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1,337
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Dataset results
1,337 results for “Neuropathy”
Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy
GEO Series GSE207930. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Sural nerve of progressive and non-progressive diabetic neuropathy patients
GEO Series GSE24290. Homo sapiens. 35 samples. Type: Expression profiling by array.
A Genome Wide Association Study Reveals Genetic Predisposition for Bortezomib-Induced Peripheral Neuropathy in Multiple Myeloma by Variation in the PREP1-CBS locus.
GEO Series GSE65777. Homo sapiens. 469 samples. Type: SNP genotyping by SNP array; Genome variation profiling by SNP array.
The Alteration of M6A-tagged Transcript Profiles in The Retina of Rats After Traumatic Optic Neuropathy
GEO Series GSE165520. Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing; Other.
Schwann cell-specific ablation of Beclin 1 impairs peripheral myelination and leads to a progressive motor and sensory neuropathy
GEO Series GSE247435. Mus musculus. 16 samples. Type: Expression profiling by array.
Transcriptional Profiling of Diabetic Neuropathy in BKS-db/db Mouse, a Model for Type 2 Diabetes
GEO Series GSE27382. Mus musculus. 13 samples. Type: Expression profiling by array.
Longitudinal RNA sequencing of skin and DRG neurons in mice with paclitaxel-induced peripheral neuropathy
GEO Series GSE185084. Mus musculus. 120 samples. Type: Expression profiling by high throughput sequencing.
mouse sciatic nerve profile of CMT1A peripheral neuropathy model, caused by PMP22 overexpression
GEO Series GSE1962. Mus musculus. 2 samples. Type: Expression profiling by SAGE.
Gene expression profiles of diabetic kidney disease and neuropathy in eNOS knockout mice
GEO Series GSE159060. synthetic construct; Mus musculus. 76 samples. Type: Expression profiling by high throughput sequencing.
Exploration for blood biomarkers of human long non-coding RNAs predicting oxaliplatin-induced chronic neuropathy through iPS cell-derived sensory neuron analysis
GEO Series GSE290071. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Sympathetic neuropathy of the bone marrow haematopoietic stem cell niche is essential for myeloproliferative neoplasms
GEO Series GSE55801. Mus musculus. 4 samples. Type: Expression profiling by array.
Disease mechanisms in peripheral neuropathies due to altered Pmp22 gene dosage or a Pmp22 point mutation
GEO Series GSE1947. Mus musculus. 21 samples. Type: Expression profiling by array.
Rosiglitazone Treatment Reduces Diabetic Neuropathy in STZ treated DBA/2J mice
GEO Series GSE11343. Mus musculus. 19 samples. Type: Expression profiling by array.
Gene expression profiles of hiPSC-derived retinal ganglion cells in MT-ND4 mutated Leber's hereditary optic neuropathy
GEO Series GSE103619. Homo sapiens. 3 samples. Type: Expression profiling by array.
Genome wide association study on neuropathy in multiple myeloma
GEO Series GSE66903. Homo sapiens. 116 samples. Type: Genome variation profiling by SNP array; SNP genotyping by SNP array.
Expression data from a Charcot-Marie-Tooth 1B neuropathy mouse model
GEO Series GSE40610. Mus musculus. 24 samples. Type: Expression profiling by array.
Macrophages protect against sensory axon degeneration in diabetic neuropathy
GEO Series GSE255553. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Diabetic peripheral neuropathy is associated with changes in the frequency and function of circulating Natural Killer cells: results of a pilot study in patients with diabetic foot.
<p><strong><span>Background: </span></strong><span>Diabetic critical limb-threatening ischemia (CLTI) is a severe vascular disease with a high incidence of amputation and death. Circulating inflammatory markers may represent early diagnostic and prognostic tools. We previously showed that patients with diabetes mellitus and CLTI bear low abundance and impaired functionality of pro-angiogenic CD34<sup>+</sup> hematopoietic stem and progenitor cells (HSPCs) and high frequency of natural killer cells (NKs). However, no study assessed the frequency, phenotype, and function of NKs in the early stage of CLTI characterized by neuropathy.<strong> Methods: </strong>We enrolled 177 subjects sorted into 5 groups reflecting CLTI progression: 1) non-diabetic healthy controls (n=25), diabetic patients 2) without neurovascular complications (n=27), 3) with peripheral neuropathy (n=39), 4) with peripheral neuropathy and foot lesions (n=42), 5) with peripheral neuroischemia and foot lesions (n=44). We assessed the frequency of circulating B-, CD4<sup>+,</sup> and CD8<sup>+</sup> T-cells, NKs, and CD34<sup>+</sup>HSPCs, by a flow cytometry (FC)-based diagnostic kit. We investigated by FC the frequency of circulating NK subpopulations in donors with diabetic neuropathy (n=16) and controls (n=16). We characterized FACS-sorted circulating NKs secretome by antibody membrane arrays and we tested its pro-angiogenic potential<em> in vitro</em> and <em>in vivo</em> in <em>Hirudo verbana</em>.<strong> Results: </strong>Using age and sex-adjusted logistic multivariate models, we observed a decrease in CD34<sup>+</sup>HSPCs in all diabetic groups compared to control. Interestingly, NK frequency was increased in diabetic patients with neuropathy. Although the frequency of angiogenic NKs was similar in all groups, functionally, NKs from patients with diabetic neuropathy showed impaired degranulation <em>in vitro</em>, and reduced angiogenic ability <em>in vitro </em>and <em>in vivo</em>. Neuropathic NKs showed downregulation of angiogenic factors (IL-8, PDGF-B) and upregulation of factors related to monocyte/macrophage migration, effectively recruiting macrophages <em>in vivo</em>.<strong> Conclusion:</strong> By a routine laboratory test, we identified a specific cellular signature for patients with diabetes mellitus and peripheral neuropathy that includes low CD34<sup>+</sup>HSPCs and high NK frequency. Moreover, we show for the first time a functional impairment of NKs in neuropathic patients. If confirmed in larger cohorts, FACS detection of the circulating anti-angiogenic NK cell populations could be used for the early diagnosis of diabetic CLTI, a still unmet clinical need.</span></p>
Rood's Approach and Oxaliplatin-induced Peripheral Neuropathy in Colorectal Cancer Patients
ClinicalTrials.gov study NCT05882396. IPD Sharing: NO. Countries: 0. Publications: 0.
Efficacy of Administration of ACE-Inhibition on Autonomic and Peripheral Neuropathy in Patients With Diabetes Mellitus
ClinicalTrials.gov study NCT03031834. IPD Sharing: NO. Countries: 0. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.