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235 results for “silica”
NanoValid D.5.47 Annex 2: Inter-laboratory comparison on measurand Surface Charge (Zeta Potential) of 15 nm Lys-SNPs-B1 Silica Nanoparticles Particles
<p>An inter-laboratory comparison on the surface charge, expressed as zeta potential <em>ζ</em>, of nanoscaled SiO<sub>2</sub> has been performed using #14 BAM ~15 nm Lys-SNPs-B1 Silica nanoparticles (see D.5.41/5.42). The comparability of results delivered by participants has been tested.</p> <p>The Task 5.4 of NanoValid is designed to test, compare and validate current methods to measure and characterize physicochemical properties of selected engineered nanoparticles. The measurand is <em>Surface charge expressed as zeta-Potential</em>. The measurements are to be accompanied by estimates of the uncertainties at a confidence level of 95%, deduced from the standard uncertainties. Therefore an uncertainty budget comprising statistical (Type A) and systematic (Type B) errors has to be established and delivered for the measurand.</p>
Dataset for "Temperature dependence of Young's modulus, damping and dilatation during repeated thermal cycling of silica refractories for high-temperature thermal energy storage (TES) "
Open the record for dataset details and reuse information.
In Situ-Forming Gels Loaded with Stimuli-Responsive Gated Mesoporous Silica Nanoparticles for Local Sustained Drug Delivery
<p>A novel combination of in situ-forming hydrogels of hyaluronic acid with gated mesoporous materials was developed to design depots for local sustained release of chemotherapeutics. The depot consists of a hyaluronic-based gel loaded with redox-responsive mesoporous silica nanoparticles loaded with safranin O or doxorubicin and capped with polyethylene glycol chains containing a disulfide bond. The nanoparticles are able to deliver the payload in the presence of the reducing agent, glutathione (GSH), that promotes the cleavage of the disulfide bonds and the consequent pore opening and cargo delivery. Release studies and cellular assays demonstrated that the depot can successfully liberate the nanoparticles to the media and, subsequently, that the nanoparticles are internalized into the cells where the high concentration of GSH induces cargo delivery. When the nanoparticles were loaded with doxorubicin, a significant reduction in cell viability was observed. Our research opens the way to the development of new depots that enhance the local controlled release of chemotherapeutics by combining the tunable properties of hyaluronic gels with a wide range of gated materials.</p>
High-Capacity Mesoporous Silica Nanocarriers of siRNA for Applications in Retinal Delivery
<p>The main cause of subretinal neovascularisation in wet age-related macular degeneration (AMD) is an abnormal expression in the retinal pigment epithelium (RPE) of the vascular endothelial growth factor (VEGF). Current approaches for the treatment of AMD present considerable issues that could be overcome by encapsulating anti-VEGF drugs in suitable nanocarriers, thus providing better penetration, higher retention times, and sustained release. In this work, the ability of large pore mesoporous silica nanoparticles (LP-MSNs) to transport and protect nucleic acid molecules is exploited to develop an innovative LP-MSN-based nanosystem for the topical administration of anti-VEGF siRNA molecules to RPE cells. siRNA is loaded into LP-MSN mesopores, while the external surface of the nanodevices is functionalised with polyethylenimine (PEI) chains that allow the controlled release of siRNA and promote endosomal escape to facilitate cytosolic delivery of the cargo. The successful results obtained for VEGF silencing in ARPE-19 RPE cells demonstrate that the designed nanodevice is suitable as an siRNA transporter.</p>
MRI-based sensing of pH-responsive content release from mesoporous silica nanoparticles
<p>A proof of principle study toward developing a novel methodology which could be applicable for a non-invasive monitoring of the release of cargo molecules from therapeutic and diagnostic nanoparticles, as well as for possible monitoring of tissue pH variations. This was achieved by quantifying changes in longitudinal relaxation time (T<sub>1</sub>) before and after the pH-responsive release of contrast agents, for magnetic resonance imaging (MRI), from the pores of mesoporous silica nanoparticles (MSNs). The pores were filled with the FDA-approved contrast agent Gadobutrol (GdB), and its retention inside the pores ensured by covalent attachment of β-cyclodextrin monoaldehyde to hydrazine-functionalized MSN, through acidification-cleavable hydrazone linkage. The release kinetics of GdB was measured by fluorescence spectroscopy which revealed that the release of the contrast agent was enhanced at pH 5.0 in comparison to the release at pH 6.0 and 7.4. Furthermore, the changes in T<sub>1</sub>, occurring in response to the enhanced release of GdB from the pores of MSN at weakly acidic conditions, were successfully demonstrated by MRI measurements. It is envisioned that this approach using contrast agent-loaded nanoparticles before the treatment with the drug-filled analogs, could be applied in the future for tracking the locations and efficacies of nanomedicines for therapeutic cargo delivery.</p>
pH-Responsive Release of Ruthenium Metallotherapeutics from Mesoporous Silica-Based Nanocarriers
<div> <p>Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.</p> <p> </p> </div> <h2>Notes</h2>
Mesoporous Silica Nanoparticles for pH-Responsive Delivery of Iridium Metallotherapeutics and Treatment of Glioblastoma Multiforme
<p>Using nanoparticles for controlled drug delivery to cancer, in response to its weakly acidic environment, represents a promising approach toward increasing the effectiveness and reducing the adverse effects of cancer therapy. Hence, the aim of this study is to construct novel mesoporous silica nanoparticle (MSN)-based acidification-responsive drug delivery systems for targeted cancer therapy. Herein, the surface of MSN is covalently functionalized with Ir(III)-based complex through a pH-cleavable hydrazone-based linker and characterized by nitrogen sorption, SEM, FTIR, EDS, TGA, DSC, DLS, and zeta potential measurements. Enhanced release of Ir(III)-complexes is evidenced by UV/VIS spectroscopy at the weakly acidic environments (pH 5 and pH 6) in comparison to the release at physiological conditions. The in vitro toxicity of the prepared materials is tested on healthy MRC-5 cells while their potential for the efficient treatment of glioblastoma multiforme is demonstrated on the U251 cell line.</p>
Figure 7 in Recycling resources: silica of diatom frustules as a source for spicule building in Antarctic siliceous demosponges
Figure 7. Silicon isotope data of sponge spicules, free-swimming diatoms and seawater. A. Silicon isotope (δ30Si) composition for sponges, diatoms and seawater of Deception Island. B. Comparison of our data for δ30Si/ δ29Si in sponges, diatoms and seawater from Deception Island, with values reported in previous datasets of sponges, diatoms and seawater (Hendry et al., 2010; Wille et al., 2010).
Figure 5. Vesicles with silica-like granules within sponge cells. A in Recycling resources: silica of diatom frustules as a source for spicule building in Antarctic siliceous demosponges
Figure 5. Vesicles with silica-like granules within sponge cells. A, an amoeboid sponge cell (spc) in P. areolatus showing a cytoplasm packed with vesicles and an ingested diatom (di) within a large digestive vesicle. Note that three different granule types were identified by microanalysis in the section of this species: silica granules (si), and lead granules (Pb). B–C, highly vesiculated, amoeboid sponge cell in He. pilosus. Note the silica-like granules (si) first present within vesicles and later incorporated within the cytoplasm. D, amoeboid sponge cell in P. areolatus showing an ingested diatom (di) and silica-like granules (si).
Figure 6 in Recycling resources: silica of diatom frustules as a source for spicule building in Antarctic siliceous demosponges
Figure 6. Microanalysis of the content of silica-like vesicles, sponge spicules and diatoms within the sponge tissues. A, sponge cell, probably an amoebocyte (c), of P. areolatus showing accumulation of silica-like granules in the cytoplasm (SiV). B, sclerocyte-like cell (c) of M. tridens showing accumulation of silica-granules in vesicles (SiV). C, diatom (di) engulfed by a sponge cell in M. tridens. D, sclerocyte (sc) of P. areolatus making spicules (sp). E, elemental profile of Figure 6A. F, elemental profile of Figure 6B. G, elemental profile of Figure 6C. H, elemental profile of Figure 6D. Note that the EDX probe measurements were taken on the white circles marked in the images.
Figure 4 in Recycling resources: silica of diatom frustules as a source for spicule building in Antarctic siliceous demosponges
Figure 4. Diatoms (di) ingested by amoeboid sponge cells (spc). A–D, sponge cells (spc) digesting diatoms (di) in P. areolatus. Note the large lipid (li) droplets present within diatoms (di) and later accumulated in the cytoplasm of sponge cells (spc). E–F, sponge cells (spc) digesting diatoms (di) in K. variolosa. Note the silica-like (si) granules being dissolved from the diatom frustule and the well-developed Golgi apparatus (g).
FIGURES – 7. SEM images of Craspedostauros laevissimus from different populations. 42. Close up of the central area externally, showing the weakly expanded central raphe endings and the cribrate areolae with usually four to five peripheral pores and up to one central pore (sample 13). 43. Close up of the central area internally, showing the narrow stauros located in a wider hyaline area, the central raphe endings with double helictoglossa, and the rounded to rectangular areolar openings internally (sample 13). 44. Close up of the apex, showing the bent distal raphe endings, cribrate areoale with up to six peripheral pores and up to two central pores (sample 13). 45. Close ups of both the valve exterior and interior (sample 11), showing the weakly expanded central raphe endings externally; the areolae near the raphe with usually four to five peripheral pores and one central pore; the central raphe endings with double helictoglossa and the rounded areolar openings internally. 46. Internal valve view, showing the narrow transverse rib of silica at the valve center (strauros) and the central raphe endings with double helictoglossa (sample 11). 47. Close up of the apex of the same valve internally, showing the rounded to square or rectangular areolar openings (sample 11). Scale bars = 5 μm (Fig. 46); 1 μm (Figs 42–45,47). in The genus Craspedostauros E.J.Cox (Bacillariophyta) on the coasts of Livingston Island, Maritime Antarctica
FIGURES – 7. SEM images of Craspedostauros laevissimus from different populations. 42. Close up of the central area externally, showing the weakly expanded central raphe endings and the cribrate areolae with usually four to five peripheral pores and up to one central pore (sample 13). 43. Close up of the central area internally, showing the narrow stauros located in a wider hyaline area, the central raphe endings with double helictoglossa, and the rounded to rectangular areolar openings internally (sample 13). 44. Close up of the apex, showing the bent distal raphe endings, cribrate areoale with up to six peripheral pores and up to two central pores (sample 13). 45. Close ups of both the valve exterior and interior (sample 11), showing the weakly expanded central raphe endings externally; the areolae near the raphe with usually four to five peripheral pores and one central pore; the central raphe endings with double helictoglossa and the rounded areolar openings internally. 46. Internal valve view, showing the narrow transverse rib of silica at the valve center (strauros) and the central raphe endings with double helictoglossa (sample 11). 47. Close up of the apex of the same valve internally, showing the rounded to square or rectangular areolar openings (sample 11). Scale bars = 5 μm (Fig. 46); 1 μm (Figs 42–45,47).
Polarisation-independent ultrafast laser selective etching processing in fused silica
<p>Data files for the manuscript: Polarisation-independent ultrafast laser selective etching processing in fused silica</p>
Self-Dispersing Silica Fume Nanoparticles: A Valuable Admixture for Ultra High Performance Concrete
<p>These are the supporting information for the publication Self-Dispersing Silica Fume Nanoparticles: A Valuable Admixture for Ultra High Performance Concrete</p>
Prediction of Compressive Strength of Concrete with Silica, Ash and Fiber Using Fuzzy Logic Method
<p>Prediction of Compressive Strength of Concrete with Silica, Ash and Fiber Using Fuzzy Logic Method</p> <p>References</p>
Data for "Anomalous ionic transport in tunable angstrom-size water films on silica"
<p>This file corresponds to data of the paper:</p> <p>"Anomalous ionic transport in tunable angstrom-size water films on silica"</p>
Molecular Dynamics simulations of acqueous glycerol spreading on a silica-like surface
<p>This dataset contains the results of Molecular Dynamics simulations of quasi-2D water-glycerol liquid droplets, spreading on silica-like surfaces. The goal of the simulations is to quantify the contact line friction coefficient by regressing over the dynamic contact angle and the contact line speed.</p> <p>The pattern "Glycerol***" refers to the mass fraction of glycerol ("000": pure water, "100": pure glycerol). Each folder contains configuration files and compressed output molecular trajectories. The contact angle and the contact line speed are computed from density maps binned on-the-fly using a customized Gromacs version (<a href="https://github.com/pjohansson/gromacs-flow-field">https://github.com/pjohansson/gromacs-flow-field</a>); frames are placed in a tarball ("spread-*p-r1.tar.gz").</p> <p>The zipped folder 'scripts.zip' contains a self-contained library of functions to read density maps and a Jupyter notebook with an example of density reading and plotting.</p> <p>Simulations are performed with Gromacs. We refer to the code documentation for further information (<a href="https://manual.gromacs.org/">https://manual.gromacs.org/</a>).</p>
Linear-to-Circular Polarization Conversion with Full-Silica Meta-Optics to Reduce Nonlinear Effects in High-Energy Lasers - Nature Com - Dataset
<p>Data from the Nature Communication paper entitled "Linear-to-Circular Polarization Conversion with Full-Silica Meta-Optics to Reduce<br> Nonlinear Effects in High-Energy Lasers"</p> <p>.OPJU files can be opened with ORIGINLab</p> <p>. MAT files can be opened with MATLAB/SCILAB</p>
FIGURES 2–4 in Two new species of silica-scaled chrysophytes (Chrysophyceae, Synurales) Mallomonas kicherica and M. sibirica water bodies of Eastern Siberia, Russia
FIGURES 2–4. Mallomonas kicherica sp. nov. Figure 2. Tips of bristles with teeth and bristle's foot. Figures 3–4, scales with labyrinthlike reticulation on the dome and transverse ribs, except for the area between the first and second, are connected in random order by short ribs-jumpers. SEM Scale bars: 2 μm.
FIGURES 5–11 in Two new species of silica-scaled chrysophytes (Chrysophyceae, Synurales) Mallomonas kicherica and M. sibirica water bodies of Eastern Siberia, Russia
FIGURES 5–11. Scales of Mallomonas sibirica sp. nov. from different types of habitats. Figure 5. Body scales with subcircular and smooth dome, evenly spaced transverse ribs and rounded depressions between them. The posterior rim, wide and smooth, bears numerous internal struts. The posterior flange has struts and scattered rounded depressions in the base plate that are not evenly spaced, from Lake Baikal, TEM. Figure 6. Body scale from the type habitat, Lake Ulu, SEM. Figures 7. Body scale, the dome is subcircular, ornamented with struts, undersurface view of the scales, from Lake Labynkyr, SEM. Figures 8. Body scale, the dome is subcircular patterned with rounded depressions, from Lake Labynkyr, SEM. Figure 9. Body scale, from a mixing zone of the Yenisei River and the Kara Sea waters, SEM. Figures 10–11. Body scale, undersurface view of the scales, from Lake Labynkyr, SEM. Scale bars: 2 μm.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.