and spectrum of artificial light at night in disrupting behavior of a nocturnal rodent
<p>The influence of light spectral properties on circadian rhythms is of substantial interest to laboratory-based investigation of the circadian system and to field-based understanding of the effects of artificial light at night. The tradeoffs between intensity and spectrum regarding masking behaviors are largely unknown, even for well-studied organisms. We used a custom LED illumination system to document the response of wild type house mice (Mus musculus) to 1-hr nocturnal exposure of all combinations of four intensity levels (0.01, 0.5, 5, and 50 lx) and three correlated color temperatures (CCT; 1750, 1950, and 3000 K). Higher intensities of light (50 lx) suppressed cage activity substantially, and consistently more for the higher CCT light (91% for 3000 K; 53% for 1750 K). At the lower intensities (0.01 lx), mean activity was increased, with the greatest increases for the lowest CCT (12.3% increase at 1750 K; 3% increase at 3000 K). Multiple linear regression confirmed the influence of both CCT (p&lt;0.001) and intensity (p&lt;0.001) on changes in activity (r2=0.66, F9,171=3.33; p<0.001) with the scaled effect size of intensity 3.6 times greater than CCT. Activity suppression was significantly lower for male than female mice (p&lt;0.0001). Assessment of light-evoked cFos expression in the suprachiasmatic nucleus at 50 lx showed no significant difference between high and low CCT exposure. The significant differences by spectral composition illustrate a need to account for light spectrum in circadian studies of behavior and confirm that spectral controls can mitigate some, but certainly not all, of the effects of light pollution on species in the wild.</p>
Strong lensing of tidal disruption events: Detection rates in imaging surveys
<p>The unlensed and strongly lensed tidal disruption event (TDE) catalogs at the fiducial temperature of T = 20,000 K for the L1 and L2 luminosity models separately. The L1 luminosity model is an observationally driven upper limit defined by 1% of stellar fallback material (produced in the disruption of a 0.1 Msun main-sequence star) turning into radiation. The L2 luminosity model is defined by self-crossing shocks of stellar debris. Each line of a file represents a TDE (unlensed or lensed), so to compute the TDE detection rate one would need to iterate through the entire file, sum over the TDE weighting factors, and apply magnitude cuts according to the desired survey limit. For the lensed catalogs, further normalization by any oversampling factors is needed. These catalogs assume a survey area of 20,000 deg^2; the observational limiting magnitude is 27.0 (AB) for each band, so one can choose a brighter limiting survey magnitude with mag (AB) < 27.0. </p>
Citizen Science Reports on Aurora Sighting and Technological Disruptions during the 10 May 2024 Geomagnetic Storm – ARCTICS Survey
<div> <div> <div> <div> <p>The geomagnetic storm that began on 10 May 2024 provided stunning auroral displays observed worldwide. This dataset contains data collected via an online survey designed and distributed by the "Auroral Research Coordination – Towards Internationalised Citizen Science" (ARCTICS) collaboration sponsored by the International Space Science Institute (ISSI) in Bern, Switzerland (see https://collab.issibern.ch/arctics/). A total of 696 observers from over 30 countries filled in the survey and reported on aurora sightings and experienced disruptions in technological systems during the superstorm.</p> <p>The dataset consists of two data files in the CSV format and a text file providing a detailed description of the data. The collected data have been anonymised and pre-processed to obtain a homogeneous data set.</p> <p>Dataset associated with the <span>egusphere-2024-2174 preprint by Grandin et al. ("<span>The geomagnetic superstorm of 10 May 2024: Citizen science observations</span>"), submitted to Geoscience Communication.</span></p> </div> </div> </div> </div>
Tidal dissipation and evolution of white dwarfs around massive black holes: an eccentric path to tidal disruption
<p>MESA inlists associated with <a href="https://ui.adsabs.harvard.edu/?#abs/2017MNRAS.468.2296V">Tidal dissipation and evolution of white dwarfs around massive black holes: an eccentric path to tidal disruption</a></p>
The Pseudomonas aeruginosa T6SS delivers a periplasmic toxin that disrupts bacterial cell morphology - 6H56
<p>VgrG2b X-ray diffraction data for PDB entry 6H56.</p> <p>=> VgrG2b_p3: Native protein, one dataset</p> <p>=> VgrG2b_SeMet: Se-Met protein, four datasets</p> <p>Data were collected at beamline I02 of Diamond Light Source on 24 Jun 2013 (VgrG2b_p3) and at beamline I04 of Diamond Light Source on 17 Apr 2014 (VgrG2b_SeMet).</p>
AT 2021hdr: a candidate tidal disruption of a gas cloud by a binary super massive black hole system
<p>In this dataset we provide tables for the Zwicky Transient Facility (ZTF) and Swift observations presented in the paper "AT 2021hdr: a candidate tidal disruption of a gas cloud by a binary super massive black hole system", accepted for publication in the Astronomy and Astrophysics Journal (Hernández-García et al. 2024). </p> <p> </p> <p>Files description:</p> <p>-ztf_table:_zenodo.csv: Log of the ZTF forced photometry observations. Include the dates in MJD, filter, apparent magnitudes, and difference fluxes.</p> <p>- swift_table_zenodo.csv: Log of the Swift observations, including the observation ID, date (in MJD), exposure time, count-rate in the 0.5-10 keV energy band, and UV fluxes in the UVW2 and UVM2 filters. </p>
Data for Marshall et al, "Microbial metabolism disrupts cytokine activity to impact host immune response"
<p>Raw data for publication "Microbial metabolism disrupts cytokine activity to impact host immune response", Marshall EKP et al. The archive is organized into folders containing raw data pertaining to each figure.</p>
Genetic disruption of synthesis pathways of Arabidopsis secondary metabolites dramatically affects root-associated nematode populations directly and via modulation of microbial communities
<p>Dataset of nematode, fungal and bacterial sequence reads of Arabidopsis roots. Dataset of fungal and bacterial sequence reads of Arabidopsis microbial suspension. DNA concentration of Arabidopsis root microbial suspension. Meloidogyne incognita J2 invasion into tomato roots. qPCR dataset of Meloidogyne hapla infection pressure into Arabidopsis roots. </p>
Data supplement for: Disrupting cortico-cerebellar communication impairs dexterity
<p>This dataset, along with the corresponding code, is a supplement to "Disrupting cortico-cerebellar communication impairs dexterity" (Guo*, Sauerbrei* et al., eLife 2021). It consists of single-unit electrophysiology data from the pontine nuclei, Purkinje cells, cerebellar nuclei, and motor cortex of awake mice, along with measurements of the hand position of mice performing reaching movements.</p> <p>These data address the question of how the dynamics of motor cortex and cerebellum interact to control skilled reaching. First, we recorded from neurons in the pontine nuclei (PN), the bridge between cerebral cortex and the cerebellum, as mice reached to and grasped food pellets. Most PN neurons were strongly modulated by an acoustic go cue, by movement onset, or by both. Optogenetic stimulation of the PN strongly entrained spiking in Purkinje cells and the cerebellar nuclei, and induced transients in some motor cortical neurons. PN stimulation during a reach-to-grasp task induced a range of deficits, including decreases in success rate, increases in the standard deviation of hand position, increases in movement duration, and overreaching of the target. During movement, PN stimulation altered neural activity in the cerebellar nuclei and motor cortex, and a velocity decoding analysis revealed that these shifts in activity were consistent with the kinematic effects of stimulation. Our findings suggest that interaction between motor cortex and the cerebellum is essential for fine-tuning movements to enable accurate and precise behavior.</p> <p>Code required to generate the figures is available in the companion repository on Zenodo, and a list of which scripts generate which figure panels is contained in /docs/README.</p>
On the utilization of Disruptive Technologies for Municipality-wide Policy Making
<p>Disruptive technologies (DTs) aim to introduce innovative elements with the immediate goal of changing citizens' behavior and the optimization of certain processes in either the private or public sector. The sector, especially "e-governance" has adopted several DT-based systems and is open to exploring new technologies that could be potentially useful for the sector's administration. This paper proposes a DT-based framework for the early detection of misinformation, the identification and prioritization of emerging and significant issues that refer to the municipality, and the recommendation of counter-actions that could be applied for each identified issue. The proposed framework aims to be applied initially at the municipal level as this is a more limited community for the framework's study and evaluation. News feeds and information posted on social media platforms will be the key information included in the proposed framework, aiming at sensing the public opinion and extracting issues and topics that concern a municipality's citizens. Through social media platforms, users tend to post, among other, concerns or issues they face within the local community, and thus useful content can be extracted and used for the identification of emerging and significant issues. The main advantage of this framework is the utilization of information from different data sources and their processing in order to immediately inform the relevant authority about the most important issues, allowing them to act in a proactive way. The expected outcome of the proposed framework is to raise the citizens' awareness of the issues of the local society and restrict criminality and violence in the municipality.</p>
Accurate measurement of microsatellite length by disrupting its tandem repeat structure
<p>Read, first copy, and template tables for microsatellite data pertaining to the manuscript: "Accurate measurement of microsatellite length by disrupting its tandem repeat structure". </p>
A dominant-negative SOX18 mutant disrupts multiple regulatory layers essential to transcription factor activity
<p>Few genetically dominant mutations involved in human disease have been fully explained at the molecular level. In cases where the mutant gene encodes a transcription factor, the dominant-negative mode of action of the mutant protein is particularly poorly understood. Here, we studied the genome-wide mechanism underlying a dominant-negative form of the SOX18 transcription factor (SOX18<sup>RaOp</sup>) responsible for both the classical mouse mutant <u>Ra</u>gged <u>Op</u>ossum and the human genetic disorder Hypotrichosis-Lymphedema-Telangiectasia-Renal Syndrome. Combining three single-molecule imaging assays in living cells together with genomics and proteomics analysis, we found that SOX18<sup>RaOp</sup> disrupts the system through an accumulation of molecular interferences which impair several functional properties of the wild-type SOX18 protein, including its target gene selection process. The dominant-negative effect is further amplified by poisoning the interactome of its wild-type counterpart, which perturbs regulatory nodes such as SOX7 and MEF2C. Our findings explain in unprecedented detail the multi-layered process that underpins the molecular aetiology of dominant-negative transcription factor function.</p>
Alexithymia disrupts verbal short-term memory
<p>While some research have now started to show long-term memory (LTM) deficits in</p> <p>alexithymia, short-term memory (STM) remained largely unexplored. We investigated</p> <p>whether the STM trace for emotion and neutral words might also be disrupted by</p> <p>alexithymia. Forty four participants were randomly assigned to study 1 in which the</p> <p>to-be-memorized 6-words lists were composed of words belonging to the same</p> <p>valence (i.e., pure lists condition, Study 1) and 44 other participants were randomly</p> <p>assigned to study 2 in which 6-words lists were composed of embedded neutral and</p> <p>emotional words (i.e., mixed lists condition). All the participants completed the</p> <p>Toronto-Alexithymia Scale (TAS-20) and a current mood states scale (PANAS).</p> <p>Results showed that a main effect of Alexithymia was observed in the pure lists</p> <p>condition while no alexithymia groups effect emerged in the mixed lists condition. In</p> <p>the pure lists condition only, correlation analyses confirmed that alexithymia</p> <p>significantly and negatively correlated with recall accuracy. The results are discussed</p> <p>with regard to the influence of alexithymia on the proposed role of 1) semantic</p> <p>organization of LTM on STM performance in the pure lists condition, and 2)</p> <p>attentional capture by emotion words in the mixed lists condition.</p>
Qatar Peninsula' High Vulnerability to Oil Spills and its Implication for the Potential Disruption in Global Gas Supply (Datasets)
<p>Outputs of oil spill dispersal simulations performed backward in time using OpenDrift for the following study:</p> <p>Anselain, T., Heggy, E., Dobbelaere, T., & Hanert, E. (2022). Qatar Peninsula’ High Vulnerability to Oil Spills and its Implication for the Potential Disruption in Global Gas Supply. <em>Nature Sustainability</em>. In press.</p>
Data for "Ceramide-1-phosphate transfer protein enhances lipid transport by disrupting hydrophobic lipid–membrane contacts"
<p>Data for "Ceramide-1-phosphate transfer protein enhances lipid transport by disrupting hydrophobic lipid–membrane contacts" by Julia R Rogers and Phillip L Geissler (<a href="https://doi.org/10.1371/journal.pcbi.1010992">Rogers, J. R.; Geissler, P. L. <em>PLoS Comput. Biol.</em> <strong>2023</strong>, <em>19</em>, e1010992</a>; bioRxiv DOI: https://doi.org/10.1101/2022.09.10.507427). All input coordinates, topologies, and parameter files in addition to equilibrium simulation trajectories and analysis results are provided.</p>
Data for: Limited host availability disrupts the genetic correlation between virulence and transmission
<p>Virulence is expected to be linked to parasite fitness via transmission. However, it is not clear whether this relationship is genetically determined, nor if it differs when transmission occurs continuously during, or only at the end of, the infection period. Here, we used inbred lines of the macro-parasitic spider mite <em>Tetranychus urticae</em> to disentangle genetic vs non-genetic correlations among traits, while varying parasite density and opportunities for transmission. A positive genetic correlation between virulence and the number of transmitting stages produced was found under continuous transmission. However, if transmission occurred only at the end of the infection period, this genetic correlation disappeared. Instead, we observed a negative relationship between virulence and the number of transmitting stages, driven by density dependence. Thus, within-host density dependence caused by reduced opportunities for transmission may hamper selection for higher virulence, providing a novel explanation as to why limited host availability leads to lower virulence.</p>
Saul Flores data for manuscript in ECOLOGY: Extreme drought disrupts plant phenology: insights from 35 years of cloud forest data in Venezuela
<p>Venezuela cloud forest phenology data for tree flowers and fruits.</p>
Survival data and code: Camouflage using 3D surface disruption
<p class="MsoNormal">Disruptive markings are common in animal patterns and can provide camouflage benefits by concealing the body's true edges and/or by breaking the surface of the body into multiple depth planes. Disruptive patterns that are accentuated by high contrast borders are most likely to provide false depth cues to enhance camouflage, but studies to date have used visual detection models or humans as predators. We presented 3D-printed moth-like targets to wild bird predators to determine whether: (1) 3D prey with disrupted body surfaces have higher survival than 3D prey with continuous surfaces, (2) 2D prey with disruptive patterns or enhanced edge markings have higher survival than non-patterned 2D prey. We found a survival benefit for 3D prey with disrupted surfaces, even after accounting for luminance differences among the treatments. There was no evidence that false depth cues provided the same protective benefits as physical surface disruption in 3D prey, perhaps because our treatments did not mimic the complexity of patterns found in natural animal markings. Our findings indicate that disruption of surface continuity is an important strategy for concealing a 3D body shape.</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.