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29,897 results for “activism”
Data for: Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques
<p>Recording and modulating neural activity <em>in vivo</em> enables investigations of the neurophysiology underlying behavior and disease, but there is a dearth of translational tools for simultaneous recording and localized receptor-specific modulation. We addressed this limitation by translating multifunctional fiber neurotechnology previously only available for rodent studies to enable cortical and subcortical neural recording and modulation in macaques. In the premotor cortex and putamen, we recorded single-neuron activity and local field potential oscillations during intracranial GABA infusions while a macaque performed a working memory task. We also recorded neuronal activity during saline, artificial cerebrospinal fluid, and no infusion control experiments. We characterized the dynamic effects of local infusions with multiple time series analysis techniques, including spectrotemporal analysis and state-space modeling. This dataset and accompanying software toolbox provide detailed insight into the electrophysiological effect of neurotransmitter receptor modulation in both cortical and subcortical structures in an awake macaque. </p>
Data from: Scn2a insufficiency alters spontaneous neuronal Ca2+ activity in somatosensory cortex during wakefulness
<p class="MsoNormal">SCN2A protein-truncating variants (PTV) can result in neurological disorders such as autism spectrum disorder and intellectual disability, but they are less likely to cause epilepsy in comparison to missense variants. While<em> <span>i</span>n vitro </em>studies showed PTV reduce action potential firing, consequences at <em>in vivo</em> network level remain elusive. Here, we generated a mouse model of Scn2a insufficiency using antisense oligonucleotides (Scn2a ASO mice), which recapitulated key clinical feature of SCN2A PTV disorders. Simultaneous two-photon <span>Ca<sup>2+</sup></span> imaging and electrocorticography (ECoG) in awake mice showed that spontaneous <span>Ca<sup>2+</sup></span> transients in somatosensory cortical neurons, as well as their pairwise co-activities were generally decreased in Scn2a ASO mice during spontaneous awake state and induced seizure state. The reduction of neuronal activities and paired co-activity are mechanisms associated with motor, social and cognitive deficits observed in our mouse model of severe Scn2a insufficiency, indicating these are likely mechanisms driving SCN2A PTV pathology.</p>
Libraries generated in: Using Machine Learning to Predict the Antibacterial Activity of Ruthenium Complexes
<p>Libraries generated in the manuscript: "<strong>Using Machine Learning to Predict the Antibacterial Activity of Ruthenium Complexes"</strong>. The libraries can be generated locally by running the code provided on <a href="https://github.com/TheFreiLab/RutheniumML">GitHub</a>, but are also provided here free to download.</p>
User preference optimization for control of ankle exoskeletons using sample efficient active learning
<p>A major challenge to the widespread success of augmentative exoskeletons is accurately adjusting the controller to provide cooperative assistance with their wearer. Often, the controller parameters are ``tuned'' to optimize a physiological or biomechanical objective. However, these approaches are resource-intensive, while typically only enabling optimization of a single objective. In reality, the exoskeleton user experience is derived from many factors, including comfort and stability, among others. This work introduces an approach to conveniently tune four parameters of the exoskeleton controller that maximize user preference. We use an evolutionary algorithm to recommend potential parameters, which are ranked by a neural network that is pre-trained with previously collected preference data. The controller parameters that have the highest preference ranking are provided to the exoskeleton, and the wearer provides feedback as forced-choice comparisons. Our approach was able to converge on controller parameters preferred by the wearer compared to randomized parameters with an accuracy of 88% on average. The result indicates that the proposed algorithm was able to identify users' preferences while requiring less than 50 queries to users. This work demonstrates user preference can be used to tune high-dimensional controller spaces easily and accurately, which shows the potential of translating lower-limb wearable technologies into our daily lives.</p>
Combining active and passive temperature signals for estimating sediment depths
<p>This dataset contains the results of the experimental campaign and how data were collected on the the <a href="https://co-udlabs.eu/">Co-UDlabs</a> Transnational Access project: <em>Characterization of thermal properties in sediment samples from urban drainage systems with temperature probes</em>, by Langeveld et al. The Transnational Access project was funded under the European Union’s Horizon 2020 research and innovation programme under grant agreement No 101008626.</p> <p>The experiments were designed to further develop an innovative methodology for measuring sediment bed deposits in UDS based on temperature data analysis (<a href="https://doi.org/10.5281/zenodo.7258998">Anta et al., 2022</a>; <a href="https://doi.org/10.1039/D2EW00820C">Regueiro-Picallo et al., 2023</a>). Particularly, the aim of these experiments was to prove the application of this methodology for measuring sewer sediment accumulation. Therefore, the main tasks of this project were the development of a system based on active temperature sensors and its application in the measurement of sediment thermal properties of UDS. Furthermore, this system included additional temperature sensors installed at different height locations to allow the estimation of the sediment depth. The purpose of these measurements is to deepen the understanding of sedimentation and sediment transport processes.</p> <p>The data are described so that others can use and reproduce.</p>
Code repository for: Base editing mutagenesis maps functional alleles to tune human T cell activity
<p>Jupyter notebook and supplemental datasets required to created critical figures for the publication.</p>
"The sound comes from a meadow in the Sierra Nevada Mountains in California. The meadow is at an elevation of 2400 meters near a mountain named Olancha Peak, which is 3700 meters in altitude. Ihave a group of friends with which Ibackpack (trek) into the mountains. Our goal was to spend some time in the mountains and hike to the top of Olancha Peak (…) By the time we reached the meadow, we were in a forest and there was still snow on the ground in some places. We took the trip in June of 2006. The Sierra Nevada Mountains are a large mountain range. Much of the range is protected by national parks or preserved areas we call 'wilderness areas' (…) Ihave been backpacking for nearly 40 years and Iwill hopefully continue with this challenging activity for 40 years more! Many of my friends are much younger than Iam and it gives me much satisfaction to be able to have as much or more stamina for this activity than they have! When we are on these trips, we hike up peaks, catch fish, drink some whiskey around campfires and enjoy our time in the beautiful solitude. My memories of this trip were of the steep, hot hike from the desert to the cool meadow; the overall beauty of the nature, the absolute solitude of our campsite near the meadow; the strenuous hike to the top of Olancha Peak; the camaraderie of my friends; and, of course the sound of the frogs in the meadow. The frog sounds were astounding to me and Iwould listen in awe of the creature's instinctual desire to reproduce and continue the existence of their kind. Surely there were different species in the meadow for some of the frog sounds were different than others. The sounds only occurred after the Sun went down for the evening. Istood next to the creek in the meadow and recorded the sounds using my digital camera." [Peter/plentz1960]16 in Collecting Sounds. Online Sharing of Field Recordings as Cultural Practice
"The sound comes from a meadow in the Sierra Nevada Mountains in California. The meadow is at an elevation of 2400 meters near a mountain named Olancha Peak, which is 3700 meters in altitude. Ihave a group of friends with which Ibackpack (trek) into the mountains. Our goal was to spend some time in the mountains and hike to the top of Olancha Peak (…) By the time we reached the meadow, we were in a forest and there was still snow on the ground in some places. We took the trip in June of 2006. The Sierra Nevada Mountains are a large mountain range. Much of the range is protected by national parks or preserved areas we call 'wilderness areas' (…) Ihave been backpacking for nearly 40 years and Iwill hopefully continue with this challenging activity for 40 years more! Many of my friends are much younger than Iam and it gives me much satisfaction to be able to have as much or more stamina for this activity than they have! When we are on these trips, we hike up peaks, catch fish, drink some whiskey around campfires and enjoy our time in the beautiful solitude. My memories of this trip were of the steep, hot hike from the desert to the cool meadow; the overall beauty of the nature, the absolute solitude of our campsite near the meadow; the strenuous hike to the top of Olancha Peak; the camaraderie of my friends; and, of course the sound of the frogs in the meadow. The frog sounds were astounding to me and Iwould listen in awe of the creature's instinctual desire to reproduce and continue the existence of their kind. Surely there were different species in the meadow for some of the frog sounds were different than others. The sounds only occurred after the Sun went down for the evening. Istood next to the creek in the meadow and recorded the sounds using my digital camera." [Peter/plentz1960]16
Lithospheric structure controls the sequentially active detachment faulting at the Longqi segment on the Southwest Indian Ridge
<p><strong>supplementary materials for "Lithospheric structure controls the sequentially active detachment faulting at the Longqi segment on the Southwest Indian Ridge"</strong></p>
Figure 6 in Seminiferous tubule number and surface: validation of objective parameters to estimate reproduction activity of male European anchovy (Engraulis encrasicolus, L.)
Figure 6. – Histological changes in testis development of Engraulis encrasicolus at the different reproductive maturity stages. A: Stage I, represented only by spermatogonia cells, inactive spermatogenesis, the number of the fields concerned in the biometric analysis N = 236. B: Stage II, active spermatogenesis with primary spermatogenium multiplication and tubular size increase, the number of the fields concerned in the biometric analysis N = 241. C: Stage III, active spermatogenesis, spermatozoa are concentrated in the light of the seminiferous tubules, the number of the fields concerned in the biometric analysis N = 125. D: Stage IV, spermiation, the number of the fields concerned in the biometric analysis N = 93. E: Stage V, seminiferous tubules are empty, spermatozoa are eliminated by release or resorption, the number of the fields concerned in the biometric analysis N = 988.
Figure 4 in Seminiferous tubule number and surface: validation of objective parameters to estimate reproduction activity of male European anchovy (Engraulis encrasicolus, L.)
Figure 4. – Mean values of the gonadosomatic index (GSI, represented in percentage) in Engraulis encrasicolus male collected in the Gulf of Bejaia from October 2007 to May 2008. Data are represented as Mean ± SEM. (values indicates the number of fishes).
Figure 1 in Seminiferous tubule number and surface: validation of objective parameters to estimate reproduction activity of male European anchovy (Engraulis encrasicolus, L.)
Figure 1. – Photomicrograph of male anchovy testicular tissue illustrating the seminiferous tubules in stage I.
Figure 4 in Comparison of feeding apparatus and feeding intensity of the European sardine (Sardina pilchardus) off Morocco in two Atlantic upwelling areas with different seasonal activity
Figure 4. – Box plots of mean gill raker number of young and adult of Sardina pilchardus in the Atlantic area B off Morocco.
Figure 3 in Comparison of feeding apparatus and feeding intensity of the European sardine (Sardina pilchardus) off Morocco in two Atlantic upwelling areas with different seasonal activity
Figure 3. –Monthly variation of fullness index of Sardina pilchardus from the areas B and C during 2003.
Composite activity type and stride-specific energy expenditure estimation model for thigh-worn accelerometry
<p>This repository contains code and data for the research project 'Estimation of activity induced energy expenditure using thigh-worn accelerometry and machine learning approaches'.</p> <ul> <li>The <strong>code </strong>subfolder contains Jupyter Notebooks and a Python file with helper functions. Further, the models subfolder contains the trained models.</li> <li>The <strong>data </strong>subfolder contains the raw accelerometer files (AX) as well as the raw data from the indirect calorimetry (CPET). Further, different processing files can be found here. The file log_master.csv contains the sociodemographic and timestamp data.</li> <li>The <strong>figures</strong> subfolder contains all relevant figures, which are created as part of running the Jupyter Notebooks. These figures are also part of the research publication.</li> </ul>
Study to Investigate the Clinical and Parasiticidal Activity and Pharmacokinetics of Different Doses of Artefenomel and Ferroquine in Patients With Uncomplicated Plasmodium Falciparum Malaria
ClinicalTrials.gov study NCT03660839. IPD Sharing: YES. Countries: 5. Publications: 1.
Study to Evaluate the Safety and Efficacy of Secukinumab 300 mg and 150 mg in Adult Patients With Active Psoriatic Arthritis (PsA) After 16 Weeks of Treatment Compared to Placebo
ClinicalTrials.gov study NCT02798211. IPD Sharing: UNDECIDED. Countries: 2. Publications: 1.
A Randomized, Double-Blind, Placebo Controlled, Two-Period Cross-Over, Proof of Activity Study to Evaluate the Effects of TAK-041 on Motivational Anhedonia as Add-On to Antipsychotics in Participants
ClinicalTrials.gov study NCT03319953. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Biologic Therapy
ClinicalTrials.gov study NCT03345836. IPD Sharing: YES. Countries: 48. Publications: 7.
Study of Power Doppler Ultrasound (PDUS) to Measure Response of Secukinumab Treatment in Patients With Active Psoriatic Arthritis (PsA)
ClinicalTrials.gov study NCT02662985. IPD Sharing: UNDECIDED. Countries: 17. Publications: 1.
Postmarketing Vedolizumab Milk-Only Lactation Study in Lactating Women With Active Ulcerative Colitis or Crohn's Disease
ClinicalTrials.gov study NCT02559713. IPD Sharing: YES. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.