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612 results for “imprinting”

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dryad28/100

Data from: Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation–dependent and –independent mechanisms

The mouse Igf2/H19 locus is regulated by genomic imprinting, in which the paternally methylated H19 imprinting control region (ICR) plays a critical role in mono-allelic expression of the genes in the locus. Although the maternal allele–specific insulator activity of the H19 ICR in regulating imprinted Igf2 expression has been well established, the detailed mechanism by which the H19 ICR controls mono-allelic H19 gene expression has not been fully elucidated. In this study, we evaluated the effect of H19 ICR orientation on imprinting regulation in mutant mice in which the H19 ICR sequence was inverted at the endogenous locus. When the inverted-ICR allele was paternally inherited, the methylation level of the H19 promoter was decreased and the H19 gene was derepressed, suggesting that methylation of the H19 promoter is essential for complete repression of H19 gene expression. Unexpectedly, when the inverted allele was maternally inherited, the expression level of the H19 gene was lower than that of the WT allele, even though the H19 promoter remained fully hypomethylated. These observations suggested that the polarity of the H19 ICR is involved in controlling imprinted H19 gene expression on each parental allele, dependent or independent on DNA methylation of the H19 promoter.

opencc-zeroNov 2021View details →

zenodo28/100

FIGURE 2 in Imprint of a Helcophorus Fairmaire, 1881: the first net-winged beetle (Coleoptera Lycidae) from Rovno amber

FIGURE 2. Pronotum and the base of elytra of Helcophorus (Thibeteros) ekaterinae, sp. nov.

opennotspecifiedApr 2022View details →

zenodo28/100

FIGURE 1 in Imprint of a Helcophorus Fairmaire, 1881: the first net-winged beetle (Coleoptera Lycidae) from Rovno amber

FIGURE 1. General view of Helcophorus (Thibeteros) ekaterinae, sp. nov.

opennotspecifiedApr 2022View details →

dryad28/100

Data from: Natural epigenetic polymorphisms lead to intraspecific variation in Arabidopsis gene imprinting

Imprinted gene expression occurs during seed development in plants and is associated with differential DNA methylation of parental alleles, particularly at proximal transposable elements (TEs). Imprinting variability could contribute to observed parent-of-origin effects on seed development. We investigated intraspecific variation in imprinting, coupled with analysis of DNA methylation and small RNAs, among three Arabidopsis strains with diverse seed phenotypes. The majority of imprinted genes were parentally biased in the same manner among all strains. However, we identified several examples of allele-specific imprinting correlated with intraspecific epigenetic variation at a TE. We successfully predicted imprinting in additional strains based on methylation variability. We conclude that there is standing variation in imprinting even in recently diverged genotypes due to intraspecific epiallelic variation. Our data demonstrate that epiallelic variation and genomic imprinting intersect to produce novel gene expression patterns in seeds.

opencc-zeroJul 2014View details →

dryad28/100

Untangling the imprints of climate, geography and land use/cover on bird diversity in the South American Gran Chaco

Aim: To evaluate the structure of bird communities throughout the South American Gran Chaco determining the effects of climate, geography, and land use/land cover in bird beta diversity, as well as to understand the beta-diversity processes underlying land-use changes across broad spatial ranges. Taxon: Birds. Location: South American Gran Chaco. Methods: We constructed a site-by-species matrix with occurrence probabilities of 293 bird species across 2669 spatial units tiling completely the study area. Based on this matrix, we calculated pairwise dissimilarities scores and performed a hierarchical cluster analysis for describing the spatial configuration of dissimilarities. The clustering result was spatially represented through an original venation map with boundaries between sites widened in the function of their distance in the dendrogram. We used the Generalized Dissimilarity Modelling approach to model beta diversity, using geographic distance, climatic and land use/land cover information as predictors. We mapped beta-diversity patterns using color theory and the HSV color model. Results: We identified two main clusters of sites across the Gran Chaco, which represent environmentally different sites and harbour very distinct assemblages of species. These main groups are separated by two natural delimiters: The Bermejo-Pilcomayo interfluvium and the Lower Paraná floodplain. Overall, we observed that the percentage of cropland and climatic variables were important shapers of bird beta diversity. Main conclusions: We provide the first area-wide assessment of land use/land cover effects on bird beta diversity for the Gran Chaco. The distribution of croplands has a marked influence on bird beta diversity at regional scale highlighting the role of anthropic changes in reshaping bird beta diversity within the ecoregion. Taking into account the global increasing conversion of forests into croplands, a growing footprint of land use changes over geographical patterns of bird diversity in forest biomes can be anticipated.

opencc-zeroOct 2021View details →

ClinicalTrials.gov28/100

A Study of Intensity-Modulated Pleural Radiation Therapy (IMPRINT) in People With Thymic Cancer That Has Spread to the Lining of the Lungs and Chest

ClinicalTrials.gov study NCT05354570. IPD Sharing: YES. Countries: 1. Publications: 0.

controlledIPD-YESFeb 2026View details →

ClinicalTrials.gov28/100

Pembrolizumab in Preventing Lung Cancer in Patients With Stage I-II Non-Small Cell Lung Cancer or High-Risk Pulmonary Nodules, the IMPRINT-Lung Study

ClinicalTrials.gov study NCT03634241. IPD Sharing: Not stated. Countries: 1. Publications: 0.

restrictedIPD-UNDECIDEDFeb 2026View details →

dryad28/100