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1,055 results for “insomnia”
Effects of Melatonin on Insomnia Symptoms in Older Adults
ClinicalTrials.gov study NCT00230737. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Central amygdala somatostatin neurons modulate stress-induced sleep-onset insomnia
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Data from: Hypothalamic circuitry underlying stress-induced insomnia and peripheral immunosuppression
<p>The neural substrates of insomnia/hyperarousal induced by stress remain unknown. Here, we show that restraint stress leads to hyperarousal associated with strong activation of corticotropin-releasing hormone neurons in the paraventricular nucleus of hypothalamus (CRH<sup>PVN</sup>) and hypocretin neurons in the lateral hypothalamus (Hcrt<sup>LH</sup>). CRH<sup>PVN</sup> neurons directly innervate Hcrt<sup>LH</sup> neurons and optogenetic stimulation of LH-projecting CRH<sup>PVN</sup> neurons elicits hyperarousal. CRISPR-Cas9-mediated knockdown of the <i>crh</i> gene in CRH<sup>PVN</sup> neurons abolishes hyperarousal induced by stimulating LH-projecting CRH<sup>PVN</sup> neurons. Genetic ablation of Hcrt neurons or <i>crh</i> gene knockdown significantly counteracts restraint stress-induced hyperarousal. As stress is further associated with changes in immune function, we used single-cell mass cytometry by time of flight (CyTOF) to analyze peripheral blood and found extensive changes to immune cell distribution and functional responses during wakefulness upon optogenetic stimulation of CRH<sup>PVN</sup> neurons. Our findings suggest both central and peripheral systems are synergistically engaged in the response to stress via CRH<sup>PVN</sup> circuitry.</p>
Supplementary Figure S3 The leave-one-out analysis of the association between insomnia and MetS components genetically in the reverse MR analysis.
<p>This figure described the leave-one-out analysis of the association between insomnia and MetS components genetically in the reverse MR analysis.</p>
Supplementary Figure S2.The funnel plots of the association between insomnia and MetS components genetically in the reverse MR analysis.
<p>This figure described the funnel plots of the association between insomnia and MetS components genetically in the reverse MR analysis.</p>
Relationships Between Childhood Bullying/Domestic Violence Experience and Insomnia among Employees in Japan
<p>Data were obtained from a survey of the Tsukuba Science City Network in Tsukuba.<br> This survey was an anonymous web questionnaire entitled The 7th Life Environment and Workplace Stress Survey from February to March 2017.</p> <p>7175 people (average age, 44 years; 4509 men and 2666 women) aged 20 to 65 years.</p>
Dose-finding Study Assessing the Efficacy, Safety, and Pharmacokinetics of Daridorexant in Subjects Aged 10 to < 18 Years With Insomnia Disorder
ClinicalTrials.gov study NCT05423717. IPD Sharing: NO. Countries: 6. Publications: 0.
Efficacy of Hypno-ear-acupuncture on Insomnia in Advanced Cancer Patients
ClinicalTrials.gov study NCT06532188. IPD Sharing: NO. Countries: 1. Publications: 2.
Auricular Acupressure for Hemodialysis Patients With Insomnia
ClinicalTrials.gov study NCT03015766. IPD Sharing: YES. Countries: 1. Publications: 4.
A Digital Cognitive Behavioural Therapy for Insomnia Intervention in Mild Cognitive Impairment and Mild Dementia
ClinicalTrials.gov study NCT07363928. IPD Sharing: NO. Countries: 1. Publications: 13.
The Effect of Foot Bath and Lavender Oil Sniffing on the Severity of Insomnia in Cancer Patients
ClinicalTrials.gov study NCT05288244. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI)
ClinicalTrials.gov study NCT07385105. IPD Sharing: NO. Countries: 1. Publications: 1.
Cognitive Behavioral Therapy for Insomnia in People With Chronic Obstructive Pulmonary Disease(COPD)
ClinicalTrials.gov study NCT01072292. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Cognitive Behavioral Therapy for Insomnia Among Different Types of Shift Workers
ClinicalTrials.gov study NCT02523079. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of CBT-I and Lemborexant Medication for Different Subtypes of Chronic Insomnia
ClinicalTrials.gov study NCT06779149. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Mojzisova Method on Pain, Menstrual Symptom and Insomnia in PD
ClinicalTrials.gov study NCT06460870. IPD Sharing: NO. Countries: 1. Publications: 10.
Quetiapine for Primary Insomnia Patients : A Randomized Controlled Trial
ClinicalTrials.gov study NCT00328822. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Investigating the Use of taVNS to Treat Insomnia in Individuals With Breast Cancer (taVNS-insomnia-BC)
ClinicalTrials.gov study NCT06006299. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy of Ramelteon in Subjects With Chronic Insomnia
ClinicalTrials.gov study NCT00671086. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Validation of Therapeutic Effects of Cefaly on Insomnia
ClinicalTrials.gov study NCT04838067. IPD Sharing: Not stated. Countries: 1. Publications: 2.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.