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1,254 results for “alpha-synuclein”
Enhanced mTORC1 signaling and protein synthesis in pathologic alpha-synuclein cellular and animal models of Parkinson’s disease
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Direct visualisation of Alpha-Synuclein Oligomers in Human Brain
<p>Code for direct visualisation of α-synuclein oligomers in human brain tissue</p>
Polarisation camera TAB-PAINT dataset of alpha-synuclein fibrils using Nile red
<p>Alpha-synuclein fibrils were deposited on PLL-coated and argon plasma-cleaned coverslides. A low concentration of Nile Red (~1 nM) was added for PAINT imaging, and fluorescent beads for post-acquisition drift correction.</p> <p>The data was collected on a fluorescence microscope (Eclipse Ti-U, Nikon) with a polarisation camera (CS505MUP, Thorlabs). The molecules were excited with a 515 nm laser using epi-illumination with a measured power density at the sample plane of 6.08 kW/cm^2. An exposure time of 50 ms was used. The following filters were used: dichroic (Di03-R514-t1, Semrock) and emission filter (FF01-515/LP and FF01-650/200, Semrock). A 60x oil-immersion objective (Plan Apo, 60xA/1.40 Oil, DIC H, inf/0.17 WD 0.21, Nikon) was used for detection.</p>
Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease
<p>Raw data for the manuscript "Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease"</p>
The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines.
<p>Raw data corresponding to graphs in publication: The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines. Files are titled with the figure number. Each graph is on a different tab within the excel spreadsheet.</p>
Circular dichroism spectroscopic and small-angle neutron scattering analysis of alpha-synuclein and bacteriorhodopsin in bicontinuous microemulsions
<p>The membrane proteins (MPs) alpha-synuclein (ASYN) and bacteriorhodopsin (BR) were readily incorporated into bicontinuous microemulsions (BMEs) formed by two microemulsion systems: water/heptane/Aerosol-OT (AOT)/CK-2,13 and water/dodecane/sodium dodecyl sulfate (SDS)/1-pentanol. (CK-2,13 is an alkyl ethoxylate possessing two alkyl tail groups of carbon chain length 2 and 13 and an average degree of ethoxylation of 5.6.) MPs were encapsulated in BMEs through preparation of Winsor-III systems at optimal salinity, with the anionic surfactants AOT and SDS providing the driving force for extraction. Dissolution of ASYN in BMEs greatly increased the former's alpha-helicity, similar to ASYN's behavior in the presence of biomembranes, while BME- and vesicle-encapsulated BR possessed similar secondary structure. Small-angle neutron scattering (SANS) results clearly demonstrated the direct interaction of MPs with the surfactants, resulting in a decrease of surface area per volume for surfactant monolayers due to decreased<span> surfactant efficiency. The SANS signal for ASYN was isolated through the use of neutron contrast matching for the surfactants through partial deuteration of water and oil</span><span><span>, one of the first reports</span></span><span> of contrast matching </span><span><span>for</span></span><span> BMEs in the literature. The SANS results of the contrast matched sample reflected similar aggregation for ASYN in BMEs as was reported previously for vesicles and SDS solution. </span><span><span>This study</span></span><span> demonstrate</span><span><span>s</span></span><span> the potential use of BMEs as MP host systems for conducting biochemical reactions such as the conversion of sunlight into adenosine triphosphate (ATP) by BR and studyi</span>ng fundamental behavior of MPs, such as the role of ASYN dysfunction in Parkinson's disease, as well as for isolation and purification of MPs via Winsor-III -based extraction.</p>
Alpha-synuclein ColabFold modeling
<p>ColabFold modeling of wild-type human alpha-synuclein and a variant carrying a Ser129Asp mutation</p>
Phenylbutyrate Response as a Biomarker for Alpha-synuclein Clearance From the Brain
ClinicalTrials.gov study NCT02046434. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Establishing Alpha-synuclein RT-QuIC Assay as a Diagnostic Technique in REM Sleep Behaviour Disorder
ClinicalTrials.gov study NCT04266457. IPD Sharing: UNDECIDED. Countries: 1. Publications: 24.
Quantification of Phosphorylated Alpha-synuclein in Cutaneous Biopsies as a Prospective Biomarker in Parkinson's Disease
ClinicalTrials.gov study NCT06621602. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Iron, Alpha-Synuclein, and Lymphocyte-activation Gene-3 in Ischemic Stroke
ClinicalTrials.gov study NCT05748587. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Alpha-synuclein in Cerebrospinal Fluid to Differentiate Alzheimer's Disease From Lewy Body Disease.
ClinicalTrials.gov study NCT01876459. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Circular dichroism spectroscopic and small-angle neutron scattering analysis of alpha-synuclein and bacteriorhodopsin in bicontinuous microemulsions
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Constitutive nuclear accumulation of endogenous alpha-synuclein in mice causes motor impairment and cortical dysfunction, independent of protein aggregation
<p>Dataset for all quantification performed in the affiliated manuscript.</p>
Data for 'Alpha-synuclein oligomers form by secondary nucleation'
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Unconventional secretion of alpha-synuclein mediated by palmitoylated DNAJC5 oligomers
<p>Alpha-synuclein (α-syn), a major component of Lewy bodies found in Parkinson’s disease (PD) patients, has been found exported outside of cells and may mediate its toxicity via cell-to-cell transmission. Here, we reconstituted soluble, monomeric α-syn secretion by the expression of DnaJ homolog subfamily C member 5 (DNAJC5) in HEK293T cells. DNAJC5 undergoes palmitoylation and anchors on the membrane. Palmitoylation is essential for DNAJC5-induced α-syn secretion, and the secretion is not limited by substrate size or unfolding. Cytosolic α-syn is actively translocated and sequestered in an endosomal membrane compartment in a DNAJC5-dependent manner. Reduction of α-syn secretion caused by a palmitoylation-deficient mutation in DNAJC5 can be reversed by a membrane-targeting peptide fusion-induced oligomerization of DNAJC5. The secretion of endogenous α-syn mediated by DNAJC5 is also found in a human neuroblastoma cell line, SH-SY5Y, differentiated into neurons in the presence of retinoic acid, and in human-induced pluripotent stem cell-derived midbrain dopamine neurons. We propose that DNAJC5 forms a palmitoylated oligomer to accommodate and export α-syn.</p>
Environmental enrichment prevents transcriptional disturbances induced by alpha-Synuclein overexpression
GEO Series GSE96961. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Differential microglial responses to structurally distinct alpha-synuclein polymorphs
GEO Series GSE305401. Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing.
Brain region-specific and systemic transcriptomic dysregulation in a human alpha-synuclein overexpressing rat model
GEO Series GSE281984. Rattus norvegicus. 60 samples. Type: Expression profiling by high throughput sequencing.
Genome-Wide Profiling of DNA Methylation and Gene Expression induced by Alpha-Synuclein in Murine Microglia
GEO Series GSE158982. Mus musculus. 39 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.