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1,186
datasets available to search
ShareScore release 0.9.0
Dataset results
1,186 results for “defensiveness”
Oleic acid-dependent modulation of Nitric Oxide Associated 1 protein levels regulate nitric oxide mediate signaling in plant defense.
GEO Series GSE36797. Arabidopsis thaliana. 12 samples. Type: Expression profiling by array.
Functional analysis of lipid acyl hydrolases in Arabidopsis antimicrobial defense: plp2 Botrytis cinerea
GEO Series GSE15972. Arabidopsis thaliana. 8 samples. Type: Expression profiling by array.
Evidence for novel cell defense mechanisms sustained by dimethyl fumarate in multiple sclerosis patients: the HuR/SOD2 cascade
<p><strong>Introduction - T</strong>his database includes the raw data linked with the paper <em>Evidence for novel cell defense mechanisms sustained by dimethyl fumarate in multiple sclerosis patients: the HuR/SOD2 cascade.</em></p> <p>In this paper, we reported the HuR protein levels in peripheral blood mononuclear cells (PBMCs) from MS patients before and after dimethyl fumarate (DMF) treatment compared to healthy controls (HC). Considering that HuR may act on different targets playing a protective role against oxidative stress, we had the goal of disclosing whether MnSOD could represent a new molecular target of HuR and the potential influence of DMF treatment on this interaction .</p> <p><strong>Methods - </strong>PBMCs from 20 patients with MS and 20 matched HC were used to evaluate HuR, MnSOD and Nrf2 protein content by Western blot, before and after 12 months of DMF treatment.</p> <p>Immunoprecipitation experiments coupled with RNA extraction in PBMCs were performed to explore whether MnSOD mRNA could be physically bound by HuR and whether this binding could be affected by 12 months of DMF treatment.</p> <p><strong>Results </strong>- In PBMCs, HuR protein interacts with MnSOD transcript both in HC and in MS patients naïve to disease modifying treatment. This interaction is positively affected by 12 months of DMF treatment. PBMCs from MS patients have a lower HuR and MnSOD protein content compared to matched HC (HuR: p<0.01, MnSOD p<0.01). Of interest, 12 months of DMF treatment in MS patients restore the amount of both HuR protein and MnSOD enzyme to the levels observed in HC. We also confirmed that Nrf2 is an HuR target, and we report that its levels are significantly increased in MS patients naïve to disease modifying treatment and remain elevated following DMF administration.</p>
Transcriptome and metabolome profiling reveals key pathways and metabolites involved in defense response of upland cotton against Verticillium dahliae
GEO Series GSE221845. Gossypium hirsutum. 12 samples. Type: Expression profiling by high throughput sequencing.
Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defense in KRAS-mutant lung cancer
GEO Series GSE265860. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Profile expression of genes involved in plant reaction to lead: uptake tolerance and defense.
GEO Series GSE6157. Arabidopsis thaliana. 6 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.