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13,587 results for “specification”
Sex-specific mRNA and miRNA expression data from Drosophila larvae, pupae and adults [miRNA]
GEO Series GSE57321. Drosophila melanogaster; synthetic construct. 12 samples. Type: Non-coding RNA profiling by array.
SnowEx23 Oct22 Laser Snow Microstructure Specific Surface Area Low-snow V001
This data set reports vertical profiles of snow reflectance and specific surface area (SSA) collected in October 2022 as part of the NASA SnowEx 2023 Alaska field campaign. Measurements were taken from three snow pits located within the Upper Kuparuk Toolik (UKT) field site, a coastal tundra environment in the North Slope region of the northern Alaska coastal plain. Reflectance was measured in situ using a 1310 nm integrating sphere laser device (IceCube) and converted to SSA during data processing (Gallet et al., 2009). SSA data collected from the same study sites in October 2023 and March 2023 are available as <a href="https://doi.org/10.5067/BSEP59ADC6XN">SnowEx23 Laser Snow Microstructure Specific Surface Area Data, Version 1</a> and <a href="https://nsidc.org/data/snex23_ssa_so/versions/1">SnowEx23 Laser Snow Microstructure Specific Surface Area Snow-off Data, Version 1</a>.
SnowEx23 Laser Snow Microstructure Specific Surface Area Data V001
Preliminary: This data set reports vertical profiles of snow reflectance and specific surface area (SSA) in Alaska, USA, in two regions, the Fairbanks region characterized by spruce taiga forest and the arctic coast region characterized by coastal tundra. Reflectance was measured in situ using a 1310 nm and a 945 nm integrating sphere laser device and converted to SSA.
Spaceflight adaptation requires organ specific alterations in the proteomes of Arabidopsis
Life in spaceflight demonstrates remarkable adaptive processes within the specialized environments of space vehicles which are subject to the myriad of attending and unique environmental issues associated with orbital trajectories. To examine the adaptive processes that occur in plants in space, leaves and roots from Arabidopsis seedlings that were grown from seed for 12 days on the International Space Station and preserved on orbit in RNAlater were returned to earth and analyzed using iTRAQ broad scale proteomics procedures.
SnowEx17 Laser Snow Microstructure Specific Surface Area Data V001
This data set reports vertical profiles of snow reflectance, specific surface area (SSA), and optical equivalent diameter (grain size) at Grand Mesa, Colorado, USA, a snow-covered, forested study site about 40 miles east of the city of Grand Junction, CO. Reflectance was measured <em>in situ</em> using a 1310 nm integrating sphere laser device and converted to SSA and optical equivalent diameter.
37-Day microgravity exposure in 16-Week female C57BL/6J mice during the NASA Rodent Research 1 mission is associated with bone loss specific to weight-bearing skeletal sites (femur and vertebrae, micro computed tomography)
Exposure to weightlessness in microgravity and elevated space radiation are associated with rapid bone loss in mammals, but questions remain about their mechanisms of action and relative importance. In this study, we tested the hypothesis that bone loss during spaceflight in Low Earth Orbit is primarily associated with site-specific microgravity unloading of weight-bearing sites in the skeleton. Microcomputed tomography and histological analyses of bones from mice space flown on ISS for 37 days in the NASA Rodent Research-1 experiment show significant site-specific cancellous and cortical bone loss occurring in the femur, but not in L2 vertebrae. The lack of bone degenerative effects in the spine in combination with same-animal paired losses in the femur suggests that space radiation levels in Low Earth Orbit or other systemic stresses are not likely to significantly contribute to the observed bone loss. Remarkably, spaceflight is also associated with accelerated progression of femoral head endochondral ossification. This suggests the microgravity environment promotes premature progression of secondary ossification during late stages of skeletal maturation at 21 weeks. Furthermore, mice housed in the NASA ISS Rodent Habitat during 1g ground controls maintained or gained bone relative to mice housed in standard vivarium cages that showed significant bone mass declines. These findings suggest that housing in the Rodent Habitat with greater topological enrichment from 3D wire-mesh surfaces may promote increased mechanical loading of weight-bearing bones and maintenance of bone mass. In summary, our results indicate that in female mice approaching skeletal maturity, mechanical unloading of weight-bearing sites is the major cause of bone loss in microgravity, while sites loaded predominantly by muscle activity, such as the spine, appear unaffected. Additionally, we identified early-onset of femoral head epiphyseal plate secondary ossification as a novel spaceflight skeletal unloading effect that may lead to premature long bone growth arrest in microgravity. This study derives results from femur and vertebrae using the micro computed tomography assay.
Formal Specification and Verification of a Coordination Protocol for an Automated Air Traffic Control System
We detail all of the facets of adapting classical model checking to a real aerospace system, in- cluding deriving the formal model and a set of specifications from natural language descriptions. To ensure the model checking results are meaningful, we have to ensure that both the model and specifications correctly reflect the intentions of the designers, thus we employ model validation and property debugging techniques. We demonstrate the utility of enhancing LTL satisfiability checking by taking the fairness constraints of the system model into consideration. We argue that specification debugging in real applications deserves more attention in future research efforts, and the utility of a system formalization, model and specification debugging, and verification trilogy for model checking real systems under development. In this paper we assume there are no hardware failures or lost messages. As the AAC design develops and hardware details are decided by AAC designers, we plan to take the failure rates of the chosen components into consideration, i.e. by extending our work to probabilistic model checking using PRISM [19]. Previous work has reported on analyzing the safety of air traffic control systems using simulation [3] or fault trees [1]. By extending the model we designed in this paper, we can carry out safety analysis using PRISM to capture the dynamic interactions in the AAC.
Specific Host Metabolite and Gut Microbiome Alterations Are Associated with Bone-loss During Spaceflight
Understanding the axis of the human microbiome and physiological homeostasis is an essential task in managing deep-space travel associated health risks. The NASA led Rodent Research 5 mission enabled an ancillary investigation of the gut microbiome varying exposure to microgravity (flight) relative to ground controls in the context of previously shown bone mineral density (BMD) loss that was observed in these flight groups. We demonstrate elevated abundance of Lactobacillus murinus and Dorea sp. during microgravity exposure relative to ground control through whole genome sequencing and 16S rRNA analyses. Specific functionally assigned gene clusters of Lactobacillus murinus and Dorea sp. capable of producing metabolites, lactic acid, leucine/isoleucine, and glutathione are enriched. These metabolites are elevated in the microgravity-exposed host serum through LC-MS/MS metabolomic analysis. Along with BMD loss, ELISA analysis reveals increases of osteocalcin and reductions in tartrate-resistant acid phosphatase 5b signifying additional loss of bone homeostasis in flight.
Requirements Specifications for Prognostics: An Overview
With recent advancements in prognostics methodologies there has been a significant interest in maturing Prognostics and Health Management (PHM) to increase its technology readiness level for onboard deployments. Active research is underway both in industry and academia to address shortcomings in availability of run-to-failure data, accelerated aging environments, real-time prognostics algorithms, uncertainty representation and management (URM) techniques, prognostics performance evaluation, etc., to name a few. At this juncture it is highly desirable to close the loop by connecting the high level customer requirements for mission planning and execution to performance specifications for prognostics methodologies at the lower technical level. This calls for integrating the pragmatics of safety, reliability, cost, and real-time viability into the prognostics methodologies to establish a connection between top-down and bottom-up approaches currently pursued in the PHM community. In this paper we identify key areas that must be addressed to bridge these gaps and provide an overview of how these areas have been addressed in part at various levels. We also discuss on how these issues can be further developed into a comprehensive and more coherent portfolio of technologies that will ultimately lead to specifying guidelines for prognostics performance.
SnowEx23 Laser Snow Microstructure Specific Surface Area Snow-off Data V001
This data set reports vertical profiles of snow reflectance and specific surface area (SSA) from two study sites in Alaska, USA collected as part of the NASA SnowEx 2023 field campaign. The study sites include a boreal forest environment in the Fairbanks region of central Alaska (the Bonanza Creek Experimental Forest, the Caribou Poker Creek watershed and Farmers Loop/Creamer’s Field), and a coastal tundra environment in the North Slope region of northern Alaska (the Arctic coastal plain and Upper Kuparuk Toolik). Reflectance was measured in situ using an A2 Photonic Sensor IceCube (1310 nm). Measured reflectance values were converted to SSA during data processing following the methods of Gallet et al., (2009). Snow-on SSA data from these same study sites were collected in March 2023 and are available as <a href="https://nsidc.org/data/snex23_ssa/versions/1">SnowEx23 Laser Snow Microstructure Specific Surface Area Data, Version 1</a>.
SnowEx20 Laser Snow Microstructure Specific Surface Area Data V001
This data set contains vertical profiles of snow reflectance, specific surface area (SSA), and spherical equivalent snow grain diameter. Data were collected during the SnowEx 2020 Grand Mesa, Colorado Intensive Observation Period between 27 January and 12 February 2020. Reflectance was measured at snow pits using one of two integrating sphere laser devices, IRIS (InfraRed IntegraXng Sphere) or IceCube. SSA and spherical equivalent diameter were then derived from reflectance.
Detecting Tumor Specific Antigen-Reactive T cells from Tumor Infiltrating Lymphocytes via Interaction Dependent Fucosyl-biotinylation [RNA-seq]
GEO Series GSE145596. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
FJ004: Dopaminergic subset specification as a model for molecular mechanisms of neuronal vulnerability in Parkinson's Disease
GEO Series GSE57234. Mus musculus. 6 samples. Type: Expression profiling by array.
Sequencing data of AQP2-specific inhibitor Steviol against colorectal cancer
GEO Series GSE283029. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Pig-specific skin transcriptional responses after intradermal administration of flagellin
GEO Series GSE72256. Sus scrofa. 32 samples. Type: Expression profiling by array.
Sex-specific transcriptional differences in Gulf War Illness patients under stressful conditions
GEO Series GSE286345. Homo sapiens. 242 samples. Type: Expression profiling by high throughput sequencing.
Circulating extracellular vesicles with liver-specific RNA species are potential biomarkers for early cholestasis-induced liver fibrosis [mRNA-seq]
GEO Series GSE166753. Mus musculus. 12 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Whole transcriptome analysis of unmutated sporadic ALS patients’ peripheral blood reveals phenotype-specific gene expression signature
GEO Series GSE288704. Homo sapiens. 66 samples. Type: Expression profiling by high throughput sequencing.
Host response in murine fecal peritonitis differs upon the specific fecal microbiota
GEO Series GSE70714. Mus musculus. 14 samples. Type: Expression profiling by array.
Glycan-Specific Natural Antibodies Mediate Blockade of Endogenous Retrovirus Emergence and Recognize a Broad-spectrum of Exogenous Viruses
GEO Series GSE207247. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.