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1,188 results for “Deltas”
RNA-Sequencing of B-Lymphoblastic Leukemia with Glucocorticoids and PI3K Delta Inhibition
Mononuclear cells were isolated from bone marrow or peripheral blood of 7 pediatric subjects with B-lymphoblastic leukemia at the time of diagnosis. To determine the effect of PI3K delta inhibition on glucocorticoid-induced gene regulation, B-lymphoblastic leukemia cells were treated with glucocorticoids +/- the PI3K delta inhibitor, idelalisib, for 24 hours prior to RNA extraction and sequencing. Biological replicates were performed for 4 of the 7 subjects; 2 of these subjects had specimens demonstrating an additive response to the combination of glucocorticoids and idelalisib in viability testing in vitro, and 2 subjects' specimens demonstrated a synergistic response. All 7 subjects were analyzed together and the 4 specimens with biological replicates were also evaluated in an additional analysis. An average of 40 million reads per specimen and treatment condition were obtained. We compared gene expression in each treatment condition to vehicle-treated cells and expression in glucocorticoid or idelalisib only treated cells to combination treated cells. Using a high dose of dexamethasone (25 or 50 nM) and an equivalent dose of prednisolone, we found that the addition of idelalisib (500 nM) enhanced prednisolone-induced gene regulation but not dexamethasone-induced gene regulation. Surprisingly, the specimens with additive response to combination therapy demonstrated enhancement of prednisolone-induced gene regulation with the addition of idelalisib, while the specimens with synergistic responses did not. Raw sequencing data (FASTQ) and count tables will be available through dbGaP.
Diverging Deltas_data and code
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RNA-seq of mutant delta POX07277 after transfer from glucose medium to Avicel medium for 24 hours
GEO Series GSE152624. Penicillium oxalicum. 6 samples. Type: Expression profiling by high throughput sequencing.
Major outputs for source apportionment of fine secondary inorganic aerosol over the Pearl River Delta region using a hybrid method
<p>The results for our work can be downloaded from this URL. The source impact estimates were simulated by CAMx (v6.4) with the module of PSAT in January, April, July, and October 2015. Matlab R2017b was used to perform spatial interpolation, optimization, and statistics calculations.</p>
B6 MS2 reporter in Bcd-1X (delta-bcd) data
<p>MS2-MCP live imaging data of the synthetic B6 MS2 reporter in Bcd-1X (bcd-delta/+) used for the manuscript: Fernandes, Tran et al. Synthetic deconstruction of <em>hunchback </em>regulation by Bicoid</p>
Z2B6 MS2 reporter in Bcd-1X (delta-bcd) data
<p>MS2-MCP live imaging data of the synthetic Z2B6 MS2 reporter in Bcd-1X (bcd-delta/+) used for the manuscript: Fernandes, Tran et al. Synthetic deconstruction of <em>hunchback </em>regulation by Bicoid</p>
hb-P2 MS2 reporter in Bcd-1X (delta-bcd) data
<p>MS2-MCP live imaging data of the hb-P2 MS2 reporter in Bcd-1X (bcd-delta/+) used for the manuscript: Fernandes, Tran et al. Synthetic deconstruction of <em>hunchback </em>regulation by Bicoid</p>
B9 MS2 reporter in Bcd-1X (delta-bcd) data
<p>MS2-MCP live imaging data of the synthetic B9 MS2 reporter in Bcd-1X (bcd-delta/+) used for the manuscript: Fernandes, Tran et al. Synthetic deconstruction of <em>hunchback </em>regulation by Bicoid</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.