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287 results for “respiratory syncytial virus”
Data from: Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production
Although respiratory syncytial virus (RSV) is responsible for more human deaths each year than influenza, its pathogenic mechanisms are poorly understood. Here high-resolution quantitative imaging, bioenergetics measurements and mitochondrial membrane potential- and redox-sensitive dyes are used to define RSV's impact on host mitochondria for the first time, delineating RSV-induced microtubule/dynein-dependent mitochondrial perinuclear clustering, and translocation towards the microtubule-organizing centre. These changes are concomitant with impaired mitochondrial respiration, loss of mitochondrial membrane potential and increased production of mitochondrial reactive oxygen species (ROS). Strikingly, agents that target microtubule integrity the dynein motor protein, or inhibit mitochondrial ROS production strongly suppresses RSV virus production, including in a mouse model with concomitantly reduced virus-induced lung inflammation. The results establish RSV's unique ability to co-opt host cell mitochondria to facilitate viral infection, revealing the RSV-mitochondrial interface for the first time as a viable target for therapeutic intervention.
Data for : New mucosal bivalent live-attenuated vaccine is protective against Human Metapneumovirus and Respiratory Syncytial Virus
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Computational Evidence for Bisartan Arginine Blockers as Next-Generation Pan-Antiviral Therapeutics Targeting SARS-CoV-2, Influenza, and Respiratory Syncytial Viruses (RawData)
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Azithromycin to Prevent Wheezing Following Severe Respiratory Syncytial Virus (RSV) Bronchiolitis
ClinicalTrials.gov study NCT01486758. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Co-administration Study of an Investigational Live-Attenuated Respiratory Syncytial Virus Vaccine in Infants and Toddlers
ClinicalTrials.gov study NCT06397768. IPD Sharing: YES. Countries: 3. Publications: 0.
Effects of JNJ-53718678 in Adult and Adolescent Participants Who Had a Hematopoietic Stem Cell Transplantation and Who Are Infected With Respiratory Syncytial Virus (RSV)
ClinicalTrials.gov study NCT04056611. IPD Sharing: YES. Countries: 17. Publications: 0.
Efficacy, Immunogenicity, and Safety Study of a Respiratory Syncytial Virus Vaccine in Infants and Toddlers
ClinicalTrials.gov study NCT06252285. IPD Sharing: YES. Countries: 16. Publications: 0.
Study to Evaluate the Safety and Immune Response of an Investigational Vaccine for the Prevention of RSV (Respiratory Syncytial Virus) and (hMPV) Human Metapneumovirus Infection in Participants Aged 6
ClinicalTrials.gov study NCT06583031. IPD Sharing: YES. Countries: 1. Publications: 0.
Study of a Respiratory Syncytial Virus Candidate Encapsulated in a Lipid Nanoparticle Based Formulation in Adults Aged 18 to 50 Years and 60 Years and Older
ClinicalTrials.gov study NCT05639894. IPD Sharing: YES. Countries: 3. Publications: 0.
A Study to Examine Respiratory Combination Vaccines Against Respiratory Syncytial Virus (RSV) and Flu in Older Adults
ClinicalTrials.gov study NCT05788237. IPD Sharing: NO. Countries: 1. Publications: 0.
Prevention Strategy for Respiratory Syncytial Virus (RSV) Infections in Infants in France
ClinicalTrials.gov study NCT06881953. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study on the Immune Response, Safety and the Occurrence of Respiratory Syncytial Virus (RSV)-Associated Respiratory Tract Illness After Administration of RSV OA Vaccine in Adults 60 Years and Older
ClinicalTrials.gov study NCT06551181. IPD Sharing: YES. Countries: 7. Publications: 0.
Efficacy, Pharmacokinetics, and Safety of Presatovir in Hospitalized Adults With Respiratory Syncytial Virus (RSV) Infection
ClinicalTrials.gov study NCT02135614. IPD Sharing: Not stated. Countries: 11. Publications: 0.
Innate Immunity and Respiratory Syncytial Virus (RSV) Infection in Children
ClinicalTrials.gov study NCT00593918. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects of Preventive Treatment for Respiratory Syncytial (RS) Virus Infection During Infancy on Later Atopic Asthma in Preterm Infants
ClinicalTrials.gov study NCT01545245. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Intranasal Challenge of Healthy Adults With Respiratory Syncytial Virus (RSV)
ClinicalTrials.gov study NCT01475305. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Burden of Respiratory Syncytial Virus (RSV) in the United Kingdom From 1995 to 2009
ClinicalTrials.gov study NCT01706302. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Evaluating the Infectivity, Safety and Immunogenicity of Respiratory Syncytial Virus Vaccines, RSV 6120/∆NS1 and RSV 6120/F1/G2/∆NS1, in RSV-Seropositive Children and RSV-Seronegative Infants and Chil
ClinicalTrials.gov study NCT03596801. IPD Sharing: Not stated. Countries: 1. Publications: 0.
An Investigational Drug Study to Treat Respiratory Symptoms Associated With Respiratory Syncytial Virus (RSV) Bronchiolitis (0476-272)
ClinicalTrials.gov study NCT00076973. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Repeated Cross Sectional Surveillance Study To Determine the Respiratory Syncytial Virus (RSV) Immunization Rates in German Infants
ClinicalTrials.gov study NCT06824207. IPD Sharing: YES. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.