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228
datasets available to search
ShareScore release 0.9.0
Dataset results
228 results for “model therapy”
Genetic signature of prostate cancer mouse models resistant to optimized hK2 targeted alpha-particle therapy
GEO Series GSE147850. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Substrate reduction therapy using Genz-667161 reduces levels of pathogenic components in a mouse model of neuronopathic forms of Gaucher disease
GEO Series GSE151133. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcome in a Parkinson's disease model
GEO Series GSE204796. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Evaluation of the efficacy of radiodynamic therapy using talaporfin sodium in human pancreatic cancer MIA PaCa-2 xenograft models
GEO Series GSE312155. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Modeling Luminal breast cancer heterogeneity: Combination therapy to suppress hormone receptor negative cells in Luminal disease
GEO Series GSE55350. Homo sapiens. 6 samples. Type: Expression profiling by array.
STimulator of INterferon Genes (STING) primed intra-articular cellular therapy improves gait and histologic outcomes in a murine osteoarthritis model
GEO Series GSE276262. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Patient derived model of UBA5-associated encephalopathy identifies defects in neurodevelopment and highlights potential therapies [scRNA-seq]
GEO Series GSE252497. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
ATP7B Gene Therapy of Autologous Reprogrammed Hepatocytes Alleviates Copper Accumulation in a Murine Model of Wilson’s Disease
GEO Series GSE197948. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
miR-22 gene therapy as a novel option for HCC treatment in part via augmentation of retinoic acid but silencing IL17 signaling in orthotopic murine models
GEO Series GSE215753. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
A RAS(ON) multi-selective inhibitor combination therapy triggers long-term tumor control through senescence-associated tumor-immune equilibrium in preclinical models of PDAC
GEO Series GSE293456. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic profile of three-dimensional tissue-engineered human skeletal muscle model of Pompe disease and recombinant protein therapy
GEO Series GSE159062. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
Human Ex Vivo Lung Perfusion: A Model System to study Lung diseases and direct targeted therapies
GEO Series GSE146436. Homo sapiens. 26 samples. Type: Expression profiling by high throughput sequencing.
Data from: Quantifying post- laser ablation prostate therapy changes on MRI via a domain-specific biomechanical model: preliminary findings
Focal laser ablation destroys cancerous cells via thermal destruction of tissue by a laser. Heat is absorbed, causing thermal necrosis of the target region. It combines the aggressive benefits of radiation treatment (destroying cancer cells) without the harmful side effects (due to its precise localization). MRI is typically used pre-treatment to determine the targeted area, and post-treatment to determine efficacy by detecting necrotic tissue, or tumor recurrence. However, no system exists to quantitatively evaluate the post-treatment effects on the morphology and structure via MRI. To quantify these changes, the pre- and post-treatment MR images must first be spatially aligned. The goal is to quantify (a) laser-induced shape-based changes, and (b) changes in MRI parameters post-treatment. The shape-based changes may be correlated with treatment efficacy, and the quantitative effects of laser treatment over time is currently poorly understood. This work attempts to model changes in gland morphology following laser treatment due to (1) patient alignment, (2) changes due to surrounding organs such as the bladder and rectum, and (3) changes due to the treatment itself. To isolate the treatment-induced shape-based changes, the changes from (1) and (2) are first modeled and removed using a finite element model (FEM). A FEM models the physical properties of tissue. The use of a physical biomechanical model is important since a stated goal of this work is to determine the physical shape-based changes to the prostate from the treatment, and therefore only physical real deformations are to be allowed. A second FEM is then used to isolate the physical, shape-based, treatment-induced changes. We applied and evaluated our model in capturing the laser induced changes to the prostate morphology on eight patients with 3.0 Tesla, T2-weighted MRI, acquired approximately six months following treatment. Our results suggest the laser treatment causes a decrease in prostate volume, which appears to manifest predominantly at the site of ablation. After spatially aligning the images, changes to MRI intensity values are clearly visible at the site of ablation. Our results suggest that our new methodology is able to capture and quantify the degree of laser-induced changes to the prostate. The quantitative measurements reflecting of the deformation changes can be used to track treatment response over time.
Bulk RNA-seq count matrices from manuscript: "Therapeutic efficacy of intracerebral hematopoietic stem cell gene therapy in an Alzheimer's disease mouse model"
<p>Gene expression profile of microglia-like cells in the central nervous system (CNS) after transplantation of hematopoietic stem/progenitor cells (HSPC). </p> <p>Different cell subsets and delivery routes are tested to induce a robust and exclusive engraftment of HSPCs and their progeny in the CNS of mice transplant recipients.</p>
Sequential therapy data from a deterministic and semi-stochastic PKPD model
<p>The dataset contains all data generated for the manuscript 'Sequential therapy in the lab and in the patient'. The models used to generate the data are described in the Methods section. The code is available at:https://zenodo.org/record/7376833, the repository further contains a README file that describes the dataset in detail. </p>
A clinical model to predict successful renal replacement therapy (RRT) discontinuation in patients with Acute Kidney Injury (AKI)
<p>The dataset used to generate analysis included in the study "A clinical model to predict successful renal replacement therapy (RRT) discontinuation in patients with Acute Kidney Injury (AKI)"</p>
Prospective Validation and Application of an Artificial Intelligence-based Model for Evaluating the Efficacy of Breast Cancer Patients After Neoadjuvant Therapy
ClinicalTrials.gov study NCT06649565. IPD Sharing: NO. Countries: 1. Publications: 0.
Mechanism of Response to IMFINZI Neoadjuvant Therapy in Non-small Cell Lung Cancer Patients Based on Multiple-omics Models
ClinicalTrials.gov study NCT04646837. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparison of Learning Models in Physical Therapy Education
ClinicalTrials.gov study NCT06397495. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
An Assistant Model for Anti-VEGF Therapy Decision
ClinicalTrials.gov study NCT07328776. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.