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249 results for “infection tolerance”
Tolerance and Efficacy of Amiklin Administration During Nosocomial Infections Complicating COVID-19 in the ICU
ClinicalTrials.gov study NCT05511129. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Data from: House finch populations differ in early inflammatory signaling and pathogen tolerance at the peak of Mycoplasma gallisepticum infection
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Data from: Parasite infection and decreased thermal tolerance: impact of proliferative kidney disease (PKD) on a wild salmonid fish in the context of climate change
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Data from: Tolerance and overcompensation to infection by Phytophthora infestans in the wild perennial climber Solanum dulcamara
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Data from: An immunological marker of tolerance to infection in wild rodents
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Data from: Maternal allocation of carotenoids increases tolerance to bacterial infection in brown trout
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Data from: Patterns of host-parasite adaptation in three populations of monarch butterflies infected with a naturally occurring protozoan disease: virulence, resistance, and tolerance
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Data from: Sexual antagonism for resistance and tolerance to infection in Drosophila melanogaster
A critical task in evolutionary genetics is to explain the persistence of heritable variation in fitness-related traits such as immunity. Ecological factors can maintain genetic variation in immunity, but less is known about the role of other factors, such as antagonistic pleiotropy, on immunity. Sexually dimorphic immunity—with females often being more immune-competent—may maintain variation in immunity in dioecious populations. Most eco-immunological studies assess host resistance to parasites rather than the host's ability to maintain fitness during infection (tolerance). Distinguishing between resistance and tolerance is important as they are thought to have markedly different evolutionary and epidemiological outcomes. Few studies have investigated tolerance in animals, and the extent of sexual dimorphism in tolerance is unknown. Using males and females from 50 Drosophila melanogaster genotypes, we investigated possible sources of genetic variation for immunity by assessing both resistance and tolerance to the common bacterial pathogen Pseudomonas aeruginosa. We found evidence of sexual dimorphism and sexual antagonism for resistance and tolerance, and a trade-off between the two traits. Our findings suggest that antagonistic pleiotropy may be a major contributor to variation in immunity, with implications for host–parasite coevolution.
Data from: The genetic architecture of defence as resistance to and tolerance of bacterial infection in Drosophila melanogaster
Defence against pathogenic infection can take two forms: resistance and tolerance. Resistance is the ability of the host to limit a pathogen burden, whereas tolerance is the ability to limit the negative consequences of infection at a given level of infection intensity. Evolutionarily, a tolerance strategy that is independent of resistance could allow the host to avoid mounting a costly immune response and, theoretically, to avoid a co-evolutionary arms race between pathogen virulence and host resistance. Biomedically, understanding the mechanisms of tolerance and how they relate to resistance could potentially yield treatment strategies that focus on health improvement instead of pathogen elimination. To understand the impact of tolerance on host defence and identify genetic variants that determine host tolerance, we defined genetic variation in tolerance as the residual deviation from a binomial regression of fitness under infection against infection intensity. We then performed a genomewide association study to map the genetic basis of variation in resistance to and tolerance of infection by the bacterium Providencia rettgeri. We found a positive genetic correlation between resistance and tolerance, and we demonstrated that the level of resistance is highly predictive of tolerance. We identified 30 loci that predict tolerance, many of which are in genes involved in the regulation of immunity and metabolism. We used RNAi to confirm that a subset of mapped genes have a role in defence, including putative wound repair genes grainy head and debris buster. Our results indicate that tolerance is not an independent strategy from resistance, but that defence arises from a collection of physiological processes intertwined with canonical immunity and resistance.
Data and code for "The restriction factor pastrel is associated with host vigor, viral titer, and variation in disease tolerance during Drosophila C Virus infection"
<p>Raw data and R code for:</p> <p>Kutzer M, Gupta V, Neophytou K, Doublet V, Monteith KM, Vale PF. The restriction factor pastrel is associated with host vigor, viral titer, and variation in disease tolerance during Drosophila C Virus infection. bioRxiv. 2022; 2022.06.09.495537. doi:<a href="https://doi.org/10.1101/2022.06.09.495537">10.1101/2022.06.09.495537</a></p> <p>Data files are:</p> <p>titre.csv. -viral titre for 10 DGRP lines, males and females, 6 doses of DCV, measured 3 days post-infection<br> survival.csv -survival for 10 DGRP lines, males and females, 6 doses of DCV.<br> fecundity.csv - number of offspring produced by females of 10 DGRP lines when infected with 6 doses of DCV.<br> expression_MK. Baseline and infected expression of G9a and Upd3 for 10 DGRP lines, males and females, following exposure to 10e7 DCV IU/ml.</p>
Data from: Health trajectories reveal the dynamic contributions of host genetic resistance and tolerance to infection outcome
Resistance and tolerance are two alternative strategies hosts can adopt to survive infections. Both strategies may be genetically controlled. To date, the relative contribution of resistance and tolerance to infection outcome is poorly understood. A bioluminescent Listeria monocytogenes (Lm) infection challenge model on four genetically diverse mouse strains was used to study the genetic determination and dynamic contributions of host resistance and tolerance to listeriosis, a serious food-borne infectious disease in humans. Conventional statistical analyses revealed significant genetic variation in both resistance and tolerance, but could not capture the time-dependent relative importance of either strategy. These limitations were overcome by the development of novel statistical tools to analyse individual infection trajectories portraying simultaneous changes in infection severity and health. Based on these tools, early expression of resistance followed later by expression of tolerance, emerged as important hallmarks for surviving Lm infections. Trajectory analysis further revealed that survivors and non-survivors follow distinct infection paths, which are also genetically determined, and provided new survival thresholds as objective endpoints in infection experiments. Future studies may use trajectories as novel traits for mapping and identifying genes that control infection dynamics and outcome. A Matlab script for user-friendly trajectory analysis is provided.
A Randomized Study of Activity, Safety, and Tolerance of Oral Ro 24-7429 (Tat Antagonist) in Patients With HIV Infection
ClinicalTrials.gov study NCT00000760. IPD Sharing: Not stated. Countries: 1. Publications: 2.
TMC125-C227: A Phase II Randomized, Active-Controlled, Open Label Trial to Investigate the Efficacy and Tolerability of TMC125 in HIV-1 Infected Subjects, Who Are PI-Naive and With Documented Genotypi
ClinicalTrials.gov study NCT00225303. IPD Sharing: Not stated. Countries: 0. Publications: 1.
A Study to Test the Safety, Tolerance, and Metabolism of Abacavir (1592U89, ABC) With Standard Zidovudine (ZDV) Therapy in Newborn Infants Born to HIV-1 Infected Women
ClinicalTrials.gov study NCT00000864. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Safety, Tolerance, Efficacy and Pharmacokinetics of Multiple Doses of sCD4-PE40 in the Treatment of HIV-Infected Individuals
ClinicalTrials.gov study NCT00002087. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety, Tolerability, Pharmacokinetics, and Anti-Retroviral Activity of MK-8558 Monotherapy in Anti-Retroviral-Naïve HIV-1 Infected Participants (MK-8558-002)
ClinicalTrials.gov study NCT03859739. IPD Sharing: YES. Countries: 2. Publications: 0.
An Open-Label, Staggered Rising Dose Cohort Study Assessing the Pharmacokinetics, Safety, and Tolerance of BI-RG-587 in Combination With Zidovudine in Patients With HIV Infection (CD4+ Cell Count < 40
ClinicalTrials.gov study NCT00000649. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy, Safety and Tolerability of Ribavirin Monotherapy Followed by Combined Treatment With Ribavirin and Hydroxychloroquine in Patients Infected With Hepatitis C
ClinicalTrials.gov study NCT01833845. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Phase I, Open Label Trial to Evaluate the Safety, Tolerance and Biological Effects of SDZ ILE-964 (Recombinant Human Interleukin-3, RhIL-3) in HIV Infected Patients With Cytopenia
ClinicalTrials.gov study NCT00002258. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Safety and Tolerability Study of Doripenem Compared With Cefepime in Children Hospitalized With Complicated Urinary Tract Infections
ClinicalTrials.gov study NCT01110408. IPD Sharing: Not stated. Countries: 12. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.