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30,334 results for “Responsiveness”
Twenty years of Salix height in response to experimental manipulation of browsing and water table, northern range of Yellowstone National Park
<p>This respository contains multiple datasets collected during a 20 year investigation of the responses of willow (<em>Salix </em>spp.) communities in Yellowstone National Park after the restoration of large carnivores. The study sought to understand whether the restoration of wolves to the food web cause a change in the state of willow communities that occured while wolves were absent. Each dataset has a corresonding file of metadata. </p>
Malaria drives unique regulatory responses across multiple immune cells during human infection
<p>To investigate malaria driven transcriptional changes in specific immune cell subsets, we sorted live PBMCs from 6 malaria infected donors (day 0), and two subsequent time points after drug treatment (day 7 and 28), along with PBMCs from 2 healthy controls. We performed scRNAseq of these cells, and used clustering and sub-clustering to identify specific immune cell subsets. Differential gene analysis between day 0 and day 28 was performed for each cell cluster and sub-cluster. Key transcriptional changes were confirmed at the protein level with additional donor samples.</p>
Grandmaternal allergen sensitization reprograms epigenetic and airway responses to allergen in second generation offspring
<p><strong>SUPPLEMENTARY FIGURE LEGEND</strong></p> <p><strong>Supplemental Figure 1. Grandmaternal allergen sensitization during pregnancy regulates differentially methylated cytosines in airway epithelium of second-generation offspring at baseline and after allergen sensitization</strong>. Grandmaternal HDM exposure resulted in 1,390 DMCs in airway epithelium of F2 offspring at baseline (F0 HDM•F2 Base vs F0 Veh•F2 Base). F2 HDM sensitization alone resulted in 1,467 DMCs (F0Veh•F2Sens vs F0 Veh•F2 Base). In contrast, HDM sensitization in F2 mice from HDM-exposed founders resulted in 3,756 total DMCs (F0 HDM•F2 Sens vs F0 HDM•F2 Base). N=8 total for each group (n=4 males and n=4 females).</p> <p> </p> <p><strong>Supplemental Figure 2. Gene ontology analysis of DMCs in airway epithelium of second-generation offspring</strong>. Gene ontology analysis of DMCs in airway epithelium of F2 mice identified enriched biological processes (individual small circles), which were then grouped based on functional annotation using Cytoscape Enrichment Map (larger, labeled, black circles). Each small circle represents an individual biological process and size is proportional to number of involved genes, while connecting edges represent shared genes between individual biological processes. (A) Gene ontology analysis showing enriched biological processes due to grandmaternal HDM exposure in F2 offspring at baseline (F0 HDM•F2 Base versus F0 VEH•F2 Base). (B) Gene ontology analysis showing effects of HDM sensitization alone on enriched biological processes in F2 offspring from vehicle-exposed F0 mice (F0 Veh•F2 Sens vs F0 VEH•F2 Base). (C) Gene ontology analysis showing potentiating effects of F0 grandmaternal HDM exposure on enriched biological processes after HDM sensitization in F2 mice (F0 HDM•F2 Sens vs F0 HDM•F2 Base). N=8 total for each group (n=4 males and n=4 females).</p> <p> </p> <p><strong>Supplementary Figure 3. Differential methylation is linked to altered gene expression in airway epithelium of second-generation offspring. </strong>A subset of F2 airway epithelial genes identified during differentially-methylated pathway analyses were analyzed by real-time RT-PCR to assess for expression. Grandmaternal HDM exposure significantly increased Smad3 expression at baseline and potentiated its response after F2 HDM sensitization. Paxillin expression was also increased after HDM sensitization compared to non-sensitized F2 descendants from HDM exposed founders, although this difference did not meet statistical significance (<em>p</em> = 0.06). No differences were observed between Ets3, Cdh3, or Cacna1d expression between groups. *<em>p</em> < 0.05. Delta CT values were analyzed with two-way ANOVA and Tukey’s post-test. N=8 total for each group (n=4 males “open circles” and n=4 females “closed circles”), except for F0 HDM•F2 Base, n=5.</p> <p> </p> <p><strong>Supplementary Figure 4. Grandmaternal allergen exposure during pregnancy regulates vagal ganglia cytosine methylation in second-generation offspring at baseline and after allergen sensitization</strong>. Grandmaternal HDM sensitization during pregnancy resulted in 901 DMCs in F2 mice at baseline (F0 HDM•F2 Base vs F0 Veh•F2 Base). F2 HDM sensitization alone resulted in 1,467 DMCs (F0Veh•F2Sens vs F0 Veh•F2 Base). In contrast, HDM sensitization in F2 mice from HDM-sensitized F0 grandmaternal founders resulted in 1,787 total DMCs (F0 HDM•F2 Sens vs F0 HDM•F2 Base). N=8 total for each group (n=4 males and n=4 females).</p> <p> </p> <p><strong>Supplementary Figure 5. Grandmaternal allergen sensitization during pregnancy modifies epigenetic signatures in second-generation offspring in a tissue-specific manner. </strong>Only rarely were differentially methylated genes shared between vagal ganglia neurons and airway epithelium in all groups. Specifically, neurons and epithelium in non-sensitized F2 mice from grandmaternal HDM-sensitized F0 founders shared only 15 genes in common (light blue circles). Neurons and epithelium in HDM-sensitized F2 mice from Vehicle-exposed grandmaternal founders shared only 9 genes in common (grey circles). Neurons and epithelium in HDM-sensitized F2 mice from HDM-sensitized grandmaternal F0 founders shared only 41 genes in common. N=8 total for each group (n=4 males and n=4 females).</p> <p> </p> <p><strong>Supplementary Figure 6. Gene ontology analysis of biological process enrichment in vagal ganglia from second-generation offspring</strong>. Gene ontology analysis of DMCs in vagal ganglia of F2 mice identified enriched biological processes (individual small circles), which were then grouped based on functional annotation using Cytoscape Enrichment Map (larger, labeled, black circles). Each small circle represents an individual biological process and size is proportional to number of involved genes, while connecting edges represent shared genes between individual biological processes. (A) Gene ontology analysis showing effects of HDM sensitization on biological process enrichment in F2 offspring from vehicle-exposed F0 mice (F0 Veh•F2 Sens vs F0 VEH•F2 Base). (B) Gene ontology analysis showing potentiating effects of F0 grandmaternal HDM sensitization on biological process enrichment in F2 mice after HDM sensitization (F0 HDM•F2 Sens vs F0 HDM•F2 Base). N=8 total for each group (n=4 males and n=4 females).</p> <p> </p> <p><strong>Supplemental Figure 7. Quantification of airway sensory nerve density using 3D confocal microscopy.</strong> Airway epithelial substance P-positive sensory nerves were analyzed in whole mount specimens using immunofluorescence and 3-dimensional confocal microscopy. Total nerve length and the number of branch points were quantified from nerve models generated based on substance P-positive voxels. Top) Representative images of substance P-expressing nerves (purple, top left) and nerve modeling (white filaments, top right). Bottom) Nerve length (left) and the number of branch points (right) were similar between untreated F2 mice from HDM exposed grandmothers and vehicle exposed grandmothers. N=6 both groups (n=3 males “open circles” and n=3 females “closed circles”).</p> <p> </p> <p><strong>SUPPLEMENTAL TABLES</strong></p> <p><strong>Supplemental Table S1.</strong> Pathways identified by DMC analysis that were not present on DMR analysis in airway epithelium of second-generation F2 mice. All DMR-associated pathways were also identified by DMC analysis, as indicated in Table 1 in main text.</p> <p> </p> <p><strong>Supplemental Table S2. </strong>Over-represented transcription factor binding sites in DMRs of airway epithelium and vagal ganglia from F2 mice before and after allergen sensitization.</p> <p> </p> <p><strong>Supplemental Table S3. </strong>Pathway identified by DMC analysis in vagal ganglia of second-generation F2 mice. All DMR-associated pathways were also identified by DMC analysis, as indicated in Table 3 in main text.</p> <p> </p> <p><strong>SUPPLEMENTARY DATA FILES</strong></p> <p><strong>Lebold&Cook_DMC_Gene List.xlsx. </strong></p> <p><strong>Lebold&Cook_DMR Gene List.xlsx.</strong></p> <p>Differentially methylated cytosines (DMC) and regions (DMR) source data files.</p>
Supplement to the "Response to the Referee" of the article "Simulation of marine stratocumulus using the super-droplet method: Numerical convergence and comparison to a double-moment bulk scheme"
<p>This is the supplement to the "Response to the Referee" of the article "Simulation of marine stratocumulus using the super-droplet method: Numerical convergence and comparison to a double-moment bulk scheme".</p> <p><a href="https://zenodo.org/api/files/87a1c801-d2f8-4c0c-b408-db56481cf97d/Movie%201_w_theta_v_t.mp4">Movie 1_w_theta_v_t.mp4</a>: Time evolution of vertical profiles of buoyancy production and its decomposition.</p> <p><a href="https://zenodo.org/api/files/6eabdd4d-61fd-4f7a-8656-0c9d1fb7ce6f/Movie%202_scatter_w_theta_v_t.mp4">Movie 2_scatter_w_theta_v_t.mp4</a>: Time evolution of scatter plots of w vs theta_v.</p> <p><a href="https://zenodo.org/api/files/6eabdd4d-61fd-4f7a-8656-0c9d1fb7ce6f/Movie%203_boy_incloud_real_z_t.mp4">Movie 3_boy_incloud_real_z_t.mp4</a>: Time evolution of buoyancy production and cloud fraction, and time series of cloud cover.</p> <p><a href="https://zenodo.org/api/files/2f5a17d9-6cb1-4769-88cd-65fd8efd0225/qr_cross.mp4">qr_cross.mp4</a>: Time evolution of cross section of rain water mixing ratio (q<sub>r</sub>) of SDM and SN14 simulation.</p>
Data & figures: Comparison between Large-Scale Observed and Simulated Antarctic Sea-Ice Variability Response to Changes in Atmospheric and Oceanic Circulation
<p>These are the model data, key figures, and Python code generated during the project titled “Comparison between Large-Scale Observed and Simulated Antarctic Sea-Ice Variability Response to Changes in Atmospheric and Oceanic Circulation." This project was undertaken during a 3-month research scholarship at the Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research, funded by the Helmholtz Visiting Researcher Grant, a program promoted by the Helmholtz Information and Data Science Academy (HIDA). Statistical methods pertain to the coupling of sea surface temperature and Antarctic sea-ice interactions. These methods can be applied to observations, reanalysis, and earth system model data</p>
Gridcell response to widespread afforestation using a Convection Permitting Model
<p>This folder contains gridcell absolute differences due to afforestation in:</p> <p>1. Evaporation<br> 2. Rainfall<br> 3. Runoff<br> 4. Overall Soil Moisture</p> <p>These are calculated for the overall period and for each season by calculating the difference between the afforestation and control land cover scenarios.</p> <p>There are also two maps which show the change in the topsoil moisture and the second layer below for summer.</p>
Characterization of the anti-spike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies
<p>Research on COVID-19 vaccination in immune-deficient/disordered people (IDP) has primarily focused on cancer and organ transplantation populations. In a prospective cohort of 195 IDP and 35 healthy volunteers, anti-spike IgG was detected in 88% of IDP post-dose 2, increasing to 93% by six months post-dose 3. Despite high seroconversion, median IgG levels for IDP never surpassed 1/3 that of healthy volunteers. IgG binding to Omicron BA.1 was lower than all other variants. Angiotensin-converting enzyme 2 pseudo-neutralization (% inhibition) was only modestly correlated with anti-spike IgG concentration. IgG levels were not significantly altered by participants' use of different mRNA-based vaccines, immunomodulating treatments, and prior SARS-CoV-2 infections. While our data show that three doses of COVID-19 vaccinations induce anti-spike IgG in most IDP, additional doses are needed to achieve the levels of protection in healthy volunteers. Due to the strikingly reduced IgG response to Omicron BA.1, the efficacy of additional vaccinations, including bivalent vaccines, should be studied in this population.</p>
Hydration and evaporative water loss of lizards change in response to temperature and humidity acclimation
<p>Data and code associated with the 2023 publication in the Journal of Experimental Biology (doi:10.1242/jeb.246459).</p>
Data for: European seabass show variable responses in their group swimming features after tag implantation
<p>Data for: European seabass show variable responses in their group swimming features after tag implantation</p><p>Please read the README.txt file before working with the data.</p>
BBC Maida Vale Impulse Response Dataset
<p>This repository presents a dataset of spatial impulse responses measured from the BBC Maida Vale Studios.</p><p>The measurements were undertaken in Summer/Autumn 2021 by researchers from the University of York, led by Prof Gavin Kearney and Prof Helena Daffern and team members of BBC R&D. </p><p>The measured studio live rooms presented here are studios MV4 and MV5.</p><p>The dataset for each room includes:</p><p>- Higher Order Ambisonic (3rd Order) spatial impulse responses for 3DOF/6DOF rendering.</p><p>- Reference KEMAR binaural measurements</p><p>- ISO-3382 measurements.</p><p>- Readme files for each room. </p><p> </p><p><strong>Important notes: </strong></p><p>- If you use this dataset, please cite the following paper in your work:</p><p>Kearney, G., Daffern, H., Cairns, P., Hunt, A., Lee, B., Cooper, J., Tsagkarakis, P., Rudzki, T. and Johnston, D., 2022, September. Measuring the Acoustical Properties of the BBC Maida Vale Recording Studios for Virtual Reality. In <i>Acoustics</i> (Vol. 4, No. 3, pp. 783-799). MDPI.</p><p>- Source orientations have been measured in the four cardinal directions (N, E, S, W) and impulse responses can be combined to simulate sources with first order directivity patterns. See paper above for further details. </p><p>- For 3DOF/6DOF measurements, Ambix config files are also included for quick audition of the IRs using an appropriate convolver (e.g. MCFX convolver http://www.matthiaskronlachner.com/?p=1910). </p><p>- The ISO measurements should not be used for auralisation.</p><p>- Measurements taken from the same source-receiver position should ideally not be used directly. If you wish to simulate the same source/receiver position for natural reverberation foldback, then the direct sound portion should be removed as the frequency reponse of this component will be imbalanced, and should be replaced with direct monitoring of a close miked source via your soundcard. </p><p>If you have any questions about the dataset, please contact gavin.kearney@york.ac.uk</p><p> </p><p> </p>
A Multicenter Study to Assess Response to Influenza Vaccine in Multiple Sclerosis Participants Treated With Ofatumumab
ClinicalTrials.gov study NCT04667117. IPD Sharing: YES. Countries: 1. Publications: 1.
Exploring the Immune Response to SARS-CoV-2 modRNA Vaccines in Patients With Secondary Progressive Multiple Sclerosis (AMA-VACC)
ClinicalTrials.gov study NCT04792567. IPD Sharing: YES. Countries: 1. Publications: 1.
Efficacy, Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy (ADT) in Patients With Major Depressive Disorder (MDD) Who Have Had an Inadequate Response to Anti
ClinicalTrials.gov study NCT03738215. IPD Sharing: YES. Countries: 7. Publications: 1.
Study of Power Doppler Ultrasound (PDUS) to Measure Response of Secukinumab Treatment in Patients With Active Psoriatic Arthritis (PsA)
ClinicalTrials.gov study NCT02662985. IPD Sharing: UNDECIDED. Countries: 17. Publications: 1.
Mechanistic Drivers of Acute PAPE Responsiveness: Muscle Architecture, Contractile Kinetics, and Excitability in a Randomized Controlled Trial
ClinicalTrials.gov study NCT06982937. IPD Sharing: NO. Countries: 1. Publications: 1.
EValuating trEatment RESponses of Dupilumab Versus Omalizumab in Type 2 Patients
ClinicalTrials.gov study NCT04998604. IPD Sharing: YES. Countries: 17. Publications: 2.
Evaluating the Response to Two Antiretroviral Medication Regimens in HIV-Infected Pregnant Women, Who Begin Antiretroviral Therapy Between 20 and 36 Weeks of Pregnancy, for the Prevention of Mother-to
ClinicalTrials.gov study NCT01618305. IPD Sharing: YES. Countries: 7. Publications: 1.
A Study Comparing Risankizumab to Placebo in Participants With Active Psoriatic Arthritis (PsA) Who Have a History of Inadequate Response to or Intolerance to at Least One Disease Modifying Anti-Rheum
ClinicalTrials.gov study NCT03675308. IPD Sharing: YES. Countries: 39. Publications: 9.
Physiology of GERD and Treatment Response
ClinicalTrials.gov study NCT04292470. IPD Sharing: NO. Countries: 1. Publications: 2.
Predictors of Response in Chronic Stroke
ClinicalTrials.gov study NCT04283253. IPD Sharing: YES. Countries: 1. Publications: 6.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.