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30,948 results for “Profile”
Datset and scripts for "Systematic occurrence cycle of typical RH-profiles during the MJO: evidence for ubiquitous pre-moistening"
<p>This repository contains data and scripts for the GRL paper:</p> <p><strong>Systematic occurrence cycle of typical RH-profiles during the MJO: evidence for ubiquitous pre-moistening</strong></p> <p>by Carsten Abraham, Colin Goldblatt, and Adrian Matthews.</p> <p>The <strong>data </strong>directory holds postprocessed data for the plots.</p> <p>The <strong>scripts</strong> directory holds the scripts to produce plots in the paper. </p> <p>The clustering and information about the raw data can be retrieved from </p> <p>https://journals.ametsoc.org/view/journals/atsc/79/9/JAS-D-21-0270.1.xml</p> <p>and</p> <p>https://journals.ametsoc.org/view/journals/atsc/aop/JAS-D-22-0119.1/JAS-D-22-0119.1.xml</p>
Heritable variation in thermal profiles is associated with reproductive success in the world's largest bird
<p><span>Organisms inhabiting extreme thermal environments, such as desert birds, have evolved spectacular adaptations to thermoregulate during hot and cold conditions. However, our knowledge of selection for thermoregulation and the potential for evolutionary responses is limited, particularly for large organisms experiencing extreme temperature fluctuations. Here we use thermal imaging to quantify selection and genetic variation in thermoregulation in ostriches (<em>Struthio</em> <em>camelus</em>), the world's largest bird species that is experiencing increasingly volatile temperatures. We found that females that are better at </span><span>regulating their head temperatures ('thermoregulatory capacity') had higher egg-laying rates under hotter conditions. </span><span>Thermoregulatory capacity was both heritable and showed signatures of local adaptation: females originating from more unpredictable climates were better at regulating their head temperatures in response to temperature fluctuations. Together these results reveal that past and present evolutionary processes have shaped genetic variation in thermoregulatory capacity, which appears to protect critical organs, such as the brain, from extreme temperatures during reproduction.</span></p>
Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain potent super-agonists with improved developability profiles-primary dataset
<div class="c-message_kit__blocks c-message_kit__blocks--rich_text"> <div class="c-message__message_blocks c-message__message_blocks--rich_text"> <div class="p-block_kit_renderer"> <div class="p-block_kit_renderer__block_wrapper p-block_kit_renderer__block_wrapper--first"> </div> </div> </div> </div> <p>Interleukin-2 (IL-2) had been been engineered up to now by yeast display and in silico rational design. In this article we reshaped IL-2 interface with the IL-2 receptor beta subunit to increase binding affinity between both interacting partners, using phage display. Multiple IL-2 mutated variants were selected from large phage-displayed libraries, showing shared molecular patterns. An accumulation of negative charges in the segment 81-87 of IL-2 primary sequence was observed, as well as the strong preponderance of the replacement I92L. The first feature contributed to an optimized electrostatic complementarity between IL-2 and IL-2 receptor beta chain, resulting in higher affinity and faster association kinetics than the ones of previously reported H9 superkine retrieved from yeast display libraries. The presence of a Leu residue at position 92 was the key molecular determinant for a favourable biophysical profile characterized by high stability and production in mammalian-cell based recombinant systems, and decreased aggregation propensity. The new beta super-binders behaved as potent super agonists, both in vitro and in vivo. The latter scenario showed their better preformance when compared to both non-mutated IL-2 and H9. The current dataset contains source data for graphics showing frequency mutations and charge distribution among unselected variants contained in phage-displayed libraries and selected clones enriched after selection on immobilized beta chain. Data showing the direct comparison between different IL-2 mutated variants produced as Fc-fusion proteins are also presented. The comparison includes the results of beta chain binding assays (ELISA), proliferation and phosphorylation assays in vitro, in vivo expansion of lymphocyte populations and anti-tumor activity in animal models. Taken together, the above described data support the unique features of the new beta super-binders and their potential as immunostimulatory and anti-cancer agents.</p>
Data for: Simultaneous subset tracing and miRNA profiling of tumor-derived exosomes via dual-surface-protein orthogonal barcoding
<p><span>The clinical potential of miRNA-based liquid biopsy has been largely limited by the heterogeneous sources in plasma and tedious assay processes. </span><span>Here we develop a precise and robust one-pot assay called dual-surface-protein</span><span>-guided</span><span> orthogonal recognition of tumor-derived exosomes and in-situ profiling of microRNAs (SORTER) to detect tumor-derived exosomal miRNAs and enhance the diagnostic accuracy of prostate cancer (PCa). The SORTER utilizes two allosteric aptamers against exosomal marker CD63 and tumor marker EpCAM to create an orthogonal labeling barcode and achieve selective sorting of tumor-specific exosome subtypes. Furthermore, the labeled barcode on tumor-derived exosomes initiated targeted membrane fusion with liposome probes to import miRNA detection reagents, enabling in-situ sensitive profiling of tumor-derived exosomal miRNAs. With a signature of six miRNAs, SORTER differentiated PCa and benign prostatic hyperplasia with an accuracy of 100%. Notably, the diagnostic accuracy reached 90.6% in the classification of metastatic and non-metastatic PCa. We envision that the SORTER will promote the clinical adaptability of miRNA-based liquid biopsy.</span></p>
HG002 data for Profiling Chromatin Accessibility in Humans Using Adenine Methylation and Long-Read Sequencing
<p>This dataset includes 6mA frequency data for the HG002 native DNA (untreated) sample sequenced on nanopore r9.4.1.</p>
NA12878 and MCF7 data for Profiling Chromatin Accessibility in Humans Using Adenine Methylation and Long-Read Sequencing
<p>This dataset includes 5mC and 6mA frequency data for NA12878 and MCF7 EcoGII-treated chromatin samples sequenced on nanopore r9.4.1.</p>
Data from Genome scale metabolic network modelling for metabolic profile predictions
<p>Data used to produce figures 4, 5 and 6 in the paper Genome scale metabolic network modelling for metabolic profile predictions.</p>
Aerosol, Temperature and Water Vapor profiling during the BIOSPHERE Athens Campaign (June-August 2023) - NTUA
<p>Level 2 of the lidar data obtained by the EOLE and DEPOLE lidar systems in the National Technical University of Athens (NTUA), during the EURAMET European Partnership on Metrology (EPM) project BIOSPHERE (June - August 2023). </p>
Nuclear morphological profiles for Image2Reg
<p>This dataset contains the nuclear morphological profiles of over 1 million cells and was retrieved from the data set from Rohban et al. (2017) in May 2021. The file should be located at data/resources/images/rohban/metadata to reproduce the analyses in the manuscript Image2Reg making use of the morphological profiles.</p>
Multiomics Profiling of CSF in Cardiac Arrest Survivors
ClinicalTrials.gov study NCT07090577. IPD Sharing: NO. Countries: 1. Publications: 3.
Relationship Between Insulin Resistance and Statin Induced Type 2 Diabetes, and Integrative Personal Omics Profiling
ClinicalTrials.gov study NCT02437084. IPD Sharing: NO. Countries: 1. Publications: 20.
PD and PK Profiles of Switching Between Cangrelor and Ticagrelor Following Ticagrelor Pre-treatment
ClinicalTrials.gov study NCT04634162. IPD Sharing: NO. Countries: 1. Publications: 1.
Mentor Siltex® Contour Profile Gel Mammary Prosthesis Clinical Trial
ClinicalTrials.gov study NCT00812097. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety, Tolerability and Pharmacokinetic Profile of Ascending Oral Doses of MMV390048, Part A
ClinicalTrials.gov study NCT02783820. IPD Sharing: YES. Countries: 1. Publications: 1.
EMPOWIR:Enhance the Metabolic Profile of Women With Insulin Resistance
ClinicalTrials.gov study NCT00618072. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Explorative Efficacy Profile of Neurexan® in an Experimental Acute Stress Setting in Healthy Subjects
ClinicalTrials.gov study NCT01703819. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Attenuation of the Side Effect Profile of Regadenoson: Study With Aminophylline in Patients With Severe Kidney Disease Undergoing Myocardial Perfusion Imaging
ClinicalTrials.gov study NCT01336140. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Geriatric Assessment & Genetic Profiling to Personalize Therapy in Older Adults With Acute Myeloid Leukemia
ClinicalTrials.gov study NCT03226418. IPD Sharing: NO. Countries: 1. Publications: 3.
Safety Profile of Insulin Like Growth Factor-1 (IGF-I) Administration in Adolescents
ClinicalTrials.gov study NCT00516386. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Proof of Concept Study to Evaluate the Safety Profile of Plitidepsin in Patients With COVID-19
ClinicalTrials.gov study NCT04382066. IPD Sharing: YES. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.