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1,260
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Dataset results
1,260 results for “Pharmacology”
Transcriptomic profiling of human senescent cells in the setting of pharmacological intervention (NAD+ and NMN)
GEO Series GSE156038. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Pharmacological inhibition of the MAPK pathway ameliorates RIT1M90I-driven cardiac tissue hypertrophy.
GEO Series GSE207187. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
On target: Transcriptomic analysis of 12 human iPSC-derived cell phenotypes shows precision in an extensive pharmacological investigation [set 2]
GEO Series GSE295447. Homo sapiens. 840 samples. Type: Expression profiling by high throughput sequencing.
Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers [ATAC-seq]
GEO Series GSE241445. Homo sapiens. 42 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Targets of pharmacological histone deacetylase inhibition in human umbilical vein endothelial cells
GEO Series GSE5856. Homo sapiens. 6 samples. Type: Expression profiling by array.
Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers [PRO-seq]
GEO Series GSE241447. Homo sapiens. 8 samples. Type: Other.
Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers [ChIP-seq]
GEO Series GSE241446. Homo sapiens. 11 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Novel human full-thickness three-dimensional non-keratinized mucous membrane model for pharmacological studies in wound healing
GEO Series GSE119035. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Pharmacologic Inhibition of Epigenetic Modification Reveals Targets of Aberrant Promoter Methylation in Ewing Sarcoma
GEO Series GSE44934. Homo sapiens. 22 samples. Type: Expression profiling by array.
Transcriptome sequencing of HepG2 cells upon treatment of Butyrolactone I (PQY09) or derivatives (PQY23_1) butenolide compounds for exploring the targets of PQYs to further study the pharmacological a
GEO Series GSE200538. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers [RNA-seq]
GEO Series GSE241448. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
Human Sarcopenic Myoblasts Can Be Rescued by Pharmacological Reactivation of HIF-1α
<p>Cirillo F, Mangiavini L, La Rocca P, Piccoli M, Ghiroldi A, Rota P, Tarantino A, Canciani B, Coviello S, Messina C, Ciconte G, Pappone C, Peretti GM, Anastasia L. Human Sarcopenic Myoblasts Can Be Rescued by Pharmacological Reactivation of HIF-1α. Int J Mol Sci. 2022 Jun 26;23(13):7114. doi: 10.3390/ijms23137114. PMID: 35806119; PMCID: PMC9267002.</p> <p>Abstract</p> <p>Sarcopenia, an age-related decline in muscle mass and strength, is associated with metabolic disease and increased risk of cardiovascular morbidity and mortality. It is associated with decreased tissue vascularization and muscle atrophy. In this work, we investigated the role of the hypoxia inducible factor HIF-1α in sarcopenia. To this end, we obtained skeletal muscle biopsies from elderly sarcopenic patients and compared them with those from young individuals. We found a decrease in the expression of HIF-1α and its target genes in sarcopenia, as well as of <em>PAX7</em>, the major stem cell marker of satellite cells, whereas the atrophy marker MURF1 was increased. We also isolated satellite cells from muscle biopsies and cultured them in vitro. We found that a pharmacological activation of HIF-1α and its target genes caused a reduction in skeletal muscle atrophy and activation of <em>PAX7</em> gene expression. In conclusion, in this work we found that HIF-1α plays a role in sarcopenia and is involved in satellite cell homeostasis. These results support further studies to test whether pharmacological reactivation of HIF-1α could prevent and counteract sarcopenia.</p> <p> </p>
Dataset for the project "LRRK2 as a novel pharmacological target for treatment of neurodegenerative diseases" (GR-2016-02362548)
<p>Dataset for the project "LRRK2 as a novel pharmacological target for treatment of neurodegenerative diseases" (GR-2016-02362548).</p> <p><strong>Aim 1:</strong></p> <p>Understanding whether LRRK2 mediates neuroinflammation triggered by PD and AD misfolded proteins using in vitro and in vivo models.</p> <p><strong>Aim 2:</strong></p> <p>Exploring whether and how LRRK2-related neuroinflammation affects hiPSC-derived neuronal function.</p> <p><strong>Aim 3:</strong></p> <p>Exploring whether hiPSC-derived neurons carrying LRRK2 mutation/variant are more vulnerable to neuroinflammation.</p> <p> </p> <p>The present dataset contains the following folders:</p> <p><strong>1- Aim 1</strong></p> <p>- In vitro</p> <p> - Attivazione infiammazione</p> <p> - Generazione proteina amiloide</p> <p> - LRRK2 infiammazione</p> <p>- In vivo</p> <p> - Generazione proteina amiloidi</p> <p> - Infiammazione abeta</p> <p> - Infiammazione asyn</p> <p> - Microglia-Astrociti abeta</p> <p> - Microglia-Astrociti asyn </p> <p> </p> <p><strong>2- Aim 2</strong></p> <p>- hiPSC Col RNASeq</p> <p>- hiPSC DA RNASEq</p> <p>- Neuroni colinergici</p> <p>- Neuroni dopaminergici</p> <p> </p> <p><strong>3- Aim 3</strong></p> <p>- Gentotyping human cells</p>
Effects of TREM-1 pharmacological blockade within aortas of apoE KO mice
GEO Series GSE161216. Mus musculus. 4 samples. Type: Expression profiling by RT-PCR.
Starving advanced prostate cancer cells by pharmacological gluose deprivation with a resveratrol trimer trans-Gnetin H
GEO Series GSE240104. Homo sapiens; Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
Pharmacological inhibition of lipid import and transport proteins in ovarian cancer
GEO Series GSE212702. Homo sapiens. 84 samples. Type: Expression profiling by high throughput sequencing.
Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma
GEO Series GSE223011. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Systems pharmacology dissection of cell specific cholesterol regulation mechanisms
<p>Documentation of codes used for modeling cholesterol regulation in the manuscript "Systems pharmacology dissection of cell specific cholesterol regulation mechanisms"</p>
Network pharmacology to reveal the molecular mechanisms of rutaceous plant-derived limonin ameliorating non-alcoholic steatohepatitis
<p>raw data of Network pharmacology to reveal the molecular mechanisms of rutaceous plant-derived limonin ameliorating non-alcoholic steatohepatitis</p>
Treatment of adults with sleep apnea: a systematic review of randomized non-pharmacological trials with network meta-analysis
<p>Dataset for analyses and additional data</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.