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3,047 results for “maternal”
Maternal affection
Inscribed at back right: 'E.H. BAILY, R.A./sculp. London/1841' Baily exhibited a plaster group of a mother and child entitled Affection etc.' at the Royal Academy in 1823 and subsequently carved several variants in marble. One of these is dated 1837, and is now in the Victoria and Albert Museum: it is thought to be the work called Group, Maternal Affection' that he exhibited at the Royal Academy in 1837. The Fitzwilliam's marble is a copy of this, carved four years later. Maternal Affection was so popular that it was also reproduced on a reduced scale in Parian ware, a newly invented type of porcelain. This made the composition available to aspiring middle class collectors. https://data.fitzmuseum.cam.ac.uk/id/object/31039 Source: Objaverse 1.0 / Sketchfab
Data from: incubation as a driver of maternal effects: temperature influences levels of yolk maternally derived 5α-dihydrotestosterone
<p>In birds, maternal hormones deposited into eggs in response to environmental stimuli can impact offspring phenotype. Although less studied, environmental conditions can also influence females' incubation behavior, which might play a role in regulating embryo exposure to maternal hormones through changes in incubation temperature that affect the activity of the enzymes responsible for converting testosterone (T) to 5α-dihydrotestosterone (DHT) or estradiol. Here, we tested the hypothesis that the initial T content of the yolk and incubation temperature determine exposure to T metabolites during early embryo development. In the Japanese quail (<em>Coturnix japonica</em>), we experimentally manipulated yolk T and incubation temperature (38° C versus 36° C) and analyzed DHT and estradiol titers on day four of incubation. We found that eggs with experimentally increased T and those incubated at 36° C showed higher DHT concentration in egg yolk (with no synergistic effect of the two treatments). Estradiol titers were not affected by T manipulation or incubation temperature. Our study suggests that incubation temperature influences DHT titers and may act as an understudied source of maternal influence on offspring phenotype.</p>
Data from: Avian offspring prenatal DNA methylation response to maternal corticosterone dosing during reproduction
<p>Avian embryos develop in an egg composition which reflects both maternal condition and the recent environment of their mother. In birds, yolk corticosterone (CORT) influences development by impacting pre- and postnatal growth, as well as nestling stress responses and development. One possible mechanism through which maternal CORT may affect offspring development is via changes to offspring DNA methylation. We sought to investigate this, for the first time in birds, by quantifying the impact of manipulations to maternal CORT on offspring DNA methylation. We non-invasively manipulated plasma CORT concentrations of egg-laying female zebra finches (<em>Taeniopygia </em><em>castanotis</em>) with an acute dose of CORT administered around the time of ovulation and collected their eggs. We then assessed DNA methylation in the resulting embryonic tissue and in their associated vitelline membrane blood vessels, during early development (5 days after lay), using two established methods - liquid chromatography–mass spectrometry (LC-MS) and methylation-sensitive amplification fragment length polymorphism (MS-AFLP). LC-MS analysis showed that global DNA methylation was lower in embryos from CORT-treated mothers, compared to control embryos. In contrast, blood vessel DNA from eggs from CORT-treated mothers showed global methylation increases, compared to control samples. There was a higher proportion of global DNA methylation in the embryonic DNA of second clutches, compared to first clutches. Locus-specific analyses using MS-AFLP did not reveal a treatment effect. Our results indicate that an acute elevation of maternal CORT around ovulation impacts DNA methylation patterns in their offspring. This could provide a mechanistic understanding of how a mother's experience can affect her offspring's phenotype.</p>
Human Placental Lactogen (Human Chorionic Somataomammotropin) and Oxytocin during Pregnancy: Individual Patterns and Association with Maternal-Fetal Attachment, Anxiety, and Depression
<p>Dataset from Human Placental Lactogen (Human Chorionic Somataomammotropin) and Oxytocin during Pregnancy: Individual Patterns and Association with Maternal-Fetal Attachment, Anxiety, and Depression</p>
Do maternal allocations towards offspring quality and quantity ameliorate the effects of predators on offspring survival?
<p>Reproductive allocation is often balanced between the quantity and quality of offspring. Ecological stresses, like exposure to predators, can cause organisms to shift their allocations along this continuum. While the consequences of such plastic shifts for offspring performance are often untested, they are critical to understanding the potential long-term benefits of manipulating predation risk as an agricultural pest management technique. Predation risk induces reductions in egg production and increases in nutritional condition due to maternal provisioning in Colorado potato beetles (<em>Leptinotarsa decemlineata, </em>CPB). Here we tested whether reductions in density or increases in offspring condition, which may increase per-capita larval survival, can compensate for the reduction in total egg production, especially when offspring are exposed to predators. In two field trials, we manipulated the density and condition of larval CPB and measured survival through development to adulthood in field cages with and without predaceous stink bugs (<em>Podisus maculiventris</em>). As expected, cages with the higher initial larval densities had more larvae and adults surviving in the treatments without predators –about 30-50% survival across densities. When predators were present this relationship did not hold because of density-dependent predation. Larval condition interacted with density and impacted larval survival in both trials albeit in different ways. In Trial 1, unprovisioned beetles had higher survival at the higher densities, in Trial 2 provisioned beetles had higher survival across densities.</p> <p><em>Synthesis and Applications:</em> Overall, our test of the effects of predation risk via manipulations of larval density and condition revealed few net compensatory benefits to the prey of reduced density and higher condition. Benefits to the prey of shifts in allocation from the quantity to quality of offspring may depend on factors that influence the strength of density dependence, including predation intensity. Our results suggest a new strategy of taking advantage of the reductions in prey density due to the non-consumptive effects of predators as a pest management approach to protect plants.</p>
Data from: Maternal age effects on offspring lifespan and reproduction vary within a species
<p>Across diverse taxa, offspring from older mothers have decreased lifespan and fitness. Little is known about the extent to which maternal age effects vary among genotypes for a given species, however, except for studies of a few arthropod species. To investigate the presence and degree of intraspecific variability in maternal age effects, we compared lifespan, reproductive schedule, and lifetime reproductive output of offspring produced by young, middle-aged, and old mothers in four strains of rotifers in the <em>Brachionus plicatilis </em>species complex. We found significant variability among strains in the magnitude and direction of maternal age effects on offspring life history traits. In one strain, offspring of young mothers lived 20% longer than offspring of old mothers, whereas there were no significant effects of maternal age on lifespan for other strains. Depending on strain, advanced maternal age had positive effects, negative effects, or no effect on lifetime reproductive output. Across strains, older mothers produced offspring that had higher maximum daily reproduction early in life. Effects of maternal age on offspring vital rates could not be explained by changes in trade-offs between lifespan and reproduction. This study documents intraspecific variability in maternal age effects in an additional clade. Investigating intraspecific variability is critical for understanding the ubiquity of maternal age effects and their role in the evolution of life history and aging.</p>
Maternal investment and early thermal conditions affect performance and antipredator responses
<p>Exposure to increased temperatures during early development can lead to phenotypic plasticity in morphology, physiology, and behaviour across a range of ectothermic animals. In addition, maternal effects are known to be important contributors to phenotypic variation in offspring. Whether the two factors interact to shape offspring morphology and behaviour has been barely explored. This is critical since climate change is expected to impact both incubation temperature and maternal resource allocation and stress levels. Using a fully factorial design, and Bayesian multivariate mixed models, we explored how the manipulation of early thermal environment and yolk-quantity in eggs affected the morphology, performance and antipredator behaviour of two sympatric Australian skink species (<em>Lampropholis delicata</em> and <em>L. guichenoti</em>). We found that juveniles from the hot treatment were larger than those on the cold treatment in <em>L. guichenoti</em> but not <em>L. delicata</em>. Using repeated behavioural measures for individual lizards, we found an interaction between incubation temperature and maternal investment in performance, with running speed being affected in a species-specific way by the treatment. We predicted that changes in performance should influence antipredator responses. In support of this prediction, we found that maternal investment impacted antipredator behaviour, with animals from the yolk-reduced and cold treatment resuming activity faster after a simulated predatory attack in <em>L. delicata</em>. However, the prediction was not supported in <em>L. guichenoti</em>. Our results highlight the importance of exploring the multifaceted role that environments play across generations to understand how different anthropogenic factors will impact wildlife in the future.</p>
Data from: Family dynamics reveal that female house mice preferentially breed in their maternal community
<p>Whether females breed in their natal group is an important factor in the evolution of extended families in animal sociality. Breeding in natal groups comes with costs and benefits, depending on group size and presence of older relatives, including mothers. Studying the consequences of breeding in the natal versus another group provides insight into the decisions and trade-offs governing the formation and structure of family groups. We investigated the family dynamics of a population of free-ranging commensal house mice. Using dynamic community detection on long term datasets, we determined which females first bred in their natal group. We then looked at how this influenced breeding success. We found most females (77%) exhibited strong philopatry, breeding in their natal groups. Breeding elsewhere was only somewhat predictable at very large and very small group sizes. Despite their philopatric preference, breeding elsewhere made no difference in how quickly and successfully a female bred. However, presence of their mother did lead females to breed sooner when born during high breeding activity, when competition over reproduction is high. Based on these results, potential loss of reproductive success from leaving the natal group does not seem to be the main driver of philopatry in female house mice. The effect of the presence of mothers suggests that benefiting from established social connections promotes breeding in the natal group. Mothers providing benefits also implies a lack of conflict between generations, which will be important for the development of stable social groups.</p>
Maternal effects of climate warming and nitrogen deposition vary with home and introduced ranges
<p>Maternal effects allow offspring to cope with changing environments. While the immediate effects of climate warming and nitrogen (N) deposition are well documented, their maternal effects have been little studied. We conducted a 6-year maternal experiment with <i>Solidago canadensis</i>, native to North America and invasive in China, and two offspring experiments to address how maternal warming, maternal N-addition and population source interacted to influence offspring performance. Maternal effects of warming and N-addition on seed traits, leaf dry matter content, and whole-plant biomass were stronger in <i>S. canadensis</i> offspring from China than in offspring from North America. Matched maternal-offspring environments allowed offspring to perform better compared to mismatched environments; offspring grown under warming flowered and produced seeds within a growing season only when their maternal plants were previously exposed to warming. Offspring environments influenced its performance and also modulated maternal effects. We suggest that the maternal effects of simulated climate warming and N deposition could vary ranges, and our findings imply that maternal warming could advance the reproductive phenology of offspring.</p>
Maternal food restriction during pregnancy affects offspring development and swimming performance in a placental live-bearing fish
<p>How pregnant mothers allocate limited resources to different biological functions such as maintenance, somatic growth, and reproduction can have profound implications for early life development and survival of offspring. Here we examined the effects of maternal food restriction during pregnancy on offspring in the matrotrophic (i.e. mother-nourishment throughout gestation) live-bearing fish species <em>Phalloptychus januarius</em> (Poeciliidae). We fed pregnant females either with a 'low-food' or 'high-food' ration for six weeks and quantified the consequences for offspring size and body fat at birth and one week after birth. We further measured fast-start escape performance of offspring at birth, as well as swimming kinematics during prey capture at zero, two, and seven days after birth. We found that the length of maternal food restriction during pregnancy negatively affected offspring dry mass and lean dry mass at birth, as well as body fat gain during the first week after birth. Moreover, it impacted the locomotor performance of offspring during prey capture at, and during the first week after, birth. We did not observe an effect of food restriction on fast-start escape performance of offspring. Our study suggests that matrotrophic poeciliid fish are maladapted to unpredictably fluctuating resource environments, because sudden reductions in maternal food availability during pregnancy result in smaller offspring with slower postnatal body fat gain and an inhibition of postnatal improving swimming skills during feeding, potentially leading to lower competitive abilities after birth.</p>
Maternal Mediterranean diet in pregnancy and newborn DNA methylation: a meta-analysis in the PACE Consortium
<p>Higher adherence to the Mediterranean diet during pregnancy may be related to offspring cord blood DNA methylation. In a meta-analysis of epigenome-wide association studies (EWAS) in 2802 mother-child pairs from 5 cohorts we calculated the relative Mediterranean diet (rMED) score and an adjusted rMED excluding alcohol (rMEDp). rMEDp was associated with cord blood DNA methylation at cg23757341.</p>
Maternal Glycemic Dysregulation During Pregnancy and Neonatal Blood DNA Methylation: Meta-analyses of Epigenome-Wide Association Studies
<p>Maternal glycemic dysregulation during pregnancy increases the risk of adverse health outcomes in her offspring, a risk thought to be linearly related to maternal hyperglycemia. It is hypothesized that changes in offspring DNA methylation (DNAm) underline these associations. To address this hypothesis, we conducted fixed-effects meta-analyses of epigenome-wide association study (EWAS) results from eight birth cohorts investigating relationships between cord blood DNAm and fetal exposure to maternal glucose (Nmaximum= 3,503), insulin (Nmaximum= 2,062), and area under the curve of glucose (AUCgluc) following oral glucose tolerance tests (Nmaximum = 1,505). Inflation and bias was addressed with the bacon Bioconductor package for individual cohorts and the meta-analysis results and reported model estimates and standard errors are adjusted. Greater maternal AUCgluc during pregnancy was associated with lower cord blood DNAm at neighboring CpGs cg26974062 and cg02988288 in TXNIP. Follow-up analyses show that these changes may have functional and later-life consequences and warrant further mediation and causal analysis. </p> <p>The corresponding paper can be found here: https://doi.org/10.2337/dc21-1701.</p> <p>Upload of this dataset was completed by The EWAS Catalog team. The data can be queried along with hundreds of other EWAS at ewascatalog.org. To upload your EWAS summary statistics and have a Zenodo DOI generated for you go to ewascatalog.org/upload.</p>
Antenatal depression: Associations with birth and neonatal outcomes among women attending maternity care in Harare, Zimbabwe
<p>This is a dataset used to describe the results in a manuscript submitted to PLoS ONE</p>
Inverse Lansing effect: Maternal age and provisioning affecting daughters' longevity and male offspring production
<p>Maternal age effects on offspring life history are known in a variety of organisms, with offspring of older mothers typically having lower life expectancy (Lansing Effect). However there is no consensus on generality and mechanisms of this pattern. We tested predictions of Lansing Effect in several <em>Daphnia magna</em> clones and observed clone-specific magnitude and even direction of the maternal age effect on offspring longevity. We also report ambidirectional, genotype-specific effects of maternal age on daughters' propensity to produce male offspring. Focusing on two clones with contrasting life-histories, we demonstrate that maternal age effects can be explained by lipid provisioning of embryos by mothers of different ages. Individuals from a single-generation maternal age reversal treatment showed intermediate lifespan and intermediate lipid content at birth. In the clone characterized by the "inverse Lansing Effect" neonates produced by older mothers showed higher mitochondrial membrane potential in neural tissues than their counterparts born to younger mothers. We conclude that an "inverse Lansing Effect" is possible, and hypothesize that it may be caused by age-specific maternal lipid provisioning creating a calorically restricted environment during embryonic development, which, in turn reduces fecundity and increases lifespan.</p>
Maternally-transferred thyroid hormones and life-history variation in birds
<p><span>1. In vertebrates, thyroid hormones (THs) play an important role in the regulation of growth, development, metabolism, photoperiodic responses and migration. Maternally transferred THs are important for normal early-phase embryonic development when embryos are not able to produce endogenous THs. Previous studies have shown that variation in maternal THs within the physiological range can influence offspring phenotype.</span></p> <p><span>2. Given the essential functions of maternal THs in development and metabolism, THs may be a mediator of life-history variation across species. </span></p> <p><span>3. We tested the hypothesis that differences in life histories are associated with differences in maternal TH transfer across species. Using birds as a model, we specifically tested whether maternally transferred yolk THs co-vary with migratory status, developmental mode, and traits related to pace-of-life (e.g. basal metabolic rate, maximum lifespan).</span></p> <p><span>4. We collected un-incubated eggs (n = 1-21 eggs per species, median = 7) from 34 wild and captive bird species across 17 families and 6 orders to measure yolk THs (both triiodothyronine, T3 and thyroxine, T4), compiled life-history trait data from the literature, and used Bayesian phylogenetic mixed models to test our hypotheses.</span></p> <p><span>5. Our models indicated that both concentrations and total amounts of the two main forms of THs (T3 and T4) were higher in the eggs of migratory species compared to resident species, and total amounts were higher in the eggs of precocial species, which have longer prenatal developmental periods, than in those of altricial species. However, maternal yolk THs did not show clear associations with pace-of-life related traits, such as fecundity, basal metabolic rate, or maximum lifespan.</span></p> <p><span>6. We quantified interspecific variation in maternal yolk THs in birds and our findings suggest higher maternal TH transfer is associated with the precocial mode of development and migratory status. Whether maternal THs represent a part of the mechanism underlying the evolution of precocial development and migration or a consequence of such life histories is currently unclear. We therefore encourage further studies to explore the physiological mechanisms and evolutionary processes underlying these patterns.</span></p>
Maternal survival costs in an asocial mammal: Data and analysis
<p><strong>Abstract. </strong>Maternal characteristics, social dynamics, and environmental factors can all influence reproduction and survival as well as shape trade-offs that might arise between these components of fitness. Short-lived mammals like the golden-mantled ground squirrel (GMGS; <em>Callospermophilus lateralis</em>) tend to maximize effort towards current reproduction at the expense of survival but may be complicated by other aspects of the species' life history and environment.. Here, we use 25 years of data (1995-2020) collected from a population of GMGS at the Rocky Mountain Biological Research Laboratory in Gothic, Colorado, to test the effect of several maternal characteristics (e.g., age, experience, timing of litter emergence), social context (e.g., litter sex ratio, kin density), and environmental context (e.g., date of bare ground, length of vegetative growing season) on survival of reproductive female GMGS using Cox proportional hazard models. Our results indicated that social dynamics (i.e., density) and environmental conditions (i.e., standardized first day of permanent snow cover and length of growing season) explained significant variation in annual maternal survival, while maternal characteristics did not. A higher density of related breeding females and the total number of females (both related and unrelated to the focal mother) were associated with an increase in the mortality hazard. A later standardized date of the first day of permanent snow cover and a shorter growing season both reduced the maternal mortality hazard. Together, our results suggest that factors extrinsic to the squirrels affect maternal survival, and thus may also influence local population growth and dynamics in GMGS and other short-lived, territorial mammal species.</p>
Macroclimatic and maternal effects on the evolution of reproductive traits in lizards
<p>Much of life-history theory rests on fundamental assumptions about constraints on the acquisition and allocation of energy to growth and reproduction. In general, the allocation of energy to reproduction depends on maternal size, which in turn depends on environmental factors experienced throughout the life of the mother. Here, we used phylogenetic path analyses to evaluate competing hypotheses about the environmental and maternal drivers of reproductive traits in lizards. In doing so, we discovered that precipitation, rather than temperature, has shaped the evolution of the life history. Specifically, environments with greater rainfall have enabled the evolution of larger maternal size. In turn, these larger mothers produce larger clutches of larger offspring. However, annual precipitation has a negative direct effect on offspring size, despite the positive indirect effect mediated by maternal size. Possibly, the evolution of offspring size was driven by the need to conserve water in dry environments, because small organisms are particularly sensitive to water loss. Since we found that body size variation among lizards is related to a combination of climatic factors, mainly precipitation and perhaps primary production, our study challenges previous generalizations (e.g., temperature-size rule and Bergmann's rule) and suggests alternative mechanisms underlying the evolution of body size.</p>
Maternal and/or direct supplementation with a combination of a casein hydrolysate and yeast β-glucan on postweaning performance and intestinal health in the pig
<p>A 2 <span>× </span>2 factorial experiment was conducted to investigate the effect of maternal supplementation from day 83 of gestation and/or direct supplementation from weaning of a bovine casein hydrolysate plus a yeast β‑glucan (CH-YBG) on pig performance and intestinal health on day ten post‑weaning. Twenty cross bred gilts <span>(Large White × Landrace) were randomly assigned to one of two dietary groups (<em>n</em> = 10 gilts/group): basal diet (basal sows) and basal diet supplemented with </span>CH‑YBG (supplemented sows)<span> from day 83 of gestation until weaning (2g/sow/day). At weaning, 120 pigs (6 pigs/sow) were selected. The two dam groups were further divided, resulting in four experimental groups (10 replicates/group; 3 pigs/pen) as follows: 1) BB (basal sows + basal pigs); 2) BS (basal sows + supplemented pigs); 3) SB (supplemented sows + basal pigs); 4) SS (supplemented sows + supplemented pigs). Supplemented pigs were offered 0.5g CH‑YBG/kg of feed for 10 days post-weaning. On day 10 post‑weaning, 1 pig/pen was humanely sacrificed and samples were taken from the gastrointestinal tract for analysis. Pigs weaned from supplemented sows (SS, SB) had reduced faecal scores and incidence of diarrhoea (P<0.05) compared to pigs weaned from basal sows (BB, BS), with SS pigs not displaying the transient rise in faecal scores seen in the other three groups from day 3 to day 10 post‑weaning (P<0.05). Pigs weaned from supplemented sows had reduced feed intake (P<0.05), improved feed efficiency (P<0.05), increased butyrate concentrations (P<0.05), increased abundance of </span><em><span>Lactobacillus </span></em><span>(P<0.05) </span><span>and decreased abundance of </span><em><span>Enterobacteriaceae</span></em><span><em> </em>and <em>Campylobacteraceae </em>(P<0.05) compared to pigs weaned from basal sows. In conclusion, maternal supplementation increased the abundance of <em>Lactobacillus </em>and decreased the abundance of <em>Enterobacteriaceae </em>and <em>Campylobacteraceae </em>while also increasing butyrate concentrations. The combination of maternal and direct supplementation led to pigs having the lowest faecal scores compared to all other groups.</span></p>
Maternal Dietary Glycemic Index and Glycemic Load in Pregnancy and Offspring Cord Blood DNA Methylation
<p><strong>Abstract</strong></p> <p><strong>Objective</strong>: Suboptimal nutrition in pregnancy is associated with worse offspring cardiometabolic health. DNA methylation may be an underlying mechanism. We meta-analyzed epigenome-wide association studies (EWASs) of maternal dietary glycemic index and load with cord blood DNA methylation.</p> <p><strong>Research Design and Methods</strong>: We calculated maternal glycemic index and load from food frequency questionnaires, and ran EWASs on cord blood DNA methylation in 2003 mother-offspring pairs from three cohorts. Analyses were additionally stratified by maternal BMI categories. We looked-up the findings in EWASs of maternal glycemic traits and BMI, and in EWASs of birthweight and child BMI. We examined associations with gene expression in child blood in the online Human Early Life Exposome eQTM catalogue and in 223 adipose tissue samples.</p> <p><strong>Results</strong>: Maternal glycemic index and load were associated with cord blood DNA methylation at 41 cytosine-phosphate-guanine sites (CpGs, P<1.17x10<sup>-7</sup>), mostly in mothers with overweight/obesity. We did not observe overlap with CpGs associated with maternal glycemic traits, BMI or child birthweight or BMI. Only DNA methylation at cg24458009 and cg23347399 was associated with expression of <em>PCED1B</em> and <em>PCDHG</em>, respectively, in child blood, and DNA methylation at cg27193519 was associated with expression of <em>TFAP4</em>, <em>ZNF500</em>, <em>PPL</em> and <em>ANKS3</em> in child subcutaneous adipose tissue.</p> <p><strong>Conclusions</strong>: We observed multiple associations of maternal glycemic index and load during pregnancy with cord blood DNA methylation, mostly in mothers with overweight/obesity; some of these CpGs were associated with gene expression. Additional studies are required to further explore functionality, uncover causality, and study pathways to offspring health.</p>
Randomised trials in maternal and perinatal health in low- and middle-income countries from 2010 to 2019: A systematic scoping review
<p><strong>Objectives: </strong>To identify and map all trials in maternal health conducted in low- and middle-income countries (LMIC) over the 10-year period 2010-2019, to identify geographical and thematic trends, as well as compare to global causes of maternal death and pre-identified priority areas.</p> <p><strong>Design: </strong>Systematic scoping review.</p> <p><strong>Primary and secondary outcome measures: </strong>Extracted data included location, study characteristics and whether trials corresponded to causes of mortality and identified research priority topics.</p> <p><strong>Results: </strong>Our search identified 7,269 articles, 874 of which were included for analysis. Between 2010 and 2019, maternal health trials conducted in LMICs more than doubled (50 to 114). Trials were conducted in 61 countries – 231 trials (26.4%) were conducted in Iran. Only 225 trials (25.7%) were aligned with a cause of maternal mortality. Within these trials, pre-existing medical conditions, embolism, obstructed labour, and sepsis were all under-represented when compared with number of maternal deaths globally. Large numbers of studies were conducted on priority topics such as labour and delivery, obstetric haemorrhage, and antenatal care. Hypertensive disorders of pregnancy, diabetes, and health systems and policy – despite being high-priority topics – had relatively few trials.</p> <p><strong>Conclusion: </strong>Despite trials conducted in LMICs increasing from 2010 to 2019, there were significant gaps in geographical distribution, alignment with causes of maternal mortality, and known research priority topics. The research gaps identified provide guidance and insight for future research conducted in low-resource settings.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.